Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation

Wijffels, 1995, Atrial fibrillation begets atrial fibrillation, Circulation, 92, 1954, 10.1161/01.CIR.92.7.1954

Nattel, 2002, New ideas about atrial fibrillation 50 years on, Nature, 415, 219, 10.1038/415219a

Nattel, 2007, Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation, Physiol Rev, 87, 425, 10.1152/physrev.00014.2006

Dobrev, 2006, Electrical remodeling in atrial fibrillation, Herz, 31, 108, 10.1007/s00059-006-2787-9

Vest, 2005, Defective cardiac ryanodine receptor regulation during atrial fibrillation, Circulation, 111, 2025, 10.1161/01.CIR.0000162461.67140.4C

Christ, 2004, L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases, Circulation, 110, 2651, 10.1161/01.CIR.0000145659.80212.6A

Van Wagoner, 1999, Atrial L-type Ca2+ currents and human atrial fibrillation, Circ Res, 85, 428, 10.1161/01.RES.85.5.428

Hove-Madsen, 2004, Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes, Circulation, 110, 1358, 10.1161/01.CIR.0000141296.59876.87

Wehrens, 2003, FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death, Cell, 113, 829, 10.1016/S0092-8674(03)00434-3

El-Armouche, 2006, Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation, Circulation, 114, 670, 10.1161/CIRCULATIONAHA.106.636845

Burashnikov, 2003, Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity, Circulation, 107, 2355, 10.1161/01.CIR.0000065578.00869.7C

Gaborit, 2007, Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart, J Physiol, 582, 675, 10.1113/jphysiol.2006.126714

Li, 2005, Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice, Circ Res, 96, 1274, 10.1161/01.RES.0000172556.05576.4c

Verheule, 2004, Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1, Circ Res, 94, 1458, 10.1161/01.RES.0000129579.59664.9d

Mitchell, 1998, Measurement of heart rate and Q-T interval in the conscious mouse, Am J Physiol, 274, H747

Shannon, 2002, Quantitative assessment of the SR Ca2+ leak-load relationship, Circ Res, 91, 594, 10.1161/01.RES.0000036914.12686.28

Schrickel, 2002, Induction of atrial fibrillation in mice by rapid transesophageal atrial pacing, Basic Res Cardiol, 97, 452, 10.1007/s003950200052

Zahradnikova, 1993, Procaine effects on single sarcoplasmic reticulum Ca2+ release channels, Biophys J, 64, 991, 10.1016/S0006-3495(93)81465-6

Venetucci, 2006, Reducing ryanodine receptor open probability as a means to abolish spontaneous Ca2+ release and increase Ca2+ transient amplitude in adult ventricular myocytes, Circ Res, 98, 1299, 10.1161/01.RES.0000222000.35500.65

Wehrens, 2004, Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2, Science, 304, 292, 10.1126/science.1094301

Curran, 2007, Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase, Circ Res, 100, 391, 10.1161/01.RES.0000258172.74570.e6

Kannankeril, 2006, Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy, Proc Natl Acad Sci U S A, 103, 12179, 10.1073/pnas.0600268103

Lehnart, 2006, Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias, Proc Natl Acad Sci U S A, 103, 7906, 10.1073/pnas.0602133103

Qu, 2006, Dynamics and cardiac arrhythmias, J Cardiovasc Electrophysiol, 17, 1042, 10.1111/j.1540-8167.2006.00567.x

Kovoor, 2001, Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model, J Am Coll Cardiol, 37, 2136, 10.1016/S0735-1097(01)01304-3

Wakimoto, 2001, Induction of atrial tachycardia and fibrillation in the mouse heart, Cardiovasc Res, 50, 463, 10.1016/S0008-6363(01)00264-4

Kumagai, 2003, Antiarrhythmic effects of JTV-519, a novel cardioprotective drug, on atrial fibrillation/flutter in a canine sterile pericarditis model, J Cardiovasc Electrophysiol, 14, 880, 10.1046/j.1540-8167.2003.03050.x

Wehrens, 2004, Novel therapeutic approaches for heart failure by normalising calcium cycling, Nat Rev Drug Discov, 3, 565, 10.1038/nrd1440