Intestinal Glutamate Metabolism

The Journal of Nutrition - Tập 130 Số 4 - Trang 978S-982S - 2000
P J Reeds1, Douglas G. Burrin, Barbara J. Stoll, Farook Jahoor
1U.S. Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Aw, 1992, Intestinal absorption and lymphatic transport of peroxidized lipids in rats: effect of exogenous GSH, Am. J. Physiol, 263, G665

Ball, R. O., House, J. D., Wykes, L. J. & Pencharz, P. B. (1996) A piglet model for neonatal amino acid metabolism during total parenteral nutrition. Tumbleson, M. E.Schook, L. B. eds. Advances in Swine in Biomedical Research:713–731Plenum PressNew York, NY.

Battezzati, 1995, Oxidation of glutamic acid by the splanchnic bed in humans, Am. J. Physiol, 269, E269

Berthold, 1991, Uniformly labelled algal protein used to determine amino acid essentiality in vivo, Proc. Natl. Acad. Sci. U.S.A, 88, 8091, 10.1073/pnas.88.18.8091

Berthold, 1995, Isotopic evidence for the differential regulation of arginine and proline synthesis in man, Metabolism, 44, 466, 10.1016/0026-0495(95)90053-5

Blachier, 1993, Intestinal arginine metabolism during development, Evidence for de novo synthesis of L-arginine in newborn pig enterocytes. Eur. J. Biochem, 216, 109

Brunengraber, 1997, Applications of mass isotopomer analysis to nutrition research, Annu. Rev. Nutr, 17, 559, 10.1146/annurev.nutr.17.1.559

Burrin, 1997, Alternative fuels in the gastrointestinal tract, Curr. Opin. Gastroenterol, 13, 165, 10.1097/00001574-199703000-00015

Darcy-Vrillon, 1994, Glucose, galactose, and glutamine metabolism in pig isolated enterocytes during development, Pediatr. Res, 36, 175, 10.1203/00006450-199408000-00007

Darmaun, 1997, Glutamine metabolism in very low birth weight infants, Pediatr. Res, 41, 391, 10.1203/00006450-199703000-00015

Davis, 1994, Amino acid composition of human milk is not unique, J. Nutr, 124, 1126, 10.1093/jn/124.7.1126

Ebner, 1994, Growth and metabolism of gastrointestinal and skeletal muscle tissues in protein-malnourished neonatal pigs, Am. J. Physiol, 266, R1736

Fleming, 1991, Nutrient utilization by cells isolated from rat jejunum, cecum and colon, J. Nutr, 121, 869, 10.1093/jn/121.6.869

Fleming, 1997, Glucose and glutamine provide similar proportions of energy to mucosal cells of rat small intestine, Am. J. Physiol, 273, G968

Jahoor, 1996, Protein-deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation, J. Nutr, 125, 1462

Kight, 1993, Nutrient oxidation by rat intestinal epithelial cells is concentration dependent, J. Nutr, 123, 876, 10.1093/jn/123.5.876

Kight, 1995, Oxidation of glucose carbon entering the TCA cycle is reduced by glutamine in small intestine epithelial cells, Am. J. Physiol, 268, G879

Matthews, 1993, Splanchnic bed utilization of glutamine and glutamic acid in humans, Am. J. Physiol, 264, E848

Moughan, 1992, The piglet as a model animal for studying aspects of digestion and absorption in milk-fed human infants, World Rev. Nutr. Diet, 67, 41

Murphy, 1996, Proline is synthesized from glutamate during intragastric infusion but not during intravenous infusion in neonatal piglets, J. Nutr, 126, 878, 10.1093/jn/126.4.878

Neame, 1957, The transamination of glutamic and aspartic acids during absorption by the small intestine of the dog in vivo, J. Physiol, 135, 442, 10.1113/jphysiol.1957.sp005722

Pascual, 1998, In vivo glucose contribution to glutamate synthesis is maintained while its contribution to acetyl CoA is lowered in adult mice fed a restricted amount of carbohydrate J, Nutr, 128, 733

Reeds, 1997, Integration of amino acid and carbon intermediary metabolism: studies with uniformly labeled tracers and mass isotopomer analysis, Eur. J. Pediatr, 156, S50, 10.1007/PL00014272

Reeds, P. J., Burrin, D. G., Davis, T. A., Stoll, B., Wykes, L. J., Wray-Cahen, D., Jahoor, F., Dudley, M. A., Fiorotto, M. L. & Gannon, N. J. (1997b) The piglet as a model for the study of growth, development and nutrition. Cranwell, P. D. eds. Manipulating Pig Production VI:1–27APSA Melbourne, Australia.

Reeds, 1997, Enteral glutamate is the preferential precursor for mucosal glutathione synthesis in the piglet, Am. J. Physiol, 273, E408

Reeds, 1996, Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract of infant pigs, Am. J. Physiol, 270, E413

Stoll, 1997, Phenylalanine utilization by the gut and liver measured with intravenous and intragastric tracers in pigs, Am. J. Physiol, 274, G1811

Stoll, 1998, (1998a) Dietary amino acids are the preferential source of hepatic protein synthesis in piglets, J. Nutr, 128, 1517, 10.1093/jn/128.9.1517

Stoll, 1998, Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk-replacer fed piglets, J. Nutr, 128, 606, 10.1093/jn/128.3.606

Watford, 1994, Glutamine metabolism in rat small intestine: synthesis of three-carbon products in isolated enterocytes, Biochim. Biophys. Acta, 1200, 73, 10.1016/0304-4165(94)90029-9

Wilmore, 1997, Metabolic support of the gastrointestinal tract: potential gut protection during intensive cytotoxic therapy, Cancer, 79, 1794, 10.1002/(SICI)1097-0142(19970501)79:9<1794::AID-CNCR23>3.0.CO;2-S

Windmueller, 1982, Glutamine utilization by the small intestine, Adv. Enzymol. Relat. Areas Mol. Biol, 53, 201

Windmueller, 1974, Uptake and metabolism of plasma glutamine by the small intestine, J. Biol. Chem, 249, 5070, 10.1016/S0021-9258(19)42329-6

Windmueller, 1975, Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood, Arch. Biochem. Biophys, 171, 662, 10.1016/0003-9861(75)90078-8

Windmueller, 1976, Metabolism of absorbed aspartate, asparagine, and arginine by rat small intestine in vivo, Arch. Biochem. Biophys, 175, 670, 10.1016/0003-9861(76)90558-0

Windmueller, 1978, Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine, J. Biol. Chem, 253, 69, 10.1016/S0021-9258(17)38270-4

Windmueller, H. G. & Spaeth, A. E. (1980) Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine. Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats Quantitative importance of glutamine glutamate, and aspartate. J. Biol. Chem. 255 107–112.

Wu, 1996, An important role for pentose cycle in the synthesis of citrulline and proline from glutamine in porcine enterocytes, Arch. Biochem. Biophys, 336, 224, 10.1006/abbi.1996.0552

Wu, 1998, Intestinal mucosal amino acid catabolism, J. Nutr, 128, 1249, 10.1093/jn/128.8.1249

Wu, 1997, Endogenous synthesis of arginine plays an important role in maintaining arginine homeostasis in postweaning growing pigs, J. Nutr, 127, 2342, 10.1093/jn/127.12.2342

Wu, 1995, Arginine synthesis in enterocytes of neonatal pigs, Am. J. Physiol, 269, R621

Wu, 1995, Glutamine and glucose metabolism in enterocytes of the neonatal pig, Am. J. Physiol, 268, R334

Yu, 1990, Quantitative role of splanchnic region in leucine metabolism: L-[1-13C,15N]leucine and substrate balance studies, Am. J. Physiol, 259, E36