Integrated Laplacian‐based phase unwrapping and background phase removal for quantitative susceptibility mapping

NMR in Biomedicine - Tập 27 Số 2 - Trang 219-227 - 2014
Wei Li1, Alexandru Avram1,2, Bing Wu1,3, Xue Xiao1,4, Chunlei Liu1,5
1Brain Imaging and Analysis Center, School of Medicine, Duke University, Durham, NC, USA
2Section on Tissue Biophysics and Biomimetics, National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA
3GE Healthcare, Beijing, China
4Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China
5Department of Radiology, School of Medicine, Duke University, Durham, NC, USA

Tóm tắt

Quantitative susceptibility mapping (QSM) is a recently developed MRI technique that provides a quantitative measure of tissue magnetic susceptibility. To compute tissue magnetic susceptibilities based on gradient echoes, QSM requires reliable unwrapping of the measured phase images and removal of contributions caused by background susceptibilities. Typically, the two steps are performed separately. Here, we present a method that simultaneously performs phase unwrapping and HARmonic (background) PhasE REmovaL using the LAplacian operator (HARPERELLA). Both numerical simulations and in vivo human brain images show that HARPERELLA effectively removes both phase wraps and background phase, whilst preserving all low spatial frequency components originating from brain tissues. When compared with other QSM phase preprocessing techniques, such as path‐based phase unwrapping followed by background phase removal, HARPERELLA preserves the tissue phase signal in gray matter, white matter and cerebrospinal fluid with excellent robustness, providing a convenient and accurate solution for QSM. The proposed algorithm is provided, together with QSM and susceptibility tensor imaging (STI) tools, in a shared software package named ‘STI Suite’. Copyright © 2013 John Wiley & Sons, Ltd.

Từ khóa


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Thông tin xuất bản

NMR in Biomedicine

Tập 27 Số 2

219-227

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