Insulin resistance is a cardiovascular risk factor in humans

Urbina, 2010, Prevalence of increased arterial stiffness in children with type 1 diabetes mellitus differs by measurement site and sex: the SEARCH for diabetes in youth study, J Pediatr, 156, 731, 10.1016/j.jpeds.2009.11.011 Shah, 2015, Arterial stiffness in adolescents and young adults with and without type 1 diabetes: the SEARCH CVD study, Pediatr Diabetes, 16, 367, 10.1111/pedi.12279 Ikezaki, 2017, Cardiovascular disease prevalence and insulin resistance in the kyushu-okinawa population study and the Framingham offspring study, Journal of clinical lipidology, 11, 348, 10.1016/j.jacl.2017.01.014 Haffner, 1990, Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?, J Am Med Assoc, 263, 2893, 10.1001/jama.1990.03440210043030 Tzagournis, 1968, Interrelationships of hyperinsulinism and hypertriglyceridemia in young patients with coronary heart disease, Circulation, 38, 1156, 10.1161/01.CIR.38.6.1156 Bacha, 2016, Insulin resistance, role of metformin and other non-insulin therapies in pediatric type 1 diabetes, Pediatr Diabetes, 17, 545, 10.1111/pedi.12337 Eddy, 2009, Relationship of insulin resistance and related metabolic variables to coronary artery disease: a mathematical analysis, Diabetes Care, 32, 361, 10.2337/dc08-0854 Welborn, 1979, Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations, Diabetes Care, 2, 154, 10.2337/diacare.2.2.154 Pyorala, 1998, Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen study, Circulation, 98, 398, 10.1161/01.CIR.98.5.398 Fuller, 1983, Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whitehall study, Br Med J, 287, 867, 10.1136/bmj.287.6396.867 Vaccaro, 1992, Relationship of postload plasma glucose to mortality with 19-yr follow-up. Comparison of one versus two plasma glucose measurements in the Chicago peoples gas company study, Diabetes Care, 15, 1328, 10.2337/diacare.15.10.1328 Welin, 1992, Hyperinsulinaemia is not a major coronary risk factor in elderly men. The study of men born in 1913, Diabetologia, 35, 766, 10.1007/BF00429098 1999, Glucose tolerance and mortality: comparison of WHO and American diabetes association diagnostic criteria. The DECODE study group. European diabetes epidemiology group. Diabetes epidemiology: collaborative analysis of diagnostic criteria in Europe, Lancet, 354, 617, 10.1016/S0140-6736(98)12131-1 2001, Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria, Arch Intern Med, 161, 397, 10.1001/archinte.161.3.397 Coutinho, 1999, The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years, Diabetes Care, 22, 233, 10.2337/diacare.22.2.233 Kodama, 2012, Fasting and post-challenge glucose as quantitative cardiovascular risk factors: a meta-analysis, J Atherosclerosis Thromb, 19, 385, 10.5551/jat.10975 Ford, 2010, Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence, J Am Coll Cardiol, 55, 1310, 10.1016/j.jacc.2009.10.060 Sarwar, 2010, Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review, PLoS Med, 7, e1000278, 10.1371/journal.pmed.1000278 Haffner, 2000, Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state, Circulation, 101, 975, 10.1161/01.CIR.101.9.975 Hanley, 2002, Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart study, Diabetes Care, 25, 1177, 10.2337/diacare.25.7.1177 Robins, 2003, Insulin resistance and cardiovascular events with low HDL cholesterol: the Veterans Affairs HDL Intervention Trial (VA-HIT), Diabetes Care, 26, 1513, 10.2337/diacare.26.5.1513 Saely, 2005, The metabolic syndrome, insulin resistance, and cardiovascular risk in diabetic and nondiabetic patients, J Clin Endocrinol Metab, 90, 5698, 10.1210/jc.2005-0799 Hedblad, 2002, Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death, Diabet Med : a journal of the British Diabetic Association, 19, 470, 10.1046/j.1464-5491.2002.00719.x Jeppesen, 2007, Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: a population-based study, J Am Coll Cardiol, 49, 2112, 10.1016/j.jacc.2007.01.088 Tan, 2017, The association between insulin resistance, metabolic syndrome, and ischemic heart disease among Rumoi residents, Journal of general and family medicine, 18, 360, 10.1002/jgf2.94 Rutter, 2005, Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham offspring study, Diabetes, 54, 3252, 10.2337/diabetes.54.11.3252 Gast, 2012, Insulin resistance and risk of incident cardiovascular events in adults without diabetes: meta-analysis, PLoS One, 7, e52036, 10.1371/journal.pone.0052036 Zhang, 2017, Fasting insulin, insulin resistance, and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis, Biosci Rep, 37, 10.1042/BSR20170947 Yanase, 2004, Insulin resistance and fasting hyperinsulinemia are risk factors for new cardiovascular events in patients with prior coronary artery disease and normal glucose tolerance, Circ J. J Circul Soc, 68, 47, 10.1253/circj.68.47 Tenenbaum, 2007, Insulin resistance is associated with increased risk of major cardiovascular events in patients with preexisting coronary artery disease, Am Heart J, 153, 559, 10.1016/j.ahj.2007.01.008 Yip, 1998, Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease, J Clin Endocrinol Metab, 83, 2773, 10.1210/jcem.83.8.5005 Zethelius, 2005, Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp, Diabetologia, 48, 862, 10.1007/s00125-005-1711-9 Faerch, 2012, Does insulin resistance drive the association between hyperglycemia and cardiovascular risk?, PLoS One, 7, e39260, 10.1371/journal.pone.0039260 Haffner, 1992, Prospective analysis of the insulin-resistance syndrome (syndrome X), Diabetes, 41, 715, 10.2337/diab.41.6.715 Despres, 1996, Hyperinsulinemia as an independent risk factor for ischemic heart disease, N Engl J Med, 334, 952, 10.1056/NEJM199604113341504 Rubins, 2002, Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT), Arch Intern Med, 162, 2597, 10.1001/archinte.162.22.2597 Alexander, 2003, NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older, Diabetes, 52, 1210, 10.2337/diabetes.52.5.1210 Fontbonne, 1991, Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up, Diabetologia, 34, 356, 10.1007/BF00405009 Yarnell, 1994, Insulin in ischaemic heart disease: are associations explained by triglyceride concentrations? The Caerphilly prospective study, Br Heart J, 71, 293, 10.1136/hrt.71.3.293 Ninomiya, 2004, Association of the metabolic syndrome with history of myocardial infarction and stroke in the Third national Health and nutrition examination survey, Circulation, 109, 42, 10.1161/01.CIR.0000108926.04022.0C Lakka, 2002, The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men, J Am Med Assoc, 288, 2709, 10.1001/jama.288.21.2709 Dekker, 2005, Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study, Circulation, 112, 666, 10.1161/CIRCULATIONAHA.104.516948 Sundstrom, 2006, Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study, BMJ, 332, 878, 10.1136/bmj.38766.624097.1F Sattar, 2008, Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies, Lancet, 371, 1927, 10.1016/S0140-6736(08)60602-9 Gami, 2007, Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies, J Am Coll Cardiol, 49, 403, 10.1016/j.jacc.2006.09.032 Martin, 1968, Insulin sensitivity and vascular disease in insulin-dependent diabetics, Br Med J, 2, 81, 10.1136/bmj.2.5597.81 Martin, 1987, The relationship of acute insulin sensitivity to the progression of vascular disease in long-term type 1 (insulin-dependent) diabetes mellitus, Diabetologia, 30, 149, 10.1007/BF00274219 Orchard, 2003, Insulin resistance-related factors, but not glycemia, predict coronary artery disease in type 1 diabetes: 10-year follow-up data from the Pittsburgh Epidemiology of Diabetes Complications Study, Diabetes Care, 26, 1374, 10.2337/diacare.26.5.1374 Schauer, 2011, Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: the CACTI study, Diabetes, 60, 306, 10.2337/db10-0328 Nathan, 1993, The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus, N Engl J Med, 329, 977, 10.1056/NEJM199309303291401 Nathan, 2003, Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus, N Engl J Med, 348, 2294, 10.1056/NEJMoa022314 Polak, 2011, Progression of carotid artery intima-media thickness during 12 years in the diabetes control and complications trial/epidemiology of diabetes interventions and complications (DCCT/EDIC) study, Diabetes, 60, 607, 10.2337/db10-0296 Nathan, 2005, Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes, N Engl J Med, 353, 2643, 10.1056/NEJMoa052187 Cleary, 2006, The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study, Diabetes, 55, 3556, 10.2337/db06-0653 Genuth, 2013, Effects of prior intensive versus conventional therapy and history of glycemia on cardiac function in type 1 diabetes in the DCCT/EDIC, Diabetes, 62, 3561, 10.2337/db12-0546 Fullerton, 2014, Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus, Cochrane Database Syst Rev, CD009122 Nathan, 2013, Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions, Diabetes, 62, 3976, 10.2337/db13-1093 Frohlich-Reiterer, 2014, Predictors of increasing BMI during the course of diabetes in children and adolescents with type 1 diabetes: data from the German/Austrian DPV multicentre survey, Arch Dis Child, 99, 738, 10.1136/archdischild-2013-304237 van Vliet, 2010, Overweight is highly prevalent in children with type 1 diabetes and associates with cardiometabolic risk, J Pediatr, 156, 923, 10.1016/j.jpeds.2009.12.017 Bergman, 2012, Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes, J Clin Endocrinol Metab, 97, 1663, 10.1210/jc.2011-3172 Olson, 2002, Subclinical atherosclerosis and estimated glucose disposal rate as predictors of mortality in type 1 diabetes, Ann Epidemiol, 12, 331, 10.1016/S1047-2797(01)00269-1 Olson, 2002, Glycemia (or, in women, estimated glucose disposal rate) predict lower extremity arterial disease events in type 1 diabetes, Metab Clin Exp, 51, 248, 10.1053/meta.2002.30021 Kilpatrick, 2007, Insulin resistance, the metabolic syndrome, and complication risk in type 1 diabetes: "double diabetes" in the Diabetes Control and Complications Trial, Diabetes Care, 30, 707, 10.2337/dc06-1982 Shah, 2015, Insulin sensitivity and arterial stiffness in youth with type 1 diabetes: the SEARCH CVD study, J Diabetes Complicat, 29, 512, 10.1016/j.jdiacomp.2015.02.004 Dabelea, 2003, Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study, Diabetes, 52, 2833, 10.2337/diabetes.52.11.2833 Koivisto, 1996, Cardiovascular disease and its risk factors in IDDM in Europe. EURODIAB IDDM complications study group, Diabetes Care, 19, 689, 10.2337/diacare.19.7.689 Snell-Bergeon, 2003, Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control, Diabetes Care, 26, 2923, 10.2337/diacare.26.10.2923 Meinert, 1970, A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results, Diabetes, 19, 789 Goldner, 1971, Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. 3. Clinical implications of UGDP results, J Am Med Assoc, 218, 1400, 10.1001/jama.1971.03190220020005 Knatterud, 1978, Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VII. Mortality and selected nonfatal events with insulin treatment, J Am Med Assoc, 240, 37, 10.1001/jama.1978.03290010041020 Abraira, 1997, Cardiovascular events and correlates in the veterans Affairs diabetes feasibility trial. Veterans Affairs cooperative study on glycemic control and complications in type II diabetes, Arch Intern Med, 157, 181, 10.1001/archinte.1997.00440230053007 Duckworth, 2009, Glucose control and vascular complications in veterans with type 2 diabetes, N Engl J Med, 360, 129, 10.1056/NEJMoa0808431 1998, Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group, Lancet, 352, 837, 10.1016/S0140-6736(98)07019-6 Gerstein, 2008, Effects of intensive glucose lowering in type 2 diabetes, N Engl J Med, 358, 2545, 10.1056/NEJMoa0802743 Ismail-Beigi, 2010, Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial, Lancet, 376, 419, 10.1016/S0140-6736(10)60576-4 Patel, 2008, Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes, N Engl J Med, 358, 2560, 10.1056/NEJMoa0802987 Johansen, 2012, Effect of intensive multifactorial treatment compared with routine care on aortic stiffness and central blood pressure among individuals with screen-detected type 2 diabetes: the ADDITION-Denmark study, Diabetes Care, 35, 2207, 10.2337/dc12-0176 Turnbull, 2009, Intensive glucose control and macrovascular outcomes in type 2 diabetes, Diabetologia, 52, 2288, 10.1007/s00125-009-1470-0 Ray, 2009, Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials, Lancet, 373, 1765, 10.1016/S0140-6736(09)60697-8 Boussageon, 2011, Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials, BMJ, 343, d4169, 10.1136/bmj.d4169 1998, Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group, Lancet, 352, 854, 10.1016/S0140-6736(98)07037-8 Zoungas, 2010, Severe hypoglycemia and risks of vascular events and death, N Engl J Med, 363, 1410, 10.1056/NEJMoa1003795 Out, 2018, Metformin-associated prevention of weight gain in insulin-treated type 2 diabetic patients cannot be explained by decreased energy intake: a post hoc analysis of a randomized placebo-controlled 4.3-year trial, Diabetes Obes Metab, 20, 219, 10.1111/dom.13054 Steele, 2014, Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia, J Am Med Assoc, 311, 279, 10.1001/jama.2013.283980 Page, 1995, Clinical characteristics of subjects with a missense mutation in glucokinase, Diabet Med J Brit Diabetic Assoc, 12, 209, 10.1111/j.1464-5491.1995.tb00460.x Inchiostro, 1994, Evidence of higher insulin resistance in NIDDM patients with ischaemic heart disease, Diabetologia, 37, 597, 10.1007/BF00403379 Bonora, 2002, HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study, Diabetes Care, 25, 1135, 10.2337/diacare.25.7.1135 Ronnemaa, 1991, High fasting plasma insulin is an indicator of coronary heart disease in non-insulin-dependent diabetic patients and nondiabetic subjects, Arterioscler Thromb : a journal of vascular biology, 11, 80, 10.1161/01.ATV.11.1.80 Eeg-Olofsson, 2014, The triglycerides-to-HDL-cholesterol ratio and cardiovascular disease risk in obese patients with type 2 diabetes: an observational study from the Swedish National Diabetes Register (NDR), Diabetes Res Clin Pract, 106, 136, 10.1016/j.diabres.2014.07.010 Isomaa, 2001, Cardiovascular morbidity and mortality associated with the metabolic syndrome, Diabetes Care, 24, 683, 10.2337/diacare.24.4.683 Bonadonna, 2006, The metabolic syndrome is a risk indicator of microvascular and macrovascular complications in diabetes: results from Metascreen, a multicenter diabetes clinic-based survey, Diabetes Care, 29, 2701, 10.2337/dc06-0942