Insulin as an autoantigen in NOD/human diabetes

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Steptoe, 2005, Autointmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1(+) myeloid progenitor cells that differentiate in vivo into resting dendritic cells, Diabetes, 54, 434, 10.2337/diabetes.54.2.434

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Kent, 2005, Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope, Nature, 435, 224, 10.1038/nature03625

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Congia, 1998, T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin, Proc Natl Acad Sci U S A, 95, 3833, 10.1073/pnas.95.7.3833

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Rudy, 1995, Similar peptides from two β cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes, Mol Med, 1, 625, 10.1007/BF03401603

Mannering, 2005, The insulin A-chain epitope recognized by human T cells is posttranslationally modified, J Exp Med, 202, 1191, 10.1084/jem.20051251

Mallone, 2007, CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes, Diabetes, 56, 613, 10.2337/db06-1419

Pinkse, 2005, Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes, Proc Natl Acad Sci U S A, 102, 18425, 10.1073/pnas.0508621102

Toma, 2005, Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients, Proc Natl Acad Sci U S A, 102, 10581, 10.1073/pnas.0504230102

Kimura, 2001, Peptide-specific cytotoxicity of T lymphocytes against glutamic acid decarboxylase and insulin in type 1 diabetes mellitus, Diabetes Res Clin Pract, 51, 173, 10.1016/S0168-8227(00)00225-4

Hassainya, 2005, Identification of naturally processed HLA-A2-restricted proinsulin epitopes by reverse immunology, Diabetes, 54, 2053, 10.2337/diabetes.54.7.2053

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Harrison, 2004, Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes, Diab Care, 27, 2348, 10.2337/diacare.27.10.2348

Uchigata, 1993, Patients with Graves’ disease who developed insulin autoimmune syndrome (Hirata disease) possess HLA-Bw62/Cw4/DR4 carrying DRB1*0406, J Clin Endocrinol Metab, 77, 249

Uchigata, 1995, Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome, Diabetes, 44, 1227, 10.2337/diab.44.10.1227

Eapen, 2000, Insulin desensitization with insulin lispro and an insulin pump in a 5-year-old child, Ann Allergy Asthma Immunol, 85, 395, 10.1016/S1081-1206(10)62554-9

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Madero, 2006, IgG(4)-mediated allergic reaction to glargine insulin, Allergy, 61, 1022, 10.1111/j.1398-9995.2006.01117.x

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