Interaction between α1 antitrypsin and lymphocyte surface proteases: immunoregulatory effects
Tóm tắt
Alpha 1 antitrypsin (α1-AT) is the major plasma protease inhibitor. Radioiodinated α1-AT binds to human lymphocytes. The binding is fast and reversible, and the cells can be saturated with a maximum of approximately 1.2×106 molecules of α1-AT per lymphocyte. The receptor for α1-AT is a surface-associated protease. Adition of α1-AT completely inhibits cell surface proteolytic activity. Furthermore α1-AT decreases3H-thymidine incorporation into lymphocytes stimulated by B or T cell mitogens or by allogeneic cells. Since α1-AT was shown to be produced by activated monocytes and to bind to lymphocytes, it is likely to represent a mediator of monocyte-lymphocyte interactions.
Tài liệu tham khảo
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