Intravoxel incoherent motion analysis of renal allograft diffusion with clinical and histopathological correlation in pediatric kidney transplant patients: A preliminary cross‐sectional observational study

Pediatric Transplantation - Tập 21 Số 6 - 2017
Clare B. Poynton1, Marsha M. Lee2, Yi Li1, Zoltán Lászik3, Pauline W. Worters4, John D. MacKenzie1, Jesse Courtier1
1Department of Radiology and Biomedical Imaging UCSF Benioff Children's Hospital San Francisco CA USA
2Department of Pediatrics Division of Pediatric Nephrology UCSF Benioff Children's Hospital San Francisco CA USA
3Department of Pathology UCSF Benioff Children's Hospital San Francisco CA USA
4Global Applied Science Laboratory GE Healthcare Menlo Park CA USA

Tóm tắt

AbstractThe purpose of this study was to compare IVIM values in pediatric renal transplants with histopathology and clinical management change. Fifteen pediatric renal transplant recipients (mean 15.7±2.9 years) were prospectively scanned on a 3T MR scanner with multi‐b DTI, prior to same‐day transplant biopsy. IVIM maps from 14 subjects were analyzed (one excluded due to motion). Mean values were computed from cortical ROIs and medullary ROIs corresponding to the biopsy site. Subjects were also grouped according to whether or not the biopsy resulted in a change in clinical management. Cortico‐medullary IVIM estimates and histopathologic Banff scores were correlated with KT. Cortico‐medullary IVIM differences between the “change” and “no change” groups was compared with Mann‐Whitney U test. Cortical Dp showed significant moderate negative correlation with Banff t and ci scores (KT=−0.497, P=.035 and KT=−0.46, P=.046) and moderate positive correlation with Banff i score (KT=0.527, P=.028). Cortical Pf showed significant moderate correlation with ci and ct scores (KT=0.489, P=.035 and KT=0.457, P=.043). Tissue diffusivity, Dt, estimated with IVIM was significantly different between the “change” and “no change” groups in medullary ROIs (U=6, P=.021). IVIM analysis has potential as a noninvasive biomarker in assessment of pediatric renal allograft pathology.

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Pediatric Transplantation

Tập 21 Số 6

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