Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission

Springer Science and Business Media LLC - Tập 247 Số 4 - Trang 228-233 - 1997
Ulrich Frommberger1, Joachim Bauer2, Peter Haselbauer2, Andrea Fräulin2, Dieter Riemann2, Thomas Berger2
1Department of Psychiatry, University of Freiburg, Germany
2Dept. of Psychiatry, University of Freiburg, Freiburg, Germany

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Aarden LA, de Groot ER, Schaap OL, Lansdorp PM (1987) Production of hybridoma growth factor by human monocytes. Eur J Immunol 17:1411–1416

American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders (DSM-III-R), 3rd edn, revised. American Psychiatric Press, Washington DC

Barak V, Barak Y, Levine J, Nisman B, Roisman I (1995) Changes in interleukin-1 beta and soluble interleukin-2 receptor levels in CSF and serum of schizophrenic patients. J Basic Clin Physiol Pharmacol 6:61–69

Bauer J, Ganter U, Strauss S, Stadtmüller G, Frommberger U, Bauer H, Volk B, Berger M (1992) The participation of interleukin-6 in the pathogenesis of Alzheimer’s disease. Res Immunol 143:650–656

Bauer J, Hohagen F, Ebert T, Timmer J, Ganter U, Krieger S, Lis S, Postler E, Voderholzer U, Berger M (1994) Interleukin-6 serum levels in healthy persons correspond to the sleep-wake cycle. Clin Investig 72:315

Black PH (1994) Central nervous system-immune system interactions: psychoneuroendocrinology of stress and its immune consequences. Antimicrob Agents Chemother 38:1–6

Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MBA, Mucke L (1993) Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci USA 90:10061–10065

De Rijk RH, Boelen A, Tilders FJH, Berkenbosch F (1994) Induction of plasma interleukin-6 by circulating adrenaline in the rat. Psychoneuroendocrinology 19:155–163

Ganguli R, Yang Z, Shurin G, Chengappa KNR, Brar JS, Gubbi AV, Rabin BS (1994) Serum interleukin-6 concentration in schizophrenia: elevation associated with duration of illness. Psychiatry Res 51:1–10

Hornig-Rohan M, van Bell CT, Kuhn P, Amsterdam JD (1995) Acute phase proteins in affective illness. Biol Psychiatry 37:607 (Abstract)

Joyce P, Hawes C, Mulder R, Sellman J, Wilson D, Boswell D (1992) Elevated levels of acute phase plasma proteins in major depression. Biol Psychiatry 32:1035–1041

Katila H, Appelberg B, Hurme M, Rimon R (1994) Plasma levels of interleukin-1 beta and interleukin-6 in schizophrenia, other psychoses, and affective disorders. Schizophr Res 12:29–34

Kushner I (1991) The acute phase response: from Hippocrates to cytokine biology. Eur Cytokine Netw 2:75–80

LeMay LG, Vander AJ, Kluger MJ (1991) The effects of psychological stress on plasma interleukin-6 activity in rats. Physiol Behav 47:957–961

Maes M, Scharpe S, Meltzer HY, Bosmans E, Suy E, Calabrese J, Cosyns P (1993) Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Res 49:11–27

Maes M, Meltzer HY, Bosmans E (1994a) Psychoimmune investigation in obsessive-compulsive disorder: assays of plasma transferrin, IL-2 and IL-6 receptor, and IL-1β and IL-6 concentrations. Neuropsychobiology 30:57–60

Maes M, Meltzer HY, Stevens W, Cosyns P, Blockx (1994b) Multiple reciprocal relationships between in vivo cellular immunity and hypothalamic-pituitary-adrenal axis in depression. Psychol Med 24:167–177

Maes M, Bosmans E, Calabrese J, Smith R, Meltzer H (1995a) Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers. J Psychiatr Res 29:141–152

Maes M, Meltzer H, Bosmans E, Bergmans R, Vandoolaeghe E, Ranjan R, Desnyder R (1995b) Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. J Affect Disord 34:301–309

Maimone D, Cioni C, Rosa S, Macchia G, Aloisi F, Annunziata P (1993) Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1β and TNFα. J Neuroimmunol 47:73–82

Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389

Müller N (1997) Die Rolle des Zytokinnetzwerks im ZNS und psychische Störungen. Nervenarzt 68:11–20

Norris GJ, Benveniste EN (1993) Interleukin-6 production by astrocytes: induction by the neurotransmitter norepinephrine. J Neuroimmunol 45:137–146

Overall JE, Gorham DR (1962) The Brief Psychiatric Rating Scale. Psychol Rep 10:799–812

Seidel A, Arolt V, Hunstiger M, Rink L, Behnisch A, Kirchner H (1995) Cytokine production and serum proteins in depression. Scand J Immunol 41:534–538

Shintani F, Kanba S, Maruo N, Nakaki T, Nibuya M, Suzuki E, Kinoshita N, Yagi G (1991) Serum interleukin-6 in schizophrenic patients. Life Sci 49:661–664

Sluzewska A, Rybakowski J, Laciak M, Mackiewicz A, Sobieska M, Wiktorowicz K (1995) Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine. Ann NY Acad Sci 762:474–476

Sluzewska A, Rybakowski J, Bosmans E, Sobieska M, Berghmans R, Maes M, Wiktorowicz K (1996) Indicators of immune activation in major depression. Psychiatry Res 64:161–167

Song C, Dinan T, Leonhard B (1994) Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls. J Affect Disord 30:283–288

Spitzer RL, Williams JB, Gibbon M (1987) Structured clinical interview for DSM-111-R (SCID). Biometrics Research Department, New York State Psychiatric Institute, New York

Spivak B, Radwan M, Bartur P, Mester R, Weizman A (1995) Antinuclear autoantibodies in chronic schizophrenia. Acta Psychiatr Scand 92:266–269

Stein TP, Schluter MD (1994) Excretion of IL-6 by astronauts during spaceflight. Am J Physiol 266:E448-E452

Xu HM, Wei J, Hemmings GP (1994) Changes of plasma concentrations of interleukin-lalpha and interleukin-6 with neuroleptic treatment for schizophrenia. Br J Psychiatry 164:251–253

Zhou D, Kusnecov AW, Shurin MR, Paoli M de, Rabin BS (1993) Exposure to physical and psychological stressors elevates plasma interleukin-6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 133:2523–2530