Interleukin-1β in innate inflammation, autophagy and immunity

Sims, 1988, cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily, Science, 241, 585, 10.1126/science.2969618 Gay, 1991, Drosophila Toll and IL-1 receptor, Nature, 351, 355, 10.1038/351355b0 Heguy, 1992, Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction, J Biol Chem, 267, 2605, 10.1016/S0021-9258(18)45924-8 Lemaitre, 1996, The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults, Cell, 86, 973, 10.1016/S0092-8674(00)80172-5 van der Meer, 1988, A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection, Proc Natl Acad Sci U S A, 85, 1620, 10.1073/pnas.85.5.1620 O’Neill, 2008, The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress, Immunol Rev, 226, 10, 10.1111/j.1600-065X.2008.00701.x Rosenwasser, 1979, Adherent cell function in murine T-lymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen, J Exp Med, 150, 709, 10.1084/jem.150.3.709 Dinarello, 2011, A clinical perspective of IL-1beta as the gatekeeper of inflammation, Eur J Immunol, 41, 1203, 10.1002/eji.201141550 Okamoto, 2009, Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta, J Biol Chem, 285, 6477, 10.1074/jbc.M109.064907 Croker, 2011, Neutrophils require SHP1 to regulate IL-1beta production and prevent inflammatory skin disease, J Immunol, 186, 1131, 10.4049/jimmunol.1002702 Unlu, 2007, Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene, Mol Immunol, 44, 3364, 10.1016/j.molimm.2007.02.016 Kaspar, 1994, Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1b mRNA show unequal IL-1b protein accumulation but similar polyribosome profiles, J Immunol, 153, 277, 10.4049/jimmunol.153.1.277 Bufler, 2004, Interleukin-1 homologues IL-1F7b IL-18 contain functional mRNA. instability elements within the coding region responsive to lipopolysaccharide, Biochem J, 381, 503, 10.1042/BJ20040217 Schindler, 1990, Dissociation between interleukin-1b mRNA and protein synthesis in human peripheral blood mononuclear cells, J Biol Chem, 265, 10232, 10.1016/S0021-9258(18)86936-8 Dinarello, 1987, Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro, J Immunol, 139, 1902, 10.4049/jimmunol.139.6.1902 Goldbach-Mansky, 2006, Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition, New Engl J Med, 355, 581, 10.1056/NEJMoa055137 Greten, 2007, NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta, Cell, 130, 918, 10.1016/j.cell.2007.07.009 Boni-Schnetzler, 2008, Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation, J Clin Endocrinol Metab, 93, 4065, 10.1210/jc.2008-0396 Gattorno, 2007, Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations, Arthritis Rheum, 56, 3138, 10.1002/art.22842 Wewers, 1997, IL-1b-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1b release limitation is ICE independent, J Immunol, 159, 5964, 10.4049/jimmunol.159.12.5964 Martinon, 2009, The inflammasomes: guardians of the body, Annu Rev Immunol, 27, 229, 10.1146/annurev.immunol.021908.132715 Agostini, 2004, NALP3 forms an IL-1beta processing inflammasome with increased activity in Muckle-Wells auto-inflammatory disorder, Immunity, 20, 319, 10.1016/S1074-7613(04)00046-9 Hoffman, 2001, Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome, Nat Genet, 29, 301, 10.1038/ng756 Drenth, 1996, Unstimulated peripheral blood mononuclear cells from patients with the hyper-IgD syndrome produce cytokines capable of potent induction of C-reactive protein and serum amyloid A in Hep3B cells, J Immunol, 157, 400, 10.4049/jimmunol.157.1.400 Hoffman, 2011, Inflammasome and IL-1beta-mediated disorders, Curr Allergy Asthma Rep, 10, 229, 10.1007/s11882-010-0109-z Netea, 2009, Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages, Blood, 113, 2324, 10.1182/blood-2008-03-146720 Andrei, 1999, The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles, Mol Biol Cell, 10, 1463, 10.1091/mbc.10.5.1463 Andrei, 2004, Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes, Proc Natl Acad Sci U S A, 101, 9745, 10.1073/pnas.0308558101 Gardella, 2000, Secretion of bioactive interleukin-1beta by dendritic cells is modulated by interaction with antigen specific T cells, Blood, 95, 3809, 10.1182/blood.V95.12.3809 Perregaux, 2000, ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood, J Immunol, 165, 4615, 10.4049/jimmunol.165.8.4615 Elssner, 2004, A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release, J Immunol, 172, 4987, 10.4049/jimmunol.172.8.4987 Qu, 2007, Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages, J Immunol, 179, 1913, 10.4049/jimmunol.179.3.1913 Brough, 2007, Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death, J Cell Sci, 120, 772, 10.1242/jcs.03377 Suzuki, 2007, Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages, PLoS Pathog, 3, e111, 10.1371/journal.ppat.0030111 Kahlenberg, 2005, Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis, J Immunol, 175, 7611, 10.4049/jimmunol.175.11.7611 Maedler, 2002, Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets, J Clin Invest, 110, 851, 10.1172/JCI200215318 Pascual, 2005, Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade, J Exp Med, 201, 1479, 10.1084/jem.20050473 Al-Shukaili, 2008, A comparative study of interleukin-1beta production and p2×7 expression after ATP stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls, Inflammation, 31, 84, 10.1007/s10753-007-9052-0 Sluyter, 2004, Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytes, J Immunol, 172, 3399, 10.4049/jimmunol.172.6.3399 Sluyter, 2004, P2X7 receptor polymorphism impairs extracellular adenosine 5’-triphosphate-induced interleukin-18 release from human monocytes, Genes Immun, 5, 588, 10.1038/sj.gene.6364127 Lee, 2007, P2X7 receptor polymorphism and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation, Haematologica, 92, 651, 10.3324/haematol.10810 Chessell, 2005, Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain, Pain, 114, 386, 10.1016/j.pain.2005.01.002 Hewinson, 2008, A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes, J Immunol, 180, 8410, 10.4049/jimmunol.180.12.8410 Pelegrin, 2006, Pannexin-1 mediates large pore formation interleukin-1beta release by the ATP-gated P2X7 receptor, EMBO J, 25, 5071, 10.1038/sj.emboj.7601378 Kanneganti, 2007, Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling, Immunity, 26, 433, 10.1016/j.immuni.2007.03.008 Derks, 2004, Regeneration and tolerance factor modulates the effect of adenosine triphosphate-induced interleukin 1 beta secretion in human macrophages, Hum Immunol, 65, 676, 10.1016/j.humimm.2004.04.006 Zhou, 2010, Thioredoxin-interacting protein links oxidative stress to inflammasome activation, Nat Immunol, 11, 136, 10.1038/ni.1831 Meissner, 2008, Superoxide dismutase 1 regulates caspase-1 and endotoxic shock, Nat Immunol, 9, 866, 10.1038/ni.1633 van de Veerdonk, 2010, Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease, Proc Natl Acad Sci U S A, 107, 3030, 10.1073/pnas.0914795107 Meissner, 2010, Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease, Blood, 116, 1570, 10.1182/blood-2010-01-264218 van de Veerdonk, 2011, Anakinra for the inflammatory complications of chronic granulomatous disease, Neth J Med, 69, 95 Fantuzzi, 1997, Response to local inflammation of IL-1b converting enzyme-deficient mice, J Immunol, 158, 1818, 10.4049/jimmunol.158.4.1818 Zheng, 1995, Resistance to fever induction and impaired acute-phase response in interleukin-1b deficient mice, Immunity, 3, 9, 10.1016/1074-7613(95)90154-X Fantuzzi, 1997, Physiological and cytokine responses in interleukin-1b-deficient mice after zymosan-induced inflammation, Am J Physiol, 273, R400 Fantuzzi, 1996, Effect of endotoxin in IL-1b-deficient mice, J Immunol, 157, 291, 10.4049/jimmunol.157.1.291 Faggioni, 1998, IL-1b mediates leptin induction during inflammation, Am J Physiol, 274, R204 Krelin, 2007, Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors, Cancer Res, 67, 1062, 10.1158/0008-5472.CAN-06-2956 McInnes, 2007, Cytokines in the pathogenesis of rheumatoid arthritis, Nat Rev Immunol, 7, 429, 10.1038/nri2094 McInnes, 2011, The pathogenesis of rheumatoid arthritis, New Engl J Med, 365, 2205, 10.1056/NEJMra1004965 Schett, 2013, How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy, Nat Med, 19, 822, 10.1038/nm.3260 Joosten, 1999, IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation, J Immunol, 163, 5049, 10.4049/jimmunol.163.9.5049 Joosten, 1996, Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra, Arthritis Rheum, 39, 797, 10.1002/art.1780390513 Zwerina, 2007, TNF-induced structural joint damage is mediated by IL-1, Proc Natl Acad Sci U S A, 104, 11742, 10.1073/pnas.0610812104 van de Loo, 1995, Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis, Arthritis Rheum, 38, 164, 10.1002/art.1780380204 van de Loo, 1992, Protection against cartilage proteoglycan synthesis inhibition by antiinterleukin 1 antibodies in experimental arthritis, J Rheumatol, 19, 348 van de Loo, 1989, Direct effect of murine rIL-1 on cartilage metabolism in vivo, Agents Actions, 26, 153, 10.1007/BF02126590 Santambrogio, 1993, Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor, J Immunol, 151, 1116, 10.4049/jimmunol.151.2.1116 Ku, 2001, Selective interleukin-1 converting enzyme (ICE/Caspase-1) inhibition with pralnacasan (HMR 3480/VX-740) reduces inflammation and joint destruction in murine type II collagen-induced arthritis (CIA), Arthritis Rheum, 44, 1134 Saijo, 2002, Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells, Arthritis Rheum, 46, 533, 10.1002/art.10172 Mori, 1996, Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice, J Immunol, 157, 3178, 10.4049/jimmunol.157.7.3178 Campbell, 2001, Severe inflammatory arthritis and lymphadenopathy in the absence of TNF, J Clin Invest, 107, 1519, 10.1172/JCI12724 Joosten, 2008, T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17, Arthritis Rheum, 58, 98, 10.1002/art.23152 So, 2007, A pilot study of IL-1 inhibition by anakinra in acute gout, Arthritis Res Ther, 9, R28, 10.1186/ar2143 So, 2010, Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study, Arthritis Rheum, 62, 3064, 10.1002/art.27600 Joosten, 2010, Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis, Arthritis Rheum, 62, 3237, 10.1002/art.27667 Joosten, 2009, Inflammatory arthritis in caspase 1 gene-deficient mice: Contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta, Arthritis Rheum, 60, 3651, 10.1002/art.25006 Guma, 2009, Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation, Arthritis Rheum, 60, 3642, 10.1002/art.24959 Coeshott, 1999, Converting enzyme-independent release of TNFa and IL-1b from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase-3, Proc Natl Acad Sci U S A, 96, 6261, 10.1073/pnas.96.11.6261 Sugawara, 2001, Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells, J Immunol, 167, 6568, 10.4049/jimmunol.167.11.6568 Schlesinger, 2011, Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: results of a double-blind, randomised study, Ann Rheum Dis, 70, 1264, 10.1136/ard.2010.144063 Numanami, 2003, Serine protease inhibitors modulate chemotactic cytokine production by human lung fibroblasts in vitro, Am J Physiol Lung Cell Mol Physiol, 284, L882, 10.1152/ajplung.00211.2002 Klionsky, 2007, Autophagy: from phenomenology to molecular understanding in less than a decade, Nat Rev Mol Cell Biol, 8, 931, 10.1038/nrm2245 Schmid, 2007, Innate and adaptive immunity through autophagy, Immunity, 27, 11, 10.1016/j.immuni.2007.07.004 Saitoh, 2008, Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production, Nature, 456, 264, 10.1038/nature07383 Harris, 2011, Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation, J Biol Chem, 286, 9587, 10.1074/jbc.M110.202911 Nakahira, 2011, Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Nat Immunol, 12, 222, 10.1038/ni.1980 Tschopp, 2010, NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?, Nat Rev Immunol, 10, 210, 10.1038/nri2725 Crisan, 1866, Inflammasome-independent modulation of cytokine response by autophagy in human cells, PLoS One, 6, e6 Hampe, 2007, A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1, Nat Genet, 39, 207, 10.1038/ng1954 Rioux, 2007, Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis, Nat Genet, 39, 596, 10.1038/ng2032 Henckaerts, 2011, Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease, Inflamm Bowel Dis, 17, 1392, 10.1002/ibd.21486 Lapaquette, 2010, Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly, Cell Microbiol, 12, 99, 10.1111/j.1462-5822.2009.01381.x Plantinga, 2011, Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2, Gut, 60, 1229, 10.1136/gut.2010.228908 Cooney, 2010, NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation, Nat Med, 16, 90, 10.1038/nm.2069 Homer, 1641, ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis, Gastroenterology, 139, 1630, 10.1053/j.gastro.2010.07.006 Travassos, 2010, Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry, Nat Immunol, 11, 55, 10.1038/ni.1823 Kuballa, 2008, Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant, PLoS One, 3, e3391, 10.1371/journal.pone.0003391 Oh, 2012, Modulation of pathogen recognition by autophagy, Front Immunol, 3, 44, 10.3389/fimmu.2012.00044 Ponpuak, 2010, Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties, Immunity, 32, 329, 10.1016/j.immuni.2010.02.009 Kundu, 2008, Basic principles and relevance to disease, Annu Rev Pathol-Mech, 3, 427, 10.1146/annurev.pathmechdis.2.010506.091842 Marquez, 2009, Role of ATG16L1 Thr300Ala Polymorphism in Inflammatory Bowel Disease: A Study in the Spanish Population and a Meta-analysis, Inflamm Bowel Dis, 15, 1697, 10.1002/ibd.21001 Zhang, 2009, ATG16L1 T300A polymorphism and Crohn's disease susceptibility: evidence from 13,022 cases and 17,532 controls, Hum Genet, 125, 627, 10.1007/s00439-009-0660-7 Buffen, 2013, Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β), J Biol Chem, 288, 8658, 10.1074/jbc.M112.412841 Nakanishi, 2001, Interleukin-18 regulates both Th1 and Th2 responses, Ann Rev Immunol, 19, 423, 10.1146/annurev.immunol.19.1.423 Schmitz, 2005, IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines, Immunity, 23, 479, 10.1016/j.immuni.2005.09.015 Wilson, 2007, Development, cytokine profile and function of human interleukin 17-producing helper T cells, Nat Immunol, 8, 950, 10.1038/ni1497 Dinarello, 2011, Interleukin-1 in the pathogenesis and treatment of inflammatory diseases, Blood, 117, 3720, 10.1182/blood-2010-07-273417 Chizzolini, 2008, Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion, Blood, 112, 3696, 10.1182/blood-2008-05-155408 Henley, 2004, Aryl hydrocarbon receptor-mediated posttranscriptional regulation of IL-1beta, Arch Biochem Biophys, 422, 42, 10.1016/j.abb.2003.11.022 Moreira, 2011, The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A, J Clin Invest, 121, 4420, 10.1172/JCI44999 Hughes, 2010, Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue, Immunity, 32, 803, 10.1016/j.immuni.2010.06.007