Integrative analysis of miRNA in cartilage-derived extracellular vesicles and single-cell RNA-seq profiles in knee osteoarthritis

Michael, 2010, The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee, Dtsch Arztebl Int, 107, 152 Sharma, 2021, Osteoarthritis of the knee, N. Engl. J. Med., 384, 51, 10.1056/NEJMcp1903768 Felson, 2007, Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study, Arthritis Rheum., 57, 6, 10.1002/art.22464 Barbour, 2014, Meeting physical activity guidelines and the risk of incident knee osteoarthritis: a population-based prospective cohort study, Arthritis Care Res., 66, 139, 10.1002/acr.22120 Wang, 2021, Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis, Cell Death Dis., 12, 10.1038/s41419-021-03832-3 Abels, 2016, Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake, Cell. Mol. Neurobiol., 36, 301, 10.1007/s10571-016-0366-z Tkach, 2016, Communication by extracellular vesicles: where we are and where we need to go, Cell, 164, 1226, 10.1016/j.cell.2016.01.043 Zhang, 2020, Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B, Cancer Lett., 490, 54, 10.1016/j.canlet.2020.07.008 Karakas, 2017, Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease-results from the large AtheroGene study, Eur. Heart J., 38, 516 Leistner, 2016, Transcoronary gradients of vascular miRNAs and coronary atherosclerotic plaque characteristics, Eur. Heart J., 37, 1738, 10.1093/eurheartj/ehw047 McDonald, 2015, Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation, J. Am. Coll. Cardiol., 65, 2314, 10.1016/j.jacc.2015.03.549 Zhang, 2017, Emerging roles for MicroRNAs in diabetic microvascular disease: novel targets for therapy, Endocr. Rev., 38, 145, 10.1210/er.2016-1122 Xie, 2022, Exploration of exosomal miRNAs from serum and synovial fluid in arthritis patients, Diagnostics, 12, 10.3390/diagnostics12020239 Wang, 2021, ATF4-modified serum exosomes derived from osteoarthritic mice inhibit osteoarthritis by inducing autophagy, IUBMB Life, 73, 146, 10.1002/iub.2414 Zhao, 2018, Synovial fluid-derived exosomal lncRNA PCGEM1 as biomarker for the different stages of osteoarthritis, Int. Orthop., 42, 2865, 10.1007/s00264-018-4093-6 Gao, 2020, Association between cytokines and exosomes in synovial fluid of individuals with knee osteoarthritis, Mod. Rheumatol., 30, 758, 10.1080/14397595.2019.1651445 Ji, 2019, Single-cell RNA-seq analysis reveals the progression of human osteoarthritis, Ann. Rheum. Dis., 78, 100, 10.1136/annrheumdis-2017-212863 Sun, 2020, Single-cell RNA-seq analysis identifies meniscus progenitors and reveals the progression of meniscus degeneration, Ann. Rheum. Dis., 79, 408, 10.1136/annrheumdis-2019-215926 Ferguson, 2018, Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes, Nat. Commun., 9, 3634, 10.1038/s41467-018-05573-y Stephenson, 2018, Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation, Nat. Commun., 9, 791, 10.1038/s41467-017-02659-x Vella, 2017, Intercellular resistance to BRAF inhibition can Be mediated by extracellular vesicle-associated PDGFR beta, Neoplasia, 19, 932, 10.1016/j.neo.2017.07.002 Aibar, 2017, SCENIC: single-cell regulatory network inference and clustering, Nat. Methods, 14, 1083, 10.1038/nmeth.4463 Garcia-Martin, 2022, MicroRNA sequence codes for small extracellular vesicle release and cellular retention, Nature, 601, 446, 10.1038/s41586-021-04234-3 Kalluri, 2020, The biology, function, and biomedical applications of exosomes, Science, 367, 10.1126/science.aau6977 Keller, 2020, Decoy exosomes provide protection against bacterial toxins, Nature, 579, 260, 10.1038/s41586-020-2066-6 Harischandra, 2017, Exosomes in toxicology: relevance to chemical exposure and pathogenesis of environmentally linked diseases, Toxicol. Sci., 158, 3, 10.1093/toxsci/kfx074 Kato, 2014, Exosomes from IL-1beta stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes, Arthritis Res. Ther., 16, R163, 10.1186/ar4679 Withrow, 2016, Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis, Arthritis Res. Ther., 18, 286, 10.1186/s13075-016-1178-8 Wang, 2020, Forkhead box C1 promotes the pathology of osteoarthritis by upregulating beta-catenin in synovial fibroblasts, FEBS J., 287, 3065, 10.1111/febs.15178 Nakamura, 2016, Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration, JCI Insight, 1, 10.1172/jci.insight.86820 Anderson, 2017, miR-483 targets SMAD4 to suppress chondrogenic differentiation of human mesenchymal stem cells, J. Orthop. Res., 35, 2369, 10.1002/jor.23552 Zhou, 2021, MiR-485-3p promotes proliferation of osteoarthritis chondrocytes and inhibits apoptosis via Notch2 and the NF-kappaB pathway, Immunopharmacol. Immunotoxicol., 43, 370, 10.1080/08923973.2021.1918150 Zou, 2020, MiR-375 mediates chondrocyte metabolism and oxidative stress in osteoarthritis mouse models through the JAK2/STAT3 signaling pathway, Cells Tissues Organs, 208, 13 Zhang, 2021, Circ_0001103 alleviates IL-1 beta-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375, Clin. Immunol., 227, 10.1016/j.clim.2021.108718 Li, 2020, MicroRNA-375 exacerbates knee osteoarthritis through repressing chondrocyte autophagy by targeting ATG2B, Aging-Us, 12, 7248, 10.18632/aging.103073 Huang, 2021, Bioinformatics analysis of miRNA and mRNA expression profiles to reveal the key miRNAs and genes in osteoarthritis, J. Orthop. Surg. Res., 16, 10.1186/s13018-021-02201-2 Han, 2023, LncRNA ZFAS1 protects chondrocytes from IL-1 beta-induced apoptosis and extracellular matrix degradation via regulating miR-7-5p/FLRT2 axis, J. Orthop. Surg. Res., 18, 10.1186/s13018-023-03802-9 Li, 2017, Identification of differentially expressed microRNAs in knee anterior cruciate ligament tissues surgically removed from patients with osteoarthritis, Int. J. Mol. Med., 40, 1105, 10.3892/ijmm.2017.3086 Wang, 2023, Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-Kappa B pathways, Int. Immunopharm., 115, 10.1016/j.intimp.2022.109624 Zou, 2021, Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation, Phytomedicine, 91, 10.1016/j.phymed.2021.153657 Liao, 2020, Advanced oxidation protein products increase TNF-alpha and IL-1 beta expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression, Redox Biol., 28, 10.1016/j.redox.2019.101306 Akasaki, 2014, FoxO transcription factors support oxidative stress resistance in human chondrocytes, Arthritis Rheumatol., 66, 3349, 10.1002/art.38868 Tia, 2018, Role of Forkhead Box O (FOXO) transcription factor in aging and diseases, Gene, 648, 97, 10.1016/j.gene.2018.01.051 Joachim, 2017, Centriolar satellites control GABARAP ubiquitination and GABARAP-mediated autophagy, Curr. Biol., 27, 2123, 10.1016/j.cub.2017.06.021 Akasaki, 2014, Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis, Osteoarthritis Cartilage, 22, 162, 10.1016/j.joca.2013.11.004 Hata, 2005, A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes, Mol. Cell Biol., 25, 1971, 10.1128/MCB.25.5.1971-1979.2005 Tominaga, 2008, CCAAT/Enhancer-binding protein beta promotes osteoblast differentiation by enhancing Runx2 activity with ATF4, Mol. Biol. Cell, 19, 5373, 10.1091/mbc.e08-03-0329 Hirata, 2012, C/EBP beta and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2 alpha as the inducer in chondrocytes, Hum. Mol. Genet., 21, 1111, 10.1093/hmg/ddr540 Wang, 2009, Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription, Development, 136, 4143, 10.1242/dev.043281 Nakamura, 2011, Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25, Nat. Commun., 2, 10.1038/ncomms1242 Rhee, 2017, Inhibition of BATF/JUN transcriptional activity protects against osteoarthritic cartilage destruction, Ann. Rheum. Dis., 76, 427, 10.1136/annrheumdis-2015-208953 Sun, 2019, EGR1 promotes the cartilage degeneration and hypertrophy by activating the Kruppel-like factor 5 and beta-catenin signaling, Bba-Mol Basis Dis, 1865, 2490, 10.1016/j.bbadis.2019.06.010 Prieto-Alhambra, 2015, Hormone replacement therapy and mid-term implant survival following knee or hip arthroplasty for osteoarthritis: a population-based cohort study, Ann. Rheum. Dis., 74, 557, 10.1136/annrheumdis-2013-204043 Pan, 2015, Response to: 'Does it make sense to investigate whether the offspring of people with a total knee replacement for severe primary knee osteoarthritis have a higher risk of worsening knee pain?' by Lei et al, Ann. Rheum. Dis., 74, 10.1136/annrheumdis-2015-207620 Koster, 2015, Racial disparity in arthroplasty remains disjointed, Ann. Rheum. Dis., 74, 10.1136/annrheumdis-2014-206963 Schnitzer, 2015, Efficacy and safety of tanezumab monotherapy or combined with non-steroidal anti-inflammatory drugs in the treatment of knee or hip osteoarthritis pain, Ann. Rheum. Dis., 74, 1202, 10.1136/annrheumdis-2013-204905 Fort, 2007, The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane, J. Biol. Chem., 282, 31444, 10.1074/jbc.M704524200 Liu, 2022, Identification of SLC3A2 as a potential therapeutic target of osteoarthritis involved in ferroptosis by integrating bioinformatics, clinical factors and experiments, Cells-Basel, 11 Gong, 2023, Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway, Food Chem. Toxicol., 174, 10.1016/j.fct.2023.113644