Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression

Victoria A. McCarthy1, Christopher J. Ott2, Marios Phylactides1, Ann Harris1,2
1Paediatric Molecular Genetics, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
2Human Molecular Genetics Program, Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL. USA

Tài liệu tham khảo

McCarthy, 2005, The CFTR gene and regulation of its expression, Pediatr. Pulmonol., 40, 1, 10.1002/ppul.20199 Mouchel, 2004, HNF1a is involved in regulation of expression of the CFTR gene, Biochem. J., 378, 909, 10.1042/bj20031157 Ott, 2009, A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter, J. Cell Mol. Med., 13, 680, 10.1111/j.1582-4934.2008.00621.x Smith, 2000, Multiple potential intragenic regulatory elements in the CFTR gene, Genomics, 64, 90, 10.1006/geno.1999.6086 Boudreau, 2002, Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene, J. Biol. Chem., 277, 31909, 10.1074/jbc.M204622200 Silberg, 2000, Cdx1 and cdx2 expression during intestinal development, Gastroenterology, 119, 961, 10.1053/gast.2000.18142 Kim, 2002, Signaling and transcriptional control of pancreatic organogenesis, Curr. Opin. Genet. Dev., 12, 540, 10.1016/S0959-437X(02)00338-6 Fogh, 1977, Absence of HeLa cell contamination in 169 cell lines derived from human tumors, J. Natl. Cancer Inst., 58, 209, 10.1093/jnci/58.2.209 Fogh, 1975 Dharmsathaphorn, 1984, A human colonic tumor cell line that maintains vectorial electrolyte transport, Am. J. Physiol., 246, G204 Blackledge, 2007, CTCF mediates insulator function at the CFTR locus, Biochem. J., 408, 267, 10.1042/BJ20070429 Wingender, 2000, TRANSFAC: an integrated system for gene expression regulation, Nucleic Acids Res., 28, 316, 10.1093/nar/28.1.316 Qiu, 2007, Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth, Am. J. Pathol., 170, 152, 10.2353/ajpath.2007.060722 Jonckheere, 2007, The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells, J. Biol. Chem., 282, 22638, 10.1074/jbc.M700905200 Paul, 2007, The epigenetic signature of CFTR expression is co-ordinated via chromatin acetylation through a complex intronic element, Biochem. J., 408, 317, 10.1042/BJ20070282 Blackledge, 2009, An insulator element 3′ to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells, Nucleic Acids Res., 37, 1086, 10.1093/nar/gkn1056 Phylactides, 2002, Evaluation of potential regulatory elements identified as DNase I hypersensitive sites in the CFTR gene, Eur. J. Biochem., 2002, 553, 10.1046/j.0014-2956.2001.02679.x Ktistaki, 1997, Modulation of hepatic gene expression by hepatocyte nuclear factor 1, Science, 277, 109, 10.1126/science.277.5322.109 Duncan, 1998, Regulation of a transcription factor network required for differentiation and metabolism, Science, 281, 692, 10.1126/science.281.5377.692 Soutoglou, 2000, Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins, J. Biol. Chem., 275, 12515, 10.1074/jbc.275.17.12515 Isshiki, 2003, Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins, J. Biol. Chem., 278, 36611, 10.1074/jbc.M302681200 Gregory, 2004, Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1alpha and the caudal-related homeodomain protein 2, Mol. Pharmacol., 65, 953, 10.1124/mol.65.4.953 Farnham, 2009, Insights from genomic profiling of transcription factors, Nat. Rev. Genet., 10, 605, 10.1038/nrg2636