Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression
Tóm tắt
Từ khóa
Tài liệu tham khảo
Clayburgh, 2004, A porous defense: the leaky epithelial barrier in intestinal disease, Lab Invest, 84, 282, 10.1038/labinvest.3700050
Irvine, 2000, Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk, Gastroenterology, 119, 1740, 10.1053/gast.2000.20231
Wyatt, 1993, Intestinal permeability and the prediction of relapse in Crohn's disease, Lancet, 341, 1437, 10.1016/0140-6736(93)90882-H
Yacyshyn, 1995, CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability, Gastroenterology, 108, 132, 10.1016/0016-5085(95)90017-9
Mullin, 1990, Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability, Cancer Res, 50, 2172
Ma, 2004, TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation, Am J Physiol, 286, G367
Bruewer, 2003, Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms, J Immunol, 171, 6164, 10.4049/jimmunol.171.11.6164
Schmitz, 1999, Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6, J Cell Sci, 112, 137, 10.1242/jcs.112.1.137
Taylor, 1998, Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha, Gastroenterology, 114, 657, 10.1016/S0016-5085(98)70579-7
Zolotarevsky, 2002, A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease, Gastroenterology, 123, 163, 10.1053/gast.2002.34235
Musch, 2002, T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase, J Clin Invest, 110, 1739, 10.1172/JCI0215695
Brown, 1999, Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease, Gastroenterology, 116, 593, 10.1016/S0016-5085(99)70181-2
Ferrier, 2003, Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice, Gastroenterology, 125, 795, 10.1016/S0016-5085(03)01057-6
Suenaert, 2002, Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease, Am J Gastroenterol, 97, 2000, 10.1111/j.1572-0241.2002.05914.x
Madara, 1990, Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: physiological rearrangement of tight junctions, J Membr Biol, 116, 177, 10.1007/BF01868675
Rosenblatt, 2001, An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism, Curr Biol, 11, 1847, 10.1016/S0960-9822(01)00587-5
Mankertz, 2000, Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma, J Cell Sci, 113, 2085, 10.1242/jcs.113.11.2085
Youakim, 1999, Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin, Am J Physiol, 276, G1279
Sugi, 2001, Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function, Gastroenterology, 120, 1393, 10.1053/gast.2001.24045
Hecht, 1996, Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability, Am J Physiol, 271, C1678, 10.1152/ajpcell.1996.271.5.C1678
Yuhan, 1997, Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability, Gastroenterology, 113, 1873, 10.1016/S0016-5085(97)70006-4
Turner, 1999, Protein kinase C-dependent regulation of transepithelial resistance: the roles of myosin light chain and myosin light chain kinase, Am J Physiol, 277, C554, 10.1152/ajpcell.1999.277.3.C554
Turner, 2000, Transepithelial resistance can be regulated by the intestinal brush border Na+-H+ exchanger NHE3, Am J Physiol, 279, C1918, 10.1152/ajpcell.2000.279.6.C1918
Turner, 2000, Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na+-glucose cotransport, Dig Dis Sci, 45, 2122, 10.1023/A:1026682900586
Turner, 1997, Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation, Am J Physiol, 273, C1378, 10.1152/ajpcell.1997.273.4.C1378
Sanders, 1995, Assessment of inflammatory events in epithelial permeability: a rapid screening method using fluorescein dextrans, Epithelial Cell Biol, 4, 25
Berglund, 2001, Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na+-glucose cotransport, Am J Physiol, 281, G1487
Madara, 1989, Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers, J Clin Invest, 83, 724, 10.1172/JCI113938
Adams, 1993, IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding, J Immunol, 150, 2356, 10.4049/jimmunol.150.6.2356
Hiribarren, 1993, Effect of cytokines on the epithelial function of the human colon carcinoma cell line HT29 cl 19A, Gut, 34, 616, 10.1136/gut.34.5.616
Marano, 1993, Long-term effects of tumor necrosis factor on LLC-PK1 transepithelial resistance, J Cell Physiol, 157, 519, 10.1002/jcp.1041570311
Yoo, 2003, Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes, Am J Physiol, 284, G703
Mullin, 1992, Modulation of tumor necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeability, Am J Physiol, 263, F915
Rodriguez, 1995, Tumour necrosis factor-alpha induces morphological and functional alterations of intestinal HT29 cl. 19A cell monolayers, Cytokine, 7, 441, 10.1006/cyto.1995.0060
Soler, 1999, Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis, Eur J Cell Biol, 78, 56, 10.1016/S0171-9335(99)80007-7
Agnholt, 2001, Infliximab downregulates interferon-gamma production in activated gut T-lymphocytes from patients with Crohn's disease, Cytokine, 15, 212, 10.1006/cyto.2001.0919
Abreu, 2000, Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells, Gastroenterology, 119, 1524, 10.1053/gast.2000.20232
Bojarski, 2001, Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis, J Physiol, 535, 541, 10.1111/j.1469-7793.2001.00541.x
Nusrat, 2000, Tight junctions are membrane microdomains, J Cell Sci, 113, 1771, 10.1242/jcs.113.10.1771
Tornhamre, 1989, Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products, Eur J Pharmacol, 169, 225, 10.1016/0014-2999(89)90019-8
Miles, 1994, Antioxidant properties of aminosalicylates, Methods Enzymol, 234, 555, 10.1016/0076-6879(94)34128-1
Hasko, 2001, Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expression, Immunology, 103, 473, 10.1046/j.1365-2567.2001.01272.x
Cronstein, 1999, Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB, Proc Natl Acad Sci USA, 96, 6377, 10.1073/pnas.96.11.6377
Corredor, 2003, Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms, Am J Physiol, 284, C953, 10.1152/ajpcell.00309.2002
Wahl, 1998, Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B, J Clin Invest, 101, 1163, 10.1172/JCI992
Ahn, 2001, Efficacy of use of colonoscopy in dextran sulfate sodium induced ulcerative colitis in rats: the evaluation of the effects of antioxidant by colonoscopy, Int J Colorectal Dis, 16, 174, 10.1007/s003840000282
Gout, 2001, Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)-cystine transporter: a new action for an old drug, Leukemia, 15, 1633, 10.1038/sj.leu.2402238
Weber, 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta, Gastroenterology, 119, 1209, 10.1053/gast.2000.19458
Chen, 2003, The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion, Nat Med, 9, 575, 10.1038/nm849
Takeyoshi, 1999, Effect of FR167653 on small bowel ischemia-reperfusion injury in dogs, Dig Dis Sci, 44, 2334, 10.1023/A:1026633510390
Tamion, 1997, Gut ischemia and mesenteric synthesis of inflammatory cytokines after hemorrhagic or endotoxic shock, Am J Physiol, 273, G314