Insulina aspart en pacientes de edad avanzada

CDC, Center for Disease Control and Prevention. Percentage of Civilian, Noninstitutionalized Population with Diagnosed Diabetes by Age, United States, 1980–2009 [consultado 10-1-2012]. Disponible en: http://www.cdc.gov/diabetes/statistics/prev/national/figbyage.htm. Soriguer, 2012, Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the [email protected] Study, Diabetologia, 55, 88, 10.1007/s00125-011-2336-9 Hornick, 2008, Managing diabetes in the elderly: go easy, individualize, Cleve Clin J Med, 75, 70, 10.3949/ccjm.75.1.70 Bertoni, 2002, Diabetes-related morbidity and mortality in a national sample of U.S. elders, Diabetes Care, 25, 471, 10.2337/diacare.25.3.471 Suh, 2008, Comorbid conditions and glycemic control in elderly patients with type 2 diabetes mellitus, 1988 to 1994 to 1999 to 2004, J Am Geriatr Soc, 56, 484, 10.1111/j.1532-5415.2007.01563.x Vázquez, 2007 Krones, 2009, The rapid-acting properties of insulin aspart are preserved in elderly people with type 2 diabetes, Diabetes, Obesity and Metabolism, 11, 41, 10.1111/j.1463-1326.2008.00988.x Meneilly, 2007, A comparison of insulin aspart and regular insulin in elderly patients with type 2 diabetes, Diabetes, Obesity and Metabolism, 9, 754, 10.1111/j.1463-1326.2006.00639.x Tamás, 2001, Insulin Aspart Study Group Glycaemic control in type 1 diabetic patients using optimised insulin aspart or human insulin in a randomised multinational study, Diabetes Research and Clinical Practice, 54, 105, 10.1016/S0168-8227(01)00262-5 Hirsh, 2005, Insulin analogues, New Eng J Med, 352, 174, 10.1056/NEJMra040832 Home, 2000, For the European Insulin Aspart Study Group Insulin Aspart vs. human insulin in the management of long-term blood glucose control in Type 1 diabetes mellitus: a randomised controlled trial, Diabet Med, 17, 762, 10.1046/j.1464-5491.2000.00380.x Raskin, 2000, Use of insulin aspart, a fast-acting insulin analog, as the meal-time insulin in the management of patients with type 1 diabetes, Diabetes Care, 23, 583, 10.2337/diacare.23.5.583 Pala, 2007, A comparison of mealtime insulin aspart and human insulin in combination with metformin in type 2 diabetes patients, Diabetes Research and Clinical Practice, 78, 132, 10.1016/j.diabres.2007.02.010 Pollock, 2011, The cost effectiveness of rapid-acting insulin aspart compared with human insulin in type 2 diabetes patients: an analysis from the Japanese third-party payer perspective, Journal of Medical Economics, 14, 36, 10.3111/13696998.2010.541045 Lloyd, 2009, Cost-effectiveness of insulin aspart compared to human insulin in pregnant women with type 1 diabetes in the UK, Curr Med Res Opin, 25, 599, 10.1185/03007990802668208 Home, 1999, Comparative pharmacokinetics and pharmacodynamics of the novel rapid-acting insulin analogue, insulin aspart, in healthy volunteers, Eur J Clin Pharmacol, 55, 199, 10.1007/s002280050618 Haas, 2007, Optimizing insulin use in type 2 diabetes: role of basal and prandial insulin in long-term care facilities, J Am Med Dir Assoc, 8, 502, 10.1016/j.jamda.2007.08.002 Turnheim, 2003, When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly, Exp Gerontol, 38, 843, 10.1016/S0531-5565(03)00133-5 Sinclair, 2006, Special considerations in older adults with diabetes: meeting the challenge, Diabetes Spectrum, 19, 229, 10.2337/diaspect.19.4.229 Oiknine, 2003, Drug therapy of diabetes in the elderly, Biomed Pharmacother, 57, 231, 10.1016/S0753-3322(03)00052-0 Amiel, 2008, Hypoglycaemia in type 2 diabetes, Diabetic Medicine, 25, 245, 10.1111/j.1464-5491.2007.02341.x Cryer, 2006, Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes, J Clin Invest, 116, 1470, 10.1172/JCI28735 Leahy, 2006, Insulin management of diabetic patients on general medical and surgical floors, Endocr Pract, 12, 86, 10.4158/EP.12.S3.86 Chelliah, 2004, Hypoglycaemia in elderly patients with diabetes mellitus: causes and strategies for prevention, Drugs Aging, 21, 511, 10.2165/00002512-200421080-00003 Brod, 2007, Examining correlates of treatment satisfaction for injectable insulin in type 2 diabetes: lessons learned from a clinical trial comparing biphasic and basal analogues, Health and Quality of Life Outcomes, 5, 8, 10.1186/1477-7525-5-8 Murray, 2010, Legacy effects from DCCT and UKPDS: what they mean and implication for future diabetes trials, Curr Atheroscler Rep, 12, 432, 10.1007/s11883-010-0128-1 1996, The absence of a glycaemic threshold for the development of long-term complications, Diabetes, 45, 1289, 10.2337/diabetes.45.10.1289 2008, Effects of intensive glucose lowering in type 2 diabetes, N Engl J Med, 358, 2545, 10.1056/NEJMoa0802743 2008, Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes, N Engl J Med., 358, 2560, 10.1056/NEJMoa0802987 2009, Glucose control and vascular complications in veterans with type 2 diabetes, N Engl J Med, 360, 129, 10.1056/NEJMoa0808431 Aguilar, 2009, Relationship of hemoglobin A1c and mortality in heart failure patients with diabetes, J Am Coll Cardiol, 54, 422, 10.1016/j.jacc.2009.04.049 Currie, 2010, Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort study, Lancet, 375, 481, 10.1016/S0140-6736(09)61969-3 Landstedt-Hallin, 1999, Increased QT-dispersion during hypoglycaemia in patients with type 2 diabetes mellitus, J Intern Med, 246, 299, 10.1046/j.1365-2796.1999.00528.x Hermansen, 2004, Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal.bolus therapy for patients with type 1 diabetes, Diabetologia, 47, 622, 10.1007/s00125-004-1365-z Home, 1998, Improved glycemic control with insulin aspart: a multicenter randomized double-blind crossover trial in type 1 diabetic patients. UK Insulin Aspart Study Group, Diabetes Care, 21, 1904, 10.2337/diacare.21.11.1904 Huang, 2007, Appropiate application of evidence to the care of elderly patients with diabetes, Curr Diabetes Rev, 3, 260, 10.2174/1573399810703040260 Biesenbach, 2003, Decreased insulin requirement in relation to GFR in nephropathic type 1 and insulin-treated Type 2 diabetic patients, Diabet Med, 20, 642, 10.1046/j.1464-5491.2003.01025.x Holmes, 2005, Pharmacokinetics of insulin aspart in obesity, renal impairment, or hepatic impairment, Br J Clin Pharmacol, 60, 469, 10.1111/j.1365-2125.2005.02476.x Brunner, 2000, Postprandial administration of the insulin analogue insulin aspart in patients with type 1 diabetes mellitus, Diabetic Medicine, 17, 371, 10.1046/j.1464-5491.2000.00289.x Warren, 2004, Postprandial versus preprandial dosing of biphasic insulin aspart in elderly type 2 diabetes patients, Diabetes Res Clin Pract, 66, 23, 10.1016/j.diabres.2004.02.010 Garber, 2006, Attainment of glycaemic goals in type 2 diabetes with once-, twice-, or thrice-daily dosing with biphasic insulin aspart 70/30 (The 1-2-3 study), Diabetes, Obesity and Metabolism, 8, 58, 10.1111/j.1463-1326.2005.00563.x