Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen

Ageing Research Reviews - Tập 57 - Trang 100978 - 2020
Sidong Yang1, Feng Zhang2, Jiangtao Ma3, Wenyuan Ding1
1Department of Spine Surgery, The Third Hospital of Hebei Medical University, 139Ziqiang Rd, Shijiazhuang 050051, PR China
2Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, 139Ziqiang Rd, Shijiazhuang 050051, PR China
3Laboratory of Immunology, Hebei Provincial Institute of Orthopaedic Research, 139Ziqiang Rd, Shijiazhuang 050051, PR China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Ahn, 2002, mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs, Spine, 27, 911, 10.1097/00007632-200205010-00005

Anderson, 2005, Molecular pathogenic factors in symptomatic disc degeneration, Spine J., 5, 260S, 10.1016/j.spinee.2005.02.010

Ao, 2018, 17β-estradiol protects nucleus pulposus cells from serum deprivation-induced apoptosis and regulates expression of MMP-3 and MMP-13 through promotion of autophagy, Biochem. Biophys. Res. Commun., 503, 791, 10.1016/j.bbrc.2018.06.077

Bach, 2015, The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs, Eur. Cell. Mater., 30, 132, 10.22203/eCM.v030a10

Baron, 2005, Intervertebral disc height in treated and untreated overweight post-menopausal women, Hum. Reprod., 20, 3566, 10.1093/humrep/dei251

Bertolo, 2014, Physiological testosterone levels enhance chondrogenic extracellular matrix synthesis by male intervertebral disc cells in vitro, but not by mesenchymal stem cells, Spine J., 14, 455, 10.1016/j.spinee.2013.10.018

Boden, 1990, Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation, J. Bone Joint Surg. Am., 72, 403, 10.2106/00004623-199072030-00013

Bressler, 1999, The prevalence of low back pain in the elderly. A systematic review of the literature, Spine, 24, 1813, 10.1097/00007632-199909010-00011

Buckwalter, 1995, Aging and degeneration of the human intervertebral disc, Spine, 20, 1307, 10.1097/00007632-199506000-00022

Burke, 2002, Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators, J. Bone Joint Surg. Br., 84, 196, 10.1302/0301-620X.84B2.0840196

Burke, 2002, Spontaneous production of monocyte chemoattractant protein-1 and interleukin-8 by the human lumbar intervertebral disc, Spine, 27, 1402, 10.1097/00007632-200207010-00006

Calleja-Agius, 2009, Estrogens and the intervertebral disc, Menopause Int., 15, 127, 10.1258/mi.2009.009016

Canonico, 2007, Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study, Circulation, 115, 840, 10.1161/CIRCULATIONAHA.106.642280

Chen, 2014, Upregulation of tumor necrosis factor α and ADAMTS-5, but not ADAMTS-4, in human intervertebral cartilage endplate with modic changes, Spine, 39, E817, 10.1097/BRS.0000000000000362

Chung, 2003, The molecular basis of intervertebral disk degeneration, Orthop. Clin. North Am., 34, 209, 10.1016/S0030-5898(03)00026-9

Crandall, 2012, Breast tenderness and breast cancer risk in the estrogen plus progestin and estrogen-alone women’s health initiative clinical trials, Breast Cancer Res. Treat., 132, 275, 10.1007/s10549-011-1848-9

de Schepper, 2010, The association between lumbar disc degeneration and low back pain: the influence of age, gender, and individual radiographic features, Spine, 35, 531, 10.1097/BRS.0b013e3181aa5b33

Deng, 2012, Effect of ovariectomy on contrast agent diffusion into lumbar intervertebral disc: a dynamic contrast-enhanced MRI study in female rats, Magn. Reson. Imaging, 30, 683, 10.1016/j.mri.2012.01.001

Ding, 2013, Cell death in intervertebral disc degeneration, Apoptosis, 18, 777, 10.1007/s10495-013-0839-1

Ding, 2018, Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates, Am. J. Transl. Res., 10, 718

Doita, 1996, Immunohistologic study of the ruptured intervertebral disc of the lumbar spine, Spine, 21, 235, 10.1097/00007632-199601150-00015

Doita, 2001, Influence of macrophage infiltration of herniated disc tissue on the production of matrix metalloproteinases leading to disc resorption, Spine, 26, 1522, 10.1097/00007632-200107150-00004

Files, 2014, Effects of different hormone therapies on breast pain in recently postmenopausal women: findings from the Mayo Clinic KEEPS breast pain ancillary study, J. Womens Health (Larchmt), 23, 801, 10.1089/jwh.2014.4871

Fuhrman, 2012, Estrogen metabolism and risk of breast cancer in postmenopausal women, J. Natl. Cancer Inst., 104, 326, 10.1093/jnci/djr531

Griffith, 2010, Reduced bone perfusion in osteoporosis: likely causes in an ovariectomy rat model, Radiology, 254, 739, 10.1148/radiol.09090608

Gruber, 2002, Expression and localization of estrogen receptor-beta in annulus cells of the human intervertebral disc and the mitogenic effect of 17-beta-estradiol in vitro, BMC Musculoskelet. Disord., 3, 4, 10.1186/1471-2474-3-4

Gui, 2015, Research status on molecular basis of intervertebral disc degeneration and repairing effect of platelet-rich plasma, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 29, 123

Ha, 2005, Expression of estrogen receptor of the facet joints in degenerative spondylolisthesis, Spine, 30, 562, 10.1097/01.brs.0000154674.16708.af

Hadjipavlou, 2008, The pathophysiology of disc degeneration: a critical review, J. Bone Joint Surg. Br., 90, 1261, 10.1302/0301-620X.90B10.20910

Harburger, 2009, Integrin signalling at a glance, J. Cell. Sci., 122, 159, 10.1242/jcs.018093

Hattori, 2012, A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes, Biochem. Biophys. Res. Commun., 421, 418, 10.1016/j.bbrc.2012.03.111

Holm, 1981, Nutrition of the intervertebral disc: solute transport and metabolism, Connect. Tissue Res., 8, 101, 10.3109/03008208109152130

Hoy, 2012, A systematic review of the global prevalence of low back pain, Arthritis Rheum., 64, 2028, 10.1002/art.34347

Imada, 1995, Oophorectomy predisposes to degenerative spondylolisthesis, J. Bone Joint Surg. Br., 77, 126, 10.1302/0301-620X.77B1.7822369

James, 2018, Dysregulation of the inflammatory mediators in the multifidus muscle after spontaneous intervertebral disc degeneration SPARC-null mice is ameliorated by physical activity, Spine, 43, E1184, 10.1097/BRS.0000000000002656

Johnson, 2009, Integrins during evolution: evolutionary trees and model organisms, Biochim. Biophys. Acta, 1788, 779, 10.1016/j.bbamem.2008.12.013

Kadow, 2015, Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions, Clin. Orthop. Relat. Res., 473, 1903, 10.1007/s11999-014-3774-8

Kang, 1996, Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2, Spine, 21, 271, 10.1097/00007632-199602010-00003

Kang, 1995, Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2, Spine, 20, 2373, 10.1097/00007632-199511001-00001

Kato, 2010, GRIP1 enhances estrogen receptor alpha-dependent extracellular matrix gene expression in chondrogenic cells, Osteoarthr. Cartil., 18, 934, 10.1016/j.joca.2010.03.008

Kepler, 2011, Intervertebral disk degeneration and emerging biologic treatments, J. Am. Acad. Orthop. Surg., 19, 543, 10.5435/00124635-201109000-00005

Kepler, 2013, The molecular basis of intervertebral disc degeneration, Spine J., 13, 318, 10.1016/j.spinee.2012.12.003

LaCroix, 2011, Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial, JAMA, 305, 1305, 10.1001/jama.2011.382

Larsson, 2005, Disc related cytokines inhibit axonal outgrowth from dorsal root ganglion cells in vitro, Spine, 30, 621, 10.1097/01.brs.0000155410.48700.9e

Le, 2007, Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration, Arthritis Res. Ther., 9, R45, 10.1186/ar2198

Leitinger, 2007, Mammalian collagen receptors, Matrix Biol., 26, 146, 10.1016/j.matbio.2006.10.007

Li, 2017, 17beta-estradiol attenuates TNF-α-Induced premature senescence of nucleus pulposus cells through regulating the ROS/NF-κB pathway, Int. J. Biol. Sci., 13, 145, 10.7150/ijbs.16770

Liu, 2018, Urolithin a inhibits the catabolic effect of TNFα on nucleus pulposus cell and alleviates intervertebral disc degeneration in vivo, Front. Pharmacol., 9, 1043, 10.3389/fphar.2018.01043

Liu, 2017, Protective role of 17β-estradiol on tumor necrosis factor-α-induced apoptosis in human nucleus pulposus cells, Mol. Med. Rep., 16, 1093, 10.3892/mmr.2017.6690

Liu, 2018, 17β-Estradiol inhibits intervertebral disc degeneration by down-regulating MMP-3 and MMP-13 and up-regulating type II collagen in a rat model, Artif. Cells Nanomed. Biotechnol., 1

Luoma, 2000, Low back pain in relation to lumbar disc degeneration, Spine, 25, 487, 10.1097/00007632-200002150-00016

Lyons, 1981, Biochemical changes in intervertebral disc degeneration, Biochim. Biophys. Acta, 673, 443, 10.1016/0304-4165(81)90476-1

MacColl, 2015, Matrix metalloproteinases as regulators of vein structure and function: implications in chronic venous disease, J. Pharmacol. Exp. Ther., 355, 410, 10.1124/jpet.115.227330

Matsunaga, 2003, Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs, J. Neurosurg., 98, 63

Melrose, 2012, Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration, Spine, 37, 18, 10.1097/BRS.0b013e31820cd8d5

Millecamps, 2018, Delayed onset of persistent discogenic axial and radiating pain after a single-level lumbar intervertebral disc injury in mice, Pain, 159, 1843, 10.1097/j.pain.0000000000001284

Miller, 2017, An update on hormone therapy in postmenopausal women: mini-review for the basic scientist, Am. J. Physiol. Heart Circ. Physiol., 313, H1013, 10.1152/ajpheart.00383.2017

Ming-Yan, 2019, Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway, Biosci. Rep., 39

Miyamoto, 2000, The role of cyclooxygenase-2 and inflammatory cytokines in pain induction of herniated lumbar intervertebral disc, Kobe J. Med. Sci., 46, 13

Moore, 2006, The vertebral endplate: disc degeneration, disc regeneration, Eur. Spine J., 15, S333, 10.1007/s00586-006-0170-4

Morato, 1961, The intermediate steps in the biosynthesis of estrogens from androgens, Biochem. Biophys. Res. Commun., 6, 334, 10.1016/0006-291X(61)90140-1

Murata, 2006, Production of tumor necrosis factor-alpha from porcine nucleus pulposus cells at various time points in cell culture under conditions of nutritional deficiency, Cytokine, 34, 206, 10.1016/j.cyto.2006.05.002

Muscat, 2007, Low intervertebral disc height in postmenopausal women with osteoporotic vertebral fractures compared to hormone-treated and untreated postmenopausal women and premenopausal women without fractures, Climacteric, 10, 314, 10.1080/13697130701460640

Nachemson, 1970, In vitro diffusion of dye through the end-plates and the annulus fibrosus of human lumbar inter-vertebral discs, Acta Orthop. Scand., 41, 589, 10.3109/17453677008991550

Nagano, 1995, Distribution of the basic fibroblast growth factor and its receptor gene expression in normal and degenerated rat intervertebral discs, Spine, 20, 1972, 10.1097/00007632-199509150-00002

Nair, 2000, The ERA trial: findings and implications for the future, Climacteric, 3, 227, 10.1080/13697130008500132

Ni, 2019, TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway, J. Orthop. Surg. Res., 14, 241, 10.1186/s13018-019-1260-4

Ning, 2016, Protective effect of 17β-estradiol on hydrogen peroxide induced apoptosis of rat nucleus pulposus cells, Int. J. Clin. Exp. Med., 9, 17281

Olmarker, 1998, Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury, Spine, 23, 2538, 10.1097/00007632-199812010-00008

Park, 2001, Expression of Fas receptor on disc cells in herniated lumbar disc tissue, Spine, 26, 142, 10.1097/00007632-200101150-00006

Pelletier, 2000, Localization of androgen and estrogen receptors in rat and primate tissues, Histol. Histopathol., 15, 1261

Pimenta, 2018, Elastomeric lumbar total disc replacement: clinical and radiological results with minimum 84 months follow-up, Int. J. Spine Surg., 12, 49, 10.14444/5009

Podichetty, 2007, The aging spine: the role of inflammatory mediators in intervertebral disc degeneration, Cell. Mol. Biol. (Noisy-le-grand), 53, 4

Prince, 2015, The burden of disease in older people and implications for health policy and practice, Lancet, 385, 549, 10.1016/S0140-6736(14)61347-7

Raj, 2008, Intervertebral disc: anatomy-physiology-pathophysiology-treatment, Pain Pract., 8, 18, 10.1111/j.1533-2500.2007.00171.x

Rand, 1997, Murine nucleus pulposus-derived cells secrete interleukins-1-beta, -6, and -10 and granulocyte-macrophage colony-stimulating factor in cell culture, Spine, 22, 2598, 10.1097/00007632-199711150-00002

Roberts, 2006, Histology and pathology of the human intervertebral disc, J. Bone Joint Surg. Am., 88, 10

Rodrigues-Pinto, 2016, Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord-specific markers during early human intervertebral disc development, J. Orthop. Res., 34, 1327, 10.1002/jor.23205

Sharma, 2018, The role of adipokines in intervertebral disc degeneration, Med. Sci. Basel (Basel), 6

Sheng, 2018, Protective effect of estrogen against intervertebral disc degeneration is attenuated by miR-221 through targeting estrogen receptor α, Acta Biochim. Biophys. Sin. (Shanghai), 50, 345, 10.1093/abbs/gmy017

Simpson, 2015, Celebrating 75 years of oestradiol, J. Mol. Endocrinol., 55, T1, 10.1530/JME-15-0128

Song, 2017, Estrogen receptors involvement in intervertebral discogenic pain of the elderly women: colocalization and correlation with the expression of Substance P in nucleus pulposus, Oncotarget, 8, 38136, 10.18632/oncotarget.15421

Song, 2014, Estrogen receptor expression in lumbar intervertebral disc of the elderly: gender- and degeneration degree-related variations, Joint Bone Spine, 81, 250, 10.1016/j.jbspin.2013.09.002

Stokes, 2004, Mechanical conditions that accelerate intervertebral disc degeneration: overload versus immobilization, Spine, 29, 2724, 10.1097/01.brs.0000146049.52152.da

Studd, 2010, Ten reasons to be happy about hormone replacement therapy: a guide for patients, Menopause Int., 16, 44, 10.1258/mi.2010.010001

Sudo, 2010, Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression, J. Orthop. Res., 28, 1608, 10.1002/jor.21185

Sudo, 2011, Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration in rabbits, Arthritis Rheum., 63, 1648, 10.1002/art.30251

Séguin, 2006, Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration, Matrix Biol., 25, 409, 10.1016/j.matbio.2006.07.002

Séguin, 2005, Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue, Spine, 30, 1940, 10.1097/01.brs.0000176188.40263.f9

Takahashi, 1996, Inflammatory cytokines in the herniated disc of the lumbar spine, Spine, 21, 218, 10.1097/00007632-199601150-00011

Takatalo, 2009, Prevalence of degenerative imaging findings in lumbar magnetic resonance imaging among young adults, Spine, 34, 1716, 10.1097/BRS.0b013e3181ac5fec

Thompson, 1974, Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione, J. Biol. Chem., 249, 5364, 10.1016/S0021-9258(20)79735-8

Tolonen, 2006, Growth factor expression in degenerated intervertebral disc tissue. An immunohistochemical analysis of transforming growth factor beta, fibroblast growth factor and platelet-derived growth factor, Eur. Spine J., 15, 588, 10.1007/s00586-005-0930-6

Tolonen, 1995, Basic fibroblast growth factor immunoreactivity in blood vessels and cells of disc herniations, Spine, 20, 271, 10.1097/00007632-199502000-00003

Tolonen, 2001, Transforming growth factor beta receptor induction in herniated intervertebral disc tissue: an immunohistochemical study, Eur. Spine J., 10, 172, 10.1007/s005860000213

Urban, 1978, Diffusion of small solutes into the intervertebral disc: as in vivo study, Biorheology, 15, 203, 10.3233/BIR-1978-153-409

Urban, 1977, Nutrition of the intervertebral disk. An in vivo study of solute transport, Clin. Orthop. Relat. Res., 101, 10.1097/00003086-197711000-00012

Urban, 1982, Nutrition of the intervertebral disc: effect of fluid flow on solute transport, Clin. Orthop. Relat. Res., 296

Walker, 2004, Molecular basis of intervertebral disc degeneration, Spine J., 4, 158S, 10.1016/j.spinee.2004.07.010

Wang, 2017, Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration, Acta Biochim. Biophys. Sin. (Shanghai), 49, 1, 10.1093/abbs/gmw112

Wang, 2014, Different concentrations of 17β-estradiol modulates apoptosis induced by interleukin-1β in rat annulus fibrosus cells, Mol. Med. Rep., 10, 2745, 10.3892/mmr.2014.2514

Wang, 2014, Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies, Cell Prolif., 47, 381, 10.1111/cpr.12121

Wang, 2016, 17β-estradiol inhibites tumor necrosis Factor-α induced apoptosis of human nucleus pulposus cells via the PI3K/Akt pathway, Med. Sci. Monit., 22, 4312, 10.12659/MSM.900310

Wang, 2018, Potential therapeutic role of Co-Q10 in alleviating intervertebral disc degeneration and suppressing IL-1β-mediated inflammatory reaction in NP cells, Int. Immunopharmacol., 64, 424, 10.1016/j.intimp.2018.09.029

Wang, 2010, Effect of menopause on lumbar disk degeneration: potential etiology, Radiology, 257, 318, 10.1148/radiol.10100775

Wang, 2011, Menopause causes vertebral endplate degeneration and decrease in nutrient diffusion to the intervertebral discs, Med. Hypotheses, 77, 18, 10.1016/j.mehy.2011.03.014

Wang, 2011, Relationship between gender, bone mineral density, and disc degeneration in the lumbar spine: a study in elderly subjects using an eight-level MRI-based disc degeneration grading system, Osteoporos. Int., 22, 91, 10.1007/s00198-010-1200-y

Wei, 2016, Expression and functional roles of estrogen receptor GPR30 in human intervertebral disc, J. Steroid Biochem. Mol. Biol., 158, 46, 10.1016/j.jsbmb.2016.01.012

Weiler, 2005, Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls, Spine, 30, 44, 10.1097/01.brs.0000149186.63457.20

Wen, 2019, β‑ecdysterone protects against apoptosis by promoting autophagy in nucleus pulposus cells and ameliorates disc degeneration, Mol. Med. Rep., 19, 2440

Wiet, 2017, Mast Cell-Intervertebral disc cell interactions regulate inflammation, catabolism and angiogenesis in Discogenic back Pain, Sci. Rep., 7, 12492, 10.1038/s41598-017-12666-z

Wáng, 2016, Increased low back pain prevalence in females than in males after menopause age: evidences based on synthetic literature review, Quant. Imaging Med. Surg., 6, 199, 10.21037/qims.2016.04.06

Yang, 2018, 17β-Estradiol/extrogen receptor β alleviates apoptosis and enhances matrix biosynthesis of nucleus pulposus cells through regulating oxidative damage under a high glucose condition, Biomed. Pharmacother., 107, 1004, 10.1016/j.biopha.2018.08.084

Yang, 2014, 17β-Estradiol protects against apoptosis induced by levofloxacin in rat nucleus pulposus cells by upregulating integrin α2β1, Apoptosis, 19, 789, 10.1007/s10495-014-0965-4

Yang, 2016, Combined effect of 17β-estradiol and resveratrol against apoptosis induced by interleukin-1β in rat nucleus pulposus cells via PI3K/Akt/caspase-3 pathway, PeerJ, 4, e1640, 10.7717/peerj.1640

Yang, 2015, 17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13, Apoptosis, 20, 348, 10.1007/s10495-015-1086-4

Yang, 2015, Interleukin-1β in intervertebral disk degeneration, Clin. Chim. Acta, 450, 262, 10.1016/j.cca.2015.08.029

Zhang, 2011, Lentiviral shRNA silencing of CHOP inhibits apoptosis induced by cyclic stretch in rat annular cells and attenuates disc degeneration in the rats, Apoptosis, 16, 594, 10.1007/s10495-011-0596-y

Zhao, 2016, 17β-estradiol protects rat annulus fibrosus cells against apoptosis via α1 integrin-mediated adhesion to type I collagen: an in-vitro study, Med. Sci. Monit., 22, 1375, 10.12659/MSM.897906

Zhao, 2006, Programmed cell death in intervertebral disc degeneration, Apoptosis, 11, 2079, 10.1007/s10495-006-0290-7

Zhao, 2007, The cell biology of intervertebral disc aging and degeneration, Ageing Res. Rev., 6, 247, 10.1016/j.arr.2007.08.001