Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration

Ophthalmology - Tập 119 Số 12 - Trang 2537-2548 - 2012
Jeffrey S. Heier1, David M. Brown2, Victor Chong3, Jean‐François Korobelnik4, Peter K. Kaiser5, Quan Dong Nguyen6, Bernd Kirchhof7, Allen C. Ho8, Yuichiro Ogura9, George D. Yancopoulos10, Neil Stahl10, Robert Vitti10, Alyson J. Berliner10, Yuhwen Soo10, Majid Anderesi11, Georg Groetzbach11, Bernd Sommerauer11, Rupert Sandbrink11,12, Christian Simader13, Ursula Schmidt‐Erfurth13
1Tufts University
2Retina Consultants of Houston
3University of Oxford.
4Universitè de Bordeaux
5[Cleveland Clinic Foundation]
6Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
7UNIVERSITY OF COLOGNE
8Wills Eye Hospital
9Nagoya City University
10Regeneron Pharmaceuticals, Inc
11Bayer AG
12Heinrich Heine University Düsseldorf
13#N##TAB##TAB##TAB##TAB# Medical University of Vienna#N##TAB##TAB##TAB#

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Tài liệu tham khảo

Congdon, 2003, Important causes of visual impairment in the world today, JAMA, 290, 2057, 10.1001/jama.290.15.2057

1991, Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration, Arch Ophthalmol, 109, 1220, 10.1001/archopht.1991.01080090044025

1999, Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials–TAP report 1, Arch Ophthalmol, 117, 1329, 10.1001/archopht.117.10.1329

2001, Am J Ophthalmol, 131, 541, 10.1016/S0002-9394(01)00967-9

Yancopoulos, 2010, Clinical application of therapies targeting VEGF, Cell, 143, 13, 10.1016/j.cell.2010.09.028

Ferrara, 2009, VEGF-A: a critical regulator of blood vessel growth, Eur Cytokine Netw, 20, 158, 10.1684/ecn.2009.0170

Rosenfeld, 2006, Ranibizumab for neovascular age-related macular degeneration, N Engl J Med, 355, 1419, 10.1056/NEJMoa054481

Brown, 2006, Ranibizumab versus verteporfin for neovascular age-related macular degeneration, N Engl J Med, 355, 1432, 10.1056/NEJMoa062655

Schmidt-Erfurth, 2011, Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE study, Ophthalmology, 118, 831, 10.1016/j.ophtha.2010.09.004

Regillo, 2008, Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1, Am J Ophthalmol, 145, 239, 10.1016/j.ajo.2007.10.004

Boyer, 2009, A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration, Ophthalmology, 116, 1731, 10.1016/j.ophtha.2009.05.024

Singer, 2012, HORIZON: an open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration, Ophthalmology, 119, 1175, 10.1016/j.ophtha.2011.12.016

Martin, 2011, Ranibizumab and bevacizumab for neovascular age-related macular degeneration, N Engl J Med, 364, 1897, 10.1056/NEJMoa1102673

Martin, 2012, Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results, Ophthalmology, 119, 1388, 10.1016/j.ophtha.2012.03.053

Chakravarthy, 2012, Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial, Ophthalmology, 119, 1399, 10.1016/j.ophtha.2012.04.015

Economides, 2003, Cytokine traps: multi-component, high-affinity blockers of cytokine action, Nat Med, 9, 47, 10.1038/nm811

Holash, 2002, VEGF-Trap: a VEGF blocker with potent antitumor effects, Proc Natl Acad Sci U S A, 99, 11393, 10.1073/pnas.172398299

Heier, 2011, The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor Trap-Eye dosed as-needed after 12-week fixed dosing, Ophthalmology, 118, 1098, 10.1016/j.ophtha.2011.03.020

Stewart, 2008, Predicted biological activity of intravitreal VEGF Trap, Br J Ophthalmol, 92, 667, 10.1136/bjo.2007.134874

Brown, 2011, Primary endpoint results of a phase II study of vascular endothelial growth factor Trap-Eye in wet age-related macular degeneration, Ophthalmology, 118, 1089, 10.1016/j.ophtha.2011.02.039