Interferon alfa-2b with VMCP compared to VMCP alone for induction and interferon alfa-2b compared to controls for remission maintenance in multiple myeloma: Interim results

European Journal of Cancer and Clinical Oncology - Tập 27 - Trang S40-S45 - 1991
Heinz Ludwig1, Amos M. Cohen2, Heinz Huber3, David Nachbaur3, Walter F. Jungi4, Hansjörg Senn4, Peter Günczler5, Johannes Schüller6, Sándor Eckhardt7, Heinz L. Seewann8, Franco Cavalli9, Elke Fritz10, Michael Micksche5
11st Department of Medicine and Medical Oncology, Whilhelminenspital, Montleartstr. 37, A-1160 Vienna, Austria
2Department of Medice B, Hasharon Hospital, Petah-Tiqva, Israel
3University Department of Medicine, Innsbruck, Austria
4Department of Medicine C, Kantonspital, St. Gallen, Switzerland
5AESCA Ltd, Traiskirchen, Austria
61st Department of Medicine, Rudolfstiftung Hospital, Vienna, Austria
7National Institute of Oncology, Budapest, Hungary
8III Department of Medicine, Hospital Graz, Austria
9Division of Oncology, Ospedale San Giovanni, Bellinzona, Switzerland
101st Department of Medicine and Medical Oncology, Wilhelminenspital, Vienna, Austria

Tài liệu tham khảo

Ludwig, 1990, Interferon in der Behandlung des multiplen Myeloms, 202 Ludwig, 1980, In vitro inhibitory effect of interferon on multiple myeloma stem cells, Cancer Immunol Immunother, 9, 139, 10.1007/BF00205617 Brenning, 1986, The effect of alpha and gamma-interferon on proliferation and production of IgE and beta 2-microglobulin in the human myeloma cell line U-266 and in an alpha-interferon resistant U-266 subline, Scand J Haematol, 37, 280 Aapro, 1983, Interactions of human leukocyte interferon with vinca alkaloids and other chemotherapeutic agents against human tumors in clonogenic assay, Cancer Chemother Pharmacol, 10, 161, 10.1007/BF00255753 Ohno, 1987, Interferons in the treatment of multiple myeloma, Int J Cancer, 1, 14, 10.1002/ijc.2910390705 Alexanian, 1972, Combination chemotherapy for multiple myeloma, Cancer, 30, 382, 10.1002/1097-0142(197208)30:2<382::AID-CNCR2820300213>3.0.CO;2-C Ludwig, 1987, Combined interferon-polychemotherapy versus polychemotherapy in multiple myeloma: a phase III study, 363 Björkholm, 1990, Melphalan/prednisone versus melphalan/prednisone plus human alpha interferon therapy in patients with multiple myeloma, stages II and III, 42 Oken, 1988, Alternating cycles of VMCP with interferon (rIFN-alpha2) in the treatment of multiple myeloma, 7, 225 Wadler, 1989, Fluorouracil and recombinant alfa-2a-interferon: an active regimen against advanced colorectal carcinoma, J Clin Oncol, 7, 1769, 10.1200/JCO.1989.7.12.1769 Fossa, 1990, Recombinant interferon alpha combined with prednisone in metastatic renal cell carcinoma: reduced toxicity without reduction of the response rate, 65, 2451 Mandelli, 1990, Maintenance treatment with recombinant interferon alfa-2b in patients with multiple myeloma responding to conventional induction chemotherapy, N Engl J Med, 322, 1430, 10.1056/NEJM199005173222005 Avvisati, 1990, Interferon alfa-2b as maintenance treatment in multiple myeloma and response to second-induction treatment in relapsing patients, 36 Westin, 1990, Interferon therapy during the plateau phase of multiple myeloma: an update of the Swedish study, 34 Deicher H. Personal communication. Richard, 1981, Inhibition of cell division by interferon: changes in cell cycle characteristics and in morphology of Ehrlich ascites tumor cells in culture, J Cell Sci, 48, 259, 10.1242/jcs.48.1.259 Jett, 1980, Augmentation of human monocyte-mediated cytolysis by interferon, Cell Immunol, 54, 425, 10.1016/0008-8749(80)90222-1 Ikebuchi, 1987, Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors, 84, 9035 Herrmann, 1989, Monocyte interleukin 1 secretion is regulated by the sequential action of interferon and interleukin 2 involving monocyte surface expression of interleukin 2 receptors, Haematol Blood Transfus, 31, 299 Wallach, 1982, Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs, Nature, 299, 833, 10.1038/299833a0