Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

Journal of Experimental Medicine - Tập 203 Số 10 - Trang 2271-2279 - 2006
Spencer C. Liang1,2, Xiangyang Tan3, Deborah Luxenberg1,4, Riyez Karim3, Kyriaki Dunussi‐Joannopoulos1,4, Mary Collins1,4, Lynette A. Fouser1,4
11Inflammation
2Wyeth Research, Cambridge MA 02140, USA
32Antibody Technologies Group, Wyeth Research, Cambridge, MA 02140
4Inflammation

Tóm tắt

Th17 cells are a distinct lineage of effector CD4+ T cells characterized by their production of interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family member, at substantially higher amounts than T helper (Th)1 or Th2 cells. Similar to IL-17A, IL-22 expression was initiated by transforming growth factor β signaling in the context of IL-6 and other proinflammatory cytokines. The subsequent expansion of IL-22–producing cells was dependent on IL-23. We further demonstrate that IL-22 was coexpressed in vitro and in vivo with both IL-17A and IL-17F. To study a functional relationship among these cytokines, we examined the expression of antimicrobial peptides by primary keratinocytes treated with combinations of IL-22, IL-17A, and IL-17F. IL-22 in conjunction with IL-17A or IL-17F synergistically induced the expression of β-defensin 2 and S100A9 and additively enhanced the expression of S100A7 and S100A8. Collectively, we have identified IL-22 as a new cytokine expressed by Th17 cells that synergizes with IL-17A or IL-17F to regulate genes associated with skin innate immunity.

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Thông tin xuất bản

Journal of Experimental Medicine

Tập 203 Số 10

2271-2279

Thông tin tác giả