Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Jiajun Chen1,2,3, Tian Li1,2,3, Dehua Huang1,2,3, Wenxia Gong1,2,3, Junsheng Tian1,2,3, Xiaoxia Gao1,2,3, Xuemei Qin1,2,3, Guanhua Du1,4, Yuzhi Zhou1,2,3
1Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
2The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China
3The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan, China
4Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

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