Interaction of vascular and bone disease in patients with normal renal function and patients undergoing dialysis

Springer Science and Business Media LLC - Tập 4 Số 1 - Trang 26-33 - 2007
Paolo Raggi1, Cecilia M. Giachelli2, Antonio Bellasi1
1and A Bellasi is a research scholar in the Division of Cardiology, P Raggi is Professor of Medicine–Cardiology and Professor of Radiology, both at Emory University School of Medicine, Atlanta, GA, USA.,
2C Giachelli is a professor in the Department of Bioengineering at the University of Washington, Seattle, WA.,

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Hunt JL et al. (2002) Bone formation in carotid plaques: a clinicopathological study. Stroke 33: 1214–1219

Mohler ER III et al. (2001) Bone formation and inflammation in cardiac valves. Circulation 103: 1522–1528

Jono S et al. (2002) Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease. Circulation 106: 1192–1194

Simonet WS et al. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89: 309–319

Speer MY and Giachelli CM (2004) Regulation of cardiovascular calcification. Cardiovasc Pathol 13: 63–70

Ketteler M (2005) Fetuin-A and extraosseous calcification in uremia. Curr Opin Nephrol Hypertens 14: 337–342

Luo G et al. (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386: 78–81

Hur DJ et al. (2005) A novel MGP mutation in a consanguineous family: review of the clinical and molecular characteristics of Keutel syndrome. Am J Med Genet A 135: 36–40

Murshed M et al. (2004) Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol 165: 625–630

Coates T et al. (1998) Cutaneous necrosis from calcific uremic arteriolopathy. Am J Kidney Dis 32: 384–391

Beitz JM (2003) Calciphylaxis: a case study with differential diagnosis. Ostomy Wound Manage 49: 28–38

Price PA et al. (2000) Warfarin-induced artery calcification is accelerated by growth and vitamin D. Arterioscler Thromb Vasc Biol 20: 317–327

Essalihi R et al. (2003) A new model of isolated systolic hypertension induced by chronic warfarin and vitamin K1 treatment. Am J Hypertens 16: 103–110

Jono S et al. (2004) Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. Thromb Haemost 91: 790–794

Moe SM et al. (2005) Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD). Kidney Int 67: 2295–2304

Schafer C et al. (2003) The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 112: 357–366

Ketteler M et al. (2003) Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet 361: 827–833

Mehrotra R et al. (2005) Serum fetuin-A in nondialyzed patients with diabetic nephropathy: relationship with coronary artery calcification. Kidney Int 67: 1070–1077

Rutsch F et al. (2003) Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nat Genet 34: 379–381

Rutsch F et al. (2001) PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol 158: 543–554

Harmey D et al. (2004) Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. Am J Pathol 164: 1199–1209

Johnson K et al. (2005) Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1−/− mice. Arterioscler Thromb Vasc Biol 25: 686–691

Lomashvili KA et al. (2005) Reduced plasma pyrophosphate levels in hemodialysis patients. J Am Soc Nephrol 16: 2495–2500

Steitz SA et al. (2001) Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res 89: 1147–1154

Chen NX et al. (2002) Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells. Kidney Int 62: 1724–1731

Moe SM et al. (2003) Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. Kidney Int 63: 1003–1011

Moe SM et al. (2002) Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins. Kidney Int 61: 638–647

Kim KM (1976) Calcification of matrix vesicles in human aortic valve and aortic media. Fed Proc 35: 156–162

Proudfoot D et al. (2000) Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 87: 1055–1062

Reynolds JL et al. (2004) Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 15: 2857–2867

Bucay N et al. (1998) Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12: 1260–1268

Price PA et al. (2001) Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption. Arterioscler Thromb Vasc Biol 21: 817–824

Price PA et al. (2001) Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler Thromb Vasc Biol 21: 1610–1616

Price PA et al. (2002) SB 242784, a selective inhibitor of the osteoclastic V-H+ ATPase, inhibits arterial calcification in the rat. Circ Res 91: 547–552

Banks LM et al. (1994) Effect of degenerative spinal and aortic calcification on bone density measurements in post-menopausal women: links between osteoporosis and cardiovascular disease? Eur J Clin Invest 24: 813–817

McFarlane SI et al. (2004) Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link? Endocrine 23: 1–10

van Meurs JB et al. (2004) Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350: 2033–2041

Mantovani A et al. (1997) Endothelial activation by cytokines. Ann NY Acad Sci 832: 93–116

Cohen-Solal ME et al. (1993) Peripheral monocyte culture supernatants of menopausal women can induce bone resorption: involvement of cytokines. J Clin Endocrinol Metab 77: 1648–1653

Mundy G et al. (1999) Stimulation of bone formation in vitro and in rodents by statins. Science 286: 1946–1949

Edwards CJ et al. (2000) Oral statins and increased bone-mineral density in postmenopausal women. Lancet 355: 2218–2219

Meier CR et al. (2000) Statin drugs and the risk of fracture. JAMA 284: 1921–1922

von der Recke P et al. (1999) The association between low bone mass at the menopause and cardiovascular mortality. Am J Med 106: 273–278

Kado DM et al. (2000) Rate of bone loss is associated with mortality in older women: a prospective study. J Bone Miner Res 15: 1974–1980

Tanko LB et al. (2005) Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res 20: 1912–1920

Barrett-Connor E et al. (2006) Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women. N Engl J Med 355: 125–137

Samelson EJ et al. (2004) Metacarpal cortical area and risk of coronary heart disease: the Framingham Study. Am J Epidemiol 159: 589–595

van der Klift M et al. (2002) Bone mineral density and the risk of peripheral arterial disease: the Rotterdam Study. Calcif Tissue Int 70: 443–449

Mussolino ME et al. (2003) Bone mineral density and mortality in women and men: the NHANES I epidemiologic follow-up study. Ann Epidemiol 13: 692–697

Magnus JH and Broussard DL (2005) Relationship between bone mineral density and myocardial infarction in US adults. Osteoporos Int 16: 2053–2062

Trivedi DP and Khaw KT (2001) Bone mineral density at the hip predicts mortality in elderly men. Osteoporos Int 12: 259–265

Marcovitz PA et al. (2005) Usefulness of bone mineral density to predict significant coronary artery disease. Am J Cardiol 96: 1059–1063

Uyama O et al. (1997) Bone changes and carotid atherosclerosis in postmenopausal women. Stroke 28: 1730–1732

Sinnott B et al. (2006) Coronary calcification and osteoporosis in men and postmenopausal women are independent processes associated with aging. Calcif Tissue Int 78: 195–202

Aoyagi K et al. (2001) Low bone density is not associated with aortic calcification. Calcif Tissue Int 69: 20–24

Kiel DP et al. (2001) Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int 68: 271–276

Hak AE et al. (2000) Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler Thromb Vasc Biol 20: 1926–1931

Schulz E et al. (2004) Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab 89: 4246–4253

Fukagawa M et al. (2002) Renal osteodystrophy and secondary hyperparathyroidism. Nephrol Dial Transplant 17 (Suppl 10): S2–S5

Moe SM (2001) Current issues in the management of secondary hyperparathyroidism and bone disease. Perit Dial Int 21 (Suppl 3): S241–S246

Parfitt AM (1997) The hyperparathyroidism of chronic renal failure: a disorder of growth. Kidney Int 52: 3–9

Morii H et al. (2004) Management of calcium and bone abnormalities in hemodialysis patients. Semin Nephrol 24: 446–448

Block GA et al. (2004) Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 15: 2208–2218

Stevens LA et al. (2004) Calcium, phosphate, and parathyroid hormone levels in combination and as a function of dialysis duration predict mortality: evidence for the complexity of the association between mineral metabolism and outcomes. J Am Soc Nephrol 15: 770–779

Li X et al. (2006) Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. Circ Res 98: 905–912

Jono S et al. (2000) Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 87: E10–E17

Block GA et al. (2005) Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis. Kidney Int 68: 1815–1824

Raggi P et al. (2002) Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 39: 695–701

Matsuoka M et al. (2004) Impact of high coronary artery calcification score (CACS) on survival in patients on chronic hemodialysis. Clin Exp Nephrol 8: 54–58

Blacher J et al. (2001) Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 38: 938–942

Chertow GM et al. (2002) Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int 62: 245–252

Raggi P et al. (2005) Decrease in thoracic vertebral bone attenuation with calcium-based phosphate binders in hemodialysis. J Bone Miner Res 20: 764–772

London GM et al. (2004) Arterial calcifications and bone histomorphometry in end-stage renal disease. J Am Soc Nephrol 15: 1943–1951

Taal MW et al. (2003) Total hip bone mass predicts survival in chronic hemodialysis patients. Kidney Int 63: 1116–1120

Raggi P et al. (2004) Valvular calcification in hemodialysis patients randomized to calcium-based phosphorus binders or sevelamer. J Heart Valve Dis 13: 134–141

Nitta K et al. (2004) Effects of cyclic intermittent etidronate therapy on coronary artery calcification in patients receiving long-term hemodialysis. Am J Kidney Dis 44: 680–688

Teng M et al. (2003) Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N Engl J Med 349: 446–456

Watson KE et al. (1997) Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation 96: 1755–1760

Hruska KA et al. (2005) Bone morphogenetic proteins in vascular calcification. Circ Res 97: 105–114

Callister TQ et al. (1998) Effect of HMG-CoA reductase inhibitors on coronary artery disease as assessed by electron-beam computed tomography. N Engl J Med 339: 1972–1978

Bekker PJ et al. (2004) A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 19: 1059–1066