Intrinsic disorder in scaffold proteins: Getting more from less
Tài liệu tham khảo
Albert, 2000, Error and attack tolerance of complex networks, Nature, 406, 378, 10.1038/35019019
Andrade, 1995, HEAT repeats in the Huntington's disease protein, Nat. Genet., 11, 115, 10.1038/ng1095-115
Andrade, 2001, Protein repeats: structures, functions, and evolution, J. Struct. Biol., 134, 117, 10.1006/jsbi.2001.4392
Aoki, 1985, Ontogenetic changes in the cyclic adenosine 3′,5′-monophosphate-stimulatable phosphorylation of cat visual cortex proteins, particularly of microtubule-associated protein 2 (MAP 2): effects of normal and dark rearing and of the exposure to light, J. Neurosci., 5, 2465, 10.1523/JNEUROSCI.05-09-02465.1985
Avalos, 2002, Structure of a Sir2 enzyme bound to an acetylated p53 peptide, Mol. Cells, 10, 523, 10.1016/S1097-2765(02)00628-7
Bang, 2001, The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system, Circ. Res., 89, 1065, 10.1161/hh2301.100981
Bar, 1969, Adenyl cyclase and hormone action. I. Effects of adrenocorticotropic hormone, glucagon, and epinephrine on the plasma membrane of rat fat cells, Proc. Natl. Acad. Sci. U.S.A., 63, 350, 10.1073/pnas.63.2.350
Bax, 2001, The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation, Structure (Camb.), 9, 1143, 10.1016/S0969-2126(01)00679-7
Berg, 1990, The influence of macromolecular crowding on thermodynamic activity: solubility and dimerization constants for spherical and dumbbell-shaped molecules in a hard-sphere mixture, Biopolymers, 30, 1027, 10.1002/bip.360301104
Bhattacharyya, 2006, The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway, Science, 311, 10.1126/science.1120941
Bienkiewicz, 2002, Functional consequences of preorganized helical structure in the intrinsically disordered cell-cycle inhibitor p27(Kip1), Biochemistry, 41, 752, 10.1021/bi015763t
Bordoli, 2007, Assessment of disorder predictions in CASP7, Proteins, 69, 129, 10.1002/prot.21671
Bourhis, 2004, The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner, Virus. Res., 99, 157, 10.1016/j.virusres.2003.11.007
Brenman, 1996, Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains, Cell, 84, 757, 10.1016/S0092-8674(00)81053-3
Brenman, 1996, Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein, J. Neurosci., 16, 7407, 10.1523/JNEUROSCI.16-23-07407.1996
Brown, 2002, Evolutionary rate heterogeneity in proteins with long disordered regions, J. Mol. Evol., 55, 104, 10.1007/s00239-001-2309-6
Brzovic, 2003, Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex, Proc. Natl. Acad. Sci. U.S.A., 100, 5646, 10.1073/pnas.0836054100
Burack, 2000, Signal transduction: hanging on a scaffold, Curr. Opin. Cell. Biol., 12, 211, 10.1016/S0955-0674(99)00078-2
Burns-Hamuro, 2005, Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange, Protein Sci., 14, 2982, 10.1110/ps.051687305
Bussell, 2001, Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein, J. Biol. Chem., 276, 45996, 10.1074/jbc.M106777200
Bustos, 2006, Intrinsic disorder is a key characteristic in partners that bind 14-3-3 proteins, Proteins, 63, 35, 10.1002/prot.20888
Caffrey, 1999, The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades, J. Mol. Evol., 49, 567, 10.1007/PL00006578
Callaghan, 2004, Studies of the RNA degradosome-organizing domain of the Escherichia coli ribonuclease RNase E, J. Mol. Biol., 340, 965, 10.1016/j.jmb.2004.05.046
Callaghan, 2003, Quaternary structure and catalytic activity of the Escherichia coli ribonuclease E amino-terminal catalytic domain, Biochemistry, 42, 13848, 10.1021/bi0351099
Callebaut, 1997, Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives, Cell. Mol. Life Sci., 53, 621, 10.1007/s000180050082
Campen, A., Williams, R.M., Brown, C.J., Uversky, V.N., Dunker, A.K., in press. TOP-ID: a new amino acid scale measuring propensity for intrinsic disorder. Protein Pept. Lett. 15.
Carpousis, 2002, The Escherichia coli RNA degradosome: structure, function and relationship in other ribonucleolytic multienzyme complexes, Biochem. Soc. Trans., 30, 150, 10.1042/bst0300150
Chen, 1998, Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells, Mol. Cells, 2, 317, 10.1016/S1097-2765(00)80276-2
Chen, 2006, Primary structure-based function characterization of BRCT domain replicates in BRCA1, Biochem. Biophys. Res. Commun., 345, 188, 10.1016/j.bbrc.2006.03.239
Cheng, 2006, Abundance of intrinsic disorder in protein associated with cardiovascular disease, Biochemistry, 45, 10448, 10.1021/bi060981d
Cheng, 2006, Rational drug design via intrinsically disordered protein, Trends Biotechnol., 24, 435, 10.1016/j.tibtech.2006.07.005
Cheng, 2007, Mining alpha-helix-forming molecular recognition features with cross species sequence alignments, Biochemistry, 46, 13468, 10.1021/bi7012273
Choi, 1994, Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae, Cell, 78, 499, 10.1016/0092-8674(94)90427-8
Clapperton, 2004, Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer, Nat. Struct. Mol. Biol., 11, 512, 10.1038/nsmb775
Cobb, 1999, MAP kinase pathways, Prog. Biophys. Mol. Biol., 71, 479, 10.1016/S0079-6107(98)00056-X
Coghlan, 1995, Association of protein kinase A and protein phosphatase 2B with a common anchoring protein, Science, 267, 108, 10.1126/science.7528941
Colledge, 1999, AKAPs: from structure to function, Trends Cell Biol., 9, 216, 10.1016/S0962-8924(99)01558-5
Connolly, 1983, Solvent-accessible surfaces of proteins and nucleic acids, Science, 221, 709, 10.1126/science.6879170
Cossins, 1991, Cell physiology. A sense of cell size, Nature, 352, 667, 10.1038/352667a0
D'Orazi, 2002, Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis, Nat. Cell Biol., 4, 11, 10.1038/ncb714
Dajani, 2003, Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex, EMBO J., 22, 494, 10.1093/emboj/cdg068
Daughdrill, 1997, The C-terminal half of the anti-sigma factor, FlgM, becomes structured when bound to its target, sigma 28, Nat. Struct. Biol., 4, 285, 10.1038/nsb0497-285
Daughdrill, 1998, The C-terminal half of the anti-sigma factor FlgM contains a dynamic equilibrium solution structure favoring helical conformations, Biochemistry, 37, 1076, 10.1021/bi971952t
Daughdrill, 2007, Dynamic behavior of an intrinsically unstructured linker domain is conserved in the face of negligible amino acid sequence conservation, J. Mol. Evol., 65, 277, 10.1007/s00239-007-9011-2
Daughdrill, 2005, Natively Disordered Proteins, 271
Davis-Searles, 1998, Sugar-induced molten-globule model, Biochemistry, 37, 17048, 10.1021/bi981364v
Dedmon, 2002, FlgM gains structure in living cells, Proc. Natl. Acad. Sci. U.S.A., 99, 12681, 10.1073/pnas.202331299
Deng, 2006, BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution, Nucleic Acids Res., 34, 1416, 10.1093/nar/gkl010
Denning, 2003, Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded, Proc. Natl. Acad. Sci. U.S.A., 100, 2450, 10.1073/pnas.0437902100
Denning, 2007, Rapid evolution exposes the boundaries of domain structure and function in natively unfolded FG nucleoporins, Mol. Cell Proteomics, 6, 272, 10.1074/mcp.M600309-MCP200
Dhanasekaran, 2007, Scaffold proteins of MAP-kinase modules, Oncogene, 26, 3185, 10.1038/sj.onc.1210411
Dosztanyi, 2006, Disorder and sequence repeats in hub proteins and their implications for network evolution, J. Proteome Res., 5, 2985, 10.1021/pr060171o
Dosztanyi, 2005, The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins, J. Mol. Biol., 347, 827, 10.1016/j.jmb.2005.01.071
Duan, 2006, Studies on titin PEVK peptides and their interaction, Arch. Biochem. Biophys., 454, 16, 10.1016/j.abb.2006.07.017
Dunker, 2002, Intrinsic disorder and protein function, Biochemistry, 41, 6573, 10.1021/bi012159+
Dunker, 2002, Identification and functions of usefully disordered proteins, Adv. Protein Chem., 62, 25, 10.1016/S0065-3233(02)62004-2
Dunker, 2005, Flexible nets. The roles of intrinsic disorder in protein interaction networks, FEBS J., 272, 5129, 10.1111/j.1742-4658.2005.04948.x
Dunker, 1998, Protein disorder and the evolution of molecular recognition: theory, predictions and observations, Pac. Symp. Biocomput., 473
Dunker, 2001, Intrinsically disordered protein, J. Mol. Graph. Model., 19, 26, 10.1016/S1093-3263(00)00138-8
Dunker, 2001, The protein trinity-linking function and disorder, Nat. Biotechnol., 19, 805, 10.1038/nbt0901-805
Dunker, 2000, Intrinsic protein disorder in complete genomes, Genome Inform. Ser. Workshop Genome Inform., 11, 161
Dyson, 2002, Coupling of folding and binding for unstructured proteins, Curr. Opin. Struct. Biol., 12, 54, 10.1016/S0959-440X(02)00289-0
Dyson, 2005, Intrinsically unstructured proteins and their functions, Nat. Rev. Mol. Cell Biol., 6, 197, 10.1038/nrm1589
Edwards, 2000, A-kinase anchoring proteins: protein kinase A and beyond, Curr. Opin. Cell Biol., 12, 217, 10.1016/S0955-0674(99)00085-X
Ekman, 2006, What properties characterize the hub proteins of the protein–protein interaction network of Saccharomyces cerevisiae?, Genome Biol., 7, R45, 10.1186/gb-2006-7-6-r45
Elion, 1998, Routing MAP kinase cascades, Science, 281, 1625, 10.1126/science.281.5383.1625
Elion, 2001, The Ste5p scaffold, J. Cell Sci., 114, 3967, 10.1242/jcs.114.22.3967
Elion, 2005, Signal transduction. Signaling specificity in yeast, Science, 307, 687, 10.1126/science.1109500
Erickson, 1997, Stretching single protein molecules: titin is a weird spring, Science, 276, 1090, 10.1126/science.276.5315.1090
Evans, 2002, Endocytosis and vesicle trafficking, Curr. Opin. Struct. Biol., 12, 814, 10.1016/S0959-440X(02)00395-0
Feng, 1994, Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions, Science, 266, 1241, 10.1126/science.7526465
Fink, 2005, Natively unfolded proteins, Curr. Opin. Struct. Biol., 15, 35, 10.1016/j.sbi.2005.01.002
Fischer, 1991, Calpain-mediated proteolysis of microtubule associated proteins MAP1B and MAP2 in developing brain, Neurochem. Res., 16, 891, 10.1007/BF00965538
Flaugh, 2001, Effects of macromolecular crowding on the intrinsically disordered proteins c-Fos and p27(Kip1), Biomacromolecules, 2, 538, 10.1021/bm015502z
Foray, 2003, A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein, EMBO J., 22, 2860, 10.1093/emboj/cdg274
Friedrich, 1990, Protein structure: the primary substrate for memory, Neuroscience, 35, 1, 10.1016/0306-4522(90)90115-K
Friedrich, 1991, MAP2: a sensitive cross-linker and adjustable spacer in dendritic architecture, FEBS Lett., 295, 5, 10.1016/0014-5793(91)81371-E
Fulton, 1982, How crowded is the cytoplasm?, Cell, 30, 345, 10.1016/0092-8674(82)90231-8
Furuhashi, 2001, Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway, Mol. Cell Biol., 21, 5132, 10.1128/MCB.21.15.5132-5141.2001
Fuxreiter, 2004, Preformed structural elements feature in partner recognition by intrinsically unstructured proteins, J. Mol. Biol., 338, 1015, 10.1016/j.jmb.2004.03.017
Gaiser, 2004, Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1, Biochemistry, 43, 15983, 10.1021/bi049550q
Garner, 1999, Predicting binding regions within disordered proteins, Genome Inform. Ser. Workshop Genome Inform., 10, 41
Gisler, 2003, PDZK1: II. An anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells, Kidney Int., 64, 1746, 10.1046/j.1523-1755.2003.00267.x
Gisler, 2003, PDZK1: I. A major scaffolder in brush borders of proximal tubular cells, Kidney Int., 64, 1733, 10.1046/j.1523-1755.2003.00266.x
Gisler, 2001, Interaction of the type IIa Na/Pi cotransporter with PDZ proteins, J. Biol. Chem., 276, 9206, 10.1074/jbc.M008745200
Goh, 2002, Classification of scale-free networks, Proc. Natl. Acad. Sci. U.S.A., 99, 12583, 10.1073/pnas.202301299
Gold, 2006, Lining the pockets of kinases and phosphatases, Curr. Opin. Struct. Biol., 16, 693, 10.1016/j.sbi.2006.10.006
Groves, 1999, Topological characteristics of helical repeat proteins, Curr. Opin. Struct. Biol., 9, 383, 10.1016/S0959-440X(99)80052-9
Gunasekaran, 2003, Extended disordered proteins: targeting function with less scaffold, Trends Biochem. Sci., 28, 81, 10.1016/S0968-0004(03)00003-3
Gunasekaran, 2004, Analysis of ordered and disordered protein complexes reveals structural features discriminating between stable and unstable monomers, J. Mol. Biol., 341, 1327, 10.1016/j.jmb.2004.07.002
Gustin, 1998, MAP kinase pathways in the yeast Saccharomyces cerevisiae, Microbiol. Mol. Biol. Rev., 62, 1264, 10.1128/MMBR.62.4.1264-1300.1998
Halpain, 1990, Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2, Neuron, 5, 237, 10.1016/0896-6273(90)90161-8
Hamuro, 2002, Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS), J. Mol. Biol., 321, 703, 10.1016/S0022-2836(02)00419-9
Harrison, 2006, Surviving the breakup: the DNA damage checkpoint, Annu. Rev. Genet., 10.1146/annurev.genet.40.051206.105231
Hart, 1998, Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta, Curr. Biol., 8, 573, 10.1016/S0960-9822(98)70226-X
Hausken, 1994, Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5, J. Biol. Chem., 269, 24245, 10.1016/S0021-9258(19)51074-2
Haynes, 2006, Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes, PLoS Comput. Biol., 2, e100, 10.1371/journal.pcbi.0020100
Hernandez, 1986, Physicochemical characterization of the heat-stable microtubule-associated protein MAP2, Eur. J. Biochem., 154, 41, 10.1111/j.1432-1033.1986.tb09356.x
Higurashi, 2008, Identification of transient hub proteins and the possible structural basis for their multiple interactions, Protein Sci., 17, 72, 10.1110/ps.073196308
Hofmann, 2002, Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2, Nat. Cell. Biol., 4, 1, 10.1038/ncb715
Hohenstein, 2003, BRCA1: a scaffold for p53 response?, Trends Genet., 19, 489, 10.1016/S0168-9525(03)00193-8
Hollenbeck, 2002, The role of helix stabilizing residues in GCN4 basic region folding and DNA binding, Protein Sci., 11, 2740, 10.1110/ps.0211102
Holt, 1993, Caseins as rheomorphic proteins: interpretation of primary and secondary structures of the αs1-, β-, and κ-caseins, J. Chem. Soc., Faraday Trans., 89, 2683, 10.1039/FT9938902683
Hoshi, 1990, Biophysical and molecular mechanisms of Shaker potassium channel inactivation, Science, 250, 533, 10.1126/science.2122519
Hoshijima, 2006, Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures, Am. J. Physiol. Heart Circ. Physiol., 290, H1313, 10.1152/ajpheart.00816.2005
Hua, 1998, Transcriptional activator-coactivator recognition: nascent folding of a kinase-inducible transactivation domain predicts its structure on coactivator binding, Biochemistry, 37, 5858, 10.1021/bi9800808
Huang, 1997, D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain, Proc. Natl. Acad. Sci. U.S.A., 94, 11184, 10.1073/pnas.94.21.11184
Hung, 2002, PDZ domains: structural modules for protein complex assembly, J. Biol. Chem., 277, 5699, 10.1074/jbc.R100065200
Hurley, 2007, Structural basis for regulation of protein phosphatase 1 by inhibitor-2, J. Biol. Chem., 282, 28874, 10.1074/jbc.M703472200
Huttley, 2000, Adaptive evolution of the tumour suppressor BRCA1 in humans and chimpanzees. Australian breast cancer family study, Nat. Genet., 25, 410, 10.1038/78092
Iakoucheva, 2002, Intrinsic disorder in cell-signaling and cancer-associated proteins, J. Mol. Biol., 323, 573, 10.1016/S0022-2836(02)00969-5
Iakoucheva, 2001, Aberrant mobility phenomena of the DNA repair protein XPA, Protein Sci., 10, 1353, 10.1110/ps.40101
Jaffe, 2004, Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways, Mol. Cell. Biol., 24, 1736, 10.1128/MCB.24.4.1736-1746.2004
Jakab, 2002, Mechanisms sensing and modulating signals arising from cell swelling, Cell. Physiol. Biochem., 12, 235, 10.1159/000067895
Jensen, 1998, BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression, Oncogene, 16, 1097, 10.1038/sj.onc.1201861
Jeong, 2001, Lethality and centrality in protein networks, Nature, 411, 41, 10.1038/35075138
Jones, 2003, Prediction of disordered regions in proteins from position specific score matrices, Proteins, 53, 573, 10.1002/prot.10528
Jones, 1997, Analysis of protein-protein interaction sites using surface patches, J. Mol. Biol., 272, 121, 10.1006/jmbi.1997.1234
Karush, 1950, Heterogeneity of the binding sites of bovine serum albumin, J. Am. Chem. Soc., 72, 2705, 10.1021/ja01162a099
Kerrien, 2007, IntAct–open source resource for molecular interaction data, Nucleic Acids Res., 35, D561, 10.1093/nar/gkl958
Kim, 1995, Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases, Nature, 378, 85, 10.1038/378085a0
Kim, 2004, PDZ domain proteins of synapses, Nat. Rev., 5, 771, 10.1038/nrn1517
Kim, 2008, The role of disorder in interaction networks: a structural analysis, Mol. Syst. Biol., 4, 179, 10.1038/msb.2008.16
Kinderman, 2006, A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase, Mol. Cells, 24, 397, 10.1016/j.molcel.2006.09.015
Klauck, 1996, Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein, Science, 271, 1589, 10.1126/science.271.5255.1589
Kriwacki, 1996, Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity, Proc. Natl. Acad. Sci. U.S.A., 93, 11504, 10.1073/pnas.93.21.11504
Kroeze, 2003, G-protein-coupled receptors at a glance, J. Cell. Sci., 116, 4867, 10.1242/jcs.00902
Kussie, 1996, Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain, Science, 274, 948, 10.1126/science.274.5289.948
Lacy, 2004, p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding, Nat. Struct. Mol. Biol., 11, 358, 10.1038/nsmb746
Lee, 2000, Local structural elements in the mostly unstructured transcriptional activation domain of human p53, J. Biol. Chem., 275, 29426, 10.1074/jbc.M003107200
Leterrier, 1982, Interactions between neurofilaments and microtubule-associated proteins: a possible mechanism for intraorganellar bridging, J. Cell Biol., 95, 982, 10.1083/jcb.95.3.982
Lewis, 1988, Microtubule-associated protein MAP2 shares a microtubule binding motif with tau protein, Science, 242, 936, 10.1126/science.3142041
Li, 2004, A map of the interactome network of the metazoan C. elegans, Science, 303, 540, 10.1126/science.1091403
Li, 1999, Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage, J. Biol. Chem., 274, 11334, 10.1074/jbc.274.16.11334
Li, 1999, Predicting protein disorder for N-, C-, and internal regions, Genome Inform. Ser. Workshop Genome Inform., 10, 30
Li, 1995, Mutagenesis of the regulatory subunit (RII beta) of cAMP-dependent protein kinase II beta reveals hydrophobic amino acids that are essential for RII beta dimerization and/or anchoring RII beta to the cytoskeleton, J. Biol. Chem., 270, 1935, 10.1074/jbc.270.4.1935
Lim, 2000, Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein, J. Biol. Chem., 275, 20578, 10.1074/jbc.M001887200
Linding, 2003, Protein disorder prediction: implications for structural proteomics, Structure (Camb.), 11, 1453, 10.1016/j.str.2003.10.002
Linding, 2003, GlobPlot: exploring protein sequences for globularity and disorder, Nucleic Acids Res., 31, 3701, 10.1093/nar/gkg519
Litman, 2005, BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ, Cancer Cell, 8, 255, 10.1016/j.ccr.2005.08.004
Liu, 2003, NORSp: predictions of long regions without regular secondary structure, Nucleic Acids Res., 31, 3833, 10.1093/nar/gkg515
Liu, 2002, Loopy proteins appear conserved in evolution, J. Mol. Biol., 322, 53, 10.1016/S0022-2836(02)00736-2
Liu, 2006, Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia, EMBO J., 25, 1646, 10.1038/sj.emboj.7601057
Long, 2005, Crystal structure of a mammalian voltage-dependent Shaker family K+ channel, Science, 309, 897, 10.1126/science.1116269
Lowe, 2002, Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A, Biochemistry, 41, 15625, 10.1021/bi0268910
Luby-Phelps, 2000, Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area, Int. Rev. Cytol., 192, 189, 10.1016/S0074-7696(08)60527-6
Luo, 2004, Axin: a master scaffold for multiple signaling pathways, Neurosignals, 13, 99, 10.1159/000076563
Luo, 2003, Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation, J. Biol. Chem., 278, 37451, 10.1074/jbc.M305277200
Luo, 2005, Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions, J. Biol. Chem., 280, 5054, 10.1074/jbc.M412340200
Ma, 2006, Titin as a giant scaffold for integrating stress and SH3-mediated signaling pathways: the clustering of novel overlap ligand motifs in the elastic PEVK segment, J. Biol. Chem., 10.1074/jbc.M604525200
Ma, 2002, Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin, FEBS Lett., 532, 273, 10.1016/S0014-5793(02)03655-4
Magidovich, 2006, Intrinsically disordered C-terminal segments of voltage-activated potassium channels: a possible fishing rod-like mechanism for channel binding to scaffold proteins, Bioinformatics, 10.1093/bioinformatics/btl137
Magidovich, 2007, Intrinsic disorder in the C-terminal domain of the Shaker voltage-activated K+ channel modulates its interaction with scaffold proteins, Proc. Natl. Acad. Sci. U.S.A., 104, 13022, 10.1073/pnas.0704059104
Main, 2003, The folding and design of repeat proteins: reaching a consensus, Curr. Opin. Struct. Biol., 13, 482, 10.1016/S0959-440X(03)00105-2
Malbon, 2004, AKAP (A-kinase anchoring protein) domains: beads of structure-function on the necklace of G-protein signalling, Biochem. Soc. Trans., 32, 861, 10.1042/BST0320861
Malbon, 2004, AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes, Biochem. J., 379, 1, 10.1042/bj20031648
Marcotte, 1999, A census of protein repeats, J. Mol. Biol., 293, 151, 10.1006/jmbi.1999.3136
Marcus, 1994, Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module, Proc. Natl. Acad. Sci. U.S.A., 91, 7762, 10.1073/pnas.91.16.7762
Marinissen, 2005, Scaffold proteins dictate Rho GTPase-signaling specificity, Trends Biochem. Sci., 30, 423, 10.1016/j.tibs.2005.06.006
Mark, 2005, Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?, J. Mol. Biol., 345, 275, 10.1016/j.jmb.2004.10.045
Marshall, 2001, Peptide interactions with G-protein coupled receptors, Biopolymers, 60, 246, 10.1002/1097-0282(2001)60:3<246::AID-BIP10044>3.0.CO;2-V
Matus, 1988, Microtubule-associated proteins: their potential role in determining neuronal morphology, Annu. Rev. Neurosci., 11, 29, 10.1146/annurev.ne.11.030188.000333
Matus, 1994, Stiff microtubules and neuronal morphology, Trends Neurosci., 17, 19, 10.1016/0166-2236(94)90030-2
McConnachie, 2006, AKAP signaling complexes: getting to the heart of the matter, Trends Mol. Med., 12, 317, 10.1016/j.molmed.2006.05.008
McNulty, 2006, Macromolecular crowding in the Escherichia coli periplasm maintains alpha-synuclein disorder, J. Mol. Biol., 355, 893, 10.1016/j.jmb.2005.11.033
Michel, 2002, AKAP mediated signal transduction, Annu. Rev. Pharmacol. Toxicol., 42, 235, 10.1146/annurev.pharmtox.42.083101.135801
Minton, 1981, Excluded volume as a determinant of macromolecular structure and reactivity, Biopolymers, 20, 2093, 10.1002/bip.1981.360201006
Minton, 2000, Implications of macromolecular crowding for protein assembly, Curr. Opin. Struct. Biol., 10, 34, 10.1016/S0959-440X(99)00045-7
Minton, 2000, Protein folding: thickening the broth, Curr. Biol., 10, R97, 10.1016/S0960-9822(00)00301-8
Mishra, 2006, Human protein reference database–2006 update, Nucleic Acids Res., 34, D411, 10.1093/nar/gkj141
Mohan, 2006, Analysis of molecular recognition features (MoRFs), J. Mol. Biol., 362, 1043, 10.1016/j.jmb.2006.07.087
Montoro, 1993, N-methyl-d-aspartate stimulates the dephosphorylation of the microtubule-associated protein 2 and potentiates excitatory synaptic pathways in the rat hippocampus, Neuroscience, 54, 859, 10.1016/0306-4522(93)90580-9
Mucsi, 2003, Binding-induced folding transitions in calpastatin subdomains A and C, Protein Sci., 12, 2327, 10.1110/ps.03138803
Mujtaba, 2004, Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation, Mol. Cells, 13, 251, 10.1016/S1097-2765(03)00528-8
Musacchio, 1994, Structure and function of the SH3 domain, Prog. Biophys. Mol. Biol., 61, 283, 10.1016/0079-6107(94)90003-5
Nauert, 2003, Identification of an IQGAP1/AKAP79 complex in beta-cells, J. Cell. Biochem., 90, 97, 10.1002/jcb.10604
Obradovic, 2005, Exploiting heterogeneous sequence properties improves prediction of protein disorder, Proteins, 61, 176, 10.1002/prot.20735
Oldfield, 2005, Comparing and combining predictors of mostly disordered proteins, Biochemistry, 44, 1989, 10.1021/bi047993o
Oldfield, 2005, Coupled folding and binding with alpha-helix-forming molecular recognition elements, Biochemistry, 44, 12454, 10.1021/bi050736e
Oldfield, 2007, Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners, BMC Genomics, 9, S1, 10.1186/1471-2164-9-S1-S1
Oldfield, 2008, Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners, BMC Genomics, 9, S1, 10.1186/1471-2164-9-S1-S1
Onitsuka, 2008, Mechanism of induced folding: both folding before binding and binding before folding can be realized in staphylococcal nuclease mutants, Proteins, 10.1002/prot.21978
Orban, 2003, Emerging roles of BRCA1 alternative splicing, Mol. Pathol., 56, 191, 10.1136/mp.56.4.191
Patil, 2006, Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networks, FEBS Lett., 580, 2041, 10.1016/j.febslet.2006.03.003
Pauling, 1940, A theory of the structure and process of formation of antibodies, J. Am. Chem. Soc., 62, 2643, 10.1021/ja01867a018
Pavletich, 1999, Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors, J. Mol. Biol., 287, 821, 10.1006/jmbi.1999.2640
Pawson, 1995, Protein modules and signalling networks, Nature, 373, 573, 10.1038/373573a0
Pawson, 2004, Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems, Cell, 116, 191, 10.1016/S0092-8674(03)01077-8
Peifer, 1994, A repeating amino acid motif shared by proteins with diverse cellular roles, Cell, 76, 789, 10.1016/0092-8674(94)90353-0
Peng, 2006, Length-dependent prediction of protein intrinsic disorder, BMC Bioinformatics, 7, 208, 10.1186/1471-2105-7-208
Perry, 2003, The ATRs, ATMs, and TORs are giant HEAT repeat proteins, Cell, 112, 151, 10.1016/S0092-8674(03)00033-3
Philpot, 1997, Experience-dependent modifications in MAP2 phosphorylation in rat olfactory bulb, J. Neurosci., 17, 9596, 10.1523/JNEUROSCI.17-24-09596.1997
Ping, 2004, Studies of effects of macromolecular crowding and confinement on protein folding and protein stability, J. Mol. Recognit., 17, 433, 10.1002/jmr.710
Polakis, 2000, Wnt signaling and cancer, Genes Dev., 14, 1837, 10.1101/gad.14.15.1837
Pontius, 1993, Close encounters: why unstructured, polymeric domains can increase rates of specific macromolecular association, Trends Biochem. Sci., 18, 181, 10.1016/0968-0004(93)90111-Y
Prilusky, 2005, FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded, Bioinformatics, 21, 3435, 10.1093/bioinformatics/bti537
Printen, 1994, Protein–protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade, Genetics, 138, 609, 10.1093/genetics/138.3.609
Quinlan, 1996, Emergence of activity-dependent, bidirectional control of microtubule-associated protein MAP2 phosphorylation during postnatal development, J. Neurosci., 16, 7627, 10.1523/JNEUROSCI.16-23-07627.1996
Quinlan, 1996, Postsynaptic mechanisms for bidirectional control of MAP2 phosphorylation by glutamate receptors, Neuron, 16, 357, 10.1016/S0896-6273(00)80053-7
Radivojac, 2007, Intrinsic disorder and functional proteomics, Biophys. J., 92, 1439, 10.1529/biophysj.106.094045
Radivojac, 2006, Calmodulin signaling: analysis and prediction of a disorder-dependent molecular recognition, Proteins, 63, 398, 10.1002/prot.20873
Rath, 2005, The structure of “unstructured” regions in peptides and proteins: role of the polyproline II helix in protein folding and recognition, Biopolymers, 80, 179, 10.1002/bip.20227
Remenyi, 2005, The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network, Mol. Cells, 20, 951, 10.1016/j.molcel.2005.10.030
Romero, 1997, Sequence data analysis for long disordered regions prediction in the calcineurin family, Genome Inform., 8, 110
Romero, 2004, Natively disordered proteins: functions and predictions, Appl. Bioinformatics, 3, 105, 10.2165/00822942-200403020-00005
Romero, 1997, Identifying disordered regions in proteins from amino acid sequence, IEEE Int. Conf. Neuronal Networks, 1, 90
Romero, 1998, Thousands of proteins likely to have long disordered regions, Pac. Symp. Biocomput., 437
Romero, 2001, Sequence complexity of disordered protein, Proteins, 42, 38, 10.1002/1097-0134(20010101)42:1<38::AID-PROT50>3.0.CO;2-3
Romero, 2006, Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms, Proc. Natl. Acad. Sci. U.S.A., 103, 8390, 10.1073/pnas.0507916103
Ruffner, 1999, BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site, Mol. Cell. Biol., 19, 4843, 10.1128/MCB.19.7.4843
Rui, 2002, SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling, J. Biol. Chem., 277, 42981, 10.1074/jbc.M208099200
Rui, 2004, Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation, EMBO J., 23, 4583, 10.1038/sj.emboj.7600475
Russo, 1996, Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex, Nature, 382, 325, 10.1038/382325a0
Rustandi, 2000, Structure of the negative regulatory domain of p53 bound to S100B(betabeta), Nat. Struct. Biol., 7, 570, 10.1038/76797
Salahshor, 2005, The links between axin and carcinogenesis, J. Clin. Pathol., 58, 225, 10.1136/jcp.2003.009506
Sanchez, 2000, Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function, Prog. Neurobiol., 61, 133, 10.1016/S0301-0082(99)00046-5
Schaeffer, 1999, Mitogen-activated protein kinases: specific messages from ubiquitous messengers, Mol. Cell. Biol., 19, 2435, 10.1128/MCB.19.4.2435
Schlessinger, 2007, Natively Unstructured Loops Differ from Other Loops, PLoS Comput. Biol., 3, e140, 10.1371/journal.pcbi.0030140
Schulz, 1979, Nucleotide Binding Proteins, 79
Schweers, 1994, Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure, J. Biol. Chem., 269, 24290, 10.1016/S0021-9258(19)51080-8
Selden, 1983, Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments, J. Biol. Chem., 258, 7064, 10.1016/S0021-9258(18)32333-0
Shibata, 2007, Crystallization and preliminary X-ray crystallographic studies of the axin DIX domain, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 63, 529, 10.1107/S1744309107022579
Shoemaker, 2000, Speeding molecular recognition by using the folding funnel: the fly-casting effect, Proc. Natl. Acad. Sci. U.S.A., 97, 8868, 10.1073/pnas.160259697
Shoemaker, 2000, Speeding molecular recognition by using the folding funnel: the fly-casting mechanism, Proc. Natl. Acad. Sci. U.S.A., 97, 8868, 10.1073/pnas.160259697
Shtilerman, 2002, Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?, Biochemistry, 41, 3855, 10.1021/bi0120906
Sickmeier, 2007, DisProt: the database of disordered proteins, Nucleic Acids Res., 35, D786, 10.1093/nar/gkl893
Sillibourne, 2002, Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450, J. Mol. Biol., 322, 785, 10.1016/S0022-2836(02)00857-4
Singh, 2007, Role of intrinsic disorder in transient interactions of hub proteins, Proteins, 66, 761, 10.1002/prot.21281
Sivakolundu, 2005, Disordered p27Kip1 exhibits intrinsic structure resembling the Cdk2/cyclin A-bound conformation, J. Mol. Biol., 353, 1118, 10.1016/j.jmb.2005.08.074
Smith, 2006, The where's and when's of kinase anchoring, Trends Biochem. Sci., 31, 316, 10.1016/j.tibs.2006.04.009
Sokolova, 2003, Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit, Proc. Natl. Acad. Sci. U.S.A., 100, 12607, 10.1073/pnas.2235650100
Spink, 2000, Structural basis of the Axin-adenomatous polyposis coli interaction, EMBO J., 19, 2270, 10.1093/emboj/19.10.2270
Sugase, 2007, Mechanism of coupled folding and binding of an intrinsically disordered protein, Nature, 447, 1021, 10.1038/nature05858
Takahashi, 1999, Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus, J. Biol. Chem., 274, 17267, 10.1074/jbc.274.24.17267
Tanji, 2002, A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta) and mediates protein kinase A-dependent inhibition of GSK-3beta, J. Biol. Chem., 277, 36955, 10.1074/jbc.M206210200
Tatusova, 1999, BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences, FEMS Microbiol. Lett., 174, 247, 10.1111/j.1574-6968.1999.tb13575.x
Taylor, 2005, Dynamics of signaling by PKA, Biochim. Biophys. Acta, 1754, 25, 10.1016/j.bbapap.2005.08.024
Tejedor, 1997, Essential role for dlg in synaptic clustering of Shaker K+ channels in vivo, J. Neurosci., 17, 152, 10.1523/JNEUROSCI.17-01-00152.1997
Tellam, 1983, The influence of poly(ethylene glycol) 6000 on the properties of skeletal-muscle actin, Biochem. J., 213, 651, 10.1042/bj2130651
Theurkauf, 1982, Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2, J. Biol. Chem., 257, 3284, 10.1016/S0021-9258(19)81107-9
Thompson, 2002, Recombinational DNA repair and human disease, Mutat. Res., 509, 49, 10.1016/S0027-5107(02)00224-5
Tokuriki, 2004, Protein folding by the effects of macromolecular crowding, Protein Sci., 13, 125, 10.1110/ps.03288104
Tolwinski, 2004, Rethinking WNT signaling, Trends Genet., 20, 177, 10.1016/j.tig.2004.02.003
Tompa, 2002, Intrinsically unstructured proteins, Trends Biochem. Sci., 27, 527, 10.1016/S0968-0004(02)02169-2
Tompa, 2005, The interplay between structure and function in intrinsically unstructured proteins, FEBS Lett., 579, 3346, 10.1016/j.febslet.2005.03.072
Tompa, 2004, The role of structural disorder in the function of RNA and protein chaperones, FASEB J., 18, 1169, 10.1096/fj.04-1584rev
Trombitas, 1998, Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments, J. Cell Biol., 140, 853, 10.1083/jcb.140.4.853
Tsai, 2001, Structured disorder and conformational selection, Proteins, 44, 418, 10.1002/prot.1107
Uversky, 2002, Natively unfolded proteins: a point where biology waits for physics, Protein Sci., 11, 739, 10.1110/ps.4210102
Uversky, 2002, What does it mean to be natively unfolded?, Eur. J. Biochem., 269, 2, 10.1046/j.0014-2956.2001.02649.x
Uversky, 2003, A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders, J. Biomol. Struct. Dyn., 21, 211, 10.1080/07391102.2003.10506918
Uversky, 2003, Protein folding revisited. A polypeptide chain at the folding-misfolding-nonfolding cross-roads: which way to go?, Cell. Mol. Life Sci., 60, 1852, 10.1007/s00018-003-3096-6
Uversky, 2000, Why are “natively unfolded” proteins unstructured under physiologic conditions?, Proteins, 41, 415, 10.1002/1097-0134(20001115)41:3<415::AID-PROT130>3.0.CO;2-7
Uversky, 2001, Evidence for a partially folded intermediate in alpha-synuclein fibril formation, J. Biol. Chem., 276, 10737, 10.1074/jbc.M010907200
Uversky, 2005, Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling, J. Mol. Recognit., 18, 343, 10.1002/jmr.747
Uversky, 1994, Partly folded” state, a new equilibrium state of protein molecules: four-state guanidinium chloride-induced unfolding of beta-lactamase at low temperature, Biochemistry, 33, 2782, 10.1021/bi00176a006
Uversky, 1996, Further evidence on the equilibrium “pre-molten globule state”: four-state guanidinium chloride-induced unfolding of carbonic anhydrase B at low temperature, J. Mol. Biol., 255, 215, 10.1006/jmbi.1996.0018
Vacic, 2007, Characterization of molecular recognition features, MoRFs, and their binding partners, J. Proteome Res., 6, 2351, 10.1021/pr0701411
Vallee, 1981, A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2), J. Cell Biol., 90, 568, 10.1083/jcb.90.3.568
van den Berg, 1999, Effects of macromolecular crowding on protein folding and aggregation, EMBO J., 18, 6927, 10.1093/emboj/18.24.6927
van den Berg, 2000, Macromolecular crowding perturbs protein refolding kinetics: implications for folding inside the cell, EMBO J., 19, 3870, 10.1093/emboj/19.15.3870
Venkitaraman, 2002, Cancer susceptibility and the functions of BRCA1 and BRCA2, Cell, 108, 171, 10.1016/S0092-8674(02)00615-3
Vitalis, 2007, Quantitative characterization of intrinsic disorder in polyglutamine: insights from analysis based on polymer theories, Biophys. J., 93, 1923, 10.1529/biophysj.107.110080
Vucetic, 2003, Flavors of protein disorder, Proteins, 52, 573, 10.1002/prot.10437
Vucetic, 2005, DisProt: a database of protein disorder, Bioinformatics, 21, 137, 10.1093/bioinformatics/bth476
Vucetic, 2007, Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions, J. Proteome Res., 6, 1899, 10.1021/pr060393m
Wang, 2000, BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures, Genes Dev., 14, 927, 10.1101/gad.14.8.927
Ward, 2004, The DISOPRED server for the prediction of protein disorder, Bioinformatics, 20, 2138, 10.1093/bioinformatics/bth195
Ward, 2004, Prediction and functional analysis of native disorder in proteins from the three kingdoms of life, J. Mol. Biol., 337, 635, 10.1016/j.jmb.2004.02.002
Wasylyk, 1999, p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53, Oncogene, 18, 1921, 10.1038/sj.onc.1202528
Watanabe, 2002, Molecular mechanics of cardiac titin's PEVK and N2B spring elements, J. Biol. Chem., 277, 11549, 10.1074/jbc.M200356200
Watts, 1998, Collective dynamics of ‘small-world’ networks, Nature, 393, 440, 10.1038/30918
Weinreb, 1996, NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded, Biochemistry, 35, 13709, 10.1021/bi961799n
Whitmarsh, 1998, Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals, Trends Biochem. Sci., 23, 481, 10.1016/S0968-0004(98)01309-7
Wiche, 1991, Molecular structure and function of microtubule-associated proteins, Int. Rev. Cytol., 124, 217, 10.1016/S0074-7696(08)61528-4
Widmann, 1999, Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human, Physiol. Rev., 79, 143, 10.1152/physrev.1999.79.1.143
Williams, 2001, The protein non-folding problem: amino acid determinants of intrinsic order and disorder, Pac. Symp. Biocomput., 89
Wodarz, 1998, Mechanisms of Wnt signaling in development, Annu. Rev. Cell Dev. Biol., 14, 59, 10.1146/annurev.cellbio.14.1.59
Wong, 2004, The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms, J. Biol. Chem., 279, 39366, 10.1074/jbc.M404598200
Wong, 2004, AKAP signalling complexes: focal points in space and time, Nat. Rev. Mol. Cell Biol., 5, 959, 10.1038/nrm1527
Wright, 1999, Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm, J. Mol. Biol., 293, 321, 10.1006/jmbi.1999.3110
Xie, 2007, Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins, J. Proteome Res., 6, 1917, 10.1021/pr060394e
Xie, 2007, Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions, J. Proteome Res., 6, 1882, 10.1021/pr060392u
Xing, 2003, Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex, Genes Dev., 17, 2753, 10.1101/gad.1142603
Yarden, 1999, BRCA1 interacts with components of the histone deacetylase complex, Proc. Natl. Acad. Sci. U.S.A., 96, 4983, 10.1073/pnas.96.9.4983
Zarrinpar, 2003, The structure and function of proline recognition domains, Sci. STKE, 2003, RE8, 10.1126/stke.2003.179.re8
Zhang, 1991, The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genes, Genes Dev., 5, 1080, 10.1101/gad.5.6.1080
Zhang, 2000, Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase, J. Biol. Chem., 275, 25008, 10.1074/jbc.M002491200
Zhang, 1999, Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling, J. Biol. Chem., 274, 35247, 10.1074/jbc.274.49.35247
Zhang, 2001, Differential molecular assemblies underlie the dual function of Axin in modulating the WNT and JNK pathways, J. Biol. Chem., 276, 32152, 10.1074/jbc.M104451200
Zheng, 2000, Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1, Mol. Cells, 6, 757, 10.1016/S1097-2765(00)00075-7
Zhou, 2004, Protein folding and binding in confined spaces and in crowded solutions, J. Mol. Recognit., 17, 368, 10.1002/jmr.711
Zhou, 2001, Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors, Nature, 411, 657, 10.1038/35079500
Zimmerman, 1993, Macromolecular crowding: biochemical, biophysical, and physiological consequences, Annu. Rev. Biophys. Biomol. Struct., 22, 27, 10.1146/annurev.bb.22.060193.000331
Zito, 1997, Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg, Neuron, 19, 1007, 10.1016/S0896-6273(00)80393-1
Zitzewitz, 2000, Preformed secondary structure drives the association reaction of GCN4-p1, a model coiled-coil system, J. Mol. Biol., 296, 1105, 10.1006/jmbi.2000.3507