Interleukin-17 and innate immunity in infections and chronic inflammation
Tóm tắt
Từ khóa
Tài liệu tham khảo
Awasthi, 2009, Th17 cells: from precursors to players in inflammation and infection, Int. Immunol., 21, 489, 10.1093/intimm/dxp021
Mosmann, 1989, TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties, Annu Rev. Immunol., 7, 145, 10.1146/annurev.iy.07.040189.001045
Del Prete, 1992, Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy, Allergy, 47, 450, 10.1111/j.1398-9995.1992.tb00662.x
Steinke, 2001, Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists, Respir. Res., 2, 66, 10.1186/rr40
Hueber, 2010, Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis, Sci. Transl. Med., 2, 52ra72, 10.1126/scitranslmed.3001107
Schmitt, 2014, Th9 cells, new players in adaptive immunity, Trends Immunol., 35, 61, 10.1016/j.it.2013.10.004
Korn, 2009, IL-17 and Th17 cells, Annu. Rev. Immunol., 27, 485, 10.1146/annurev.immunol.021908.132710
Eyerich, 2009, Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling, J. Clin. Investigation, 119, 3573
O'Shea, 2010, Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells, Science (New York, NY), 327, 1098, 10.1126/science.1178334
Zhu, 2010, Differentiation of effector CD4 T cell populations (*), Annu. Rev. Immunol., 28, 445, 10.1146/annurev-immunol-030409-101212
Gu, 2013, IL-17 family: cytokines, receptors and signaling, Cytokine, 64, 477, 10.1016/j.cyto.2013.07.022
Rouvier, 1993, CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene, J. Immunol., 150, 5445, 10.4049/jimmunol.150.12.5445
Wu, 2013, Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1, Nature, 496, 513, 10.1038/nature11984
Kleinewietfeld, 2013, Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells, Nature, 496, 518, 10.1038/nature11868
Kolls, 2004, Interleukin-17 family members and inflammation, Immunity, 21, 467, 10.1016/j.immuni.2004.08.018
Iwakura, 2011, Functional specialization of interleukin-17 family members, Immunity, 34, 149, 10.1016/j.immuni.2011.02.012
Miossec, 2012, Targeting IL-17 and TH17 cells in chronic inflammation, Nat. Rev. Drug Discov., 11, 763, 10.1038/nrd3794
Garlanda, 2013, The interleukin-1 family: back to the future, Immunity, 39, 1003, 10.1016/j.immuni.2013.11.010
Hirota, 2012, Regulation and function of innate and adaptive interleukin-17-producing cells, EMBO Rep., 13, 113, 10.1038/embor.2011.248
Lin, 2011, Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis, J. Immunol., 187, 490, 10.4049/jimmunol.1100123
Takatori, 2009, Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22, J. Exp. Med., 206, 35, 10.1084/jem.20072713
Crellin, 2010, Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells, J. Exp. Med., 207, 281, 10.1084/jem.20091509
Michel, 2007, Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia, J. Exp. Med., 204, 995, 10.1084/jem.20061551
Cella, 2009, A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity, Nature, 457, 722, 10.1038/nature07537
Pappu, 2010, The IL-17 family cytokines in immunity and disease, J. Clin. Immunol., 30, 185, 10.1007/s10875-010-9369-6
Geremia, 2011, IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease, J. Exp. Med., 208, 1127, 10.1084/jem.20101712
Hoshino, 2008, MPO-ANCA induces IL-17 production by activated neutrophils in vitro via classical complement pathway-dependent manner, J. Autoimmun., 31, 79, 10.1016/j.jaut.2008.03.006
Villanova, 2014, Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis, J. Invest. Dermatol., 134, 984, 10.1038/jid.2013.477
Johansen, 2011, Tumor necrosis factor alpha-mediated induction of interleukin 17C in human keratinocytes is controlled by nuclear factor kappaB, J. Biol. Chem., 286, 25487, 10.1074/jbc.M111.240671
Hueber, 2010, Mast cells express IL-17A in rheumatoid arthritis synovium, J. Immunol., 184, 3336, 10.4049/jimmunol.0903566
Toussirot, 2012, The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases, Inflamm. Allergy Drug Targets, 11, 159, 10.2174/187152812800392805
Zhang, 2003, Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system, J. Immunol., 170, 2153, 10.4049/jimmunol.170.4.2153
Curtis, 2009, Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens, Immunology, 126, 177, 10.1111/j.1365-2567.2008.03017.x
Tsai, 2013, IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection, Clin. Dev. Immunol., 2013, 267971, 10.1155/2013/267971
Cua, 2010, Innate IL-17-producing cells: the sentinels of the immune system, Nat. Rev. Immunol., 10, 479, 10.1038/nri2800
Kundu-Raychaudhuri, 2014, Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis - Xenograft model, J. Autoimmun., 55, 63, 10.1016/j.jaut.2014.07.003
Langrish, 2004, IL-12 and IL-23: master regulators of innate and adaptive immunity, Immunol. Rev., 202, 96, 10.1111/j.0105-2896.2004.00214.x
Deenick, 2007, Autoimmunity: IL-21: a new player in Th17-cell differentiation, Immunol. Cell Biol., 85, 503, 10.1038/sj.icb.7100114
Chen, 2008, Th17 cells: a new fate for differentiating helper T cells, Immunol. Res., 41, 87, 10.1007/s12026-007-8014-9
Sutton, 2009, Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity, Immunity, 31, 331, 10.1016/j.immuni.2009.08.001
Parker, 1990, Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire, J. Exp. Med., 171, 1597, 10.1084/jem.171.5.1597
Cai, 2011, Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation, Immunity, 35, 596, 10.1016/j.immuni.2011.08.001
Itohara, 1990, Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia, Nature, 343, 754, 10.1038/343754a0
Goodman, 1989, Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function, J. Exp. Med., 170, 1569, 10.1084/jem.170.5.1569
Gray, 2011, Cutting edge: identification of a motile IL-17-producing gammadelta T cell population in the dermis, J. Immunol., 186, 6091, 10.4049/jimmunol.1100427
Ribot, 2009, CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets, Nat. Immunol., 10, 427, 10.1038/ni.1717
Haas, 2009, CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells, Eur. J. Immunol., 39, 3488, 10.1002/eji.200939922
Jensen, 2008, Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma, Immunity, 29, 90, 10.1016/j.immuni.2008.04.022
Korn, 2012, Development and function of interleukin 17-producing gammadelta T cells, Ann. N Y Acad. Sci., 1247, 34, 10.1111/j.1749-6632.2011.06355.x
Caccamo, 2011, Differentiation, phenotype, and function of interleukin-17-producing human Vgamma9Vdelta2 T cells, Blood, 118, 129, 10.1182/blood-2011-01-331298
Kronenberg, 2007, On the road: progress in finding the unique pathway of invariant NKT cell differentiation, Curr. Opin. Immunol., 19, 186, 10.1016/j.coi.2007.02.009
Tatituri, 2013, Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs, Proc. Natl. Acad. Sci. U S A., 110, 1827, 10.1073/pnas.1220601110
Maggi, 2010, CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC, Eur. J. Immunol., 40, 2174, 10.1002/eji.200940257
Rossjohn, 2012, Recognition of CD1d-restricted antigens by natural killer T cells, Nat. Rev. Immunol., 12, 845, 10.1038/nri3328
Moreira-Teixeira, 2011, Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells, J. Immunol., 186, 5758, 10.4049/jimmunol.1003043
Kumar, 2014, Innate lymphoid cells: new paradigm in immunology of inflammation, Immunol. Lett., 157, 23, 10.1016/j.imlet.2013.11.003
Poggi, 2014, NK cell autoreactivity and autoimmune diseases, Front. Immunol., 5, 27
Passos, 2010, IL-6 promotes NK cell production of IL-17 during toxoplasmosis, J. Immunol., 184, 1776, 10.4049/jimmunol.0901843
Luci, 2009, Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin, Nat. Immunol., 10, 75, 10.1038/ni.1681
Satoh-Takayama, 2009, The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium, J. Immunol., 183, 6579, 10.4049/jimmunol.0901935
Sanos, 2010, Isolation of NK cells and NK-like cells from the intestinal lamina propria, Methods Mol. Biol., 612, 505, 10.1007/978-1-60761-362-6_32
Kollnberger, 2002, Cell-surface expression and immune receptor recognition of HLA-B27 homodimers, Arthritis Rheumatism, 46, 2972, 10.1002/art.10605
Scrivo, 2011, Evaluation of degranulation and cytokine production in natural killer cells from spondyloarthritis patients at single-cell level, Cytom. B Clin. Cytom., 80, 22, 10.1002/cyto.b.20549
Kim, 2009, Lymphoid tissue inducer cells: architects of CD4 immune responses in mice and men, Clin. Exp. Immunol., 157, 20, 10.1111/j.1365-2249.2009.03932.x
Cupedo, 2009, Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells, Nat. Immunol., 10, 66, 10.1038/ni.1668
Gladiator, 2013, Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection, J. Immunol., 190, 521, 10.4049/jimmunol.1202924
Buonocore, 2010, Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology, Nature, 464, 1371, 10.1038/nature08949
Sawa, 2011, RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota, Nat. Immunol., 12, 320, 10.1038/ni.2002
Sadik, 2011, Neutrophils cascading their way to inflammation, Trends Immunol., 32, 452, 10.1016/j.it.2011.06.008
Mantovani, 2011, Neutrophils in the activation and regulation of innate and adaptive immunity, Nat. Rev., 11, 519
Ley, 2007, Getting to the site of inflammation: the leukocyte adhesion cascade updated, Nat. Rev., 7, 678
Ramirez-Carrozzi, 2011, IL-17C regulates the innate immune function of epithelial cells in an autocrine manner, Nat. Immunol., 12, 1159, 10.1038/ni.2156
Li, 2010, IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury, J. Clin. Invest., 120, 331, 10.1172/JCI38702
Stone, 2010, IgE, mast cells, basophils, and eosinophils, J. Allergy Clin. Immunol., 125, S73, 10.1016/j.jaci.2009.11.017
Sakellariou, 2014, Association of Smoking with acute phase Reactants and molecules involved in bone formation in patients with ankylosing spondylitis, Arthritis Rheumatol., 66, S1130
Zizzo, 2013, IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids, J. Immunol., 190, 5237, 10.4049/jimmunol.1203017
Erbel, 2014, IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis, J. Immunol., 193, 4344, 10.4049/jimmunol.1400181
Sutherland, 2014, Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage, Nat. Immunol., 15, 1116, 10.1038/ni.3023
Murray, 2014, Macrophage activation and polarization: nomenclature and experimental guidelines, Immunity, 41, 14, 10.1016/j.immuni.2014.06.008
Wang, 2014, IL-17 induces inflammation-associated gene products in blood monocytes, and treatment with ixekizumab reduces their expression in psoriasis patient blood, J. Invest. Dermatol., 134, 2990, 10.1038/jid.2014.268
Ishigame, 2009, Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses, Immunity, 30, 108, 10.1016/j.immuni.2008.11.009
Chen, 2003, Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop, J. Biol. Chem., 278, 17036, 10.1074/jbc.M210429200
Liang, 2006, Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides, J. Exp. Med., 203, 2271, 10.1084/jem.20061308
Jovanovic, 1998, IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages, J. Immunol., 160, 3513, 10.4049/jimmunol.160.7.3513
Ouyang, 2008, The biological functions of T helper 17 cell effector cytokines in inflammation, Immunity, 28, 454, 10.1016/j.immuni.2008.03.004
Pappu, 2012, Regulation of epithelial immunity by IL-17 family cytokines, Trends Immunol., 33, 343, 10.1016/j.it.2012.02.008
Kleinschek, 2007, IL-25 regulates Th17 function in autoimmune inflammation, J. Exp. Med., 204, 161, 10.1084/jem.20061738
Reynolds, 2010, IL-17 family member cytokines: regulation and function in innate immunity, Cytokine Growth Factor Rev., 21, 413, 10.1016/j.cytogfr.2010.10.002
Dungan, 2011, Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17, Cytokine, 56, 126, 10.1016/j.cyto.2011.07.007
Kinugasa, 2000, Claudins regulate the intestinal barrier in response to immune mediators, Gastroenterology, 118, 1001, 10.1016/S0016-5085(00)70351-9
Moran, 2009, Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies, Arthritis Res. Ther., 11, R113, 10.1186/ar2772
Svendsen, 2013, The impact of genes on the occurrence of autoantibodies in rheumatoid arthritis. A study on disease discordant twin pairs, J. Autoimmun., 41, 120, 10.1016/j.jaut.2012.12.001
Kourilovitch, 2014, Diagnosis and classification of rheumatoid arthritis, J. Autoimmun., 48–49, 26, 10.1016/j.jaut.2014.01.027
Chabaud, 2000, Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis, Cytokine, 12, 1092, 10.1006/cyto.2000.0681
Andoh, 2007, Interaction between interleukin-17-producing CD4+ T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation?, J. Gastroenterology, 42, 29, 10.1007/s00535-006-1926-7
Huppert, 2010, Cellular mechanisms of IL-17-induced blood-brain barrier disruption, FASEB J. Official Publ. Fed. Am. Soc. Exp. Biol., 24, 1023
Gaffen, 2014, The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing, Nat. Rev. Immunol., 14, 585, 10.1038/nri3707
Liubchenko, 2013, Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes, J. Autoimmun., 40, 111, 10.1016/j.jaut.2012.09.001
Diani, 2015, T cell responses in psoriasis and psoriatic arthritis, Autoimmun. Rev., 14, 286, 10.1016/j.autrev.2014.11.012
Zhang, 2013, Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris, J. Autoimmun., 41, 17, 10.1016/j.jaut.2013.01.001
Modena, 2013, Cost-effectiveness of biologic treatment for rheumatoid arthritis in clinical practice: an achievable target?, Autoimmun. Rev., 12, 835, 10.1016/j.autrev.2012.11.009
Roark, 2007, Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells, J. Immunol., 179, 5576, 10.4049/jimmunol.179.8.5576
Roark, 2013, A canonical Vgamma4Vdelta4+ gammadelta T cell population with distinct stimulation requirements which promotes the Th17 response, Immunol. Res., 55, 217, 10.1007/s12026-012-8364-9
Ito, 2009, Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis, Arthritis Rheumatism, 60, 2294, 10.1002/art.24687
O'Brien, 2001, T cell receptor and function cosegregate in gamma-delta T cell subsets, Chem. Immunol., 79, 1, 10.1159/000058829
Pollinger, 2011, Th17 cells, not IL-17+ gammadelta T cells, drive arthritic bone destruction in mice and humans, J. Immunol., 186, 2602, 10.4049/jimmunol.1003370
Keijsers, 2014, Cellular sources of IL-17 in psoriasis: a paradigm shift?, Exp. Dermatol., 23, 799, 10.1111/exd.12487
Kirkham, 2014, Interleukin-17A: a unique pathway in immune-mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis, Immunology, 141, 133, 10.1111/imm.12142
Conrad, 2006, Animal models of psoriasis and psoriatic arthritis: an update, Curr. Rheumatol. Reports, 8, 342, 10.1007/s11926-006-0063-x
Noordenbos, 2012, Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis, Arthritis Rheumatism, 64, 99, 10.1002/art.33396
Raychaudhuri, 2012, IL-17 receptor and its functional significance in psoriatic arthritis, Mol. Cell. Biochem., 359, 419, 10.1007/s11010-011-1036-6
de Boer, 2010, Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques, J. Pathol., 220, 499, 10.1002/path.2667
Pantelyushin S, Haak S, Ingold B, Kulig P, Heppner FL, Navarini AA et al. Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice. J. Clin. Invest.;122:2252–2256..
Batliwalla, 2005, Microarray analyses of peripheral blood cells identifies unique gene expression signature in psoriatic arthritis, Mol. Med., 11, 21, 10.2119/2006-00003.Gulko
Bozza, 2008, Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection, J. Immunol., 180, 4022, 10.4049/jimmunol.180.6.4022
Gulen, 2010, The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation, Immunity, 32, 54, 10.1016/j.immuni.2009.12.003
Russell, 2013, Toll IL-1R8/single Ig IL-1-related receptor regulates psoriasiform inflammation through direct inhibition of innate IL-17A expression by gammadelta T cells, J. Immunol., 191, 3337, 10.4049/jimmunol.1300828
Glitzner E, Korosec A, Brunner PM, Drobits B, Amberg N, Schonthaler HB et al. Specific roles for dendritic cell subsets during initiation and progression of psoriasis. EMBO Mol. Med.;6:1312–1327..
Boltjes A, van Wijk F. Human dendritic cell functional specialization in steady-state and inflammation. Front. Immunol.;5:131..
Cooper, 2009, IL-17 and anti-bacterial immunity: protection versus tissue damage, Eur. J. Immunol., 39, 649, 10.1002/eji.200839090
Lockhart, 2006, IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection, J. Immunol., 177, 4662, 10.4049/jimmunol.177.7.4662
Okamoto Yoshida, 2010, Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung, J. Immunol., 184, 4414, 10.4049/jimmunol.0903332
Umemura, 2007, IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection, J. Immunol., 178, 3786, 10.4049/jimmunol.178.6.3786
Tam, 2012, IL-17 and gammadelta T-lymphocytes play a critical role in innate immunity against Nocardia asteroides GUH-2, Microbes Infect./Institut. Pasteur., 14, 1133, 10.1016/j.micinf.2012.05.008
Liu, 2013, The responses of gammadelta T-cells against acute Pseudomonas aeruginosa pulmonary infection in mice via interleukin-17, Pathogens Dis., 68, 44, 10.1111/2049-632X.12043
Shibata, 2007, Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production, J. Immunol., 178, 4466, 10.4049/jimmunol.178.7.4466
Cho, 2010, IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice, J. Clin. Invest., 120, 1762, 10.1172/JCI40891
Hamada, 2008, IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver, J. Immunol., 181, 3456, 10.4049/jimmunol.181.5.3456
Hamada, 2008, Importance of murine Vdelta1gammadelta T cells expressing interferon-gamma and interleukin-17A in innate protection against Listeria monocytogenes infection, Immunology, 125, 170, 10.1111/j.1365-2567.2008.02841.x
Zhang, 2013, IL-17 plays a central role in initiating experimental Candida albicans infection in mouse corneas, Eur. J. Immunol., 43, 2671, 10.1002/eji.201242891
Jie, 2014, Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection, J. Immunol., 192, 3289, 10.4049/jimmunol.1303281
Peng, 2008, Interleukin 17-producing gamma delta T cells increased in patients with active pulmonary tuberculosis, Cell. Mol. Immunol., 5, 203, 10.1038/cmi.2008.25
Asano T, Ichiki K, Koizumi S, Kaizu K, Hatori T, Fujino O et al. IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children. Cytokine;51:101–106..
Raychaudhuri, 2013, Role of IL-17 in psoriasis and psoriatic arthritis, Clin. Rev. Allergy Immunol., 44, 183, 10.1007/s12016-012-8307-1
Benham, 2013, Th17 and Th22 cells in psoriatic arthritis and psoriasis, Arthritis Res. Ther., 15, R136, 10.1186/ar4317
Chiricozzi, 2013, IL-17 targeted therapies for psoriasis, Expert Opin. Invest. Drugs, 22, 993, 10.1517/13543784.2013.806483
Leonardi, 2012, Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis, N. Engl. J. Med., 366, 1190, 10.1056/NEJMoa1109997
Papp, 2013, Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study, Br. J. Dermatol., 168, 412, 10.1111/bjd.12110
Puel, 2011, Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity, Science, 332, 65, 10.1126/science.1200439
Milner, 2008, Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome, Nature, 452, 773, 10.1038/nature06764
Papp, 2012, Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis, N. Engl. J. Med., 366, 1181, 10.1056/NEJMoa1109017
Genovese, 2013, Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study, Ann. Rheumatic Dis., 72, 863, 10.1136/annrheumdis-2012-201601
Genovese, 2014, One-year efficacy and safety results of secukinumab in patients with rheumatoid arthritis: phase II, dose-finding, double-blind, randomized, placebo-controlled study, J. Rheumatol., 41, 414, 10.3899/jrheum.130637
Genovese, 2010, LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study, Arthritis Rheumat., 62, 929, 10.1002/art.27334
Genovese, 2014, A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors, Arthritis Rheumatol., 66, 1693, 10.1002/art.38617
Martin, 2013, A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis, Arthritis Res. Ther., 15, R164, 10.1186/ar4347
Langley, 2014, Secukinumab in plaque psoriasis–results of two phase 3 trials, N. Engl. J. Med., 371, 326, 10.1056/NEJMoa1314258
McInnes, 2014, Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial, Ann. Rheumat. Dis., 73, 349, 10.1136/annrheumdis-2012-202646
Mease, 2014, Managing patients with psoriatic disease: the diagnosis and pharmacologic treatment of psoriatic arthritis in patients with psoriasis, Drugs, 74, 423, 10.1007/s40265-014-0191-y
Mease, 2014, Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis, N. Engl. J. Med., 370, 2295, 10.1056/NEJMoa1315231
Bugatti, 2011, Synovial tissue heterogeneity and peripheral blood biomarkers, Curr. Rheumatol. Reports, 13, 440, 10.1007/s11926-011-0201-y
Talamonti, 2013, Pharmacogenetics of psoriasis: HLA-Cw6 but not LCE3B/3C deletion nor TNFAIP3 polymorphism predisposes to clinical response to interleukin 12/23 blocker ustekinumab, Br. J. Dermatol., 169, 458, 10.1111/bjd.12331
Rodriguez-Carrio, 2015, Type I IFNs as biomarkers in rheumatoid arthritis: towards disease profiling and personalized medicine, Clin. Sci., 128, 449, 10.1042/CS20140554
de Punder, 2015, A Simplified Baseline Prediction model for joint damage progression in rheumatoid arthritis: a Step toward personalized medicine, J. Rheumatol., 42, 391, 10.3899/jrheum.140327
Coimbra, 2014, Brodalumab: an evidence-based review of its potential in the treatment of moderate-to-severe psoriasis, Core Evid., 9, 89, 10.2147/CE.S33940
Gordon, 2014, A 52-week, open-label study of the efficacy and safety of ixekizumab, an anti-interleukin-17A monoclonal antibody, in patients with chronic plaque psoriasis, J. Am. Acad. Dermatol., 71, 1176, 10.1016/j.jaad.2014.07.048
Gisondi, 2014, Efficacy and safety of secukinumab in chronic plaque psoriasis and psoriatic arthritis therapy, Dermatol. Ther., 4, 1, 10.1007/s13555-014-0042-5
Khanna, 2013, Ustekinumab for the treatment of Crohn's disease, Immunotherapy, 5, 803, 10.2217/imt.13.81
Yiu, 2015, Efficacy and safety of emerging immunotherapies in psoriasis, Immunotherapy, 7, 119, 10.2217/imt.14.101