Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial

JCI insight - Tập 3 Số 5 - 2018
Bruno François1,2,3, Robin Jeannet1, Thomas Daix1,3, Andrew H. Walton4, Matthew S. Shotwell5, Jacqueline Unsinger4, Guillaume Monneret6,7, Thomas Rimmelé8,7, Teresa M. Blood4, Michel Morre9, Anne Grégoire9, Gail Mayo10, Jane Blood4, Scott K. Durum11, Edward R. Sherwood10,12, Richard S. Hotchkiss4,13,14
1Inserm CIC-1435, Dupuytren University Hospital, Limoges, France.
2Inserm UMR-1092, University of Limoges, Limoges, France.
3Intensive Care Unit and
4Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA
5Department of Biostatistics, Vanderbilt University, Nashville, Tennessee, USA.
6Cellular Immunology Laboratory, Edouard Herriot hospital, Hospices Civils de Lyon, Lyon, France
7EA 7426 PI3 "Pathophysiology of Injury-induced Immunosuppression", Université Claude Bernard Lyon I-Biomérieux-Hospices Civils de Lyon, Lyon, France.
8Anesthesiology and Intensive Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
9Revimmune SAS, Paris, France.
10Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
11Cytokines and Immunity Section, National Cancer Institute, Bethesda, Maryland, USA.
12Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
13Department of Medicine and
14Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA

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