Integrins

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Calderwood, 1999, The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation, J. Biol. Chem., 274, 28071, 10.1074/jbc.274.40.28071

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Calderwood, 2002, The phosphotyrosine binding-like domain of talin activates integrins, J. Biol. Chem., 277, 21749, 10.1074/jbc.M111996200

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De Arcangelis, 2000, Integrin and ECM functions, Trends Genet., 16, 389, 10.1016/S0168-9525(00)02074-6

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Du, 1993, Long range propagation of conformational changes in integrin alpha IIb beta 3, J. Biol. Chem., 268, 23087, 10.1016/S0021-9258(19)49429-5

Emsley, 1997, Crystal structure of the I domain from integrin alpha2beta1, J. Biol. Chem., 272, 28512, 10.1074/jbc.272.45.28512

Emsley, 2000, Structural basis of collagen recognition by integrin alpha2beta1, Cell, 101, 47, 10.1016/S0092-8674(00)80622-4

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Fenczik, 1997, Complementation of dominant suppression implicates CD98 in integrin activation, Nature, 390, 81, 10.1038/36349

Frisch, 2001, Anoikis mechanisms, Curr. Opin. Cell Biol., 13, 555, 10.1016/S0955-0674(00)00251-9

Garcia, 2002, Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectin, Biochemistry, 41, 9063, 10.1021/bi025752f

Giancotti, 1999, Integrin signaling, Science, 285, 1028, 10.1126/science.285.5430.1028

Ginsberg, 1992, Inside-out integrin signalling, Curr. Opin. Cell Biol., 4, 766, 10.1016/0955-0674(92)90099-X

Gottlieb, 2000, Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis, J. Am. Acad. Dermatol., 42, 428, 10.1016/S0190-9622(00)90214-7

Hantgan, 1999, Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization, Biochemistry, 38, 14461, 10.1021/bi9907680

Hato, 1998, Complementary roles for receptor clustering and conformational change in the adhesive and signaling function of integrin αIIb β3, J. Cell Biol., 141, 1685, 10.1083/jcb.141.7.1685

Hemler, 1998, Integrin associated proteins, Curr. Opin. Cell Biol., 10, 578, 10.1016/S0955-0674(98)80032-X

Hemler, 1999, Integrins

Hemler, 2001, Specific tetraspanin functions, J. Cell Biol., 155, 1103, 10.1083/jcb.200108061

Hogg, 2000, Genetic analysis of integrin function in man, Matrix Biol., 19, 211, 10.1016/S0945-053X(00)00066-4

Huang, 2000, Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain, J. Biol. Chem., 275, 21514, 10.1074/jbc.M002286200

Hughes, 2001, Evolution of the integrin alpha and beta protein families, J. Mol. Evol., 52, 63, 10.1007/s002390010134

Hughes, 1998, Integrin affinity modulation, Trends Cell Biol., 8, 359, 10.1016/S0962-8924(98)01339-7

Hughes, 1995, The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity, J. Biol. Chem., 270, 12411, 10.1074/jbc.270.21.12411

Hughes, 1996, Breaking the integrin hinge. A defined structural constraint regulates integrin signaling, J. Biol. Chem., 271, 6571, 10.1074/jbc.271.12.6571

Hughes, 1997, Suppression of integrin activation, Cell, 88, 521, 10.1016/S0092-8674(00)81892-9

Humphries, 2000, Integrin structure, Biochem. Soc. Trans., 28, 311, 10.1042/0300-5127:0280311

Humphries, 2002, Insights into integrin-ligand binding and activation from the first crystal structure, Arthritis Res., 4, S69, 10.1186/ar563

Hynes, 1987, Integrins, Cell, 48, 549, 10.1016/0092-8674(87)90233-9

Hynes, 1992, Integrins, Cell, 69, 11, 10.1016/0092-8674(92)90115-S

Hynes, 1996, Targeted mutations in cell adhesion genes, Dev. Biol., 180, 402, 10.1006/dbio.1996.0314

Hynes, 2002, A reevaluation of integrins as regulators of angiogenesis, Nat. Med., 8, 918, 10.1038/nm0902-918

Hynes, 2000, The evolution of cell adhesion, J. Cell Biol., 150, F89, 10.1083/jcb.150.2.F89

Jackson, 2002, Alpha 4 integrin antagonists, Curr. Pharm. Des., 8, 1229, 10.2174/1381612023394737

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Lambright, 1996, The 2.0 Å crystal structure of a heterotrimeric G protein, Nature, 379, 311, 10.1038/379311a0

Lauffenburger, 1996, Cell migration, Cell, 84, 359, 10.1016/S0092-8674(00)81280-5

Lee, 1995, Two conformations of the integrin A-domain (I-domain), Structure, 3, 1333, 10.1016/S0969-2126(01)00271-4

Lee, 1995, Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18), Cell, 80, 631, 10.1016/0092-8674(95)90517-0

Li, 2001, Oligomerization of the integrin alphaIIbbeta3, Proc. Natl. Acad. Sci. USA, 98, 12462, 10.1073/pnas.221463098

Liddington, 2002, Will the real integrin please stand up?, Structure, 10, 605, 10.1016/S0969-2126(02)00766-9

Liddington, 2002, Integrin activation takes shape, J. Cell Biol., 158, 833, 10.1083/jcb.200206011

Loftus, 1997, Cell adhesion in vascular biology. New insights into integrin-ligand interaction, J. Clin. Invest., 99, 2302, 10.1172/JCI119408

Loftus, 1994, Integrin-mediated cell adhesion, J. Biol. Chem., 269, 25235, 10.1016/S0021-9258(18)47235-3

Lu, 2001, An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond, Proc. Natl. Acad. Sci. USA, 98, 2387, 10.1073/pnas.041606398

Lu, 2001, Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state, J. Biol. Chem., 276, 14642, 10.1074/jbc.M100600200

Lu, 2001, Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains, Proc. Natl. Acad. Sci. USA, 98, 2393, 10.1073/pnas.041618598

Martel, 2001, Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides, J. Biol. Chem., 276, 21217, 10.1074/jbc.M102373200

Miranti, 2002, Sensing the environment, Nat. Cell Biol., 4, E83, 10.1038/ncb0402-e83

Mould, 1997, Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies, Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha, 5, 17283

Mould, 2002, Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain, J. Biol. Chem., 277, 19800, 10.1074/jbc.M201571200

O'Neill, 2000, The platelet integrin alpha IIbbeta 3 has an endogenous thiol isomerase activity, J. Biol. Chem., 275, 36984, 10.1074/jbc.M003279200

O'Toole, 1991, Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb, Science, 254, 845, 10.1126/science.1948065

O'Toole, 1994, Integrin cytoplasmic domains mediate inside-out signal transduction, J. Cell Biol., 124, 1047, 10.1083/jcb.124.6.1047

Patil, 1999, Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions, The talin n-terminal head domain interacts with the membrane-proximal region of the beta(, 3), 28575

Pearson, 2000, Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain, Cell, 101, 259, 10.1016/S0092-8674(00)80836-3

Plow, 2000, Ligand binding to integrins, J. Biol. Chem., 275, 21785, 10.1074/jbc.R000003200

Pulkkinen, 1999, Mutation analysis and molecular genetics of epidermolysis bullosa, Matrix Biol., 18, 29, 10.1016/S0945-053X(98)00005-5

Qu, 1995, Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin, Proc. Natl. Acad. Sci. USA, 92, 10277, 10.1073/pnas.92.22.10277

Qu, 1996, The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin, Structure, 4, 931, 10.1016/S0969-2126(96)00100-1

Rosenkranz, 1999, Leukocyte-endothelial cell interactions—lessons from knockout mice, Exp. Nephrol., 7, 125, 10.1159/000020593

Scarborough, 2000, Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers, J. Med. Chem., 43, 3453, 10.1021/jm000022w

Schoenwaelder, 1999, Bidirectional signaling between the cytoskeleton and integrins, Curr. Opin. Cell Biol., 11, 274, 10.1016/S0955-0674(99)80037-4

Schwartz, 2001, Integrins and cell proliferation, J. Cell Sci., 114, 2553, 10.1242/jcs.114.14.2553

Schwartz, 2002, Networks and crosstalk, Nat. Cell Biol., 4, E65, 10.1038/ncb0402-e65

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Shimaoka, 2001, Reversibly locking a protein fold in an active conformation with a disulfide bond, Proc. Natl. Acad. Sci. USA, 98, 6009, 10.1073/pnas.101130498

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Springer, 1997, Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain, Proc. Natl. Acad. Sci. USA, 94, 65, 10.1073/pnas.94.1.65

Takada, 1993, Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies, J. Biol. Chem., 268, 17597, 10.1016/S0021-9258(19)85374-7

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Takagi, 2002, Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling, Cell, 110, 599, 10.1016/S0092-8674(02)00935-2

Tozer, 1996, Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit, J. Biol. Chem., 271, 21978, 10.1074/jbc.271.36.21978

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