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Nhịn ăn ngắt quãng hỗ trợ sự cân bằng của thành phần vi sinh vật đường ruột
International Microbiology - 2022
Tóm tắt
Có một lượng nghiên cứu chi tiết ngày càng tăng cho thấy rằng nhịn ăn ngắt quãng thực chất là một hoạt động thanh lọc về mặt sức khỏe. Đặc biệt là kể từ khi các ứng dụng kéo dài hơn 16 giờ kích hoạt quá trình tự thực bào, nó tiếp tục tác động đến tất cả các hệ thống mô và cơ quan sau cử động tái sinh bắt đầu từ cấp độ tế bào. Tương tự, ngày càng dễ hiểu hơn rằng vi sinh vật đường ruột (GM) có nhiều ảnh hưởng tích cực đến tất cả các hệ thống mô và cơ quan. Mặc dù GM bị ảnh hưởng bởi nhiều yếu tố khác nhau, nhưng thói quen ăn uống được báo cáo là yếu tố hiệu quả nhất. Do đó, việc điều tra ảnh hưởng của các phương pháp nhịn ăn khác nhau đến GM, điều này có nhiều lợi ích cho sức khỏe, là rất quan trọng. Bài nghiên cứu này nhằm xác định tác động của nhịn ăn ngắt quãng 18 giờ trong 5 tuần đối với việc hình thành GM. Một con chuột đực Wistar 12 tháng tuổi đã được chọn làm cơ sở mô hình trong nghiên cứu. Vào cuối áp dụng, bản metagenome đã được áp dụng cho nội dung manh tràng của mô ruột lấy từ những con vật bị hiến tế. Thực hành nhịn ăn ngắt quãng dẫn đến sự gia tăng đa dạng alpha, điều này thể hiện sự đa dạng vi khuẩn đáng kể, sự ổn định của tỷ lệ Firmicutes và Bacteroidetes (F/B), và việc định hình lại các giá trị có tỷ lệ cao nhất ở tất cả các giai đoạn phân loại, đặc biệt ở cấp độ họ, giống và loài. Kết quả phân tích cho thấy chương trình nhịn ăn ngắt quãng được ưa chuộng giúp cân bằng thành phần GM. Nghiên cứu này là một ví dụ quan trọng cho thấy mối liên hệ tích cực mạnh mẽ giữa nhịn ăn ngắt quãng và GM.
Từ khóa
#nhịn ăn ngắt quãng #vi sinh vật đường ruột #tự thực bào #đa dạng alpha #Firmicutes #BacteroidetesTài liệu tham khảo
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