Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

Toxicological Sciences - Tập 111 Số 2 - Trang 238-246 - 2009
Ronnie L. Yeager1, Scott A. Reisman1, Lauren M. Aleksunes1, Curtis D. Klaassen1
1Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160

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2008, Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice, Toxicol. Sci., 101, 51, 10.1093/toxsci/kfm280

2003, Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: Evidence for a contribution of the aryl hydrocarbon receptor pathway, Mol. Pharmacol., 63, 119, 10.1124/mol.63.1.119

2005, Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-mediated hepatotoxicity, Toxicol. Sci., 85, 1048, 10.1093/toxsci/kfi162

2009, Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of AhR, CAR, PXR, PPAR{alpha}, and Nrf2, Drug Metab. Dispos., 37, 847

1996, NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development, Proc. Natl. Acad. Sci. U.S.A., 93, 13943, 10.1073/pnas.93.24.13943

2005, Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways, Drug Metab. Dispos., 33, 1276, 10.1124/dmd.105.003988

2000, Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery, Biochem. Biophys. Res. Commun., 267, 184, 10.1006/bbrc.1999.1913

2007, In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers, Mol. Pharmacol., 72, 1419, 10.1124/mol.107.040238

2008, Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse, Mol. Pharmacol., 73, 1844, 10.1124/mol.108.045658

1995, The aryl hydrocarbon receptor complex, Annu. Rev. Pharmacol. Toxicol., 35, 307, 10.1146/annurev.pa.35.040195.001515

2005, Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor, Arch. Biochem. Biophys., 433, 379, 10.1016/j.abb.2004.09.031

1997, An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements, Biochem. Biophys. Res. Commun., 236, 313, 10.1006/bbrc.1997.6943

1988, Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16, J. Biol. Chem., 263, 13572

2008, Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers, Toxicol. Sci., 106, 329, 10.1093/toxsci/kfn179

2007, Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2, Biochem. Pharmacol., 73, 1853, 10.1016/j.bcp.2007.01.009

2009, Molecular mechanisms of Nrf2-mediated antioxidant response, Mol. Carcinog., 48, 91, 10.1002/mc.20465

2004, Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap ‘n’ collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): Cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction, Biochem. J., 377, 205, 10.1042/bj20031123

2004, Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity, Mol. Pharmacol., 65, 1029, 10.1124/mol.65.4.1029

2005, Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: Direct cross-talk between phase I and II drug-metabolizing enzymes, J. Biol. Chem., 280, 20340, 10.1074/jbc.M412081200

1993, Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction, Ann. N. Y. Acad. Sci., 685, 624, 10.1111/j.1749-6632.1993.tb35928.x

2000, Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis, Biochem. Pharmacol., 59, 65, 10.1016/S0006-2952(99)00310-X

2004, Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors, Mutat. Res., 555, 149, 10.1016/j.mrfmmm.2004.05.023

2003, Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse, Biochem. Biophys. Res. Commun., 303, 105, 10.1016/S0006-291X(03)00306-1

1982, Binding of 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin to a common Ah receptor site in mouse and rat hepatic cytosols, Eur. J. Biochem., 127, 39, 10.1111/j.1432-1033.1982.tb06834.x

2007, Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport, Drug Metab. Dispos., 35, 1806, 10.1124/dmd.107.015974

1974, Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene, Mol. Pharmacol., 10, 349

1976, Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase, J. Biol. Chem., 251, 4936

1982, 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity, Annu. Rev. Pharmacol. Toxicol., 22, 517, 10.1146/annurev.pa.22.040182.002505

1989, Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor, Mol. Pharmacol., 36, 121

1988, Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver, Cancer Res., 48, 4776

1999, Antioxidant response element-mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induction of human NAD(P)H:quinone oxidoreductase 1 gene expression, Biochem. Pharmacol., 58, 1649, 10.1016/S0006-2952(99)00245-2

2001, Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice, Proc. Natl. Acad. Sci. U.S.A., 98, 3410, 10.1073/pnas.051618798

2009, Increased Nrf2 activation in livers from keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species, Toxicol. Sci., 108, 35, 10.1093/toxsci/kfn267

1996, Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development, Proc. Natl. Acad. Sci. U.S.A., 93, 6731, 10.1073/pnas.93.13.6731

2002, Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor, Free Radic. Biol. Med., 33, 1268, 10.1016/S0891-5849(02)01014-6

1991, Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated hepatotoxicity in C57BL/6J and DBA/2J mice, J. Toxicol. Environ. Health, 32, 367, 10.1080/15287399109531491

2006, TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone, Toxicol. Appl. Pharmacol., 217, 363, 10.1016/j.taap.2006.09.014

1998, Dioxin causes a sustained oxidative stress response in the mouse, Biochem. Biophys. Res. Commun., 253, 44, 10.1006/bbrc.1998.9753

2002, Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray, Cancer Res., 62, 5196

2006, Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries, Mol. Pharmacol., 69, 140, 10.1124/mol.105.018705

1996, Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene, Proc. Natl. Acad. Sci. U.S.A., 93, 14960, 10.1073/pnas.93.25.14960

1995, Correlation between toxicity and effects on intermediary metabolism in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated male C57BL/6J and DBA/2J mice, Toxicol. Appl. Pharmacol., 131, 155, 10.1006/taap.1995.1057

1990, Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action, Annu. Rev. Pharmacol. Toxicol., 30, 251, 10.1146/annurev.pa.30.040190.001343

2008, Differences in gene expression and benzo[a]pyrene-induced DNA adduct formation in the liver of three strains of female mice with identical AhRb2 genotype treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and/or benzo[a]pyrene, J. Appl. Toxicol., 28, 724, 10.1002/jat.1331

1992, A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure, Proc. Natl. Acad. Sci. U.S.A., 89, 2399, 10.1073/pnas.89.6.2399