Intelligent Paper‐Free Sprayable Skin Mask Based on an In Situ Formed Janus Hydrogel of an Environmentally Friendly Polymer

Advanced healthcare materials - Tập 11 Số 12 - 2022
Caiyun Cai1, Jingyu Tang1, Yi Zhang1, Weihan Rao1, Dinglingge Cao1, Wen Guo1, Lin Yu1, Jiandong Ding1
1State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China

Tóm tắt

AbstractTraditional skin care masks usually use a piece of paper to hold the aqueous essences, which are not environmentally friendly and not easy to use. While a paper‐free mask is desired, it is faced with a dilemma of moisture holding and rapid release of encapsulated bioactive substances. Herein, a paper‐free sprayable skin mask is designed from an intelligent material—a thermogel which undergoes sol–gel‐suspension transitions upon heating—to solve this dilemma. A synthesized block copolymer of poly(ethylene glycol) and poly(lactide‐co‐glycolide) with appropriate ratios can be dissolved in water, and thus easily mixed with a biological substance. The mixture is sprayable. After spraying, a Janus film is formed in situ with a physical gel on the outside and a suspension on the inside facing skin. Thus, both moisture holding and rapid release are achieved. Such a thermogel composed of biodegradable amphiphilic block copolymers loaded with nicotinamide as a skin mask is verified to reduce pigmentation on a 3D pigmented reconstructed epidermis model and further in a clinical study. This work might be stimulating for investigations and applications of biodegradable and intelligent soft matter in the fields of drug delivery and regenerative medicine.

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Advanced healthcare materials

Tập 11 Số 12

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