Intraneuronal Aβ42 Accumulation in Human Brain

Selkoe, 1998, The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease, Trends Cell Biol, 8, 447, 10.1016/S0962-8924(98)01363-4

Iwatsubo, 1994, Visualization of A β 42(43) and A β 40 in senile plaques with end-specific A β monoclonals: evidence that an initially deposited species is A β 42(43), Neuron, 13, 45, 10.1016/0896-6273(94)90458-8

Lemere, 1996, Sequence of deposition of heterogeneous amyloid β-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation, Neurobiol Dis, 3, 16, 10.1006/nbdi.1996.0003

Xu, 1997, Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation, Proc Natl Acad Sci USA, 94, 3748, 10.1073/pnas.94.8.3748

Wild-Bode, 1997, Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42, J Biol Chem, 272, 16085, 10.1074/jbc.272.26.16085

Skovronsky, 1998, Detection of a novel intraneuronal pool of insoluble amyloid β protein that accumulates with time in culture, J Cell Biol, 141, 1031, 10.1083/jcb.141.4.1031

Hartmann, 1997, Distinct sites of intracellular production for Alzheimer's disease A β40/42 amyloid peptides, Nat Med, 3, 1016, 10.1038/nm0997-1016

Cook, 1997, Alzheimer's A β(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells, Nat Med, 3, 1021, 10.1038/nm0997-1021

Greenfield, 1999, Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides, Proc Natl Acad Sci USA, 96, 742, 10.1073/pnas.96.2.742

Perez, 1999, Mutagenesis identifies new signals for β-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42, J Biol Chem, 274, 18851, 10.1074/jbc.274.27.18851

Chui, 1999, Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation, Nat Med, 5, 560, 10.1038/8438

Stern, 1989, Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease β-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system, Am J Pathol, 134, 973

Mak, 1994, Polyclonals to β-amyloid(1–42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum, Brain Res, 667, 138, 10.1016/0006-8993(94)91725-6

LaFerla, 1997, Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization, J Clin Invest, 100, 310, 10.1172/JCI119536

Masters, 1985, Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels, EMBO J, 4, 2757, 10.1002/j.1460-2075.1985.tb04000.x

Hyman, 1989, A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles, Neurosci Lett, 101, 352, 10.1016/0304-3940(89)90559-4

Allsop, 1990, Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid β-protein of Alzheimer's disease, Am J Pathol, 136, 255

Hyman, 1986, Perforant pathway changes and the memory impairment of Alzheimer's disease, Ann Neurol, 20, 472, 10.1002/ana.410200406

Barelli, 1997, Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid β peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases, Mol Med, 3, 695, 10.1007/BF03401708

Gouras, 1998, Generation and regulation of amyloid-β peptide variants in neurons, J Neurochem, 71, 1920, 10.1046/j.1471-4159.1998.71051920.x

Borchelt, 1996, Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1–42/1–40 ratio in vitro and in vivo, Neuron, 17, 1005, 10.1016/S0896-6273(00)80230-5

Saido, 1995, Dominant and differential deposition of distinct β-amyloid peptide species, A β N3(pE), in senile plaques, Neuron, 14, 457, 10.1016/0896-6273(95)90301-1

Xu, 1998, Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides, Nat Med, 4, 447, 10.1038/nm0498-447

Stieber, 1996, In Alzheimer's disease the Golgi apparatus of a population of neurons without neurofibrillary tangles is fragmented and atrophic, Am J Pathol, 148, 415

Guo, 1998, Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease, Nat Med, 4, 957, 10.1038/nm0898-957

Hsia, 1999, Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models, Proc Natl Acad Sci USA, 96, 3228, 10.1073/pnas.96.6.3228

Moechars, 1999, Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain, J Biol Chem, 274, 6483, 10.1074/jbc.274.10.6483

Bales, 1997, Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition, Nat Genet, 17, 263, 10.1038/ng1197-263