Intralesional Injection of Collagenase Clostridium histolyticum May Increase the Risk of Late-Onset Penile Fracture

Gelbard, 2013, Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of Peyronie's disease in 2 large double-blind, randomized, placebo controlled phase 3 studies, J Urol, 190, 199 Mulhall, 2004, Subjective and objective analysis of the prevalence of Peyronie's disease in a population of men presenting for prostate cancer screening, J Urol, 171, 2350 Campbell, 2017, Understanding the cellular basis and pathophysiology of Peyronie's disease to optimize treatment for erectile dysfunction, Transl Androl Urol, 6, 46, 10.21037/tau.2016.11.01 Taylor, 2007, Peyronie's disease, Urol Clin North Am, 34, 517, 10.1016/j.ucl.2007.08.017 Smith, 2009, Penile sonographic and clinical characteristics in men with Peyronie's disease, J Sex Med, 6, 2858 Schwarzer, 2001, The prevalence of Peyronie's disease: results of a large survey, BJU Int, 88, 727, 10.1046/j.1464-4096.2001.02436.x Gelbard, 1980, Clostridial collagenase and Peyronie's disease, Urology, 15, 536, 10.1016/0090-4295(80)90028-X Gelbard, 1985, The use of collagenase in the treatment of Peyronie's disease, J Urol, 134, 280 Endo Pharmaceuticals Beilan, 2016, Suspected penile fracture after Xiaflex injection and use of a VED, Urology, 98, 4, 10.1016/j.urology.2016.07.026 Lue, 2015, Excision and patch grafting of a lateral Peyronie's plaque-utilizing a longitudinal “window” approach, Sex Med, 3, 86, 10.1002/sm2.49 Yafi, 2016, Results of SMSNA survey regarding complications following intralesional injection therapy with collagenase Clostridium histolyticum for Peyronie's Disease, J Sex Med, 13, 684 Yang, 2015, The history of collagenase Clostridium histolyticum, Sex Med Rev, 3, 289, 10.1002/smrj.54 Lipshultz, 2015, Clinical efficacy of collagenase Clostridium histolyticum in the treatment of Peyronie's disease by subgroup: results from two large, double-blind, randomized, placebo-controlled, phase III studies, BJU Int, 116, 650, 10.1111/bju.13096 Anaissie, 2017, Survey of patient and partner satisfaction following collagenase Clostridium histolyticum treatment for Peyronie's disease, Andrology, 5, 274, 10.1111/andr.12302 Goldstein, 2017, Changes in the effects of Peyronie's disease after treatment with collagenase Clostridium histolyticum: male patients and their female partners, Sex Med, 5, e124, 10.1016/j.esxm.2017.02.001 Gabrielson, 2018, Collagenase Clostridium histolyticum in the treatment of urologic disease: current and future impact, Sex Med Rev, 6, 143, 10.1016/j.sxmr.2017.03.005 Kuhlmann, 2017, Collagenase Clostridium histolyticum in the treatment of Peyronie's disease: patient selection and perspectives, Patient Prefer Adherence, 11, 431, 10.2147/PPA.S113507 Dhillon, 2015, Collagenase Clostridium histolyticum: a review in Peyronie's disease, Drugs, 75, 1405, 10.1007/s40265-015-0441-7 Gelbard, 1993, Collagenase versus placebo in the treatment of Peyronie's disease: a double-blind study, J Urol, 149, 56 Jordan, 2008, The use of intralesional clostridial collagenase injection therapy for Peyronie's disease: a prospective, single-center, non-placebo-controlled study, J Sex Med, 5, 180 Carson, 2015, Analysis of the clinical safety of intralesional injection of collagenase Clostridium histolyticum (CCH) for adults with Peyronie's disease (PD), BJU Int, 116, 815, 10.1111/bju.13120 Gelbard, 2012, Phase 2b study of the clinical efficacy and safety of collagenase Clostridium histolyticum in patients with Peyronie's disease, J Urol, 187, 2268 Levine, 2015, Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study, J Sex Med, 12, 248 Yang, 2016, Peyronie's disease and injectable collagenase Clostridium histolyticum: safety, efficacy, and improvements in subjective symptoms, Urology, 94, 143, 10.1016/j.urology.2016.04.049 Ziegelmann, 2016, Restoration of penile function and patient satisfaction with intralesional collagenase Clostridium histolyticum Injection for Peyronie's disease, J Urol, 195, 1051