Interactions between interferon γ and retinoic acid with transforming growth factor β in the induction of immune recognition molecules
Tóm tắt
The cell-surface expression of major histocompatibility (MHC) antigens and the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) is essential for target cell recognition by T lymphocytes. The expression of both classes of molecule is induced by various cytokines, notably interferon γ (IFNγ). Since transforming growth factor β (TGFβ) has been recently reported to antagonise HLA-DR induction by IFNγ we have examined, using a number of murine and human cell lines, the effect of TGFβ on IFNγ-induced MHC class I and class II and ICAM-1 expression. All of the cell lines tested expressed elevated class I MHC following IFNγ treatment. Class II MHC induction was seen on most but not all of the cells, the exceptions being among a panel of human colorectal carcinoma cell lines. A striking difference between cells of different origin was noted in the response to TGFβ. TGFβ was found to antagonise IFNγ-induced class I and class II MHC expression on C3H 10T1/2 murine fibroblasts, early-passage BALB/c mouse embryo fibroblasts, a murine oligodendroglioma cell line, and on MRC5 human fibroblasts and two human glioblastoma cell lines. Class II MHC was much more strongly inhibited (sometimes completely) than class I MHC. TGFβ also inhibited induction of class I MHC expression by IFNα. However, TGFβ did not inhibit class I or class II MHC induction by IFNγ in any of the nine colorectal carcinoma cell lines, although two of five of the lines tested were growth-inhibited by TGFβ. On the other hand, human ICAM-1 induction by IFNγ was not affected by simultaneous treatment with TGFβ in any of the cell lines. The down-regulation of IFNγ-induced MHC antigens by TGFβ is not, therefore, the result of a general antagonism of IFNγ. Retinoic acid has recently been reported to induce ICAM-1 expression on human tumour cells. We have confirmed this observation on MRC5, and the two human glioblastoma cell lines, however six colorectal carcinoma cell lines tested did not respond. In contrast to IFNγ-induced ICAM-1 expression, retinoic-acid-induced ICAM-1 expression was inhibited by TGFβ on two of the three responsive lines.
Tài liệu tham khảo
Altmann DM, Hogg N, Trowsdale J, Wilkinson D (1989) Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L-cells. Nature 338: 512
Anichini A, Mortarini R, Supino R, Parmiani G (1990) Human melanoma cells with high susceptibility to cell mediated lysis can be identified on the basis of ICAM-1 phenotype, VLA profile and invasive ability. Int J Cancer 46: 508
Barnard JA, Lyons RM, Moses HL (1990) The cell biology of transforming growth factor beta. Biochim Biophys Acta 1032: 79
Barrett-Lee P, Travers M, Luqmani Y, Coombes RC (1990) Transcripts for transforming growth factors in human breast cancer: clinical correlates. Brit J Cancer 61: 612
Betterle C, Presotto F, Caretto A, Pelizzo MR, Pedini B, Girelli ME, Busnardo B (1991) Expression of class I and class II human leukocyte antigens by thyrocytes and lymphocytic infiltration of human thyroid tumours. Cancer 67: 977
Bouillon M, Tessier P, Boulianne R, Destrempe R, Audette M (1991) Regulation by retinoic acid of ICAM-1 expression on human tumour cell lines. Biochim Biophys Acta 1097: 95
Chakrabarty S, Fan D, Varani J (1990) Modulation of differentiation and proliferation in human colon carcinoma cells by transforming growth factor beta1 and beta2. Int J Cancer 46: 493
Coffey RJ, Goustin A, Soderquist A, Shipley G, Wolfshohl J, Carpenter G, Moses H (1987) Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model. Cancer Res 47: 4590
Concha A, Esteban F, Cabrera T,et al. (1991) Tumour aggressiveness and MHC class I and II antigens in laryngeal and breast cancer. Semin Cancer Biol 2: 47
Czarnieck CW, Chiu H, Wong G, McCabe S, Palladino MA (1988) Transforming growth factor b1 alters the expression of class II histocompatibility antigens on human cells. J Immunol 140: 4217
Epstein SP, Baer R, Thornbeck G, Belsito D (1991) Immunosuppressive effects of transforming growth factor-beta: inhibition of the induction of Ia on Langerhans cells by cytokines and of the contact hypersensitivity response. J Invest Dermatol 96: 832
Figdor CG, van Kooyte Y, Keizer GD (1990) On the mode of action of LFA-1. Immunol Today 11: 277
Gerwin BI, Spillare E, Forrester K, Lehman TA, Kispert J, Welsh JA, Pfeifer AMA, Lechner JF, Baker SJ, Vogelstein B, Harris CC (1992) Mutant P53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta1. Proc Natl Acad Sci USA 89: 2759
Hersey P, Jamal O (1990) Immunohistochemical relation between DR expression on melanoma cells and infiltration by CD8+ cells. Pathology 22: 133
Hilton D, West K (1990) An evaluation of the prognostic significance of HLA-DR expression in gastric carcinoma. Cancer 66: 1154
Huber D, Phillipp J, Fontana A (1992) Protease inhibitors interfere with the transforming growth factor-beta-dependent but not the transforming growth factor-beta-independent but not the mediated immunosuppression. J Immunol 148: 277
Jetten AM, Shirley JE, Stoner G (1986) Regulation of proliferation and differentiation of respiratory tract epithelial cells by transforming growth factor-beta. Exp Cell Res 167: 539
Massague J (1990) The transforming growth factor-beta family. Annu Rev Cell Biol 6: 597
Maxwell M, Galanopoulos T, Nevillegolden J, Antoniades HN (1992) Effect of expression of transforming growth factor-beta2 in primary human glioblastomas on immunosuppression and loss of immune surveillance. J Neurosurg 76: 799
Meager A (1991) Assays for transforming growth factor-beta. J Immunol Methods 141: 1
Missero C, Cajal SR, Dotto GP (1991) Escape from transforming growth factor-beta control and oncogene cooperation in skin tumour development. Proc Natl Acad Sci USA 88:9613
Moller P, Momburg F, Koretz K, Moldenhauer G, Herfarth C, Otto HF, Hammerling GJ, Schlag P (1991) Influence of major histocompatibility complex class I and II antigens on survival in colorectal carcinoma. Cancer Res 51:729
Morris AG, Ward G, Bateman WJ (1989) Interaction ofv-Ki-ras oncogene and interferon gamma in the control of histocompatability antigen expression in mouse fibroblasts. Cell Immunol 120:470
Schluesener H (1990) Transforming growth factors type betal and beta2 suppress rat astrocyte autoantigen presentation and antagonise hyperinduction of class II major histocompatability complex antigen expression by interferon-gamma and tumour necrosis factor-alpha. J Neuroimmunol 27:41
Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425
Tada T, Ohzeki S, Utsumi K, Takiuchi H, Maramatsu M, Li X, Shimuzu J, Fujiwara H, Hamaoka T (1991) Transforming growth factor-beta-induced inhibition of T cell function; susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumour bearing state. J Immunol 146:1077
Takiuchi H, Tada T, Xiao-Fei L, Ogata M, Ikeda T, Fujimoto S, Fujiwara H, Hamaoka T (1992) Particular types of tumour cells have the capacity to convert transforming growth factor-beta from a latent to an active form. Cancer Res 52:5641
Thompson EW, Shima TB, Martin GR (1990) TGF-beta independently regulates invasiveness, chemotaxis, and proliferation of human breast cancer cells. Ann NY Acad Sci 593:363
Torre-Amione G, Beauchamp RD, Koeppen H., Park BH, Schreiber H, Moses HL, Rowley DA (1990) A highly immunogenic tumour transfected with a murine transforming growth factor-betal cDNA escapes immune surveillance. Proc Natl Acad Sci USA 87:1486
Vanky F, Wang P, Pararrayo M, Klein E (1990) Expression of the adhesion molecule ICAM-1 and major histocompatibility complex class I antigens on tumour cells is required for their interaction with autologous lymphocytes in vitro. Cancer Immunol Immunother 31:19
Vogetseder W, Feichtinger H, Schulz TF, Schwaeble W, Tabaczewski P, Mitterer M, Bock G, Marth C, Dapunt O, Mikuz G, Dierich MP (1989) Expression of 7F7-antigen, a human molecule identical to intercellular adhesion molecule-1 (ICAM-1) in human carcinomas and their stromal fibroblasts. Int J Cancer 43:768
Wahl S, McCartney-Francis N (1989) Inflammatory and immunoregulatory roles of TGF-beta. Immunol Today 10:258
Whitford P, George WD, Campbell AM (1992) Flow cytometric analysis of tumour infiltrating lymphocyte activation and tumour cell MHC class I and class II expression in breast cancer patients. Cancer Lett 61:157
Wu S, Theodorescu D, Kerbel RS, Willson JKV, Mulder KM, Humphrey LE, Brattain MG (1992) TGF-b1 is an autocrine-negative growth regulator of human colon carcinoma FET cells in vivo as revealed by transfection of an antisense expression vector. J Cell Biol 116:187
Yan ZF, Hsu S, Winawer S, Friedman E (1992) Transforming growth factor-beta1 (TGF-beta1) inhibits retinoblastoma gene expression but not pRB phosphorylation in TGF-beta1-growth stimulated colon carcinoma cells. Oncogene 7:801