Integration of network and experimental pharmacology to decipher the antidiabetic action of Duranta repens L.

Zhao, 2012, Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression, Diabetes, 61, 933, 10.2337/db11-1164 Hemmingsen, 2016, Insulin secretagogues for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus, Cochrane Database Syst Rev, 10 Shahebrahimi, 2016, Comparison clinical and metabolic effects of metformin and pioglitazone in polycystic ovary syndrome, Indian J Endocrinol Metab, 20, 805, 10.4103/2230-8210.192925 Gallwitz, 2011, GLP-1 agonists and dipeptidyl-peptidase IV inhibitors, Handb Exp Pharmacol, 203, 53, 10.1007/978-3-642-17214-4_3 Katz, 2015, The role of the kidney and sglt2 inhibitors in type 2 diabetes, Can J Diabetes, 39, S167, 10.1016/j.jcjd.2015.09.001 Carpino, 2010, Diabetes area participation analysis: a review of companies and targets described in the 2008–2010 patent literature, Expert Opin Ther Pat, 20, 1627, 10.1517/13543776.2010.533171 Sacks, 1996, The pathogenesis of type II diabetes mellitus. A polygenic disease, Am J Clin Pathol, 105, 149, 10.1093/ajcp/105.2.149 Stein, 2013, A review of the efficacy and safety of oral antidiabetic drugs, Expert Opin Drug Saf, 12, 153, 10.1517/14740338.2013.752813 Sridharan, 2011, Ayurvedic treatments for diabetes mellitus, Cochrane Database Syst Rev, 12 Covington, 2001, Traditional Chinese medicine in the treatment of diabetes, Diabetes Spectr, 14, 154, 10.2337/diaspect.14.3.154 Kooti, 2016, The role of medicinal plants in the treatment of diabetes: a systematic review, Electron Physician, 8, 1832, 10.19082/1832 Choudhury, 2017, An update on natural compounds in the remedy of diabetes mellitus: a systematic review, J Tradit Complement Med, 8, 361, 10.1016/j.jtcme.2017.08.012 Iqbal, 2004, ɑ-Glucosidase inhibitory constituents from Duranta repens, Chem Pharm Bull (Tokyo), 52, 785, 10.1248/cpb.52.785 Puri Abhijeet, 2017, Pharmacognostic, physicochemical and phytochemical investigation of leaves of Duranta repens Linn, Res J Pharmacogn Phytochem, 9, 141 Bharti, 2018, Antidiabetic phytoconstituents and their mode of action on metabolic pathways, Ther Adv Endocrinol Metab, 9, 81, 10.1177/2042018818755019 Shahat, 2005, Phytochemical investigation and antioxidant activity of Duranta repens, Phytother Res, 19, 1071, 10.1002/ptr.1766 Systèmes, 2019 Liu, 2007, BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities, Nucleic Acids Res, 35, D198, 10.1093/nar/gkl999 Li, 2018, Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics, Nucleic Acids Res, 46, D1121, 10.1093/nar/gkx1076 Yang, 2019, admetSAR 2.0: web-service for prediction and optimization of chemical ADMET properties, Bioinformatics, 35, 1067, 10.1093/bioinformatics/bty707 Lagunin, 2018, CLC-Pred: a freely available web-service for in silico prediction of human cell line cytotoxicity for drug-like compounds, PLoS ONE, 13, 10.1371/journal.pone.0191838 Szklarczyk, 2019, STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets, Nucleic Acids Res, 47, D607, 10.1093/nar/gky1131 Shannon, 2003, Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res, 13, 2498, 10.1101/gr.1239303 Khanal, 2019, In silico antidiabetic screening of borapetoside c, cordifolioside a and magnoflorine, Indian J Pharm Sci, 81, 550, 10.36468/pharmaceutical-sciences.543 Halgren, 1996, Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94, J Comput Chem, 17, 490, 10.1002/(SICI)1096-987X(199604)17:5/6<490::AID-JCC1>3.0.CO;2-P Morris, 2009, AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility, J Comput Chem, 30, 2785, 10.1002/jcc.21256 Masiello, 1998, Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide, Diabetes, 47, 224, 10.2337/diab.47.2.224 Kumar, 2012, Antidiabetic activity of alcoholic root extract of Caesalpinia digyna in streptozotocin-nicotinamide induced diabetic rats, Asian Pac J Trop Biomed, 2, S934, 10.1016/S2221-1691(12)60340-2 Seifter, 1950, The estimation of glycogen with the anthrone reagent, Arch Biochem, 25, 191 Brandstrup, 1957, The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery tissue in individuals of various ages, J Gerontol, 12, 166, 10.1093/geronj/12.2.166 King, 1959, A routine method for the estimation of lactic dehydrogenase activity, J Med Lab Technol., 16, 265 Pari, 2010, Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats, Biomed Pharmacother, 64, 477, 10.1016/j.biopha.2010.02.001 Claiborne, 1985, Catalase activity, 283 Sedlak, 1968, Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent, Anal Biochem, 25, 192, 10.1016/0003-2697(68)90092-4 Nandi, 1987, Scavenging of superoxide radical by ascorbic acid, J Biosci, 11, 435, 10.1007/BF02704692 Ohkawa, 1979, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal Biochem, 95, 351, 10.1016/0003-2697(79)90738-3 Chandran, 2015, Network pharmacology of Ayurveda formulation Triphala with special reference to anti-cancer property, Comb Chem High Throughput Screen, 18, 846, 10.2174/1386207318666151019093606 Khanal, 2019, Gene set enrichment analysis of α-glucosidase inhibitors from Ficus benghalensis, Asian Pac J Trop Biomed, 9, 263, 10.4103/2221-1691.260399 Andreadis, 2005, High-dose monotherapy vs low-dose combination therapy of calcium channel blockers and angiotensin receptor blockers in mild to moderate hypertension, J Hum Hypertens, 19, 491, 10.1038/sj.jhh.1001843 Zhang, 2019, Network pharmacology databases for traditional Chinese medicine: review and assessment, Front Pharmacol, 10, 123, 10.3389/fphar.2019.00123 Khanal, 2019, In silico docking study of limonoids from Azadirachta indica with pfpk5: a novel target for Plasmodium falciparum, Indian J Pharm Sci, 81, 326, 10.36468/pharmaceutical-sciences.514 Subramanian, 2005, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Version 2, Proc Natl Acad Sci USA, 102, 15545, 10.1073/pnas.0506580102 Ma, 2011, PTP1B inhibitor improves both insulin resistance and lipid abnormalities in vivo and in vitro, Mol Cell Biochem, 357, 65, 10.1007/s11010-011-0876-4 Galic, 2005, Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP, Mol Cell Biol, 25, 819, 10.1128/MCB.25.2.819-829.2005 Fernandez-Ruiz, 2014, Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass, PLoS One, 9, 10.1371/journal.pone.0090344 Elchebly, 1999, Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene, Science, 283, 1544, 10.1126/science.283.5407.1544 Huang, 2018, The PI3K/AKT pathway in obesity and type 2 diabetes, Int J Biol Sci, 14, 1483, 10.7150/ijbs.27173 Bischoff, 1995, The mechanism of α-glucosidase inhibition in the management of diabetes, Clin Invest Med, 18, 303 Khanal, 2020, α-Glucosidase inhibitors from Duranta repens modulate p53 signaling pathway in diabetes mellitus, Adv Tradit Med, 20, 427, 10.1007/s13596-020-00426-w Khanal, 2020, Gene ontology enrichment analysis of α-amylase inhibitors from Duranta repens in diabetes mellitus, J Diabetes Metab Disord, 10.1007/s40200-020-00554-9 Monsalve, 2013, Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases, Mediators Inflamm, 2013, 10.1155/2013/549627 Zoico, 2002, The role of cytokines in regulating protein metabolism and muscle function, Nutr Rev, 60, 39, 10.1301/00296640260085949 BC open textbooks. Protein metabolism. [2020-07-04]. https://opentextbc.ca/anatomyandphysiology/chapter/24-4-protein-metabolism/. Koundouros, 2018, Phosphoinositide 3-kinase/Akt signaling and redox metabolism in cancer, Front Oncol, 8, 160, 10.3389/fonc.2018.00160 Cohen, 1979, The SGOT/SGPT ratio––an indicator of alcoholic liver disease, Dig Dis Sci, 24, 835, 10.1007/BF01324898 Kakar, 2004, Sinusoidal dilatation and congestion in liver biopsy: is it always due to venous outflow impairment?, Arch Pathol Lab Med, 128, 901, 10.5858/2004-128-901-SDACIL Lipinski, 2004, Lead- and drug-like compounds: the rule-of-five revolution, Drug Discov Today Technol, 1, 337, 10.1016/j.ddtec.2004.11.007 Scanlan, 2006, Duranta erecta poisoning in nine dogs and a cat, Aust Vet J, 84, 367, 10.1111/j.1751-0813.2006.00039.x