International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors

Pharmacological Reviews - Tập 58 Số 4 - Trang 782-797 - 2006
Nick Z. Lu1, Suzanne E. Wardell2, Kerry L. Burnstein3, Donald Defranco4, Peter J. Fuller5, Vincent Giguère6, Richard B. Hochberg7, Lorraine I. McKay8, Jack‐Michel Renoir9, Nancy L. Weigel10, Elizabeth M. Wilson11, Donald P. McDonnell2, John A. Cidlowski1
1NATIONAL INSTITUTES OF HEALTH
2Duke University
3University of Miami
4University of Pittsburgh
5Hudson Institute of Medical Research (
6McGill University
7Yale University
8BRISTOL MYERS-SQUIBB
9Université Paris Saclay > > > >
10Baylor college of Medicine;
11University of North Carolina at Chapel Hill

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Amasheh, 2000, Differential regulation of ENaC by aldosterone in rat early and late distal colon, Ann NY Acad Sci, 915, 92, 10.1111/j.1749-6632.2000.tb05227.x

Arriza, 1987, Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor, Science (Wash DC), 237, 268, 10.1126/science.3037703

Auchus, 2004, The backdoor pathway to dihydrotestosterone, Trends Endocrinol Metab, 15, 432, 10.1016/j.tem.2004.09.004

Berger, 1998, Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism, Proc Natl Acad Sci USA, 95, 9424, 10.1073/pnas.95.16.9424

Bevan, 1999, The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1, Mol Cell Biol, 19, 8383, 10.1128/MCB.19.12.8383

Bledsoe, 2005, A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor, J Biol Chem, 280, 31283, 10.1074/jbc.M504098200

Bledsoe, 2002, Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition, Cell, 110, 93, 10.1016/S0092-8674(02)00817-6

Bray, 2003, Variations of the human glucocorticoid receptor gene (NR3C1): pathological and in vitro mutations and polymorphisms, Hum Mutat, 21, 557, 10.1002/humu.10213

Buttgereit, 2005, Optimised glucocorticoid therapy: the sharpening of an old spear, Lancet, 365, 801, 10.1016/S0140-6736(05)17989-6

Calle, 2003, Transcriptional inhibition of the human insulin receptor gene by aldosterone, J Steroid Biochem Mol Biol, 84, 543, 10.1016/S0960-0760(03)00072-4

Chang, 1988, Molecular cloning of human and rat complementary DNA encoding androgen receptors, Science (Wash DC), 240, 324, 10.1126/science.3353726

Chang, 2005, Androgen receptor-cofactor interactions as targets for new drug discovery, Trends Pharmacol Sci, 26, 225, 10.1016/j.tips.2005.03.002

Chen, 1997, Androgen and glucocorticoid receptor heterodimer formation: a possible mechanism for mutual inhibition of transcriptional activity, J Biol Chem, 272, 14087, 10.1074/jbc.272.22.14087

Chwalisz, 2005, Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis, Endocr Rev, 26, 423, 10.1210/er.2005-0001

Cidlowski, 1990, Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors, Mol Endocrinol, 4, 1427, 10.1210/mend-4-10-1427

Cole, 1995, Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation, Genes Dev, 9, 1608, 10.1101/gad.9.13.1608

Cole, 2001, GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant, Mol Cell Endocrinol, 173, 193, 10.1016/S0303-7207(00)00407-X

Craft, 1999, A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase, Nat Med, 5, 280, 10.1038/6495

de Kloet, 2000, Brain mineralocorticoid receptors and centrally regulated functions, Kidney Int, 57, 1329, 10.1046/j.1523-1755.2000.00971.x

Diamond, 1990, Transcription factor interactions: selectors of positive or negative regulation from a single DNA element, Science (Wash DC), 249, 1266, 10.1126/science.2119054

Drouin, 1993, Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene, EMBO (Eur Mol Biol Organ) J, 12, 145, 10.1002/j.1460-2075.1993.tb05640.x

Epple, 2000, Early aldosterone effect in distal colon by transcriptional regulation of ENaC subunits, Am J Physiol, 278, G718

Fagart, 2005, Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension, Nat Struct Mol Biol, 12, 554, 10.1038/nsmb939

Feldman, 2001, The development of androgen-independent prostate cancer, Nat Rev Cancer, 1, 34, 10.1038/35094009

Funder, 1993, Mineralocorticoids, glucocorticoids, receptors and response elements, Science (Wash DC), 259, 1132, 10.1126/science.8382375

Funder, 2004, Is aldosterone bad for the heart?, Trends Endocrinol Metab, 15, 139, 10.1016/j.tem.2004.03.006

Gadkar-Sable, 2005, Progesterone receptors: various forms and functions in reproductive tissues, Front Biosci, 10, 2118, 10.2741/1685

Gass, 1998, The antagonists RU486 and ZK98299 stimulate progesterone receptor binding to deoxyribonucleic acid in vitro and in vivo, but have distinct effects on receptor conformation, Endocrinology, 139, 1905, 10.1210/endo.139.4.5944

Goodman, 2006

Gregory, 2001, A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy, Cancer Res, 61, 4315

He, 2004, Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance, Mol Cell, 16, 425, 10.1016/j.molcel.2004.09.036

He, 1999, Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH2-terminal domain, J Biol Chem, 274, 37219, 10.1074/jbc.274.52.37219

He, 2002, The FXXLF motif mediates androgen receptor-specific interactions with coregulators, J Biol Chem, 277, 10226, 10.1074/jbc.M111975200

Hollenberg, 1985, Primary structure and expression of a functional human glucocorticoid receptor cDNA, Nature (Lond), 318, 635, 10.1038/318635a0

Isaacs, 1999, The biology of hormone refractory prostate cancer: why does it develop?, Urol Clin North Am, 26, 263, 10.1016/S0094-0143(05)70066-5

Jackson, 1997, The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT, Mol Endocrinol, 11, 693, 10.1210/mend.11.6.0004

Kastner, 1990, Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B, EMBO (Eur Mol Biol Organ) J, 9, 1603, 10.1002/j.1460-2075.1990.tb08280.x

Katzung, 2004

Kauppi, 2003, The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism, J Biol Chem, 278, 22748, 10.1074/jbc.M212711200

Klein, 1968, Berthold’s article: transplantation of the testes (1849), Arch Anat Histol Embryol, 51, 379

Koivisto, 1997, Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer, Cancer Res, 57, 314

Kolla, 2000, Transcriptional regulation of the human Na/K ATPase via the human mineralocorticoid receptor, Mol Cell Biochem, 204, 35, 10.1023/A:1007009700377

Kolla, 1999, Identification of a mineralocorticoid/glucocorticoid response element in the human Na/K ATPase α1 gene promoter, Biochem Biophys Res Commun, 266, 5, 10.1006/bbrc.1999.1765

Krozowski, 1983, Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity, Proc Natl Acad Sci USA, 80, 6056, 10.1073/pnas.80.19.6056

Kyprianou, 1990, Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation, Cancer Res, 50, 3748

Labrie, 2004, Major impact of hormonal therapy in localized prostate cancer—death can already be an exception, J Steroid Biochem Mol Biol, 92, 327, 10.1016/j.jsbmb.2004.10.011

Langley, 1998, Intermolecular NH2-/carboxyl-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity, J Biol Chem, 273, 92, 10.1074/jbc.273.1.92

Leonhardt, 1998, Agonist and antagonists induce homodimerization and mixed ligand heterodimerization of human progesterone receptors in vivo by a mammalian two-hybrid assay, Mol Endocrinol, 12, 1914, 10.1210/mend.12.12.0210

Li, 2005, Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor, Mol Cell, 19, 367, 10.1016/j.molcel.2005.06.026

Lin, 2005, Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor, Diabetes, 54, 1717, 10.2337/diabetes.54.6.1717

Lonard, 2005, Expanding functional diversity of the coactivators, Trends Biochem Sci, 30, 126, 10.1016/j.tibs.2005.01.001

Lu, 2005, Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes, Mol Cell, 18, 331, 10.1016/j.molcel.2005.03.025

Lubahn, 1988, Cloning of human androgen receptor complementary DNA and localization to the X chromosome, Science (Wash DC), 240, 327, 10.1126/science.3353727

Luisi, 1991, Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA, Nature (Lond), 352, 497, 10.1038/352497a0

Lydon, 1995, Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities, Genes Dev, 9, 2266, 10.1101/gad.9.18.2266

Mangal, 1997, Differential expression of uterine progesterone receptor forms A and B during the menstrual cycle, J Steroid Biochem Mol Biol, 63, 195, 10.1016/S0960-0760(97)00119-2

Mangelsdorf, 1995, The nuclear receptor superfamily: the second decade, Cell, 83, 835, 10.1016/0092-8674(95)90199-X

Marcelli, 2000, Androgen receptor mutations in prostate cancer, Cancer Res, 60, 944

Matias, 2000, Structural evidence for ligand specificity in the binding domain of the human androgen receptor: implications for pathogenic gene mutations, J Biol Chem, 275, 26164, 10.1074/jbc.M004571200

Matsumoto, 2005, Study of androgen receptor functions by genetic models, J Biochem (Tokyo), 138, 105, 10.1093/jb/mvi118

Meyer, 1990, Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor, EMBO (Eur Mol Biol Organ) J, 9, 3923, 10.1002/j.1460-2075.1990.tb07613.x

Misrahi, 1987, Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA, Biochem Biophys Res Commun, 143, 740, 10.1016/0006-291X(87)91416-1

Mozo, 1998, Glucocorticoids inhibit IL-4 and mitogen-induced IL-4Rα chain expression by different posttranscriptional mechanisms, J Allergy Clin Immunol, 102, 968, 10.1016/S0091-6749(98)70335-5

Newton, 1998, Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA, J Biol Chem, 273, 32312, 10.1074/jbc.273.48.32312

Oakley, 1996, The human glucocorticoid receptor betaisoform: expression, biochemical properties, and putative function, J Biol Chem, 271, 9550, 10.1074/jbc.271.16.9550

Pascual-Le Tallec, 2004, Human mineralocorticoid receptor A and B protein forms produced by alternative translation sites display different transcriptional activities, Eur J Endocrinol, 150, 585, 10.1530/eje.0.1500585

Poletti, 2004, The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons, Front Neuroendocrinol, 25, 1, 10.1016/j.yfrne.2004.03.001

Quigley, 1995, Androgen receptor defects: historical, clinical, and molecular perspectives, Endocr Rev, 16, 271

Rhen, 2005, Antiinflammatory action of glucocorticoids—new mechanisms for old drugs, N Engl J Med, 353, 1711, 10.1056/NEJMra050541

Rogerson, 1999, Structural determinants of aldosterone binding selectivity in the mineralocorticoid receptor, J Biol Chem, 274, 36305, 10.1074/jbc.274.51.36305

Rogerson, 2003, Interdomain interactions in the mineralocorticoid receptor, Mol Cell Endocrinol, 200, 45, 10.1016/S0303-7207(02)00413-6

Rossouw, 2002, Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial, J Am Med Assoc, 288, 321, 10.1001/jama.288.3.321

Ruijter, 1999, Molecular genetics and epidemiology of prostate carcinoma, Endocr Rev, 20, 22, 10.1210/edrv.20.1.0356

Sartorato, 2004, New naturally occurring missense mutations of the human mineralocorticoid receptor disclose important residues involved in dynamic interactions with deoxyribonucleic acid, intracellular trafficking, and ligand binding, Mol Endocrinol, 18, 2151, 10.1210/me.2003-0408

Sato, 2003, Late onset of obesity in male androgen receptor-deficient (AR KO) mice, Biochem Biophys Res Commun, 300, 167, 10.1016/S0006-291X(02)02774-2

Schreiber, 2005, Mifepristone in abortion care, Semin Reprod Med, 23, 82, 10.1055/s-2005-864036

Schulz, 2002, RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding, J Biol Chem, 277, 26238, 10.1074/jbc.M203268200

Sica, 2005, The risks and benefits of aldosterone antagonists, Curr Heart Fail Rep, 2, 65, 10.1007/s11897-005-0011-5

Smith, 2004, Coregulator function: a key to understanding tissue specificity of selective receptor modulators, Endocr Rev, 25, 45, 10.1210/er.2003-0023

Soyal, 2005, Cre-mediated recombination in cell lineages that express the progesterone receptor, Genesis, 41, 58, 10.1002/gene.20098

Stanbrough, 2006, Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer, Cancer Res, 66, 2815, 10.1158/0008-5472.CAN-05-4000

Tajima, 2000, A novel missense mutation of mineralocorticoid receptor gene in one Japanese family with a renal form of pseudohypoaldosteronism type 1, J Clin Endocrinol Metab, 85, 4690, 10.1210/jcem.85.12.7078

Tan, 1997, Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells, Mol Endocrinol, 11, 450, 10.1210/mend.11.4.9906

Taplin, 1999, Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist, Cancer Res, 59, 2511

Tetel, 1999, Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo, Mol Endocrinol, 13, 910, 10.1210/mend.13.6.0300

Trapp, 1996, Heterodimerization between mineralocorticoid and glucocorticoid receptors increases the functional diversity of corticosteroid action, Trends Pharmacol Sci, 17, 145, 10.1016/0165-6147(96)81590-2

Vegeto, 1992, The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor, Cell, 69, 703, 10.1016/0092-8674(92)90234-4

Verrey, 1987, Regulation by aldosterone of Na+,K+-ATPase mRNAs, protein synthesis, and sodium transport in cultured kidney cells, J Cell Biol, 104, 1231, 10.1083/jcb.104.5.1231

Wagner, 1998, The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor, Mol Cell Biol, 18, 1369, 10.1128/MCB.18.3.1369

Wardell, 2005, Mechanisms controlling agonist and antagonist potential of selective progesterone receptor modulators (SPRMs), Semin Reprod Med, 23, 9, 10.1055/s-2005-864030

Williams, 1998, Atomic structure of progesterone complexed with its receptor, Nature (Lond), 393, 392, 10.1038/30775

Xu, 1996, The extreme C terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressor, Proc Natl Acad Sci USA, 93, 12195, 10.1073/pnas.93.22.12195