Intramedullary Spinal Cord Tumors: Part II—Management Options and Outcomes

Global Spine Journal - Tập 6 Số 2 - Trang 176-185 - 2016
Dino Samartzis1, Chris Gillis2, Patrick Shih3, John E. O’Toole2, Richard G. Fessler2
1Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
2Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, United States
3The Neurological Brain and Spine Center, Houston, Texas, United States

Tóm tắt

Study DesignBroad narrative review.ObjectivesIntramedullary spinal cord tumors (IMSCT) are uncommon lesions that can affect any age group or sex. However, numerous IMSCT exist and the clinical course of each tumor varies. The following article addresses the various management options and outcomes in patients with IMSCT.MethodsAn extensive review of the peer-reviewed literature was performed, addressing management options and clinical outcomes of patients with IMSCT.ResultsEarly diagnosis and intervention are essential to obtain optimal functional outcome. Each IMSCT have specific imaging characteristics, which help in the clinical decision-making and prognostication. A comprehension of the tumor pathology and the clinical course associated with each tumor can allow for the proper surgical and nonsurgical management of these tumors, and reduce any associated morbidity and mortality. Recent advances in the operative management of such lesions have increased the success rate of tumor removal while minimizing iatrogenic-related trauma to the patient and, in tandem, improving patient outcomes.ConclusionsAwareness and understanding of IMSCT is imperative to design proper management and obtain optimal patient outcomes. Meticulous operative technique and the use of surgical adjuncts are essential to accomplish proper tumor removal, diminish the risk of recurrence, and preserve neurologic function. Operative management of IMSCT should be individualized and based on tumor type, location, and dimensional extensions. To assist with preoperative and intraoperative decision-making, a general algorithm is provided.

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Tài liệu tham khảo

Eiselberg A, 1931, Mitteilungen aus ben Grenz, 42, 613

Eiselberg A, 1913, Arch Klinik Chir, 102, 309

Elsberg C A, 1911, Am J Med Sci, 142, 630, 10.1097/00000441-191108000-00039

Elsberg C A Diagnosis and Treatment of Surgical Diseases of the Spinal Cord and Its Membranes Philadelphia, PA, and London, UK Saunders 1916

Elsberg C A Tumors of the Spinal Cord and the Symptoms of Irritation and Compression of the Spinal Cord and Nerve Roots: Pathology, Symptomatology, Diagnosis, and Treatment New York, NY Paul B. Hoeber 1925

10.1001/archneurpsyc.1929.02210200017003

Horrax G, 1939, Surg Gynecol Obstet, 68, 814

Stookey B, 1928, Am J Dis Child, 36, 1184

10.1016/S0002-9610(38)91252-8

10.1016/S0009-9260(71)80005-3

10.3171/jns.1979.51.4.0437

10.3171/jns.1956.13.6.0535

10.1038/sc.1977.40

10.3171/jns.1954.11.6.0616

10.3171/jns.1963.20.8.0665

10.3171/jns.1967.26.2.0276

10.3171/jns.1982.57.2.0157

10.1093/neurosurgery/31.CN_suppl_1.550

10.1148/radiology.151.2.6709919

10.1097/00007632-199211000-00021

10.1227/00006123-197805000-00010

10.1227/00006123-198106000-00009

10.1002/lsm.1900020205

10.1097/00005072-197803000-00001

10.3171/jns.2007.106.6.994

10.2176/nmc.41.246

10.1001/archneurpsyc.1945.02300010011001

10.1016/0090-3019(88)90275-3

10.1001/archneur.1987.00520170054022

10.1212/WNL.22.12.1222

Choucair A K, 1991, Oncology (Williston Park), 5, 25

10.3171/jns.1985.62.2.0227

10.1023/A:1006470523052

Fischer G, 1980, Surg Neurol, 14, 243

10.1227/00006123-199411000-00010

10.1093/neurosurgery/26.CN_suppl_1.529

10.2176/nmc.10.25

10.3171/jns.1990.72.4.0523

Yasargil M G, 1976, Surg Neurol, 141

Eichler M E Dacey R G Intramedullary spinal cord tumors In: Bridwell K H DeWald R L , eds. The Textbook of Spinal Surgery Philadelphia, PA Lippincott-Raven 1997 2089–2102

10.1023/A:1006403500801

10.3171/jns.1982.57.4.0441

10.1302/0301-620X.59B2.873974

10.1007/BF02001471

10.1016/0360-3016(83)90230-4

10.1227/01.NEU.0000360153.65238.F0

10.1097/00007632-198107000-00005

10.1097/00007632-198807000-00032

10.3171/jns.1995.83.2.0254

10.3171/jns.1985.62.2.0293

10.1227/00006123-198706000-00026

10.3171/jns.1966.24.2.0536

10.1227/00006123-198205000-00016

Bauer J D Ackerman P G Toro G Clinical Laboratory Methods. 8th ed St. Louis, MO C.V. Mosby 1974

10.1227/00006123-198508000-00012

10.2106/00004623-196850020-00005

10.2106/00004623-198163070-00010

10.1097/00003086-197103000-00023

10.3171/jns.1989.71.1.0016

Crockard H A, 1985, Ann R Coll Surg Engl, 67, 321

10.1227/00006123-199002000-00004

10.3171/jns.1975.42.4.0434

10.2106/00004623-198971070-00004

Sienkiewicz P J, 1987, Clin Orthop Relat Res, 172

10.2106/00004623-197557040-00004

Haft H, 1959, Pediatrics, 23, 1152, 10.1542/peds.23.6.1152

Constantini S, 2000, J Neurosurg, 93, 183, 10.3171/jns.2000.93.2.0183

10.1097/00006123-200211000-00010

10.3171/2009.4.SPINE08159

10.1227/00006123-199407000-00011

10.1007/s00701-009-0577-x

Brotchi J, 2006, Clin Neurosurg, 53, 209

10.1097/BRS.0b013e3181b95c6f

10.1007/s00586-005-0902-x

10.1227/01.neu.0000279729.36392.42

10.1227/00006123-198912000-00001

10.1038/sj.sc.3102130

10.3171/2009.6.SPINE08910

10.1097/BRS.0b013e3181b43484

10.1016/0090-3019(88)90158-9

10.3949/ccjm.55.2.163

10.1016/0360-3016(89)90940-1

10.1038/sj.sc.3100902

10.1148/radiology.135.2.7367644

10.1007/s007010050309

10.1227/00006123-198911000-00003

10.3171/jns.1995.82.3.0394

10.1023/A:1011886516506

10.1023/B:NEON.0000024747.66993.26

Raco A, 2005, Neurosurgery, 56, 972

10.1016/j.ijrobp.2008.04.060

10.1016/j.ijrobp.2005.09.038

10.1586/ern.09.101

10.1002/cncr.23677

10.1016/j.ijrobp.2007.04.058

10.1002/cncr.10826

10.1227/NEU.0b013e3182004c1e

10.1227/NEU.0b013e3181fe3794

10.3171/2013.3.SPINE121063

Kucia E J, 2011, Neurosurgery, 68, 57

10.1093/neuonc/not038