International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma
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Boyle, 2008
Curado, 2007, Vol. IX
Travis, 2004
Travis, 1999
WHO, 1967
WHO, 1981
Mok, 2009, Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma, N Engl J Med, 361, 947, 10.1056/NEJMoa0810699
Mitsudomi, 2010, Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial, Lancet Oncol, 11, 121, 10.1016/S1470-2045(09)70364-X
Maemondo, 2010, Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR, N Engl J Med, 362, 2380, 10.1056/NEJMoa0909530
Zhou, 2010, Efficacy results from the randomized phase III OPTIMAL (CTONG 0802) study comparing first-line erlotinib versus carboplatin (CBDCA) plus gemcitabine (GEM) in Chinese advanced non-small cell lung cancer (NSCLC) patients (PTS) with EGFR activating mutations, Ann Oncol, 21, viii1
Scagliotti, 2009, Survival without toxicity for cisplatin plus pemetrexed versus cisplatin plus gemcitabine in chemonaive patients with advanced non-small cell lung cancer: a risk-benefit analysis of a large phase III study, Eur J Cancer, 45, 2298, 10.1016/j.ejca.2009.04.033
Scagliotti, 2008, Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer, J Clin Oncol, 26, 3543, 10.1200/JCO.2007.15.0375
Ciuleanu, 2009, Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study, Lancet, 374, 1432, 10.1016/S0140-6736(09)61497-5
Scagliotti, 2009, The differential efficacy of pemetrexed according to NSCLC histology: a review of two phase III studies, Oncologist, 14, 253, 10.1634/theoncologist.2008-0232
Johnson, 2004, Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin, Oncol, 22, 2184
Cohen, 2007, FDA drug approval summary: bevacizumab (Avastin) plus Carboplatin and Paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer, Oncologist, 12, 713, 10.1634/theoncologist.12-6-713
Kodama, 2001, Prognostic value of ground-glass opacity found in small lung adenocarcinoma on high-resolution CT scanning, Lung Cancer, 33, 17, 10.1016/S0169-5002(01)00185-4
Suzuki, 2002, “Early” peripheral lung cancer: prognostic significance of ground glass opacity on thin-section computed tomographic scan, Ann Thorac Surg, 74, 1635, 10.1016/S0003-4975(02)03895-X
Takamochi, 2001, Pathologic N0 status in pulmonary adenocarcinoma is predictable by combining serum carcinoembryonic antigen level and computed tomographic findings, J Thorac Cardiovasc Surg, 122, 325, 10.1067/mtc.2001.114355
Sakurai, 2004, Grade of stromal invasion in small adenocarcinoma of the lung: histopathological minimal invasion and prognosis, Am J Surg Pathol, 28, 198, 10.1097/00000478-200402000-00007
Adler, 1992, High-resolution CT of bronchioloalveolar carcinoma, AJR Am J Roentgenol, 159, 275, 10.2214/ajr.159.2.1321558
Aoki, 2001, Peripheral lung adenocarcinoma: correlation of thin-section CT findings with histologic prognostic factors and survival, Radiology, 220, 803, 10.1148/radiol.2203001701
El-Sherif, 2006, Outcomes of sublobar resection versus lobectomy for stage I non-small cell lung cancer: a 13-year analysis, Ann Thorac Surg, 82, 408, 10.1016/j.athoracsur.2006.02.029
Nakamura, 2005, Survival following lobectomy vs limited resection for stage I lung cancer: a meta-analysis, Br J Cancer, 92, 1033, 10.1038/sj.bjc.6602414
Okada, 2006, Radical sublobar resection for small-sized non-small cell lung cancer: a multicenter study, J Thorac Cardiovasc Surg, 132, 769, 10.1016/j.jtcvs.2006.02.063
Shah, 2006, The role of transbronchial fine needle aspiration in an integrated care pathway for the assessment of patients with suspected lung cancer, J Thorac Oncol, 1, 324, 10.1016/S1556-0864(15)31589-6
Edwards, 2000, Preoperative histological classification of primary lung cancer: accuracy of diagnosis and use of the non-small cell category, J Clin Pathol, 53, 537, 10.1136/jcp.53.7.537
Cataluna, 1996, Cell type accuracy of bronchial biopsy specimens in primary lung cancer, Chest, 109, 1199, 10.1378/chest.109.5.1199
Travis, 2010, Pathologic diagnosis of advanced lung cancer based on small biopsies and cytology: a paradigm shift, J Thorac Oncol, 5, 411, 10.1097/JTO.0b013e3181d57f6e
Schunemann, 2006, An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations, Am J Respir Crit Care Med, 174, 605, 10.1164/rccm.200602-197ST
Schunemann, 2008, GRADE: assessing the quality of evidence for diagnostic recommendations. ACP J, Club, 149, 2
Schunemann, 2008, Grading quality of evidence and strength of recommendations for diagnostic tests and strategies, BMJ, 336, 1106, 10.1136/bmj.39500.677199.AE
Guyatt, 2008, What is “quality of evidence” and why is it important to clinicians?, BMJ, 336, 995, 10.1136/bmj.39490.551019.BE
Guyatt, 2008, GRADE: an emerging consensus on rating quality of evidence and strength of recommendations, BMJ, 336, 924, 10.1136/bmj.39489.470347.AD
Guyatt, 2010, GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables, J Clin Epidemiol
Loo, 2010, Subtyping of undifferentiated non-small cell carcinomas in bronchial biopsy specimens, J Thorac Oncol, 5, 442, 10.1097/JTO.0b013e3181d40fac
Nicholson, 2010, Refining the diagnosis and EGFR status of non-small cell lung carcinoma in biopsy and cytologic material, using a panel of mucin staining, TTF-1, cytokeratin 5/6, and P63, and EGFR mutation analysis, J Thorac Oncol, 5, 436, 10.1097/JTO.0b013e3181c6ed9b
Barletta, 2009, Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma, J Cell Mol Med, 13, 1977, 10.1111/j.1582-4934.2008.00594.x
Deshpande, 2009, Grading of lung adenocarcinoma: architectural versus nuclear approach, Mod Pathol, 22, 1590
Sica, 2010, A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage I tumors, Am J Surg Pathol, 34, 1155, 10.1097/PAS.0b013e3181e4ee32
Yoshizawa, 2011, Prognostic significance of the proposed IASLC/ATS/ERS revised classification of lung adenocarcinoma in 514 stage I lung adenocarcinomas, Mod Pathol, 24
Thunnissen, 2010, Reproducibility of histopathological subtypes in pulmonary adenocarcinoma, Mod Pathol, 23, 415A
Noguchi, 1995, Small adenocarcinoma of the lung. Histologic characteristics and prognosis, Cancer, 75, 2844, 10.1002/1097-0142(19950615)75:12<2844::AID-CNCR2820751209>3.0.CO;2-#
Borczuk, 2009, Invasive size is an independent predictor of survival in pulmonary adenocarcinoma, Am J Surg Pathol, 33, 462, 10.1097/PAS.0b013e318190157c
Yim, 2007, Histologic features are important prognostic indicators in early stages lung adenocarcinomas, Mod Pathol, 20, 233, 10.1038/modpathol.3800734
Goldstein, 1999, Prognostic factors in T1 NO MO adenocarcinomas and bronchioloalveolar carcinomas of the lung, Am J Clin Pathol, 112, 391, 10.1093/ajcp/112.3.391
Clayton, 1986, Bronchioloalveolar carcinomas. Cell types, patterns of growth, and prognostic correlates, Cancer, 57, 1555, 10.1002/1097-0142(19860415)57:8<1555::AID-CNCR2820570820>3.0.CO;2-N
Daly, 1991, Bronchoalveolar carcinoma: factors affecting survival, Ann Thorac Surg, 51, 368, 10.1016/0003-4975(91)90847-J
Manning, 1984, Bronchioloalveolar carcinoma: the significance of two histopathologic types, Cancer, 54, 525, 10.1002/1097-0142(19840801)54:3<525::AID-CNCR2820540324>3.0.CO;2-X
Riquet, 2006, Prognostic value of histology in resected lung cancer with emphasis on the relevance of the adenocarcinoma subtyping, Ann Thorac Surg, 81, 1988, 10.1016/j.athoracsur.2006.01.021
Goldstein, 2001, Mucinous and nonmucinous bronchioloalveolar adenocarcinomas have distinct staining patterns with thyroid transcription factor and cytokeratin 20 antibodies, Am J Clin Pathol, 116, 319, 10.1309/550P-QLJX-D84W-F6DN
Garfield, 2008, Bronchioloalveolar carcinoma: the case for two diseases, Clin Lung Cancer, 9, 24, 10.3816/CLC.2008.n.004
Garfield, 2009, The importance of distinguishing mucinous and nonmucinous bronchioloalveolar carcinomas, Lung, 187, 207, 10.1007/s00408-009-9149-3
Garfield, 2008, A comparison of survival and disease-specific survival in surgically resected, lymph node-positive bronchioloalveolar carcinoma versus nonsmall cell lung cancer: implications for adjuvant therapy, Cancer, 113, 1107, 10.1002/cncr.23662
Travis, 2005, Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma, J Clin Oncol, 23, 3279, 10.1200/JCO.2005.15.776
West, 2009, Bronchioloalveolar carcinoma: not as easy as “BAC.”, J Thorac Oncol, 4, 1047, 10.1097/JTO.0b013e3181b6ebda
Gandara, 2006, Bronchioloalveolar carcinoma: the “changing face of lung cancer.”, Clin Lung Cancer, 7, 299
Watanabe, 2002, Results of wedge resection for focal bronchioloalveolar carcinoma showing pure ground-glass attenuation on computed tomography, Ann Thorac Surg, 73, 1071, 10.1016/S0003-4975(01)03623-2
Sakurai, 2004, Bronchioloalveolar carcinoma of the lung 3 centimeters or less in diameter: a prognostic assessment, Ann Thorac Surg, 78, 1728, 10.1016/j.athoracsur.2004.05.017
Vazquez, 2009, Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: histopathologic features and their prognostic implications, Lung Cancer, 64, 148, 10.1016/j.lungcan.2008.08.009
Yamato, 2001, Early results of a prospective study of limited resection for bronchioloalveolar adenocarcinoma of the lung, Ann Thorac Surg, 71, 971, 10.1016/S0003-4975(00)02507-8
Yamada, 2004, Video-assisted thoracic surgery for pure ground-glass opacities 2 cm or less in diameter, Ann Thorac Surg, 77, 1911, 10.1016/j.athoracsur.2003.12.040
Yoshida, 2005, Limited resection trial for pulmonary ground-glass opacity nodules: fifty-case experience, J Thorac Cardiovasc Surg, 129, 991, 10.1016/j.jtcvs.2004.07.038
Koike, 2009, Limited resection for noninvasive bronchioloalveolar carcinoma diagnosed by intraoperative pathologic examination, Ann Thorac Surg, 88, 1106, 10.1016/j.athoracsur.2009.06.051
Motoi, 2008, Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis, Am J Surg Pathol, 32, 810, 10.1097/PAS.0b013e31815cb162
Carey, 1992, Alveolar atypical hyperplasia in association with primary pulmonary adenocarcinoma: a clinicopathological study of 10 cases, Thorax, 47, 1041, 10.1136/thx.47.12.1041
Weng, 1990, Multiple atypical adenomatous hyperplasia of type II pneumonocytes and bronchio-alveolar carcinoma, Histopathology, 16, 101, 10.1111/j.1365-2559.1990.tb01073.x
Nakanishi, 1990, Alveolar epithelial hyperplasia and adenocarcinoma of the lung, Arch Pathol Lab Med, 114, 363
Nakahara, 2001, Atypical adenomatous hyperplasia of the lung: a clinicopathological study of 118 cases including cases with multiple atypical adenomatous hyperplasia, Thorax, 56, 302, 10.1136/thorax.56.4.302
Miller, 1990, Bronchioloalveolar cell adenomas, Am J Surg Pathol, 14, 904, 10.1097/00000478-199010000-00002
Nakayama, 1990, Clonal growth of atypical adenomatous hyperplasia of the lung: cytofluorometric analysis of nuclear DNA content, Mod Pathol, 3, 314
Niho, 1999, Monoclonality of atypical adenomatous hyperplasia of the lung, Am J Pathol, 154, 249, 10.1016/S0002-9440(10)65271-6
Sakamoto, 2007, Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas, J Pathol, 212, 287, 10.1002/path.2165
Westra, 1996, K-ras oncogene activation in atypical alveolar hyperplasias of the human lung, Cancer Res, 56, 2224
Kohno, 2008, Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias, Carcinogenesis, 29, 957, 10.1093/carcin/bgn048
Yoshida, 2005, Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung, Lung Cancer, 50, 1, 10.1016/j.lungcan.2005.04.012
Kitamura, 1996, Atypical adenomatous hyperplasia and bronchoalveolar lung carcinoma. Analysis by morphometry and the expressions of p53 and carcinoembryonic antigen, Am J Surg Pathol, 20, 553, 10.1097/00000478-199605000-00002
Takamochi, 2001, Loss of heterozygosity on chromosomes 9q and 16p in atypical adenomatous hyperplasia concomitant with adenocarcinoma of the lung, Am J Pathol, 159, 1941, 10.1016/S0002-9440(10)63041-6
Licchesi, 2008, Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung, Clin Cancer Res, 14, 2570, 10.1158/1078-0432.CCR-07-2033
Nakanishi, 2002, Expression of human telomerase RNA component and telomerase reverse transcriptase mRNA in atypical adenomatous hyperplasia of the lung, Hum Pathol, 33, 697, 10.1053/hupa.2002.125775
Seki, 2002, Expression of eukaryotic initiation factor 4E in atypical adenomatous hyperplasia and adenocarcinoma of the human peripheral lung, Clin Cancer Res, 8, 3046
Licchesi, 2008, Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung, Carcinogenesis, 29, 895, 10.1093/carcin/bgn017
Kerr, 2004, Expression of Fhit, cell adhesion molecules and matrix metalloproteinases in atypical adenomatous hyperplasia and pulmonary adenocarcinoma, J Pathol, 203, 638, 10.1002/path.1557
Maeshima, 2010, Clinicopathologic analysis of multiple (five or more) atypical adenomatous hyperplasias (AAHs) of the lung: evidence for the AAH-adenocarcinoma sequence, J Thorac Oncol, 5, 466, 10.1097/JTO.0b013e3181ce3b73
Mori, 2001, Atypical adenomatous hyperplasia of the lung: a probable forerunner in the development of adenocarcinoma of the lung, Mod Pathol, 14, 72, 10.1038/modpathol.3880259
Kitamura, 1999, Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma, Am J Clin Pathol, 111, 610, 10.1093/ajcp/111.5.610
Koga, 2002, Lung adenocarcinoma with bronchioloalveolar carcinoma component is frequently associated with foci of high-grade atypical adenomatous hyperplasia, Am J Clin Pathol, 117, 464, 10.1309/CHXA-3MH0-B7FD-JGUL
Maeshima, 2010, Histological scoring for small lung adenocarcinomas 2 cm or less in diameter: a reliable prognostic indicator, J Thorac Oncol, 5, 333, 10.1097/JTO.0b013e3181c8cb95
Sawada, 2010, Localized mucinous bronchioloalveolar carcinoma of the lung: thin-section computed tomography and fluorodeoxyglucose positron emission tomography findings, Jpn J Radiol, 28, 251, 10.1007/s11604-009-0414-4
Oka, 2010, Surgical resection for patients with mucinous bronchioloalveolar carcinoma, Asian J Surg, 33, 89, 10.1016/S1015-9584(10)60015-2
De Oliveira Duarte Achcar, 2009, Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile, Am J Clin Pathol, 131, 694, 10.1309/AJCPBS85VJEOBPDO
Nakamura, 2007, c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis, Cancer Sci, 98, 1006, 10.1111/j.1349-7006.2007.00493.x
Kim, 2004, Dominant papillary subtype is a significant predictor of the response to gefitinib in adenocarcinoma of the lung, Clin Cancer Res, 10, 7311, 10.1158/1078-0432.CCR-04-0811
Ding, 2008, Somatic mutations affect key pathways in lung adenocarcinoma, Nature, 455, 1069, 10.1038/nature07423
Shedden, 2008, Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study, Nat Med, 14, 822, 10.1038/nm.1790
Sholl, 2009, Lung adenocarcinoma with EGFR amplification has distinct clinicopathologic and molecular features in never-smokers, Cancer Res, 69, 8341, 10.1158/0008-5472.CAN-09-2477
Dacic, 2010, Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas, Mod Pathol, 23, 159, 10.1038/modpathol.2009.154
Girard, 2009, Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases, Am J Surg Pathol, 33, 1752, 10.1097/PAS.0b013e3181b8cf03
Lee, 2009, Lung adenocarcinoma as a solitary pulmonary nodule: prognostic determinants of CT, PET, and histopathologic findings, Lung Cancer, 66, 379, 10.1016/j.lungcan.2009.02.011
Yokose, 2000, Favorable and unfavorable morphological prognostic factors in peripheral adenocarcinoma of the lung 3 cm or less in diameter, Lung Cancer, 29, 179, 10.1016/S0169-5002(00)00103-3
Lin, 2006, Prognostic value of bronchioloalveolar carcinoma component in lung adenocarcinoma, Histol Histopathol, 21, 627
Okudela, 2010, Proposal of an improved histological sub-typing system for lung adenocarcinoma—significant prognostic values for stage I disease, Int J Clin Exp Pathol, 3, 348
Silver, 1997, True papillary carcinoma of the lung: a distinct clinicopathologic entity, Am J Surg Pathol, 21, 43, 10.1097/00000478-199701000-00005
Amin, 2002, Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance, Am J Surg Pathol, 26, 358, 10.1097/00000478-200203000-00010
Miyoshi, 2003, Early-stage lung adenocarcinomas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis, Am J Surg Pathol, 27, 101, 10.1097/00000478-200301000-00011
Kamiya, 2008, Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma, Mod Pathol, 21, 992, 10.1038/modpathol.2008.79
Kawakami, 2007, Micropapillary pattern and grade of stromal invasion in pT1 adenocarcinoma of the lung: usefulness as prognostic factors, Mod Pathol, 20, 514, 10.1038/modpathol.3800765
Kuroda, 2006, Lung adenocarcinoma with a micropapillary pattern: a clinicopathological study of 25 cases, APMIS, 114, 381, 10.1111/j.1600-0463.2006.apm_340.x
Kuroda, 2005, Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report, APMIS, 113, 550, 10.1111/j.1600-0463.2005.apm_151.x
Maeda, 2009, Lung adenocarcinomas with micropapillary components, Gen Thorac Cardiovasc Surg, 57, 534, 10.1007/s11748-009-0436-y
Makimoto, 2005, Micropapillary pattern: a distinct pathological marker to subclassify tumours with a significantly poor prognosis within small peripheral lung adenocarcinoma (</=20 mm) with mixed bronchioloalveolar and invasive subtypes (Noguchi's type C tumours), Histopathology, 46, 677, 10.1111/j.1365-2559.2005.02126.x
Miyoshi, 2005, Possible mechanism of metastasis in lung adenocarcinomas with a micropapillary pattern, Pathol Int, 55, 419, 10.1111/j.1440-1827.2005.01847.x
Roh, 2004, Relationship between micropapillary component and micrometastasis in the regional lymph nodes of patients with stage I lung adenocarcinoma, Histopathology, 45, 580, 10.1111/j.1365-2559.2004.01953.x
Sanchez-Mora, 2008, Micropapillary lung adenocarcinoma: a distinctive histologic subtype with prognostic significance. Case series, Hum Pathol, 39, 324, 10.1016/j.humpath.2007.05.029
Tsutsumida, 2007, A micropapillary pattern is predictive of a poor prognosis in lung adenocarcinoma, and reduced surfactant apoprotein A expression in the micropapillary pattern is an excellent indicator of a poor prognosis, Mod Pathol, 20, 638, 10.1038/modpathol.3800780
Wislez, 2010, Non-mucinous and mucinous subtypes of adenocarcinoma with bronchioloalveolar carcinoma features differ by biomarker expression and in the response to gefitinib, Lung Cancer, 68, 185, 10.1016/j.lungcan.2009.05.021
Hata, 2010, Frequency of EGFR and KRAS mutations in Japanese patients with lung adenocarcinoma with features of the mucinous subtype of bronchioloalveolar carcinoma, J Thorac Oncol, 5, 1197, 10.1097/JTO.0b013e3181e2a2bc
Lee, 2009, Mucinous versus nonmucinous solitary pulmonary nodular bronchioloalveolar carcinoma: CT and FDG PET findings and pathologic comparisons, Lung Cancer, 65, 170, 10.1016/j.lungcan.2008.11.009
Miyake, 1995, Mucin-producing tumor of the lung: CT findings, J Thorac Imaging, 10, 96, 10.1097/00005382-199521000-00003
Casali, 2010, A single institution-based retrospective study of surgically treated bronchioloalveolar adenocarcinoma of the lung: clinicopathologic analysis, molecular features, and possible pitfalls in routine practice, J Thorac Oncol, 5, 830, 10.1097/JTO.0b013e3181d60ff5
Akira, 1999, High-resolution CT findings of diffuse bronchioloalveolar carcinoma in 38 patients, AJR Am J Roentgenol, 173, 1623, 10.2214/ajr.173.6.10584811
Kodama, 2002, Natural history of pure ground-glass opacity after long-term follow-up of more than 2 years, Ann Thorac Surg, 73, 386, 10.1016/S0003-4975(01)03410-5
Nagao, 2002, Measurement of localized ground-glass attenuation on thin-section computed tomography images: correlation with the progression of bronchioloalveolar carcinoma of the lung, Invest Radiol, 37, 692, 10.1097/00004424-200212000-00009
Saito, 2009, Initial findings and progression of lung adenocarcinoma on serial computed tomography scans, J Comput Assist Tomogr, 33, 42, 10.1097/RCT.0b013e3181633509
Yabuuchi, 2000, High-resolution CT characteristics of poorly differentiated adenocarcinoma of the peripheral lung: comparison with well differentiated adenocarcinoma, Radiat Med, 18, 343
Im, 1990, Lobar bronchioloalveolar carcinoma: ‘Angiogram sign’ on CT scans, Radiology, 176, 749, 10.1148/radiology.176.3.2167502
Tateishi, 2005, Mucin-producing adenocarcinoma of the lung: thin-section computed tomography findings in 48 patients and their effect on prognosis, J Comput Assist Tomogr, 29, 361, 10.1097/01.rct.0000162820.08909.e1
Shah, 2002, Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma, Hum Pathol, 33, 915, 10.1053/hupa.2002.126876
Finberg, 2007, Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features, J Mol Diagn, 9, 320, 10.2353/jmoldx.2007.060182
Sakuma, 2007, Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations, Am J Clin Pathol, 128, 100, 10.1309/WVXFGAFLAUX48DU6
Marchetti, 1996, Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype, J Pathol, 179, 254, 10.1002/(SICI)1096-9896(199607)179:3<254::AID-PATH589>3.0.CO;2-J
Maeshima, 2002, Mixed mucinous-type and non-mucinous-type adenocarcinoma of the lung: immunohistochemical examination and K-ras gene mutation, Virchows Arch, 440, 598, 10.1007/s00428-002-0629-6
Tam, 2006, Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features, Clin Cancer Res, 12, 1647, 10.1158/1078-0432.CCR-05-1981
Copin, 2001, Mucinous bronchioloalveolar carcinomas display a specific pattern of mucin gene expression among primary lung adenocarcinomas, HumPathol, 32, 274
Awaya, 2004, Expression of MUC1, MUC2, MUC5AC, and MUC6 in atypical adenomatous hyperplasia, bronchioloalveolar carcinoma, adenocarcinoma with mixed subtypes, and mucinous bronchioloalveolar carcinoma of the lung, Am J Clin Pathol, 121, 644, 10.1309/U4WGE9EBFJN6CM8R
Sato, 2006, Bronchioloalveolar carcinoma of mixed mucinous and nonmucinous type: immunohistochemical studies and mutation analysis of the p53 gene, Pathol Res Pract, 202, 751, 10.1016/j.prp.2006.07.002
Tsuta, 2006, Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence of cytoplasmic mucin, J Pathol, 209, 78, 10.1002/path.1947
Sica, 2008, Reassessment of the histologic spectrum of mucinous bronchioloalveolar carcinoma (mBAC), Mod Pathol, 21, 351A
Gaeta, 1999, Mucinous cystadenocarcinoma of the lung: CT-pathologic correlation in three cases, J Comput Assist Tomogr, 23, 641, 10.1097/00004728-199907000-00028
Deshpande, 2009, Clear cell change in lung adenocarcinoma: a cytologic change rather than a histologic variant, Mod Pathol, 22, 1595
Cohen, 2010, Signet ring cell features (SRCF) in lung adenocarcinoma: a cytologic feature or a histologic subtype?, Mod Pathol, 23, 404A
Rodig, 2009, Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population, Clin Cancer Res, 15, 5216, 10.1158/1078-0432.CCR-09-0802
Inamura, 2005, Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas, Am J Surg Pathol, 29, 660, 10.1097/01.pas.0000160438.00652.8b
Moran, 1992, Mucinous (so-called colloid) carcinomas of lung, Mod Pathol, 5, 634
Rossi, 2004, Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression, Am J Surg Pathol, 28, 442, 10.1097/00000478-200404000-00003
Gao, 2005, The spectrum of pulmonary mucinous cystic neoplasia: a clinicopathologic and immunohistochemical study of ten cases and review of literature, Am J Clin Pathol, 124, 62, 10.1309/52XXR6E6U0J2JX0F
Nakatani, 1998, Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms, Am J Surg Pathol, 22, 399, 10.1097/00000478-199804000-00003
Nakatani, 2002, Aberrant nuclear localization and gene mutation of beta-catenin in low-grade adenocarcinoma of fetal lung type: up-regulation of the Wnt signaling pathway may be a common denominator for the development of tumors that form morules, Mod Pathol, 15, 617, 10.1038/modpathol.3880575
Sekine, 2003, Beta-catenin mutations in pulmonary blastomas: association with morule formation, J Pathol, 200, 214, 10.1002/path.1352
Li, 2009, Primary pulmonary adenocarcinoma with intestinal differentiation mimicking metastatic colorectal carcinoma: case report and review of literature, Am J Clin Pathol, 131, 129, 10.1309/AJCPB04XWICTFERL
Hatanaka K, Tsuta K, Watanabe K, et al. Primary pulmonary adenocarcinoma with enteric differentiation resembling metastatic colorectal carcinoma: a report of the second case negative for cytokeratin 7. Pathol Res Pract. In press.
Yousem, 2005, Pulmonary intestinal-type adenocarcinoma does not show enteric differentiation by immunohistochemical study, Mod Pathol, 18, 816, 10.1038/modpathol.3800358
Rossi, 2009, A reevaluation of the clinical significance of histological subtyping of non–small-cell lung carcinoma: diagnostic algorithms in the era of personalized treatments, Int J Surg Pathol, 17, 206, 10.1177/1066896909336178
Rossi, 2009, Morphology and a limited number of immunohistochemical markers may efficiently subtype non-small-cell lung cancer, J Clin Oncol, 27, e141, 10.1200/JCO.2009.24.0515
Suh, 2011, Testing of new IASLC/ATS/ERS criteria for diagnosis of lung adenocarcinoma (AD) in small biopsies: minimize immunohistochemistry (IHC) to maximize tissue for molecular studies, Mod Pathol, 24
Hanna, 2004, Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy, J Clin Oncol, 22, 1589, 10.1200/JCO.2004.08.163
Yatabe, 2002, TTF-1 expression in pulmonary adenocarcinomas, Am J Surg Pathol, 26, 767, 10.1097/00000478-200206000-00010
Lau, 2002, Thyroid transcription factor-1: a review, Appl Immunohistochem Mol Morphol, 10, 97, 10.1097/00129039-200206000-00001
Camilo, 2006, Expression of p63, keratin 5/6, keratin 7, and surfactant-A in non-small cell lung carcinomas, Hum Pathol, 37, 542, 10.1016/j.humpath.2005.12.019
Wu, 2003, p63 and TTF-1 immunostaining. A useful marker panel for distinguishing small cell carcinoma of lung from poorly differentiated squamous cell carcinoma of lung, Am J Clin Pathol, 119, 696, 10.1309/P5ABR5KQ89RNJTFH
Chu, 2002, Expression of cytokeratin 5/6 in epithelial neoplasms: an immunohistochemical study of 509 cases, Mod Pathol, 15, 6, 10.1038/modpathol.3880483
Ordonez, 2000, Value of thyroid transcription factor-1, E-cadherin, BG8, WT1, and CD44S immunostaining in distinguishing epithelial pleural mesothelioma from pulmonary and nonpulmonary adenocarcinoma, Am J Surg Pathol, 24, 598, 10.1097/00000478-200004000-00016
Kaufmann, 2000, Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B, Histopathology, 36, 8, 10.1046/j.1365-2559.2000.00801.x
Kargi, 2007, The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas, Appl Immunohistochem Mol Morphol, 15, 415, 10.1097/PAI.0b013e31802fab75
Khayyata, 2009, Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens, Diagn Cytopathol, 37, 178, 10.1002/dc.20975
Chu, 2000, Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases, Mod Pathol, 13, 962, 10.1038/modpathol.3880175
Rivera, 2007, Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition), Chest, 132, 131S, 10.1378/chest.07-1357
Rekhtman N, Brandt SM, Sigel CS, et al. Suitability of thoracic cytology for new therapeutic paradigms in non-small cell lung carcinoma: high accuracy of tumor subtyping and feasibility of EGFR and KRAS molecular testing. J Thorac Oncol. In press.
Sigel, 2010, Subtyping of non-small cell lung carcinoma (NSCLC): comparison of cytology and small biopsy specimens, Mod Pathol, 23, 414A
Zhang, 2008, Detection and comparison of epidermal growth factor receptor mutations in cells and fluid of malignant pleural effusion in non-small cell lung cancer, Lung Cancer, 60, 175, 10.1016/j.lungcan.2007.10.011
Zakowski, 2009, Morphologic features of adenocarcinoma of the lung predictive of response to the epidermal growth factor receptor kinase inhibitors erlotinib and gefitinib, Arch Pathol Lab Med, 133, 470, 10.5858/133.3.470
Wu, 2008, Frequent EGFR mutations in malignant pleural effusion of lung adenocarcinoma, Eur Respir J, 32, 924, 10.1183/09031936.00167407
Au, 2004, P63 expression in lung carcinoma: a tissue microarray study of 408 cases, Appl Immunohistochem Mol Morphol, 12, 240, 10.1097/00129039-200409000-00010
Ang, 2010, Expression of squamous markers in lung adenocarcinoma (AD): clinicopathologic and molecular correlates, and implications for differentiation from squamous cell carcinoma (SqCC), Mod Pathol, 23, 397A
Ionescu, 2007, Nonsmall cell lung carcinoma with neuroendocrine differentiation-an entity of no clinical or prognostic significance, Am J Surg Pathol, 31, 26, 10.1097/01.pas.0000213319.04919.97
Sterlacci, 2009, Clinical relevance of neuroendocrine differentiation in non-small cell lung cancer assessed by immunohistochemistry: a retrospective study on 405 surgically resected cases, Virchows Arch, 455, 125, 10.1007/s00428-009-0812-0
Chung, 1982, Carcinoma of the lung: evaluation of histological grade and factors influencing prognosis, Ann Thorac Surg, 33, 599, 10.1016/S0003-4975(10)60819-3
Kobayashi, 2007, Risk factors for recurrence and unfavorable prognosis in patients with stage I non-small cell lung cancer and a tumor diameter of 20 mm or less, J Thorac Oncol, 2, 808, 10.1097/JTO.0b013e31814617c7
Nakazato, 2009, Nuclear grading of primary pulmonary adenocarcinomas—correlation between nuclear size and prognosis, J Thorac Oncol, 4, S495
Petersen, 2009, Core classification of lung cancer: correlating nuclear size and mitoses with ploidy and clinicopathological parameters, Lung Cancer, 65, 312, 10.1016/j.lungcan.2008.12.013
Aida, 2004, Prognostic analysis of pulmonary adenocarcinoma subclassification with special consideration of papillary and bronchioloalveolar types, Histopathology, 45, 468, 10.1111/j.1365-2559.2004.01946.x
Gleason, 1992, Histologic grading of prostate cancer: a perspective, Hum Pathol, 23, 273, 10.1016/0046-8177(92)90108-F
Kadota, 2011, Nuclear grading system predicts recurrence in stage I lung adenocarcinoma patients, Mod Pathol, 24
Li, 2008, EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression, J Mol Diagn, 10, 242, 10.2353/jmoldx.2008.070178
Lim, 2009, Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC), J Thorac Oncol, 4, 12, 10.1097/JTO.0b013e3181913e28
Savic, 2008, Comprehensive epidermal growth factor receptor gene analysis from cytological specimens of non-small-cell lung cancers, Br J Cancer, 98, 154, 10.1038/sj.bjc.6604142
Miller, 2008, Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib, J Clin Oncol, 26, 1472, 10.1200/JCO.2007.13.0062
Kimura, 2006, EGFR mutation status in tumour-derived DNA from pleural effusion fluid is a practical basis for predicting the response to gefitinib, Br J Cancer, 95, 1390, 10.1038/sj.bjc.6603428
Borczuk, 2004, Molecular signatures in biopsy specimens of lung cancer, Am J Respir Crit Care Med, 170, 167, 10.1164/rccm.200401-066OC
Zudaire, 2008, Molecular characterization of small peripheral lung tumors based on the analysis of fine needle aspirates, Histol Histopathol, 23, 33
Gordon, 2003, A prognostic test for adenocarcinoma of the lung from gene expression profiling data, Cancer Epidemiol Biomarkers Prev, 12, 905
Solomon, 2010, Core needle lung biopsy specimens: adequacy for EGFR and KRAS mutational analysis, AJR Am J Roentgenol, 194, 266, 10.2214/AJR.09.2858
Asano, 2006, Detection of EGFR gene mutation in lung cancer by mutant-enriched polymerase chain reaction assay, Clin Cancer Res, 12, 43, 10.1158/1078-0432.CCR-05-0934
Otani, 2008, Detection of EGFR gene mutations using the wash fluid of CT-guided biopsy needle in NSCLC patients, J Thorac Oncol, 3, 472, 10.1097/JTO.0b013e31816de2cd
Bepler, 2006, RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer, J Clin Oncol, 24, 4731, 10.1200/JCO.2006.06.1101
Olaussen, 2006, DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy, N Engl J Med, 355, 983, 10.1056/NEJMoa060570
Chang, 2010, The efficacy of pemetrexed as a third- or fourth-line therapy and the significance of thymidylate synthase expression in patients with advanced non-small cell lung cancer, Lung Cancer, 69, 323, 10.1016/j.lungcan.2009.12.002
Monica, 2009, Differential thymidylate synthase expression in different variants of large-cell carcinoma of the lung, Clin Cancer Res, 15, 7547, 10.1158/1078-0432.CCR-09-1641
Kang, 2010, The prognostic significance of ERCC1, BRCA1, XRCC1, and betaIII-tubulin expression in patients with non-small cell lung cancer treated by platinum- and taxane-based neoadjuvant chemotherapy and surgical resection, Lung Cancer, 68, 478, 10.1016/j.lungcan.2009.07.004
Rosell, 2009, Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. PLoS, One, 4, e5133, 10.1371/journal.pone.0005133
Savci-Heijink, 2009, The role of desmoglein-3 in the diagnosis of squamous cell carcinoma of the lung, Am J Pathol, 174, 1629, 10.2353/ajpath.2009.080778
Monica, 2009, Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung, Mod Pathol, 22, 709, 10.1038/modpathol.2009.30
Bishop, 2010, Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma, Hum Pathol, 41, 20, 10.1016/j.humpath.2009.06.014
Paez, 2004, EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy, Science, 304, 1497, 10.1126/science.1099314
Lynch, 2004, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib, N Engl J Med, 350, 2129, 10.1056/NEJMoa040938
Pao, 2004, EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib, Proc Natl Acad Sci USA, 101, 13306, 10.1073/pnas.0405220101
Azzoli, 2009, American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer, J Clin Oncol, 27, 6251, 10.1200/JCO.2009.23.5622
Pao, 2009, Integration of molecular profiling into the lung cancer clinic, Clin Cancer Res, 15, 5317, 10.1158/1078-0432.CCR-09-0913
Shaw, 2009, Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK, J Clin Oncol, 27, 4247, 10.1200/JCO.2009.22.6993
Detterbeck, 2007, Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition), Chest, 132, 202S, 10.1378/chest.07-1362
Schrump, 2008, Non-small cell lung cancer, 887
Sculier, 2008, The impact of additional prognostic factors on survival and their relationship with the anatomical extent of disease expressed by the 6th Edition of the TNM Classification of Malignant Tumors and the proposals for the 7th Edition, J Thorac Oncol, 3, 457, 10.1097/JTO.0b013e31816de2b8
Chansky, 2009, The International Association for the Study of Lung Cancer Staging Project: prognostic factors and pathologic TNM stage in surgically managed non-small cell lung cancer, J Thorac Oncol, 4, 792, 10.1097/JTO.0b013e3181a7716e
Janjigian, 2010, Pack-years of cigarette smoking as a prognostic factor in patients with stage IIIB/IV Nonsmall cell lung cancer, Cancer, 116, 670, 10.1002/cncr.24813
Miller, 2004, Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer, J Clin Oncol, 22, 1103, 10.1200/JCO.2004.08.158
West, 2006, Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group Study S0126, J Clin Oncol, 24, 1807, 10.1200/JCO.2005.04.9890
Sequist, 2007, Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer, J Clin Oncol, 25, 587, 10.1200/JCO.2006.07.3585
Sutani, 2006, Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp, Br J Cancer, 95, 1483, 10.1038/sj.bjc.6603466
Inoue, 2006, Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations, J Clin Oncol, 24, 3340, 10.1200/JCO.2005.05.4692
Inoue, 2009, First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy, J Clin Oncol, 27, 1394, 10.1200/JCO.2008.18.7658
Tamura, 2008, Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403), Br J Cancer, 98, 907, 10.1038/sj.bjc.6604249
Yoshida, 2007, Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer, J Thorac Oncol, 2, 22, 10.1016/S1556-0864(15)30013-7
Douillard, 2010, Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial, J Clin Oncol, 28, 744, 10.1200/JCO.2009.24.3030
Hirsch, 2006, Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer, J Clin Oncol, 24, 5034, 10.1200/JCO.2006.06.3958
Zhu, 2008, Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR. 21, J Clin Oncol, 26, 4268, 10.1200/JCO.2007.14.8924
Sholl, 2010, EGFR mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry, Am J Clin Pathol, 133, 922, 10.1309/AJCPST1CTHZS3PSZ
Kawahara, 2010, Molecular diagnosis of activating EGFR mutations in non-small cell lung cancer using mutation specific antibodies for immunohistochemical analysis, Clin Cancer Res, 16, 3163, 10.1158/1078-0432.CCR-09-3239
Brevet, 2010, Assessment of EGFR mutation status in lung adenocarcinoma by immunohistochemistry using antibodies specific to the two major forms of mutant EGFR, J Mol Diagn, 12, 169, 10.2353/jmoldx.2010.090140
Yu, 2009, Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer, Clin Cancer Res, 15, 3023, 10.1158/1078-0432.CCR-08-2739
Fukuoka, 2009, Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib (G) versus carboblatin/paclitaxel (C/P) in clinically selected patients (pts) with advanced non-small-cell lung cancer (NSCLC) in Asia (IPASS), J Clin Oncol, 27, 521S, 10.1200/jco.2009.27.15_suppl.8006
Kubota, 2009, Efficacy differences of pemetrexed by histology in pretreated patients with stage IIIB/IV non-small cell lung cancer: review of results from an open-label randomized phase II study, J Thorac Oncol, 4, 1530, 10.1097/JTO.0b013e3181b9e608
Zinner, 2010, Comparison of patient outcomes according to histology among pemetrexed-treated patients with stage IIIB/IV non-small-cell lung cancer in two phase II trials, Clin Lung Cancer, 11, 126, 10.3816/CLC.2010.n.017
Gronberg, 2009, Phase III study by the Norwegian lung cancer study group: pemetrexed plus carboplatin compared with gemcitabine plus carboplatin as first-line chemotherapy in advanced non-small-cell lung cancer, J Clin Oncol, 27, 3217, 10.1200/JCO.2008.20.9114
Sandler, 2006, Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer, N Engl J Med, 355, 2542, 10.1056/NEJMoa061884
Soda, 2007, Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer, Nature, 448, 561, 10.1038/nature05945
Wong, 2009, The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS, Cancer, 115, 1723, 10.1002/cncr.24181
Kwak, 2010, Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer, N Engl J Med, 363, 1693, 10.1056/NEJMoa1006448
Choi, 2010, EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors, N Engl J Med, 363, 1734, 10.1056/NEJMoa1007478
Mao, 2010, KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: a meta-analysis of 22 studies, Lung Cancer, 69, 272, 10.1016/j.lungcan.2009.11.020
Linardou, 2008, Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer, Lancet Oncol, 9, 962, 10.1016/S1470-2045(08)70206-7
Goldstraw, 2009
Goldstraw, 2007, The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac, Oncol, 2, 706
Pignon, 2008, Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group, J Clin Oncol, 26, 3552, 10.1200/JCO.2007.13.9030
Pao, 2005, KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib, PLoS Med, 2, e17, 10.1371/journal.pmed.0020017
Kim, 2005, Identification of bronchioalveolar stem cells in normal lung and lung cancer, Cell, 121, 823, 10.1016/j.cell.2005.03.032
Weir, 2007, Characterizing the cancer genome in lung adenocarcinoma, Nature, 450, 893, 10.1038/nature06358
Tanaka, 2007, Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1, Cancer Res, 67, 6007, 10.1158/0008-5472.CAN-06-4774
Colby, 2007, Lungs, 473
Wang, 2002, P63 in pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors, Hum Pathol, 33, 921, 10.1053/hupa.2002.126878
Takeuchi, 2006, Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors, J Clin Oncol, 24, 1679, 10.1200/JCO.2005.03.8224
Colby, 1998, Precursors to pulmonary neoplasia, Adv Anat Pathol, 5, 205, 10.1097/00125480-199807000-00001
Tang, 2008, Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas, Cancer Prev Res (Phila Pa), 1, 192, 10.1158/1940-6207.CAPR-08-0032
Tang, 2005, EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients, Cancer Res, 65, 7568, 10.1158/0008-5472.CAN-05-1705
Soh, 2008, Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung, J Thorac Oncol, 3, 340, 10.1097/JTO.0b013e318168d20a
Yatabe, 2008, Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer, Cancer Res, 68, 2106, 10.1158/0008-5472.CAN-07-5211
Tang, 2007, Derivation of stable microarray cancer-differentiating signatures using consensus scoring of multiple random sampling and gene-ranking consistency evaluation, Cancer Res, 67, 9996, 10.1158/0008-5472.CAN-07-1601
Koga, 2001, Clinicopathological and molecular evidence indicating the independence of bronchioloalveolar components from other subtypes of human peripheral lung adenocarcinoma, Clin Cancer Res, 7, 1730
Marchetti, 1998, FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations, J Pathol, 184, 240, 10.1002/(SICI)1096-9896(199803)184:3<240::AID-PATH20>3.0.CO;2-B
Yoshida, 2007, Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity, Jpn J Clin Oncol, 37, 907, 10.1093/jjco/hym139
Terasaki, 2003, Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization, Am J Surg Pathol, 27, 937, 10.1097/00000478-200307000-00009
Huang, 1998, Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer, Int J Oncol, 12, 553
Shigematsu, 2005, Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers, J Natl Cancer Inst, 97, 339, 10.1093/jnci/dji055
Marchetti, 2005, EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment, J Clin Oncol, 23, 857, 10.1200/JCO.2005.08.043
Ohtsuka, 2006, A clinicopathological study of resected pulmonary nodules with focal pure ground-glass opacity, Eur J Cardiothorac Surg, 30, 160, 10.1016/j.ejcts.2006.03.058
Bryant, 2010, Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways: an international validation study, PLoS One, 5, e11712, 10.1371/journal.pone.0011712
Yousem, 2008, The histopathology of BRAF-V600E-mutated lung adenocarcinoma, Am J Surg Pathol, 32, 1317, 10.1097/PAS.0b013e31816597ca
Conde, 2006, Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling, Clin Cancer Res, 12, 710, 10.1158/1078-0432.CCR-05-1362
Hirsch, 2005, Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a southwest oncology group study, J Clin Oncol, 23, 6838, 10.1200/JCO.2005.01.2823
Tanaka, 2009, Magnetic resonance imaging in peripheral lung adenocarcinoma: correlation with histopathologic features, J Thorac Imaging, 24, 4, 10.1097/RTI.0b013e31818703b7
Kim, 2008, Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung, Lung Cancer, 59, 111, 10.1016/j.lungcan.2007.08.008
Ang, 2010, Characteristic morphology and immunoprofile of lung adenocarcinoma with KRAS mutations: propensity for solid growth pattern and correlation with TTF-1 expression, Mod Pathol, 23, 396A
Saad, 2004, Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma, Am J Clin Pathol, 122, 421, 10.1309/UMF715KRG2V198YD
Sasaki, 2006, Uncommon V599E BRAF mutations in Japanese patients with lung cancer, J Surg Res, 133, 203, 10.1016/j.jss.2005.10.022
Naoki, 2002, Missense mutations of the BRAF gene in human lung adenocarcinoma, Cancer Res, 62, 7001
Tang, 2008, Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer, Br J Cancer, 99, 911, 10.1038/sj.bjc.6604559
Cappuzzo, 2009, MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients, Ann Oncol, 20, 298, 10.1093/annonc/mdn635
Engelman, 2007, MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling, Science, 316, 1039, 10.1126/science.1141478
Pao, 2005, Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain, PLoS Med, 2, e73, 10.1371/journal.pmed.0020073
Sequist, 2008, First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations, J Clin Oncol, 26, 2442, 10.1200/JCO.2007.14.8494
Nguyen, 2009, Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway, Clin Lung Cancer, 10, 281, 10.3816/CLC.2009.n.039
Takahashi, 2010, Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene, Ann Surg Oncol, 17, 889, 10.1245/s10434-009-0808-7
Inamura, 2009, EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset, Mod Pathol, 22, 508, 10.1038/modpathol.2009.2
Takeuchi, 2009, KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer, Clin Cancer Res, 15, 3143, 10.1158/1078-0432.CCR-08-3248
Yoshida A, Tsuta K, Watanabe SI, et al. Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component. Lung Cancer. In press.
Jokoji, 2010, Combination of morphological feature analysis and immunohistochemistry is useful for screening of EML4-ALK-positive lung adenocarcinoma, J Clin Pathol, 63, 1066, 10.1136/jcp.2010.081166
Inamura, 2008, EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers, J Thorac Oncol, 3, 13, 10.1097/JTO.0b013e31815e8b60
Mino-Kenudson, 2010, A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry, Clin Cancer Res, 16, 1561, 10.1158/1078-0432.CCR-09-2845
Sakairi, 2010, EML4-ALK fusion gene assessment using metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration, Clin Cancer Res, 16, 4938, 10.1158/1078-0432.CCR-10-0099
Boland, 2009, Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas, Hum Pathol, 40, 1152, 10.1016/j.humpath.2009.01.012
Beer, 2002, Gene-expression profiles predict survival of patients with lung adenocarcinoma, Nat Med, 8, 816, 10.1038/nm733
Borczuk, 2005, Lung adenocarcinoma global profiling identifies type II transforming growth factor-(beta) receptor as a repressor of invasiveness, Am J Respir Crit Care Med, 172, 729, 10.1164/rccm.200504-615OC
Shibata, 2007, Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma, Cancer Sci, 98, 985, 10.1111/j.1349-7006.2007.00483.x
Berrar, 2005, Survival trees for analyzing clinical outcome in lung adenocarcinomas based on gene expression profiles: identification of neogenin and diacylglycerol kinase alpha expression as critical factors, J Comput Biol, 12, 534, 10.1089/cmb.2005.12.534
Bianchi, 2007, Survival prediction of stage I lung adenocarcinomas by expression of 10 genes, J Clin Invest, 117, 3436, 10.1172/JCI32007
Endoh, 2004, Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction, J Clin Oncol, 22, 811, 10.1200/JCO.2004.04.109
Guo, 2006, Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma, Clin Cancer Res, 12, 3344, 10.1158/1078-0432.CCR-05-2336
Hayes, 2006, Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts, J Clin Oncol, 24, 5079, 10.1200/JCO.2005.05.1748
Inamura, 2007, A metastatic signature in entire lung adenocarcinomas irrespective of morphological heterogeneity, Hum Pathol, 38, 702, 10.1016/j.humpath.2006.11.019
Larsen, 2007, Gene expression signature predicts recurrence in lung adenocarcinoma, Clin Cancer Res, 13, 2946, 10.1158/1078-0432.CCR-06-2525
Liu, 2006, Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development, PLoS Med, 3, e232, 10.1371/journal.pmed.0030232
Sun, 2008, Non-overlapping and non-cell-type-specific gene expression signatures predict lung cancer survival, J Clin Oncol, 26, 877, 10.1200/JCO.2007.13.1516
Xi, 2005, Prediction of lymph node metastasis by analysis of gene expression profiles in primary lung adenocarcinomas, Clin Cancer Res, 11, 4128, 10.1158/1078-0432.CCR-04-2525
Potti, 2006, A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer, N Engl J Med, 355, 570, 10.1056/NEJMoa060467
Chen, 2007, A five-gene signature and clinical outcome in non-small-cell lung cancer, N Engl J Med, 356, 11, 10.1056/NEJMoa060096
Chitale, 2009, An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors, Oncogene, 28, 2773, 10.1038/onc.2009.135
Tonon, 2005, Common and contrasting genomic profiles among the major human lung cancer subtypes, Cold Spring Harb Symp Quant Biol, 70, 11, 10.1101/sqb.2005.70.021
Aviel-Ronen, 2008, Genomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar features, Proc Natl Acad Sci USA, 105, 10155, 10.1073/pnas.0709618105
Chang, 2008, Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients, Lung Cancer, 61, 328, 10.1016/j.lungcan.2008.01.009
Cappuzzo, 2005, Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer, J Natl Cancer Inst, 97, 643, 10.1093/jnci/dji112
Dacic, 2005, Patterns of allelic loss of synchronous adenocarcinomas of the lung, Am J Surg Pathol, 29, 897, 10.1097/01.pas.0000164367.96379.66
Wang, 2009, Evidence for common clonal origin of multifocal lung cancers, J Natl Cancer Inst, 101, 560, 10.1093/jnci/djp054
Girard, 2009, Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers, Clin Cancer Res, 15, 5184, 10.1158/1078-0432.CCR-09-0594
van Rens, 2002, p53 mutation analysis for definite diagnosis of multiple primary lung carcinoma, Cancer, 94, 188, 10.1002/cncr.10001
Matsuzoe, 1999, Discrimination of double primary lung cancer from intrapulmonary metastasis by p53 gene mutation, Br J Cancer, 79, 1549, 10.1038/sj.bjc.6690247
Wang, 1999, Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma, Cancer, 85, 1734, 10.1002/(SICI)1097-0142(19990415)85:8<1734::AID-CNCR13>3.0.CO;2-1
Lau, 1997, Clonal origin of multiple lung cancers: K-ras and p53 mutations determined by nonradioisotopic single-strand conformation polymorphism analysis, Diagn Mol Pathol, 6, 179, 10.1097/00019606-199708000-00001
Girard, 2010, Use of epidermal growth factor receptor/Kirsten rat sarcoma2 viral oncogene homolog mutation testing to define clonal relationships among multiple lung adenocarcinomas: comparison with clinical guidelines, Chest, 137, 46, 10.1378/chest.09-0325
Nonami, 2003, Study of the diagnostic difference between the clinical diagnostic criteria and results of immunohistochemical staining of multiple primary lung cancers, J Cardiovasc Surg (Torino), 44, 661
Vansteenkiste, 2001, Practical approach to patients presenting with multiple synchronous suspect lung lesions: a reflection on the current TNM classification based on 54 cases with complete follow-up, Lung Cancer, 34, 169, 10.1016/S0169-5002(01)00245-8
Yoshino, 1997, Postoperative prognosis in patients with non-small cell lung cancer with synchronous ipsilateral intrapulmonary metastasis, Ann Thorac Surg, 64, 809, 10.1016/S0003-4975(97)00281-6
Chung, 2009, Epidermal growth factor receptor mutation and pathologic-radiologic correlation between multiple lung nodules with ground-glass opacity differentiates multicentric origin from intrapulmonary spread, J Thorac Oncol, 4, 1490, 10.1097/JTO.0b013e3181bc9731
Balak, 2006, Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors, Clin Cancer Res, 12, 6494, 10.1158/1078-0432.CCR-06-1570
Jackman, 2006, Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib, J Clin Oncol, 24, 4517, 10.1200/JCO.2006.06.6126
Schmid, 2009, EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases, Clin Cancer Res, 15, 4554, 10.1158/1078-0432.CCR-09-0089
Monaco, 2010, A comparison of EGFR and KRAS status in primary lung carcinoma and matched metastases, Hum Pathol, 41, 94, 10.1016/j.humpath.2009.06.019
Meert, 2002, The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis, Eur Respir J, 20, 975, 10.1183/09031936.02.00296502
Berghmans, 2006, Thyroid transcription factor 1—a new prognostic factor in lung cancer: a meta-analysis, Ann Oncol, 17, 1673, 10.1093/annonc/mdl287
Mascaux, 2005, The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis, Br J Cancer, 92, 131, 10.1038/sj.bjc.6602258
Nakamura, 2005, Association of HER-2 overexpression with prognosis in nonsmall cell lung carcinoma: a metaanalysis, Cancer, 103, 1865, 10.1002/cncr.20957
Mitsudomi, 2000, Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis, Clin Cancer Res, 6, 4055
Steels, 2001, Role of p53 as a prognostic factor for survival in lung cancer: a systematic review of the literature with a meta-analysis, Eur Respir J, 18, 705, 10.1183/09031936.01.00062201
Martin, 2004, Ki-67 expression and patients survival in lung cancer: systematic review of the literature with meta-analysis, Br J Cancer, 91, 2018, 10.1038/sj.bjc.6602233
Martin, 2003, Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis, Br J Cancer, 89, 55, 10.1038/sj.bjc.6601095
Mascaux, 2006, Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results, Br J Cancer, 95, 139, 10.1038/sj.bjc.6603226
Marks, 2008, Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma, J Thorac Oncol, 3, 111, 10.1097/JTO.0b013e318160c607
Kosaka, 2009, Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma, J Thorac Oncol, 4, 22, 10.1097/JTO.0b013e3181914111
Yanaihara, 2006, Unique microRNA molecular profiles in lung cancer diagnosis and prognosis, Cancer Cell, 9, 189, 10.1016/j.ccr.2006.01.025
Raponi, 2009, MicroRNA classifiers for predicting prognosis of squamous cell lung cancer, Cancer Res, 69, 5776, 10.1158/0008-5472.CAN-09-0587
Hansell, 2008, Fleischner Society: glossary of terms for thoracic imaging, Radiology, 246, 697, 10.1148/radiol.2462070712
Godoy, 2009, Subsolid pulmonary nodules and the spectrum of peripheral adenocarcinomas of the lung: recommended interim guidelines for assessment and management, Radiology, 253, 606, 10.1148/radiol.2533090179
Lee, 2009, Usefulness of concurrent reading using thin-section and thick-section CT images in subcentimetre solitary pulmonary nodules, Clin Radiol, 64, 127, 10.1016/j.crad.2008.09.003
Takashima, 2003, Small solitary pulmonary nodules (< or =1 cm) detected at population-based CT screening for lung cancer: reliable high-resolution CT features of benign lesions, AJR Am J Roentgenol, 180, 955, 10.2214/ajr.180.4.1800955
Ishikawa, 2005, Ultrasmall pulmonary opacities on multidetector-row high-resolution computed tomography: a prospective radiologic-pathologic examination, J Comput Assist Tomogr, 29, 621, 10.1097/01.rct.0000172672.09564.8c
Kishi, 2004, Small lung tumors with the size of 1cm or less in diameter: clinical, radiological, and histopathological characteristics, Lung Cancer, 44, 43, 10.1016/j.lungcan.2003.09.024
Kim, 2007, Persistent pulmonary nodular ground-glass opacity at thin-section CT: histopathologic comparisons, Radiology, 245, 267, 10.1148/radiol.2451061682
Kim, 2009, Clinical, pathological and thin-section CT features of persistent multiple ground-glass opacity nodules: comparison with solitary ground-glass opacity nodule, Lung Cancer, 64, 171, 10.1016/j.lungcan.2008.08.002
Ikeda, 2007, Differential diagnosis of ground-glass opacity nodules: CT number analysis by three-dimensional computerized quantification, Chest, 132, 984, 10.1378/chest.07-0793
Choi, 2000, CT bronchus sign in malignant solitary pulmonary lesions: value in the prediction of cell type, Eur Radiol, 10, 1304, 10.1007/s003300000315
Takashima, 2003, CT findings and progression of small peripheral lung neoplasms having a replacement growth pattern, AJR Am J Roentgenol, 180, 817, 10.2214/ajr.180.3.1800817
Gould, 2007, Evaluation of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition), Chest, 132, 108S, 10.1378/chest.07-1353
Nakazono, 2005, Subtypes of peripheral adenocarcinoma of the lung: differentiation by thin-section CT, Eur Radiol, 15, 1563, 10.1007/s00330-004-2595-7
Zwirewich, 1991, Solitary pulmonary nodule: high-resolution CT and radiologic-pathologic correlation, Radiology, 179, 469, 10.1148/radiology.179.2.2014294
Yang, 2001, High-resolution CT analysis of small peripheral lung adenocarcinomas revealed on screening helical CT, AJR Am J Roentgenol, 176, 1399, 10.2214/ajr.176.6.1761399
Tateishi, 2005, Prediction of lung adenocarcinoma without vessel invasion: a CT scan volumetric analysis, Chest, 128, 3276, 10.1378/chest.128.5.3276
Kojima, 2010, Correlations of thin-section computed tomographic, histopathological, and clinical findings of adenocarcinoma with a bubblelike appearance, J Comput Assist Tomogr, 34, 413, 10.1097/RCT.0b013e3181d275b6
Yoshino, 2000, Pleural retraction and intra-tumoral air-bronchogram as prognostic factors for stage I pulmonary adenocarcinoma following complete resection, Int Surg, 85, 105
Kondo, 2002, Radiologic-prognostic correlation in patients with small pulmonary adenocarcinomas, Lung Cancer, 36, 49, 10.1016/S0169-5002(01)00448-2
Sakao, 2004, Predictive factors for survival in surgically resected clinical IA peripheral adenocarcinoma of the lung, Ann Thorac Surg, 77, 1157, 10.1016/j.athoracsur.2003.09.055
Kuriyama, 1999, Ground-glass opacity on thin-section CT: value in differentiating subtypes of adenocarcinoma of the lung, AJR Am J Roentgenol, 173, 465, 10.2214/ajr.173.2.10430155
Castro, 2001, Prognostic significance of percentage of bronchioloalveolar pattern in adenocarcinomas of the lung, Ann Diagn Pathol, 5, 274, 10.1053/adpa.2001.27915
Hashizume, 2008, Prognostic significance of thin-section CT scan findings in small-sized lung adenocarcinoma, Chest, 133, 441, 10.1378/chest.07-1533
Dong, 2002, Computed tomographic image comparison between mediastinal and lung windows provides possible prognostic information in patients with small peripheral lung adenocarcinoma, J Thorac Cardiovasc Surg, 124, 1014, 10.1067/mtc.2002.125647
Matsuguma, 2002, Proportion of ground-glass opacity on high-resolution computed tomography in clinical T1 N0 M0 adenocarcinoma of the lung: a predictor of lymph node metastasis, J Thorac Cardiovasc Surg, 124, 278, 10.1067/mtc.2002.122298
Ohde, 2003, The proportion of consolidation to ground-glass opacity on high resolution CT is a good predictor for distinguishing the population of non-invasive peripheral adenocarcinoma, Lung Cancer, 42, 303, 10.1016/j.lungcan.2003.07.001
Okada, 2004, Correlation between computed tomographic findings, bronchioloalveolar carcinoma component, and biologic behavior of small-sized lung adenocarcinomas, J Thorac Cardiovasc Surg, 127, 857, 10.1016/j.jtcvs.2003.08.048
Sakao, 2004, Lung adenocarcinoma can be subtyped according to tumor dimension by computed tomography mediastinal-window setting. Additional size criteria for clinical T1 adenocarcinoma, Eur J Cardiothorac Surg, 26, 1211, 10.1016/j.ejcts.2004.08.021
Seki, 2008, Lung cancer with localized ground-glass attenuation represents early-stage adenocarcinoma in nonsmokers, J Thorac Oncol, 3, 483, 10.1097/JTO.0b013e31816a4994
Takashima, 2003, High-resolution CT features: prognostic significance in peripheral lung adenocarcinoma with bronchioloalveolar carcinoma components, Respiration, 70, 36, 10.1159/000068410
Nishio, 2007, The ratio of the maximum high attenuation area dimension to the maximum tumor dimension may be an index of the presence of lymph node metastasis in lung adenocarcinomas 3 cm or smaller on high-resolution computed tomography, J Thorac Oncol, 2, 29, 10.1016/S1556-0864(15)30014-9
Shim, 2009, Prognostic significance of visceral pleural invasion in the forthcoming (seventh) edition of TNM classification for lung cancer, Lung Cancer, 65, 161, 10.1016/j.lungcan.2008.11.008
Ikehara M, Saito H, Kondo T, et al. Comparison of thin-section CT and pathological findings in small solid-density type pulmonary adenocarcinoma: prognostic factors from CT findings. Eur J Radiol. In press.
Gaeta, 2002, CT and MRI findings of mucin-containing tumors and pseudotumors of the thorax: pictorial review, Eur Radiol, 12, 181, 10.1007/s003300100934
Nakata, 2003, Prospective study of thoracoscopic limited resection for ground-glass opacity selected by computed tomography, Ann Thorac Surg, 75, 1601, 10.1016/S0003-4975(02)04815-4
Takashima, 2002, Prognostic significance of high-resolution CT findings in small peripheral adenocarcinoma of the lung: a retrospective study on 64 patients, Lung Cancer, 36, 289, 10.1016/S0169-5002(01)00489-5
Hiramatsu, 2008, Pulmonary ground-glass opacity (GGO) lesions-large size and a history of lung cancer are risk factors for growth, J Thorac Oncol, 3, 1245, 10.1097/JTO.0b013e318189f526
Austin, 2008, Carcinoma of the lung and metastatic disease of the central nervous system, Am J Respir Crit Care Med, 178, 1090, 10.1164/ajrccm.178.10.1090
Mujoomdar, 2007, Clinical predictors of metastatic disease to the brain from non-small cell lung carcinoma: primary tumor size, cell type, and lymph node metastases, Radiology, 242, 882, 10.1148/radiol.2423051707
MacMahon, 2005, Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society, Radiology, 237, 395, 10.1148/radiol.2372041887
Eisenberg, 2010, Compliance with Fleischner Society guidelines for management of small lung nodules: a survey of 834 radiologists, Radiology, 255, 218, 10.1148/radiol.09091556
MacMahon, 2010, Compliance with Fleischner Society guidelines for management of lung nodules: lessons and opportunities, Radiology, 255, 14, 10.1148/radiol.10092382
Zhao, 2009, Evaluating variability in tumor measurements from same-day repeat CT scans of patients with non-small cell lung cancer, Radiology, 252, 263, 10.1148/radiol.2522081593
Ravenel, 2008, Pulmonary nodule volume: effects of reconstruction parameters on automated measurements—a phantom study, Radiology, 247, 400, 10.1148/radiol.2472070868
Jennings, 2004, Lung tumor growth: assessment with CT–comparison of diameter and cross-sectional area with volume measurements, Radiology, 231, 866, 10.1148/radiol.2313030715
Winer-Muram, 2003, Effect of varying CT section width on volumetric measurement of lung tumors and application of compensatory equations, Radiology, 229, 184, 10.1148/radiol.2291020859
Yankelevitz, 2000, Small pulmonary nodules: volumetrically determined growth rates based on CT evaluation, Radiology, 217, 251, 10.1148/radiology.217.1.r00oc33251
de Hoop, 2010, Pulmonary ground-glass nodules: increase in mass as an early indicator of growth, Radiology, 255, 199, 10.1148/radiol.09090571
Nakata, 2004, Surgical treatments for multiple primary adenocarcinoma of the lung, Ann Thorac Surg, 78, 1194, 10.1016/j.athoracsur.2004.03.102
Zwirewich, 1990, Multicentric adenocarcinoma of the lung: CT-pathologic correlation, Radiology, 176, 185, 10.1148/radiology.176.1.2162069
Park, 2008, Pulmonary nodular ground-glass opacities in patients with extrapulmonary cancers: what is their clinical significance and how can we determine whether they are malignant or benign lesions?, Chest, 133, 1402, 10.1378/chest.07-2568
Okada, 2007, Associations among bronchioloalveolar carcinoma components, positron emission tomographic and computed tomographic findings, and malignant behavior in small lung adenocarcinomas, J Thorac Cardiovasc Surg, 133, 1448, 10.1016/j.jtcvs.2007.02.023
Higashi, 1998, Fluorine-18-FDG PET imaging is negative in bronchioloalveolar lung carcinoma, J Nucl Med, 39, 1016
Higashi, 2000, FDG PET measurement of the proliferative potential of non-small cell lung cancer, J Nucl Med, 41, 85
Higashi, 2000, FDG PET in the evaluation of the aggressiveness of pulmonary adenocarcinoma: correlation with histopathological features, Nucl Med Commun, 21, 707, 10.1097/00006231-200008000-00002
Ohtsuka, 2006, Prognostic significance of [(18)F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma, Cancer, 107, 2468, 10.1002/cncr.22268
Raz, 2006, Tumor fluoro-2-deoxy-D-glucose avidity on positron emission tomographic scan predicts mortality in patients with early-stage pure and mixed bronchioloalveolar carcinoma, J Thorac Cardiovasc Surg, 132, 1189, 10.1016/j.jtcvs.2006.06.033
Sagawa, 2006, Fluorodeoxyglucose uptake correlates with the growth pattern of small peripheral pulmonary adenocarcinoma, Surg Today, 36, 230, 10.1007/s00595-005-3123-3
Pastorino, 2009, Fluorodeoxyglucose uptake measured by positron emission tomography and standardized uptake value predicts long-term survival of CT screening detected lung cancer in heavy smokers, J Thorac Oncol, 4, 1352, 10.1097/JTO.0b013e3181bbf1dc
Nakayama, 2010, Value of integrated positron emission tomography revised using a phantom study to evaluate malignancy grade of lung adenocarcinoma: a multicenter study, Cancer, 116, 3170, 10.1002/cncr.25244
Um, 2009, Prognostic value of 18F-FDG uptake on positron emission tomography in patients with pathologic stage I non-small cell lung cancer, J Thorac Oncol, 4, 1331, 10.1097/JTO.0b013e3181b6be3e
Birchard, 2009, Early changes in tumor size in patients treated for advanced stage nonsmall cell lung cancer do not correlate with survival, Cancer, 115, 581, 10.1002/cncr.24060
Sohn, 2008, [18F]Fluorothymidine positron emission tomography before and 7 days after gefitinib treatment predicts response in patients with advanced adenocarcinoma of the lung, Clin Cancer Res, 14, 7423, 10.1158/1078-0432.CCR-08-0312
Cloran, 2010, Limitations of dual time point PET in the assessment of lung nodules with low FDG avidity, Lung Cancer, 68, 66, 10.1016/j.lungcan.2009.05.013
Ohno, 2004, Dynamic MR imaging: value of differentiating subtypes of peripheral small adenocarcinoma of the lung, Eur J Radiol, 52, 144, 10.1016/j.ejrad.2004.01.015
van Klaveren, 2009, Management of lung nodules detected by volume CT scanning, N Engl J Med, 361, 2221, 10.1056/NEJMoa0906085
Oda, 2010, Computer-aided volumetry of pulmonary nodules exhibiting ground-glass opacity at MDCT, AJR Am J Roentgenol, 194, 398, 10.2214/AJR.09.2583
Henschke, 1999, Early Lung Cancer Action Project: overall design and findings from baseline screening, Lancet, 354, 99, 10.1016/S0140-6736(99)06093-6
Henschke, 2001, Early lung cancer action project: initial findings on repeat screenings, Cancer, 92, 153, 10.1002/1097-0142(20010701)92:1<153::AID-CNCR1303>3.0.CO;2-S
Lindell, 2007, Five-year lung cancer screening experience: CT appearance, growth rate, location, and histologic features of 61 lung cancers, Radiology, 242, 555, 10.1148/radiol.2422052090
Hasegawa, 2000, Growth rate of small lung cancers detected on mass CT screening, Br J Radiol, 73, 1252, 10.1259/bjr.73.876.11205667
Henschke, 2006, Survival of patients with stage I lung cancer detected on CT screening, N Engl J Med, 355, 1763, 10.1056/NEJMoa060476
Kakinuma, 2004, Progression of focal pure ground-glass opacity detected by low-dose helical computed tomography screening for lung cancer, J Comput Assist Tomogr, 28, 17, 10.1097/00004728-200401000-00003
Sone, 2007, Long-term follow-up study of a population-based 1996–1998 mass screening programme for lung cancer using mobile low-dose spiral computed tomography, Lung Cancer, 58, 329, 10.1016/j.lungcan.2007.06.022
Pelosi, 2008, Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat study, Lung Cancer, 62, 202, 10.1016/j.lungcan.2008.03.012
Wang, 2000, Rapidly growing small peripheral lung cancers detected by screening CT: correlation between radiological appearance and pathological features, Br J Radiol, 73, 930, 10.1259/bjr.73.873.11064644
Infante, 2009, A randomized study of lung cancer screening with spiral computed tomography: three-year results from the DANTE trial, Am J Respir Crit Care Med, 180, 445, 10.1164/rccm.200901-0076OC
Bepler, 2009, Are we coming full circle for lung cancer screening a second time?, Am J Respir Crit Care Med, 180, 384, 10.1164/rccm.200906-0977ED
McMahon, 2008, Estimating long-term effectiveness of lung cancer screening in the Mayo CT screening study, Radiology, 248, 278, 10.1148/radiol.2481071446
McMahon, 2008, Adopting helical CT screening for lung cancer: potential health consequences during a 15-year period, Cancer, 113, 3440, 10.1002/cncr.23962
Gatsonis, 2011, The National Lung Screening Trial: overview and study design, Radiology, 258, 243, 10.1148/radiol.10091808
Park, 2009, EGFR gene copy number in adenocarcinoma of the lung by FISH analysis: investigation of significantly related factors on CT, FDG-PET, and histopathology, Lung Cancer, 64, 179, 10.1016/j.lungcan.2008.08.003
Yano, 2006, Epidermal growth factor receptor gene mutation and computed tomographic findings in peripheral pulmonary adenocarcinoma, J Thorac Oncol, 1, 413, 10.1016/S1556-0864(15)31604-X
Chantranuwat, 2005, Histopathologic characteristics of pulmonary adenocarcinomas with and without EGFR mutation, J Med Assoc Thai, 88, S322
Huang, 2010, Correlation of F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value and EGFR mutations in advanced lung adenocarcinoma, Med Oncol, 27, 9, 10.1007/s12032-008-9160-1
Watanabe, 2006, [F-18]Fluorodeoxyglucose positron emission tomography can predict pathological tumor stage and proliferative activity determined by Ki-67 in clinical stage IA lung adenocarcinomas, Jpn J Clin Oncol, 36, 403, 10.1093/jjco/hyl043
Vesselle, 2008, Relationship between non-small cell lung cancer FDG uptake at PET, tumor histology, and Ki-67 proliferation index, J Thorac Oncol, 3, 971, 10.1097/JTO.0b013e31818307a7
Schuchert, 2007, Anatomic segmentectomy in the treatment of stage I non-small cell lung cancer, Ann Thorac Surg, 84, 926, 10.1016/j.athoracsur.2007.05.007
Shapiro, 2009, Thoracoscopic segmentectomy compares favorably with thoracoscopic lobectomy for patients with small stage I lung cancer, J Thorac Cardiovasc Surg, 137, 1388, 10.1016/j.jtcvs.2009.02.009
Yan, 2009, Systematic review and meta-analysis of randomized and nonrandomized trials on safety and efficacy of video-assisted thoracic surgery lobectomy for early-stage non-small-cell lung cancer, J Clin Oncol, 27, 2553, 10.1200/JCO.2008.18.2733
Watanabe, 2005, Intentional limited resection for small peripheral lung cancer based on intraoperative pathologic exploration, Jpn J Thorac Cardiovasc Surg, 53, 29, 10.1007/s11748-005-1005-7
Higashiyama, 2003, Intraoperative lavage cytologic analysis of surgical margins in patients undergoing limited surgery for lung cancer, J Thorac Cardiovasc Surg, 125, 101, 10.1067/mtc.2003.92
Utsumi, 2010, Optimal sampling methods for margin cytology examination following lung excision, Interact Cardiovasc Thorac Surg, 10, 434, 10.1510/icvts.2009.212142
Asamura, 2003, A clinicopathological study of resected subcentimeter lung cancers: a favorable prognosis for ground glass opacity lesions, Ann Thorac Surg, 76, 1016, 10.1016/S0003-4975(03)00835-X
Ginsberg, 1995, Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group, Ann Thorac Surg, 60, 615, 10.1016/0003-4975(95)00537-U
Miller, 2002, Surgical treatment of non-small cell lung cancer 1 cm or less in diameter, Ann Thorac Surg, 73, 1545, 10.1016/S0003-4975(02)03525-7
Rami-Porta, 2005, Complete resection in lung cancer surgery: proposed definition, Lung Cancer, 49, 25, 10.1016/j.lungcan.2005.01.001
Ishiguro, 2010, Effect of selective lymph node dissection based on patterns of lobe-specific lymph node metastases on patient outcome in patients with resectable non-small cell lung cancer: a large-scale retrospective cohort study applying a propensity score, J Thorac Cardiovasc Surg, 139, 1001, 10.1016/j.jtcvs.2009.07.024
Darling GE, Allen MS, Landreneau RJ, et al. Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non-small cell carcinoma: results of the ACOSOG Z0030 Trial. J Thorac Cardiovasc Surg. In press.
Nomori, 2006, Omission of mediastinal lymph node dissection in lung cancer: its techniques and diagnostic procedures, Ann Thorac Cardiovasc Surg, 12, 83
Finley, 2010, Predictors of outcomes after surgical treatment of synchronous primary lung cancers, J Thorac Oncol, 5, 197, 10.1097/JTO.0b013e3181c814c5
Hayes, 2009, Breast, 347
Yatabe, 2007, Epidermal growth factor receptor mutations in lung cancers, Pathol Int, 57, 233, 10.1111/j.1440-1827.2007.02098.x
Holst, 1998, Bronchioloalveolar adenocarcinoma of lung: monoclonal origin for multifocal disease, Am J Surg Pathol, 22, 1343, 10.1097/00000478-199811000-00004
Furak, 2003, Bronchioloalveolar lung cancer: occurrence, surgical treatment and survival, Eur J Cardiothorac Surg, 23, 818, 10.1016/S1010-7940(03)00084-8
Clayton, 1988, The spectrum and significance of bronchioloalveolar carcinomas, Pathol Annu, 23, 361
Lau, 2002, Expression of thyroid transcription factor-1, cytokeratin 7, and cytokeratin 20 in bronchioloalveolar carcinomas: an immunohistochemical evaluation of 67 cases, Mod Pathol, 15, 538, 10.1038/modpathol.3880560
Sarantopoulos, 2004, Immunohistochemical analysis of lung carcinomas with pure or partial bronchioloalveolar differentiation, Arch Pathol Lab Med, 128, 406, 10.5858/2004-128-406-IAOLCW
Simsir, 2004, Differential expression of cytokeratins 7 and 20 and thyroid transcription factor-1 in bronchioloalveolar carcinoma: an immunohistochemical study in fine-needle aspiration biopsy specimens, Am J Clin Pathol, 121, 350, 10.1309/CM20WA20RW3T600L
Sonobe, 2005, Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma, Br J Cancer, 93, 355, 10.1038/sj.bjc.6602707
Ohtsuka, 2006, Clinico-pathological and biological significance of tyrosine kinase domain gene mutations and overexpression of epidermal growth factor receptor for lung adenocarcinoma, J Thorac Oncol, 1, 787, 10.1016/S1556-0864(15)30407-X
Sonobe, 2006, Lung adenocarcinoma harboring mutations in the ERBB2 kinase domain, J Mol Diagn, 8, 351, 10.2353/jmoldx.2006.050132
Ninomiya, 2009, Correlation between morphology and EGFR mutations in lung adenocarcinomas Significance of the micropapillary pattern and the hobnail cell type, Lung Cancer, 63, 235, 10.1016/j.lungcan.2008.04.017
Stenhouse, 2004, Thyroid transcription factor 1 in pulmonary adenocarcinoma, J Clin Pathol, 57, 383, 10.1136/jcp.2003.007138
Shrestha, 1998, Immunohistochemical, ultrastructural and molecular study of well differentiated adenocarcinomas of the lung predominantly composed of goblet cells, Lung Cancer, 22, 103, 10.1016/S0169-5002(98)00052-X