Interpretation of visual space under drug-induced ergotropic and trophotropic arousal

It was found that ergotropic arousal inducing drugs, such as psilocybin, a Ditran®-type ‘glycolate’ andd-amphet-amine, significantly lower human spatial distortion thresholds, i.e. these drugs, interfere with counter-adaptation to optical distortion, or the expectation to see the world undistorted. The trophotropic arousal inducing chlorpromazine® on the other hand promotes such counter-adaptation, i.e. the optimization of visual information. Optimization is independent from the rat at which the distorting stimulus is presented. Optimization is regarded here as a cortical (perceptual-behavioral) interpretive process while interference with and promotion of the optimization are subcortical influences.