Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and experimental autoimmune encephalomyelitis severity in the absence of IL-12 receptor signaling

Benson, 2000, T-cell activation and receptor downmodulation precede deletion induced by mucosally administered antigen, J. Clin. Invest., 106, 1031, 10.1172/JCI10738 Ferguson, 2003, Apoptosis, tolerance, and regulatory T cells—old wine, new wineskins, Immunol. Rev., 193, 111, 10.1034/j.1600-065X.2003.00042.x Gately, 1998, The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses, Annu. Rev. Immunol., 16, 495, 10.1146/annurev.immunol.16.1.495 Hilliard, 2000, Mechanisms of suppression of experimental autoimmune encephalomyelitis by intravenous administration of myelin basic protein: role of regulatory spleen cells, Exp. Mol. Pathol., 68, 29, 10.1006/exmp.1999.2290 Hong, 2005, Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3, Proc. Natl. Acad. Sci. U. S. A., 102, 6449, 10.1073/pnas.0502187102 Ilarregui, 2009, Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10, Nat. Immunol., 10, 981, 10.1038/ni.1772 Kennedy, 1988, Specific immune regulation of chronic-relapsing experimental allergic encephalomyelitis in mice, J. Immunol., 141, 2986, 10.4049/jimmunol.141.9.2986 Langrish, 2005, IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, J. Exp. Med., 201, 233, 10.1084/jem.20041257 Li, 2008, CD11c+CD11b+ dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis, J. Immunol., 181, 2483, 10.4049/jimmunol.181.4.2483 Mullen, 2001, Role of T-bet in commitment of TH1 cells before IL-12-dependent selection, Science, 292, 1907, 10.1126/science.1059835 Ouaked, 2009, Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1, J. Immunol., 182, 1041, 10.4049/jimmunol.182.2.1041 Parham, 2002, A receptor for the heterodimeric cytokine IL-23 Is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R, J. Immunol., 168, 5699, 10.4049/jimmunol.168.11.5699 Santambrogio, 1995, Tolerogenic forms of auto-antigens and cytokines in the induction of resistance to experimental allergic encephalomyelitis, J. Neuroimmunol., 58, 211, 10.1016/0165-5728(95)00022-T Smith, 2006, Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities, J. Autoimmun., 27, 218, 10.1016/j.jaut.2006.12.002 Trinchieri, 1998, Interleukin-12: a cytokine at the interface of inflammation and immunity, Adv. Immunol., 70, 83, 10.1016/S0065-2776(08)60387-9 Wang, 2006, Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs, J. Clin. Invest., 116, 2434 Wu, 1997, Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor, J. Immunol., 159, 1658, 10.4049/jimmunol.159.4.1658 Wu, 2000, IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites, J. Immunol., 165, 6221, 10.4049/jimmunol.165.11.6221 Zhang, 1999, Reversal of spontaneous progressive autoimmune encephalomyelitis by myelin basic protein-induced clonal deletion, Autoimmunity, 31, 219, 10.3109/08916939908994067 Zhang, 2002, The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis, J. Immunol., 168, 2501, 10.4049/jimmunol.168.5.2501 Zhang, 2003, Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system, J. Immunol., 170, 2153, 10.4049/jimmunol.170.4.2153 Zhang, 2005, A paradoxical role of APCs in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis, J. Neuroimmunol., 161, 101, 10.1016/j.jneuroim.2004.12.017 Zhao, 2008, IL-12R beta 2 promotes the development of CD4+CD25+ regulatory T cells, J. Immunol., 181, 3870, 10.4049/jimmunol.181.6.3870