Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake

American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 284 Số 2 - Trang R494-R499 - 2003
Deborah J. Clegg1, Ellen L. Air2,3, Stephen C. Benoit1, Randall S. Sakai1, Randy J. Seeley1, Stephen C. Woods1
1Departments of Psychiatry
2‡Biomedical Sciences and
3Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Cincinnati, Ohio 45267

Tóm tắt

The lateral hypothalamus (LH) has a critical role in the control of feeding and drinking. Melanin-concentrating hormone (MCH) is an orexigenic peptidergic neurotransmitter produced primarily in the LH, and agouti-related protein (AgRP) is an orexigenic peptidergic neurotransmitter produced exclusively in the arcuate (ARC), an area that innervates the LH. We assessed drinking and eating after third ventricular (i3vt) administration of MCH and AgRP. MCH (2.5, 5, and 10 μg i3vt) significantly increased food as well as water intake over 4 h when administered during either the light or the dark portion of the day-night cycle. When MCH (5 μg) was administered to rats with access to water but no food, they drank significantly more water than when given the vehicle. AgRP (7 μg i3vt), on the other hand, increased water intake but only in proportion to food intake during the dark and the light, and water intake was not increased after i3vt AgRP in the absence of food. Hence, in contrast to AgRP, MCH elicits increased water intake independent of food intake. These results are consistent with historical data linking activity of the LH with water as well as food intake.

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American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Tập 284 Số 2

R494-R499

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