Intensity, Duration, and Location of High-Definition Transcranial Direct Current Stimulation for Tinnitus Relief

Neurorehabilitation and Neural Repair - Tập 30 Số 4 - Trang 349-359 - 2016
Giriraj Singh Shekhawat1, Frederick Sundram1, Marom Bikson2, Dennis Q. Truong2, Dirk De Ridder3,4, Cathy M. Stinear1, David Welch1, Grant D. Searchfield4,1
1University of Auckland, New Zealand
2City College of New York, New York, NY, USA
3Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
4Tinnitus Research Initiative, Regensburg, Germany

Tóm tắt

Background and Objective. Tinnitus is the perception of a phantom sound. The aim of this study was to compare current intensity (center anode 1 mA and 2 mA), duration (10 minutes and 20 minutes), and location (left temporoparietal area [LTA] and dorsolateral prefrontal cortex [DLPFC]) using 4 × 1 high-definition transcranial direct current stimulation (HD-tDCS) for tinnitus reduction. Methods. Twenty-seven participants with chronic tinnitus (>2 years) and mean age of 53.5 years underwent 2 sessions of HD-tDCS of the LTA and DLPFC in a randomized order with a 1 week gap between site of stimulation. During each session, a combination of 4 different settings were used in increasing dose (1 mA, 10 minutes; 1 mA, 20 minutes; 2 mA, 10 minutes; and 2 mA, 20 minutes). The impact of different settings on tinnitus loudness and annoyance was documented. Results. Twenty-one participants (77.78%) reported a minimum of 1 point reduction on tinnitus loudness or annoyance scales. There were significant changes in loudness and annoyance for duration of stimulation, F(1, 26) = 10.08, P < .005, and current intensity, F(1, 26) = 14.24, P = .001. There was no interaction between the location, intensity, and duration of stimulation. Higher intensity (2 mA) and longer duration (20 minutes) of stimulation were more effective. Conclusions. A current intensity of 2 mA for 20-minute duration was the most effective setting used for tinnitus relief. The stimulation of the LTA and DLPFC were equally effective for suppressing tinnitus loudness and annoyance.

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Neurorehabilitation and Neural Repair

Tập 30 Số 4

349-359

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