International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat

Springer Science and Business Media LLC
Desiderio Passàli1, Veronica Barat2, Olga Cadevall3, Hugo Miguel Freire4, Ignazio Grattagliano5, Ioan Gutu6, Ralph Mösges7, А. В. Павлыш8
1International Federation ORL Societies (IFOS) Executive Board Members, Rome, Italy
2AOU Città della Salute e della Scienza di Torino, Regina Margherita Children’s Hospital, Turin, Italy
3Clínica Rotger, Quirónsalud, Palma de Mallorca, Spain
4Sociedade Portuguesa de Farmacêuticos dos Cuidados de Saúde, Coimbra, Portugal
5Italian College of General Practitioners and Primary Care, Florence, Italy
6General Practitioner, Vaslui, Romania
7Institute of Medical Statistics, and Computational Biology (IMSB), Medical Faculty, University at Cologne, Cologne, Germany
8North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia

Tóm tắt

AbstractBackgroundBenzydamine hydrochloride is a locally-acting Non-Steroidal Anti-Inflammatory Drug (NSAID) with combined local anesthetic and analgesic properties, indicated for the symptomatic relief of pain in acute sore throat. The aim of this study was to obtain an European Consensus among pharmacists, general practitioners and pediatricians on the appropriate use of benzydamine hydrochloride in the treatment of sore throat.MethodsThe authors developed a Delphi questionnaire organized into 15 statements focused on 4 topics: the mechanism of action of benzydamine, the benzydamine treatment in an adult patient and in a pediatric patient, and the advantages of benzydamine over other topical treatments. The survey was administered to a panel of to 320 participants including general practitioners, pediatricians, and pharmacists from 6 European countries (Italy, Germany, Portugal, Romania, Russia, and Spain), who rated their level of agreement or disagreement with each statement on a 6-point Likert scale. Consensus was predefined as more than 66% of the panel agreeing/disagreeing with each statement.ResultsPanelists’ agreement on statements was very high. Consensus was reached for all 15 statements in the Delphi survey, with more than 98% positive agreement on topic 4, suggesting a shared view among European healthcare professionals (HCPs) about the advantages of benzydamine over other topical treatments. A strong consensus (> 99%) was reached for all the statements of topic 1 regarding the mechanism of action of benzydamine, except for its anesthetic properties (79%). Strong agreement was reached for all statements in topics 2 and 3 regarding the treatment of acute sore throat symptoms in the adult and pediatric patient, except for one on the efficacy of benzydamine in preventing post-operative sore throat, for which it was 67%.ConclusionBecause all relevant publications on benzydamine are dated and there are no recommendations on its use for the symptomatic treatment of sore throat in European guidelines, this Delphi-based international consensus may be important in reinforcing the appropriate use and effect of benzydamine in the treatment of sore throat among health care professionals.

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