Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis
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Sospedra, 2005, Immunology of multiple sclerosis, Annu Rev Immunol, 23, 683, 10.1146/annurev.immunol.23.021704.115707
Zamvil, 1990, The T lymphocyte in experimental allergic encephalomyelitis, Annu Rev Immunol, 8, 579, 10.1146/annurev.iy.08.040190.003051
Langrish, 2005, IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, J Exp Med, 201, 233, 10.1084/jem.20041257
Zheng, 2007, Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis, Nature, 445, 648, 10.1038/nature05505
Laurence, 2007, Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation, Immunity, 26, 371, 10.1016/j.immuni.2007.02.009
Mucida, 2007, Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid, Science, 317, 256, 10.1126/science.1145697
Chen, 2006, Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis, J Clin Invest, 116, 1317, 10.1172/JCI25308
Komiyama, 2006, IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis, J Immunol, 177, 566, 10.4049/jimmunol.177.1.566
Ivanov, 2006, The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells, Cell, 126, 1121, 10.1016/j.cell.2006.07.035
Korn, 2007, Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation, Nat Med, 13, 423, 10.1038/nm1564
Nakae, 2003, Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice, J Immunol, 171, 6173, 10.4049/jimmunol.171.11.6173
Hue, 2006, Interleukin-23 drives innate and T cell-mediated intestinal inflammation, J Exp Med, 203, 2473, 10.1084/jem.20061099
Amadi-Obi, 2007, T(H)17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1, Nat Med, 13, 711, 10.1038/nm1585
Acosta-Rodriguez, 2007, Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells, Nat Immunol, 8, 942, 10.1038/ni1496
Wilson, 2007, Development, cytokine profile and function of human interleukin 17-producing helper T cells, Nat Immunol, 8, 950, 10.1038/ni1497
Matusevicius, 1999, Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis, Mult Scler, 5, 101, 10.1177/135245859900500206
Kotake, 1999, IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis, J Clin Invest, 103, 1345, 10.1172/JCI5703
Hwang, 2005, Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients, Mol Cells, 19, 180, 10.1016/S1016-8478(23)13153-0
Nielsen, 2003, Upregulation of interleukin-12 and -17 in active inflammatory bowel disease, Scand J Gastroenterol, 38, 180, 10.1080/00365520310000672
Kebir, 2007, Human T(H)17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation, Nat Med, 13, 1173, 10.1038/nm1651
Ishizu, 2005, Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis, Brain, 128, 988, 10.1093/brain/awh453
Lock, 2002, Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis, Nat Med, 8, 500, 10.1038/nm0502-500
Craner, 2003, Temporal course of upregulation of Na (v) 1.8 in Purkinje neurons parallels the progression of clinical deficit in experimental allergic encephalomyelitis, J Neuropathol Exp Neurol, 62, 968, 10.1093/jnen/62.9.968
Morris, 1994, Oligodendrocyte reactions and cell proliferation markers in human demyelinating diseases, Neuropathol Appl Neurobiol, 20, 272, 10.1111/j.1365-2990.1994.tb00969.x
Nyland, 1982, In-situ characterization of mononuclear cell infiltrates in lesions of multiple sclerosis, Neuropathol Appl Neurobiol, 8, 403, 10.1111/j.1365-2990.1982.tb00308.x
Traugott, 1983, Multiple sclerosis: distribution of T cell subsets within active chronic lesions, Science, 219, 308, 10.1126/science.6217550
Hauser, 1986, Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions, Ann Neurol, 19, 578, 10.1002/ana.410190610
Woodroofe, 1986, Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth, J Neurol Sci, 74, 135, 10.1016/0022-510X(86)90100-0
Sobel, 1988, Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue, Ann NY Acad Sci, 540, 306, 10.1111/j.1749-6632.1988.tb27082.x
Booss, 1983, Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis, J Neurol Sci, 62, 219, 10.1016/0022-510X(83)90201-0
Gay, 1997, The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion, Brain, 120, 1461, 10.1093/brain/120.8.1461
Vanden Eijnden, 2005, IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human, Eur J Immunol, 35, 469, 10.1002/eji.200425677
Acosta-Rodriguez, 2007, Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells, Nat Immunol, 8, 639, 10.1038/ni1467
Friese, 2005, Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?, Brain, 128, 1747, 10.1093/brain/awh578
Li, 2007, Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia, Brain, 130, 490, 10.1093/brain/awl273
Schönrock, 2000, Interleukin-6 expression in human multiple sclerosis lesions, Neurosci Lett, 294, 45, 10.1016/S0304-3940(00)01543-3
Woodroofe, 1993, Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization, Cytokine, 5, 583, 10.1016/S1043-4666(05)80008-0
Bettelli, 2006, Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature, 441, 235, 10.1038/nature04753
Veldhoen, 2006, TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells, Immunity, 24, 179, 10.1016/j.immuni.2006.01.001
Sutton, 2006, A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis, J Exp Med, 203, 1685, 10.1084/jem.20060285
Farina, 2007, Astrocytes are active players in cerebral innate immunity, Trends Immunol, 28, 138, 10.1016/j.it.2007.01.005
Bitsch, 2000, Tumour necrosis factor alpha mRNA expression in early multiple sclerosis lesions: correlation with demyelinating activity and oligodendrocyte pathology, Glia, 29, 366, 10.1002/(SICI)1098-1136(20000215)29:4<366::AID-GLIA7>3.0.CO;2-Y
Meeuwsen, 2003, Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli, Glia, 43, 243, 10.1002/glia.10259
Kohler, 2003, A role for macrophage inflammatory protein-3 alpha/CC chemokine ligand 20 in immune priming during T cell-mediated inflammation of the central nervous system, J Immunol, 170, 6298, 10.4049/jimmunol.170.12.6298
Kao, 2005, Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway, J Immunol, 175, 6676, 10.4049/jimmunol.175.10.6676
Furlan, 2005, Immunological patterns identifying disease course and evolution in multiple sclerosis patients, J Neuroimmunol, 165, 192, 10.1016/j.jneuroim.2005.04.012
Ambrosini, 2005, Astrocytes produce dendritic cell-attracting chemokines in vitro and in multiple sclerosis lesions, J Neuropathol Exp Neurol, 64, 706, 10.1097/01.jnen.0000173893.01929.fc
Khader, 2007, IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge, Nat Immunol, 8, 369, 10.1038/ni1449
Viglietta, 2004, Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis, J Exp Med, 199, 971, 10.1084/jem.20031579