Interactions alcool–xénobiotiques. Rôle du cytochrome P450 2E1

Pathologie Biologie - Tập 49 - Trang 696-702 - 2001
A. Meskar1, E. Plee-Gautier1, Y. Amet1, F. Berthou1, D. Lucas1
1Laboratoire de biochimie, EA 948, CHU et faculté de médecine de Brest, 29285 Brest cedex, France

Tài liệu tham khảo

Nordmann R. Le métabolisme de l'alcool et ses variations au cours de l'alcoolisme aigu et de l'alcoolisme chronique. Encycl Méd Chir (Éditions Techniques, Paris). Glandes-nutrition, 1983 ; 10384 A10 : 1-8 Lieber, 1968, Ethanol oxidation by hepatic microsomes: adaptative increase after ethanol feeding, Science, 162, 917, 10.1126/science.162.3856.917 Salmela, 1998, Respective roles of human cytochrome P450 2E1, 1A2 and 3A4 in the hepatic microsomal ethanol oxidizing system, Alcohol Clin Exp Res, 22, 2125, 10.1111/j.1530-0277.1998.tb05926.x Vermeulen, 1995, Role of metabolism in chemical toxicity, 29 Guengerich, 1991, Oxidation of toxic and carcinogenic chemicals by human cytochrome P450 enzymes, Chem Res Toxicol, 4, 391, 10.1021/tx00022a001 Ernouf, 1998, Interactions alcool-médicaments. II. Spécificités selon les classes thérapeutiques, Alcoologie, 20, 43 Nelson, 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers, and nomenclature, Pharmacogenetics, 6, 1, 10.1097/00008571-199602000-00002 Koop, 1992, Oxidative and reductive metabolism by cytochrome P450 2E1, FASEB J, 6, 724, 10.1096/fasebj.6.2.1537462 Song, 1986, Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450, J Biol Chem, 261, 16689, 10.1016/S0021-9258(18)66620-7 Teschke, 1986, Hepatic microsomal ethanol metabolism (MEOS); metabolic and clinical aspects, Alcohol Clin Exp Res, 10, 21S, 10.1111/j.1530-0277.1986.tb05176.x Lieber, 1987, Le métabolisme de l'éthanol : hépatotoxicité et interaction avec les médicaments, les carcinogènes et les vitamines, Revue de l'alcoolisme, 32, 9 Zerilli, 1995, Cytochrome P450 2E1 in rat liver, kidney and lung microsomes after chronic administration of ethanol either orally or by inhalation, Alcohol and Alcoholism, 30, 357 Takahashi, 1992, Effects of dietary fat consumption on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 in the liver of rats chronically fed ethanol, Pharmacol Toxicol, 70, 347, 10.1111/j.1600-0773.1992.tb00485.x Korourian, 1999, Diet and risk of ethanol-induced hepatotoxicity: carbohydrate-fat relationships in rats, Toxicol Sci, 47, 110, 10.1093/toxsci/47.1.110 Badger, 1993, Induction of cytochrome P450 2E1 during ethanol exposure occurs via transcription of the CYP2E1 gene when blood concentrations are high, Biochem Biophys Res Commun, 190, 780, 10.1006/bbrc.1993.1117 Perrot, 1989, Modulation of cytochrome P450 isozymes in human liver by ethanol and drug intake, Eur J Clin Investig, 19, 549, 10.1111/j.1365-2362.1989.tb00273.x Peter, 1990, Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450 IIE1, Chem Res Toxicol, 3, 566, 10.1021/tx00018a012 Raucy, 1997, Human lymphocyte cytochrome P450 2E1, a putative marker of alcohol-mediated changes in hepatic chlorzoxazone activity, Drug Metabol Dispos, 25, 1429 Lucas, 1995, Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazone hydroxylation in alcoholics during the withdrawal phase, Alcohol Clin Exp Res, 19, 362, 10.1111/j.1530-0277.1995.tb01516.x Lieber, 1999, Microsomal Ethanol-oxidizing system (MEOS): the first 30 years (1968–1998) – A review, Alcohol Clin Exp Res, 23, 991, 10.1111/j.1530-0277.1999.tb04217.x Mishin, 1998, Chlorzoxazone pharmacokinetics as a marker of hepatic cytochrome P4502E1 in humans, Am J Gastroenterol, 93, 2154, 10.1111/j.1572-0241.1998.00612.x Koop, 1990, Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450 IIE1, Bioassays, 12, 429, 10.1002/bies.950120906 Roberts, 1995, Rapid changes in cytochrome P4502E1 (CYP2E1) activity and other P450 isozymes following ethanol withdrawal in rats, Biochem Pharmacol, 49, 1665, 10.1016/0006-2952(95)00098-K Takahashi, 1993, Induction of P4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA, Hepatology, 17, 236 Hayashi, 1991, Genetic polymorphism in the 5′-flanking region change transcriptional regulation of the human cytochrome P450 IIE1 gene, J Biochem, 110, 559, 10.1093/oxfordjournals.jbchem.a123619 Lucas, 1995, Cytochrome P4502E1 genotype and chlorzoxazone metabolism in healthy and alcoholic caucasian subjects, Pharmacogenetics, 5, 298, 10.1097/00008571-199510000-00005 Hoshino, 1995, Urinary 6β-hydroxycortisol excretion in patients with alcoholic liver diseases, Res Comm Alc Sub Abuse, 16, 116 Rizzo, 1997, Impact of long-term ethanol consumption on CYP1A2 activity, Clin Pharmacol Ther, 62, 505, 10.1016/S0009-9236(97)90045-X Louis, 1994, Synergistic increases in rat hepatic cytochrome P450s by ethanol and isopentanol, J Pharmacol Exp Ther, 269, 838 Klotz, 1998, Clinical and toxicological consequences of the inductive potential of ethanol, Eur J Clin Pharmacol, 54, 7, 10.1007/s002280050412 Djordjevik, 1998, Ethanol interaction with other cytochrome P450 substrates including drugs, xenobiotics and carcinogens, Pathol Biol, 46, 760 Girre, 1994, Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics, Biochem Pharmacol, 47, 1503, 10.1016/0006-2952(94)90524-X Dilger, 1997, CYP2E1 activity in patients with alcoholic liver disease, J Hepatol, 27, 1009, 10.1016/S0168-8278(97)80144-4 Lucas, 1999, Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans, Pharmacogenetics, 9, 377, 10.1097/00008571-199906000-00013 Park, 1996, Induction of human drug-metabolizing enzymes, Br J Clin Pharmacol, 41, 477, 10.1046/j.1365-2125.1996.03482.x Thummel, 1988, Mechanism by which ethanol diminishes the hepatotoxicity of acetaminophen, J Pharmacol Exp Ther, 245, 129 Sinclair, 1998, Alcohol-mediated increases in acetaminophen hepatotoxicity- Role of CYP2E and CYP3A, Biochem Pharmacol, 55, 1557 Raucy, 1993, Bioactivation of halogenated hydrocarbons by cytochrome P450 2E1, Crit Rev Toxicol, 23, 1, 10.3109/10408449309104072 Valentine, 1996, Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression, Toxicol Appl Pharmacol, 141, 205, 10.1016/S0041-008X(96)80026-3 Yoo, 1988, Metabolism of N-nitrosodialkylamines by human liver microsomes, Cancer Res, 48, 1499 Bellec, 1996, Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes, Carcinogenesis, 17, 2029, 10.1093/carcin/17.9.2029 Yang, 1990, Cytochrome P450 IIE1: roles in nitrosamine metabolism and mechanisms of regulation, Drug Metab Rev, 22, 147, 10.3109/03602539009041082 Lucas, 1990, Ethanol-inducible cytochrome P-450: assessment of substrates specific chemical probes in rat liver microsomes, Alcohol Clin Exp Res, 14, 590, 10.1111/j.1530-0277.1990.tb01207.x Anderson, 1995, Alcohol-related cancer risk: a toxicokinetic hypothesis, Alcohol, 12, 97, 10.1016/0741-8329(94)00089-1 Lewis, 1997, Nitrosamine carcinogenesis: rodent assays, quantitative structure activity relationships, and human risk assessment, Drug Metabol Rev, 29, 1055, 10.3109/03602539709002243