Interferon regulatory factors: critical mediators of human lupus
Tóm tắt
Từ khóa
Tài liệu tham khảo
Goldblatt, 2013, Clinical aspects of autoimmune rheumatic diseases, Lancet, 382, 797, 10.1016/S0140-6736(13)61499-3
Perniok, 1998, High levels of circulating early apoptic peripheral blood mononuclear cells in systemic lupus erythematosus, Lupus, 7, 113, 10.1191/096120398678919804
Poon, 2014, Apoptotic cell clearance: basic biology and therapeutic potential, Nat Rev Immunol, 14, 166, 10.1038/nri3607
Casciola-Rosen, 1994, Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes, J Exp Med, 179, 1317, 10.1084/jem.179.4.1317
Mevorach, 1998, Complement-dependent clearance of apoptotic cells by human macrophages, J Exp Med, 188, 2313, 10.1084/jem.188.12.2313
Korb, 1997, C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited, J Immunol, 158, 4525, 10.4049/jimmunol.158.10.4525
Baumann, 2002, Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus, Arthritis Rheum, 46, 191, 10.1002/1529-0131(200201)46:1<191::AID-ART10027>3.0.CO;2-K
Botto, 1998, Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies, Nat Genet, 19, 56, 10.1038/ng0598-56
Wermeling, 2007, Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus, J Exp Med, 204, 2259, 10.1084/jem.20070600
Chen, 2011, Anti-class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages in vitro, Arthritis Res Ther, 13, R9, 10.1186/ar3230
Means, 2005, Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9, J Clin Invest, 115, 407, 10.1172/JCI23025
Barrat, 2005, Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus, J Exp Med, 202, 1131, 10.1084/jem.20050914
Lovgren, 2004, Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG, Arthritis Rheum, 50, 1861, 10.1002/art.20254
Kelly, 2006, “Endogenous adjuvant” activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60, Arthritis Rheum, 54, 1557, 10.1002/art.21819
Taniguchi, 1997, IRF-1: the transcription factor linking the interferon response and oncogenesis, Biochim Biophys Acta, 1333, M9
Nakaya, 2001, Gene induction pathways mediated by distinct IRFs during viral infection, Biochem Biophys Res Commun, 283, 1150, 10.1006/bbrc.2001.4913
Sato, 2000, Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction, Immunity, 13, 539, 10.1016/S1074-7613(00)00053-4
Paun, 2008, Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response, J Biol Chem, 283, 14295, 10.1074/jbc.M800501200
Schoenemeyer, 2005, The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling, J Biol Chem, 280, 17005, 10.1074/jbc.M412584200
Lazear, 2013, IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling, PLoS Pathog, 9, e1003118, 10.1371/journal.ppat.1003118
Dai, 2011, Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway, J Virol, 85, 10814, 10.1128/JVI.00104-11
Hooks, 1979, Immune interferon in the circulation of patients with autoimmune disease, N Engl J Med, 301, 5, 10.1056/NEJM197907053010102
Baechler, 2003, Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus, Proc Natl Acad Sci U S A, 100, 2610, 10.1073/pnas.0337679100
Bennett, 2003, Interferon and granulopoiesis signatures in systemic lupus erythematosus blood, J Exp Med, 197, 711, 10.1084/jem.20021553
Hua, 2006, Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies, Arthritis Rheum, 54, 1906, 10.1002/art.21890
Niewold, 2007, High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus, Genes Immun, 8, 492, 10.1038/sj.gene.6364408
Weckerle, 2011, Network analysis of associations between serum interferon-alpha activity, autoantibodies, and clinical features in systemic lupus erythematosus, Arthritis Rheum, 63, 1044, 10.1002/art.30187
Niewold, 2008, Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus, Arthritis Rheum, 58, 541, 10.1002/art.23191
Niewold, 2008, Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients, Arthritis Rheum, 58, 2481, 10.1002/art.23613
Niewold, 2012, IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus, Ann Rheum Dis, 71, 463, 10.1136/annrheumdis-2011-200463
Harley, 2008, Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci, Nat Genet, 40, 204, 10.1038/ng.81
Salloum, 2010, Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients, Arthritis Rheum, 62, 553, 10.1002/art.27182
Fu, 2011, Association of a functional IRF7 variant with systemic lupus erythematosus, Arthritis Rheum, 63, 749, 10.1002/art.30193
Gateva, 2009, A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus, Nat Genet, 41, 1228, 10.1038/ng.468
Lessard, 2012, Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study, Am J Hum Genet, 90, 648, 10.1016/j.ajhg.2012.02.023
Chrabot, 2013, Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis, Genes Immun, 14, 471, 10.1038/gene.2013.42
Salloum, 2011, Interferon regulatory factors in human lupus pathogenesis, Transl Res, 157, 326, 10.1016/j.trsl.2011.01.006
Niewold, 2011, Interferon alpha as a primary pathogenic factor in human lupus, J Interferon Cytokine Res, 31, 887, 10.1089/jir.2011.0071
Niewold, 2008, Age- and sex-related patterns of serum interferon-alpha activity in lupus families, Arthritis Rheum, 58, 2113, 10.1002/art.23619
Mangale, 2013, Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus, Clin Dev Immunol, 2013, 267430, 10.1155/2013/267430
Weckerle, 2012, Large-scale analysis of tumor necrosis factor alpha levels in systemic lupus erythematosus, Arthritis Rheum, 64, 2947, 10.1002/art.34483
Ghodke-Puranik, 2013, Genetics of the type I interferon pathway in systemic lupus erythematosus, Int J Clin Rheumatol, 8, 657, 10.2217/ijr.13.58
Kariuki, 2010, Genetic regulation of serum cytokines in systemic lupus erythematosus, Transl Res, 155, 109, 10.1016/j.trsl.2009.08.012
Agik, 2012, The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes, J Rheumatol, 39, 73, 10.3899/jrheum.110590
Robinson, 2011, Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-alpha and serologic autoimmunity in lupus patients, J Immunol, 187, 1298, 10.4049/jimmunol.1100857
Kariuki, 2010, Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus, Arthritis Res Ther, 12, R151, 10.1186/ar3101
Koldobskaya, 2012, Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus, Clin Dev Immunol, 2012, 682018, 10.1155/2012/682018
Ronnblom, 1990, Possible induction of systemic lupus erythematosus by interferon-alpha treatment in a patient with a malignant carcinoid tumour, J Intern Med, 227, 207, 10.1111/j.1365-2796.1990.tb00144.x
Niewold, 2005, Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C, Clin Rheumatol, 24, 178, 10.1007/s10067-004-1024-2
Kirou, 2004, Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus, Arthritis Rheum, 50, 3958, 10.1002/art.20798
Niewold, 2010, Interferon alpha in systemic lupus erythematosus, J Biomed Biotechnol, 2010, 948364, 10.1155/2010/948364
Qiao, 2013, Synergistic activation of inflammatory cytokine genes by interferon-gamma-induced chromatin remodeling and toll-like receptor signaling, Immunity, 39, 454, 10.1016/j.immuni.2013.08.009
de Weerd, 2013, Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1, Nat Immunol, 14, 901, 10.1038/ni.2667
Marie, 1998, Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7, EMBO J, 17, 6660, 10.1093/emboj/17.22.6660
Sato, 1998, Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7, FEBS Lett, 441, 106, 10.1016/S0014-5793(98)01514-2
Honda, 2005, IRF-7 is the master regulator of type-I interferon-dependent immune responses, Nature, 434, 772, 10.1038/nature03464
Honda, 2006, IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors, Nat Rev Immunol, 6, 644, 10.1038/nri1900
Kono, 2008, How dying cells alert the immune system to danger, Nat Rev Immunol, 8, 279, 10.1038/nri2215
Broz, 2013, Newly described pattern recognition receptors team up against intracellular pathogens, Nat Rev Immunol, 13, 551, 10.1038/nri3479
Shrivastav, 2013, Nucleic acid sensors and type I interferon production in systemic lupus erythematosus, Front Immunol, 4, 319, 10.3389/fimmu.2013.00319
Tamura, 2008, The IRF family transcription factors in immunity and oncogenesis, Annu Rev Immunol, 26, 535, 10.1146/annurev.immunol.26.021607.090400
Yasuda, 2005, Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways, J Immunol, 174, 6129, 10.4049/jimmunol.174.10.6129
Yasuda, 2006, CpG motif-independent activation of TLR9 upon endosomal translocation of “natural” phosphodiester DNA, Eur J Immunol, 36, 431, 10.1002/eji.200535210
Haas, 2008, The DNA sugar backbone 2′ deoxyribose determines toll-like receptor 9 activation, Immunity, 28, 315, 10.1016/j.immuni.2008.01.013
Schlee, 2009, Recognition of 5′ triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus, Immunity, 31, 25, 10.1016/j.immuni.2009.05.008
Kato, 2008, Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5, J Exp Med, 205, 1601, 10.1084/jem.20080091
Matsui, 2006, Cutting edge: role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells, J Immunol, 177, 5785, 10.4049/jimmunol.177.9.5785
Takaki, 2014, MAVS-dependent IRF3/7 bypass of interferon beta-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells, Mol Immunol, 57, 100, 10.1016/j.molimm.2013.08.007
Funabiki, 2014, Autoimmune disorders associated with gain of function of the intracellular sensor MDA5, Immunity, 40, 199, 10.1016/j.immuni.2013.12.014
Molineros, 2013, Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production, PLoS Genet, 9, e1003222, 10.1371/journal.pgen.1003222
Pothlichet, 2011, A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients, EMBO Mol Med, 3, 142, 10.1002/emmm.201000120
Zhang, 2011, The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells, Nat Immunol, 12, 959, 10.1038/ni.2091
Parvatiyar, 2012, The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response, Nat Immunol, 13, 1155, 10.1038/ni.2460
Unterholzner, 2010, IFI16 is an innate immune sensor for intracellular DNA, Nat Immunol, 11, 997, 10.1038/ni.1932
Orzalli, 2012, Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein, Proc Natl Acad Sci U S A, 109, E3008, 10.1073/pnas.1211302109
Sun, 2013, Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway, Science, 339, 786, 10.1126/science.1232458
Wu, 2013, Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA, Science, 339, 826, 10.1126/science.1229963
Kondo, 2013, DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking, Proc Natl Acad Sci U S A, 110, 2969, 10.1073/pnas.1222694110
Hornung, 2009, AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC, Nature, 458, 514, 10.1038/nature07725
Burckstummer, 2009, An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome, Nat Immunol, 10, 266, 10.1038/ni.1702
Roberts, 2009, HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA, Science, 323, 1057, 10.1126/science.1169841
Fernandes-Alnemri, 2010, The AIM2 inflammasome is critical for innate immunity to Francisella tularensis, Nat Immunol, 11, 385, 10.1038/ni.1859
Takaoka, 2007, DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response, Nature, 448, 501, 10.1038/nature06013
Chiu, 2009, RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway, Cell, 138, 576, 10.1016/j.cell.2009.06.015
Ishikawa, 2009, STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity, Nature, 461, 788, 10.1038/nature08476
Lindahl, 1969, Properties of deoxyribonuclease 3 from mammalian tissues, J Biol Chem, 244, 5014, 10.1016/S0021-9258(18)94303-6
Stetson, 2008, Trex1 prevents cell-intrinsic initiation of autoimmunity, Cell, 134, 587, 10.1016/j.cell.2008.06.032
Crow, 2006, Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus, Nat Genet, 38, 917, 10.1038/ng1845
Lee-Kirsch, 2007, A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus, J Mol Med (Berl), 85, 531, 10.1007/s00109-007-0199-9
Lee-Kirsch, 2007, Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus, Nat Genet, 39, 1065, 10.1038/ng2091
de Vries, 2010, TREX1 gene variant in neuropsychiatric systemic lupus erythematosus, Ann Rheum Dis, 69, 1886, 10.1136/ard.2009.114157
Namjou, 2011, Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort, Genes Immun, 12, 270, 10.1038/gene.2010.73
Gall, 2012, Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease, Immunity, 36, 120, 10.1016/j.immuni.2011.11.018
Zhao, 2014, Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease, Biochim Biophys Acta
Escalante, 1998, Structure of IRF-1 with bound DNA reveals determinants of interferon regulation, Nature, 391, 103, 10.1038/34224
Kusumoto, 1998, Crystallographic characterization of the DNA-binding domain of interferon regulatory factor-2 complexed with DNA, J Struct Biol, 121, 363, 10.1006/jsbi.1998.3970
Fujii, 1999, Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences, EMBO J, 18, 5028, 10.1093/emboj/18.18.5028
Chen, 2008, Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5, Nat Struct Mol Biol, 15, 1213, 10.1038/nsmb.1496
Barnes, 2002, Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes, Mol Cell Biol, 22, 5721, 10.1128/MCB.22.16.5721-5740.2002
Lin, 1999, Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains, Mol Cell Biol, 19, 2465, 10.1128/MCB.19.4.2465
Lin, 2000, Multiple regulatory domains control IRF-7 activity in response to virus infection, J Biol Chem, 275, 34320, 10.1074/jbc.M002814200
Graham, 2008, Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus, Nat Genet, 40, 1059, 10.1038/ng.200
Adrianto, 2011, Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus, Nat Genet, 43, 253, 10.1038/ng.766
Adrianto, 2012, Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus, Arthritis Rheum, 64, 3695, 10.1002/art.34642
Uematsu, 2005, Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction, J Exp Med, 201, 915, 10.1084/jem.20042372
Kaufman, 2013, Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups, Ann Rheum Dis, 72, 437, 10.1136/annrheumdis-2012-201851
Namjou, 2009, High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups, Arthritis Rheum, 60, 1085, 10.1002/art.24387
Kariuki, 2009, Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo, J Immunol, 182, 34, 10.4049/jimmunol.182.1.34
Svenungsson, 2010, A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus, Ann Rheum Dis, 69, 834, 10.1136/ard.2009.115535
Chung, 2011, Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production, PLoS Genet, 7, e1001323, 10.1371/journal.pgen.1001323
Ferreira, 2010, Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency, Nat Genet, 42, 777, 10.1038/ng.644
Kyogoku, 2004, Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE, Am J Hum Genet, 75, 504, 10.1086/423790
Kariuki, 2008, The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus, Arthritis Rheum, 58, 2818, 10.1002/art.23728
Seth, 2005, Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3, Cell, 122, 669, 10.1016/j.cell.2005.08.012
Sawalha, 2008, Common variants within MECP2 confer risk of systemic lupus erythematosus, PLoS One, 3, e1727, 10.1371/journal.pone.0001727
Webb, 2009, Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus, Arthritis Rheum, 60, 1076, 10.1002/art.24360
Takaoka, 2005, Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors, Nature, 434, 243, 10.1038/nature03308
Krausgruber, 2011, IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses, Nat Immunol, 12, 231, 10.1038/ni.1990
Barnes, 2004, Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection, J Biol Chem, 279, 45194, 10.1074/jbc.M400726200
Yasuda, 2014, Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2, PLoS One, 9, e103478, 10.1371/journal.pone.0103478
Couzinet, 2008, A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis, Proc Natl Acad Sci U S A, 105, 2556, 10.1073/pnas.0712295105
Lien, 2010, Critical role of IRF-5 in regulation of B-cell differentiation, Proc Natl Acad Sci U S A, 107, 4664, 10.1073/pnas.0911193107
Fang, 2012, Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response, Genes Immun, 13, 421, 10.1038/gene.2012.10
Cham, 2012, Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus, Clin Dev Immunol, 2012, 780436, 10.1155/2012/780436
Lazzari, 2014, IRF5-mediated signaling and implications for SLE, Clin Immunol, 153, 343, 10.1016/j.clim.2014.06.001
Mancl, 2005, Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function, J Biol Chem, 280, 21078, 10.1074/jbc.M500543200
Sigurdsson, 2008, Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus, Hum Mol Genet, 17, 872, 10.1093/hmg/ddm359
Graham, 2007, Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus, Proc Natl Acad Sci U S A, 104, 6758, 10.1073/pnas.0701266104
Graham, 2006, A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus, Nat Genet, 38, 550, 10.1038/ng1782
Sigurdsson, 2005, Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus, Am J Hum Genet, 76, 528, 10.1086/428480
Lazzari, 2014, TRIpartite Motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms, PLoS One, 9, e103609, 10.1371/journal.pone.0103609
Cherian, 2012, Brief report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus, Arthritis Rheum, 64, 3383, 10.1002/art.34571
Ning, 2011, IRF7: activation, regulation, modification and function, Genes Immun, 12, 399, 10.1038/gene.2011.21
Tsujimura, 2004, Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells, J Immunol, 172, 6820, 10.4049/jimmunol.172.11.6820
Hambleton, 2011, IRF8 mutations and human dendritic-cell immunodeficiency, N Engl J Med, 365, 127, 10.1056/NEJMoa1100066
De Jager, 2009, Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci, Nat Genet, 41, 776, 10.1038/ng.401
Feng, 2012, Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis, J Neurol Sci, 313, 48, 10.1016/j.jns.2011.09.032
Feng, 2012, Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins, Arch Neurol, 69, 1303, 10.1001/archneurol.2012.465