Interleukin-10-deficient mice develop chronic enterocolitis

Bhattacharya, 1981, A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication, J. Immunol., 127, 2488, 10.4049/jimmunol.127.6.2488

Boll, 1991

Bradley, 1987, Production and analysis of chimaeric mice, 113

Coffman, 1982, Surface antigen expression and immunoglobulin gene rearrangement during mouse pre—B cell development, Immunol. Rev., 69, 5, 10.1111/j.1600-065X.1983.tb00446.x

Dalton, 1993, Multiple defects of immune cell function in mice with disrupted interferon-γ genes, Science, 259, 1739, 10.1126/science.8456300

de Waal Malefyt, 1992, Interleukin-10, Curr. Opin. Immunol., 4, 314, 10.1016/0952-7915(92)90082-P

Dialynas, 1983, Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule, J. Immunol., 131, 2445, 10.4049/jimmunol.131.5.2445

Finkelman, 1986, Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1, 83, 9675

Fiorentino, 1989, Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones, J. Exp. Med., 170, 2081, 10.1084/jem.170.6.2081

Fiorentino, 1991, IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells, J. Immunol., 146, 3444, 10.4049/jimmunol.146.10.3444

Fiorentino, 1991, IL-10 inhibits cytokine production by activated macrophages, J. Immunol., 147, 3815, 10.4049/jimmunol.147.11.3815

Förster, 1989, Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse, Int. Immunol., 1, 321, 10.1093/intimm/1.4.321

Gazzinelli, 1992, IL-10 inhibits parasite killing and nitric oxide production by IFN-γ-activated macrophages, J. Immunol., 148, 1792, 10.4049/jimmunol.148.6.1792

Gillis, 1977, Long term culture of tumour-specific cytotoxic T cells, Nature, 268, 154, 10.1038/268154a0

Go, 1990, Interleukin 10 (IL-10), a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells, J. Exp. Med., 172, 1625, 10.1084/jem.172.6.1625

Grützmann, 1981, Vergleichende idiotypische Analyse von Rezeptoren mit Spezifität für Histokompatibilitätsantigene

Heinzel, 1991, Production of interferon-γ, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis, 88, 7011

Howard, 1993, Interleukin-10 protects mice from lethal endotoxemia, J. Exp. Med., 177, 1205, 10.1084/jem.177.4.1205

Hsieh, 1992, Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system, 89, 6065

Hsieh, 1993, Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages, Science, 260, 547, 10.1126/science.8097338

Hsu, 1981, Use of avidin—biotin—peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedure, Histochem. Cytochem., 29, 577, 10.1177/29.4.6166661

Huang, 1993, Immune response in mice that lack the interferon-γ receptor, Science, 259, 1742, 10.1126/science.8456301

Ishida, 1992, Continuous anti-interleukin-10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells, J. Exp. Med., 175, 1213, 10.1084/jem.175.5.1213

Kantor, 1991, A new nomenclature for B cells, Immunol. Today, 12, 388, 10.1016/0167-5699(91)90135-G

Kassai, 1982

Kendall, 1983, Utilization of the biotin/avidin system to amplify the sensitivity of the enzyme-linked immunosorbent assay (ELISA), J. Immunol. Meth., 56, 329, 10.1016/S0022-1759(83)80022-2

Kim, 1992, Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes, J. Immunol., 148, 3618, 10.4049/jimmunol.148.11.3618

Kitamura, 1991, A B cell—deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene, Nature, 350, 423, 10.1038/350423a0

Kühn, 1991, Generation and analysis of Interleukin-4 deficient mice, Science, 254, 707, 10.1126/science.1948049

Ledbetter, 1979, Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens, Immunol. Rev., 47, 63, 10.1111/j.1600-065X.1979.tb00289.x

LeGros, 1990, Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells, J. Exp. Med., 172, 921, 10.1084/jem.172.3.921

Leo, 1987, Identification of a monoclonal antibody specific for a murine T3 polypeptide, 84, 1374

Mansour, 1988, Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes, Nature, 336, 348, 10.1038/336348a0

Means, 1992, Progress in understanding the pathogenesis of the anemia of chronic disease, J. Am. Soc. Hematol., 80, 1639

Moore, 1993, Interleukin-10, Annu. Rev. Immunol., 11, 165, 10.1146/annurev.iy.11.040193.001121

Mosmann, 1989, Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties, Annu. Rev. Immunol., 7, 145, 10.1146/annurev.iy.07.040189.001045

Mosmann, 1991, The role of IL-10 in cross regulation of Th1 and Th2 responses, Immunol. Today, 12, A49, 10.1016/S0167-5699(05)80015-5

Mosmann, 1990, Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay, J. Immunol., 145, 2938, 10.4049/jimmunol.145.9.2938

Mosmann, 1991, Diversity of cytokine synthesis and function of mouse CD4+ T cells, Immunol. Rev., 123, 209, 10.1111/j.1600-065X.1991.tb00612.x

O'Garra, 1990, Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10, Int. Immunol., 2, 821, 10.1093/intimm/2.9.821

O'Garra, 1992, Ly-1 B (B-1) cells are the main source of B cell derived interleukin 10, Eur. J. Immunol., 22, 711, 10.1002/eji.1830220314

Rizzo, 1992, Generation of B cell memory and affinity maturation: induction with Th1 and Th2 clones, J. Immunol., 22, 711

Rousset, 1992, IL-10 is a potent growth and differentiation factor for activated human B lymphocytes, 89, 1890

Sadlack, 1993, Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene, Cell, 75, 10.1016/0092-8674(93)80067-O

Sartor, 1990, Role of intestinal microflora in initiation and perpetuation of inflammatory bowel disease, Can. J. Gastroenterol., 4, 271, 10.1155/1990/857305

Schmitz, 1993, Regulation of T helper cell cytokine expression: functional dichotomy of antigen-presenting cells, Eur. J. Immunol., 23, 191, 10.1002/eji.1830230130

Schorle, 1991, Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting, Nature, 352, 621, 10.1038/352621a0

Sher, 1992, Regulation of immunity to parasites by T cells and T cell-derived cytokines, Annu. Rev. Immunol., 10, 385, 10.1146/annurev.iy.10.040192.002125

Sher, 1991, Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection, J. Immunol., 147, 2713, 10.4049/jimmunol.147.8.2713

Sher, 1992, Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection, Immunol. Rev., 127, 183, 10.1111/j.1600-065X.1992.tb01414.x

Shull, 1992, Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease, Nature, 359, 693, 10.1038/359693a0

Silva, 1992, Interleukin 10 and interferon γ regulation of experimental Trypanosoma cruzi infection, J. Exp. Med., 175, 169, 10.1084/jem.175.1.169

Thomas, 1987, Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells, Cell, 51, 503, 10.1016/0092-8674(87)90646-5

Urban, 1992, The importance of Th2 cytokines in protective immunity to nematodes, Immunol. Rev., 127, 205, 10.1111/j.1600-065X.1992.tb01415.x