Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats

Adams, 1996, Cannabis: pharmacology and toxicology in animals and humans, Addiction, 91, 1585, 10.1111/j.1360-0443.1996.tb02264.x Begg, 2002, Modulation of the release of endogenous adenosine by cannabinoids in the myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum, Br. J. Pharmacol., 137, 1298, 10.1038/sj.bjp.0704985 Blanco-Centurión, 2006, Adenosine and sleep homeostasis in the Basal forebrain, J. Neurosci., 26, 8092, 10.1523/JNEUROSCI.2181-06.2006 Brown, 2012, Control of sleep and wakefulness, Physiol. Rev., 92, 1087, 10.1152/physrev.00032.2011 Cannazza, 2012, Simultaneous measurement of adenosine, dopamine, acetylcholine and 5-hydroxytryptamine in cerebral mice microdialysis samples by LC-ESI-MS/MS, J. Pharm. Biomed. Anal., 71, 183, 10.1016/j.jpba.2012.08.004 Carlini, 1981, Hypnotic and antiepileptic effects of cannabidiol, J. Clin. Pharmacol., 21, 417S, 10.1002/j.1552-4604.1981.tb02622.x Carrier, 2006, Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression, Proc. Natl. Acad. Sci. U.S.A., 103, 7895, 10.1073/pnas.0511232103 Chagas, 2013, Effects of acute systemic administration of cannabidiol on sleep–wake cycle in rats, J. Psychopharmacol. (Oxf.), 27, 312, 10.1177/0269881112474524 Hsiao, 2012, Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats, Neuropharmacology, 62, 373, 10.1016/j.neuropharm.2011.08.013 Huang, 2011, The role of adenosine in the regulation of sleep, Curr. Top. Med. Chem., 11, 1047, 10.2174/156802611795347654 Landolt, 2008, Sleep homeostasis: a role for adenosine in humans?, Biochem. Pharmacol., 75, 2070, 10.1016/j.bcp.2008.02.024 Mazzucchelli, 2011, Development and validation of an HPLC-UV detection assay for the determination of rufinamide in human plasma and saliva, Anal. Bioanal. Chem., 401, 1013, 10.1007/s00216-011-5126-9 Mechoulam, 2007, Cannabidiol-recent advances, Chem. Biodivers., 4, 1678, 10.1002/cbdv.200790147 Mechoulam, 1970, Chemical basis of hashish activity, Science, 169, 611, 10.1126/science.169.3945.611 Millan, 2010, Accumbens shell–hypothalamus interactions mediate extinction of alcohol seeking, J. Neurosci., 30, 4626, 10.1523/JNEUROSCI.4933-09.2010 Monti, 1977, Hypnoticlike effects of cannabidiol in the rat, Psychopharmacology (Berl.), 55, 263, 10.1007/BF00497858 Murillo-Rodríguez, 2004, The diurnal rhythm of adenosine levels in the basal forebrain of young and old rats, Neurosci., 123, 361, 10.1016/j.neuroscience.2003.09.015 Murillo-Rodríguez, 2006, Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats, FEBS Lett., 580, 4337, 10.1016/j.febslet.2006.04.102 Murillo-Rodríguez, 2008, The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent, Behav. Neurosci., 122, 1378, 10.1037/a0013278 Murillo-Rodríguez, 2011, Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats, Life Sci., 14, 504, 10.1016/j.lfs.2011.01.013 Nicholson, 2004, Effect of delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults, J. Clin. Psychopharmacol., 24, 305, 10.1097/01.jcp.0000125688.05091.8f Pajski, 2013, The mechanism of electrically stimulated adenosine release varies by brain region, Purinergic Signal., 9, 167, 10.1007/s11302-012-9343-2 Pandolfo, 2011, Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum, Eur. J. Pharmacol., 655, 38, 10.1016/j.ejphar.2011.01.013 Paxinos, 2005 Porkka-Heiskanen, 2002, Adenosine and sleep, Sleep Med. Rev., 6, 321, 10.1053/smrv.2001.0201 Porkka-Heiskanen, 2000, Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study, Neuroscience, 99, 507, 10.1016/S0306-4522(00)00220-7 Qiu, 2012, The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal, PLoS ONE, 7, e45471, 10.1371/journal.pone.0045471 Salem, 1999, Role of endogenous adenosine in the expression of opiate withdrawal in rats, Eur. J. Pharmacol., 369, 39, 10.1016/S0014-2999(99)00046-1 Sartori, 2008, Development and validation of a fast RP-HPLC method for determination of methotrexate entrapment efficiency in polymeric nanocapsules, J. Chromatogr. Sci., 46, 505, 10.1093/chromsci/46.6.505 Shimadzu Corporation, 2005