Intracorneal injection of a detachable hybrid microneedle for sustained drug delivery

Pierre, 2014, Microneedle-based drug delivery systems for transdermal route, Curr. Drug Targets, 15, 281, 10.2174/13894501113146660232 Donnelly, 2010, Microneedle-based drug delivery systems: microfabrication, drug delivery, and safety, Drug Delivery, 17, 187, 10.3109/10717541003667798 Bloomfield, 1978, Soluble gentamicin ophthalmic inserts as a drug delivery system, Arch. Ophthamol., 96, 885, 10.1001/archopht.1978.03910050487020 Sasaki, 2003, One-side-coated insert as a unique ophthalmic drug delivery system, J. Control. Release, 92, 241, 10.1016/S0168-3659(03)00362-6 Lamberts, 1978, A clinical study of slow-releasing artificial tears, Ophthalmology, 85, 794, 10.1016/S0161-6420(78)35610-4 Gurtler, 1995, Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation, J. Control. Release, 33, 231, 10.1016/0168-3659(94)00096-D Chetonia, 1998, Silicone rubber/hydrogel composite ophthalmic inserts: preparation and preliminary in vitro/in vivo evaluation, Eur. J. Pharm. Biopharm., 46, 125, 10.1016/S0939-6411(97)00168-9 Stephane, 2006, Pharmacodynamics of a new ophthalmic mydriatic insert in healthy volunteers: potential alternative as drug delivery system prior to cataract surgery, Basic Clin. Pharmacol., 98, 547, 10.1111/j.1742-7843.2006.pto_362.x Pijls, 2007, Pradofloxacin release from the OphthaCoil: a new device for sustained delivery of drugs to the eye, J. Drug Deliv. Sci. Tec., 17, 87, 10.1016/S1773-2247(07)50012-2 Maulvi, 2016, In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery, J. Control. Release, 226, 47, 10.1016/j.jconrel.2016.02.012 Carvalho, 2015, Sustained drug release by contact lenses for glaucoma treatment-a review, J. Control. Release, 202, 76, 10.1016/j.jconrel.2015.01.023 Tieppo, 2012, Sustained in vivo release from imprinted therapeutic contact lenses, J. Control. Release, 157, 391, 10.1016/j.jconrel.2011.09.087 Ali, 2007, Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow, J. Control. Release, 124, 154, 10.1016/j.jconrel.2007.09.006 Järvinen, 1995, Ocular absorption following topical delivery, Adv. Drug Deliver. Rev., 16, 3, 10.1016/0169-409X(95)00010-5 Jiang, 2007, Coated microneedles for drug delivery to the eye, Invest. Ophthalmol. Vis. Sci., 48, 4038, 10.1167/iovs.07-0066 Khandan, 2016, Fenestrated microneedles for ocular drug delivery, Sensor. Actuat. B-CHEM., 223, 15, 10.1016/j.snb.2015.09.071 Prausnitz, 2014, Intrastromal delivery of bevacizumab using microneedles to treat corneal neovascularization, Invest. Ophthalmol. Vis. Sci., 55, 7376, 10.1167/iovs.14-15257 Song, 2015, Impact insertion of transfer-molded microneedle for localized and minimally invasive ocular drug delivery, J. Control. Release, 209, 272, 10.1016/j.jconrel.2015.04.041 Holden, 1985, Effects of long-term extended contact lens wear on the human cornea, Invest. Ophthalmol. Vis. Sci, 26, 1489 Bhatnagar, 2017, Corneal delivery of besifloxacin using rapidly dissolving polymeric microneedles, Drug Deliv. Transl. Re., 1 Jensen, 1970, Axenic cultivation of large populations of Acanthamoeba castellanii (JBM), J. Parasitol., 904, 10.2307/3277503 Suryawanshi, 2015, IL-17A-mediated protection against Acanthamoeba Keratitis, J. Immunol., 194, 650, 10.4049/jimmunol.1302707 Ren, 2010, Evaluation of three different methods to establish animal models of Acanthamoeba keratitis, Yonsei Med. J., 51, 121, 10.3349/ymj.2010.51.1.121 Ge, 2013, Rapid and sensitive diagnosis of Acanthamoeba keratitis by loop-mediated isothermal amplification, Clin. Microbiol. Infect., 19, 1042, 10.1111/1469-0691.12149 Dai, 2005, A quantitative study on the adhesion property of cured SU-8 on various metallic surfaces, Microsyst. Technol., 11, 526, 10.1007/s00542-005-0587-4 Lee, 2007, Cysticidal effect on Acanthamoeba and toxicity on human keratocytes by polyhexamethylene biguanide and chlorhexidine, Cornea, 26, 736, 10.1097/ICO.0b013e31805b7e8e Kunou, 2000, Long-term sustained release of ganciclovir from biodegradable scleral implant for the treatment of cytomegalovirus retinitis, J. Control. Release, 68, 263, 10.1016/S0168-3659(00)00267-4 Chu, 2011, Separable arrowhead microneedles, J. Control. Release, 149, 242, 10.1016/j.jconrel.2010.10.033 Yu, 2017, Near-infrared light triggered and separable microneedles for transdermal delivery of metformin in diabetic rats, J. Mater. Chem. B, 5, 9507, 10.1039/C7TB02236K Hsu, 2013, Feasibility of corneal drug delivery of cysteamine using vitamin E modified silicone hydrogel contact lenses, Eur. J. Pharm. Biopharm., 85, 531, 10.1016/j.ejpb.2013.04.017