Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient

Transplantation Reviews - Tập 32 - Trang 119-126 - 2018
Miriam Manook1,2, Jean Kwun2, Steven Sacks3, Anthony Dorling3, Nizam Mamode1, Stuart Knechtle2
1Renal and Transplant Department, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
2Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
3MRC Centre for Transplantation, King's College, London, UK

Tài liệu tham khảo

Meri, 2013, Complement activation in diseases presenting with thrombotic microangiopathy, Eur J Intern Med, 24, 496, 10.1016/j.ejim.2013.05.009 George, 2014, Syndromes of thrombotic microangiopathy, N Engl J Med, 371, 654, 10.1056/NEJMra1312353 Chiurchiu, 2002, Thrombotic microangiopathy in renal transplantation, Ann Transplant, 7, 28 Tanabe, 2002, Prospective analysis of thrombotic microangiopathy after renal transplantation: comparison between cyclosporine and tacrolimus immunosuppression, Transplant Proc, 34, 1819, 10.1016/S0041-1345(02)03089-0 Ashman, 2009, Belatacept as maintenance immunosuppression for postrenal transplant de novo drug-induced thrombotic microangiopathy, Am J Transplant, 9, 424, 10.1111/j.1600-6143.2008.02482.x Caires, 2012, De novo thrombotic microangiopathy after kidney transplantation: clinical features, treatment, and long-term patient and graft survival, Transplant Proc, 44, 2388, 10.1016/j.transproceed.2012.07.039 Hutton, 1970, Renal homotransplant rejection associated with microangiopathic haemolytic anaemia, Br Med J, 3, 87, 10.1136/bmj.3.5714.87 Pillay, 1973, Selective thrombocytopenia due to localised microangiopathy of renal allografts, Lancet, 302, 988, 10.1016/S0140-6736(73)91088-X Ikeda, 2016, Two cases of kidney transplantation-associated thrombotic microangiopathy successfully treated with eculizumab, Nephrology (Carlton), 10.1111/nep.12768 Wu, 2015, The inferior impact of antibody-mediated rejection on the clinical outcome of kidney allografts which develop de novo thrombotic microangiopathy, Clin Transplant Kerr, 2012, Complement-mediated injury and protection of endothelium: lessons from atypical haemolytic uraemic syndrome, Immunobiology, 217, 195, 10.1016/j.imbio.2011.07.028 Williams, 2016, Pathology consultation on the diagnosis and treatment of thrombotic microangiopathies (TMAs), Am J Clin Pathol, 145, 158, 10.1093/ajcp/aqv086 Ho, 2005, Blood and marrow transplant clinical trials network toxicity committee consensus summary: thrombotic microangiopathy after hematopoietic stem cell transplantation, Biol Blood Marrow Transplant, 11, 571, 10.1016/j.bbmt.2005.06.001 Chua, 2015, Complement factor C4d is a common denominator in thrombotic microangiopathy, J Am Soc Nephrol, 26, 2239, 10.1681/ASN.2014050429 Satoskar, 2010, De novo thrombotic microangiopathy in renal allograft biopsies-role of antibody-mediated rejection, Am J Transplant, 10, 1804, 10.1111/j.1600-6143.2010.03178.x McCall, 2003, Prognostic significance of microvascular thrombosis in donor kidney allograft biopsies, Transplantation, 75, 1847, 10.1097/01.TP.0000063126.88887.68 Soares, 2016, Successful renal transplantation of deceased donor kidneys with 100% glomerular fibrin thrombi and acute renal failure due to disseminated intravascular coagulation, Transplantation Meehan, 2011, Thrombotic microangiopathy and peritubular capillary C4d expression in renal allograft biopsies, Clin J Am Soc Nephrol, 6, 395, 10.2215/CJN.05870710 Haas, 2014, Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions, Am J Transplant, 14, 272, 10.1111/ajt.12590 Haas, 2016, The revised (2013) Banff classification for antibody-mediated rejection of renal allografts: update, difficulties, and future considerations, Am J Transplant, 16, 1352, 10.1111/ajt.13661 Ezzelarab, 2006, Extended coagulation profiles of healthy baboons and of baboons rejecting GT-KO pig heart grafts, Xenotransplantation, 13, 522, 10.1111/j.1399-3089.2006.00342.x Lin, 2009, Coagulation dysregulation as a barrier to xenotransplantation in the primate, Transpl Immunol, 21, 75, 10.1016/j.trim.2008.10.008 Ezzelarab, 2011, Thrombocytopenia after pig-to-baboon liver xenotransplantation: where do platelets go?, Xenotransplantation, 18, 320, 10.1111/j.1399-3089.2011.00679.x Ekser, 2012, Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation, Transpl Int, 25, 882, 10.1111/j.1432-2277.2012.01506.x Cooper, 2016, The pathobiology of pig-to-primate xenotransplantation: a historical review, Xenotransplantation Orandi, 2016, Splenic irradiation for the treatment of severe antibody-mediated rejection, Am J Transplant, 10.1111/ajt.13882 Garg, 2017, Defining the phenotype of antibody-mediated rejection in kidney transplantation: advances in diagnosis of antibody injury, Transplant Rev, 31, 257, 10.1016/j.trre.2017.08.005 Zhu, 2005, The ancient origin of the complement system, EMBO J, 24, 382, 10.1038/sj.emboj.7600533 Rose, 2000, Venular thrombosis is the key event in the pathogenesis of antibody-mediated cardiac rejection, Xenotransplantation, 7, 31, 10.1034/j.1399-3089.2000.00042.x Walport, 2001, Complement. First of two parts, N Engl J Med, 344, 1058, 10.1056/NEJM200104053441406 Walport, 2001, Complement. Second of two parts, N Engl J Med, 344, 1140, 10.1056/NEJM200104123441506 Ricklin, 2016, Complement in disease: a defence system turning offensive, Nat Rev Nephrol, 12, 383, 10.1038/nrneph.2016.70 Chowdhury, 2003, Complement in renal transplantation, Nephron Clin Pract, 95, c3, 10.1159/000073012 Janeway, 2001 Kemper, 2003, Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype, Nature, 421, 388, 10.1038/nature01315 Marsh, 2001, The allogeneic T and B cell response is strongly dependent on complement components C3 and C4, Transplantation, 72, 1310, 10.1097/00007890-200110150-00022 Pratt, 2002, Local synthesis of complement component C3 regulates acute renal transplant rejection, Nat Med, 8, 582, 10.1038/nm0602-582 Galvan, 2012, C1q and phagocytosis: the perfect complement to a good meal, J Leukoc Biol, 92, 489, 10.1189/jlb.0212099 Nonaka, 2014, Evolution of the complement system, Subcell Biochem, 80, 31, 10.1007/978-94-017-8881-6_3 Posma, 2016, Coagulation and non-coagulation effects of thrombin, J Thromb Haemost, 10.1111/jth.13441 Navarro-Alvarez, 2016, The effects of exogenous administration of human coagulation factors following pig-to-baboon liver xenotransplantation, Am J Transplant, 16, 1715, 10.1111/ajt.13647 Lintner, 2016, Early components of the complement classical activation pathway in human systemic autoimmune diseases, Front Immunol, 7, 36, 10.3389/fimmu.2016.00036 Thomas, 2015, An anti-C1s monoclonal, TNT003, inhibits complement activation induced by antibodies against HLA, Am J Transplant, 15, 2037, 10.1111/ajt.13273 Yamakuchi, 2007, Antibody to human leukocyte antigen triggers endothelial exocytosis, Proc Natl Acad Sci U S A, 104, 1301, 10.1073/pnas.0602035104 Naemi, 2013, Anti-donor HLA class I antibodies: pathways to endothelial cell activation and cell-mediated allograft rejection, Transplantation, 96, 258, 10.1097/TP.0b013e3182985504 Kaplanski, 1998, Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106), Blood, 92, 1259, 10.1182/blood.V92.4.1259 Hamer, 2012, Human leukocyte antigen-specific antibodies and gamma-interferon stimulate human microvascular and glomerular endothelial cells to produce complement factor C4, Transplantation, 93, 867, 10.1097/TP.0b013e31824b3762 Naji, 2005, Induction of tissue factor expression on human umbilical vein endothelial cells by cell-specific HLA class I antibody: preliminary data, Transplant Proc, 37, 2892, 10.1016/j.transproceed.2005.08.001 Ruggeri, 2007, The role of von Willebrand factor in thrombus formation, Thromb Res, 120, S5, 10.1016/j.thromres.2007.03.011 Nightingale, 2013, The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story, J Thromb Haemost, 11, 192, 10.1111/jth.12225 van Schie, 2011, Genetic determinants of von Willebrand factor levels and activity in relation to the risk of cardiovascular disease: a review, J Thromb Haemost, 9, 899, 10.1111/j.1538-7836.2011.04243.x Sonneveld, 2014, Von Willebrand factor and ADAMTS13 in arterial thrombosis: a systematic review and meta-analysis, Blood Rev, 28, 167, 10.1016/j.blre.2014.04.003 Bendapudi, 2015, Impact of severe ADAMTS13 deficiency on clinical presentation and outcomes in patients with thrombotic microangiopathies: the experience of the Harvard TMA Research Collaborative, Br J Haematol, 171, 836, 10.1111/bjh.13658 Huber-Lang, 2017, Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions, Semin Immunopathol Huber-Lang, 2006, Generation of C5a in the absence of C3: a new complement activation pathway, Nat Med, 12, 682, 10.1038/nm1419 Foley, 2016, Complement activation in arterial and venous thrombosis is mediated by plasmin, EBioMedicine, 5, 175, 10.1016/j.ebiom.2016.02.011 Krisinger, 2012, Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway, Blood, 120, 1717, 10.1182/blood-2012-02-412080 Peerschke, 2008, Platelet mediated complement activation, Adv Exp Med Biol, 632, 81 Hattori, 1989, Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface, J Biol Chem, 264, 9053, 10.1016/S0021-9258(18)81901-9 Noone, 2016, Von Willebrand factor regulates complement on endothelial cells, Kidney Int, 90, 123, 10.1016/j.kint.2016.03.023 Sis, 2009, Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining, Am J Transplant, 9, 2312, 10.1111/j.1600-6143.2009.02761.x Lidington, 2000, Induction of decay-accelerating factor by thrombin through a protease-activated receptor 1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury, Blood, 96, 2784, 10.1182/blood.V96.8.2784 Lidington, 2005, A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated induction of decay-accelerating factor on human endothelial cells, Am J Physiol Cell Physiol, 289, C1437, 10.1152/ajpcell.00502.2004 Carson, 1990, Consecutive enzyme cascades: complement activation at the cell surface triggers increased tissue factor activity, Blood, 76, 361, 10.1182/blood.V76.2.361.361 Ikeda, 1997, C5a induces tissue factor activity on endothelial cells, Thromb Haemost, 77, 394, 10.1055/s-0038-1655974 Hamilton, 1990, Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex, J Biol Chem, 265, 3809, 10.1016/S0021-9258(19)39666-8 Sims, 1988, Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity, J Biol Chem, 263, 18205, 10.1016/S0021-9258(19)81346-7 Rataj, 2016, Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation, Xenotransplantation, 23, 117, 10.1111/xen.12218 Krarup, 2007, Simultaneous activation of complement and coagulation by MBL-associated serine protease 2, PLoS One, 2, 10.1371/journal.pone.0000623 Hess, 2012, Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation, PLoS One, 7, 10.1371/journal.pone.0035690 Gulla, 2010, Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot, Immunology, 129, 482, 10.1111/j.1365-2567.2009.03200.x Kozarcanin, 2016, The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation, J Thromb Haemost, 14, 531, 10.1111/jth.13208 Cugno, 2001, In vitro interaction of C1-inhibitor with thrombin, Blood Coagul Fibrinolysis, 12, 253, 10.1097/00001721-200106000-00005 Caccia, 2011, Interaction of C1 inhibitor with thrombin on the endothelial surface, Blood Coagul Fibrinolysis, 22, 571, 10.1097/MBC.0b013e3283494ba7 Davis, 2004, Biological effects of C1 inhibitor, Drug News Perspect, 17, 439, 10.1358/dnp.2004.17.7.863703 van der Graaf, 1983, Inactivation of kallikrein in human plasma, J Clin Invest, 71, 149, 10.1172/JCI110743 Paran, 2005, Venous and arterial thrombosis following administration of intravenous immunoglobulins, Blood Coagul Fibrinolysis, 16, 313, 10.1097/01.mbc.0000172694.85233.a8 Pusey, 2012, Plasmapheresis in immunologic renal disease, Blood Purif, 33, 190, 10.1159/000334155 Montgomery, 2016, Plasma-derived C1 esterase inhibitor for acute antibody-mediated rejection following kidney transplantation: results of a randomized double-blind placebo-controlled pilot study, Am J Transplant, 10.1111/ajt.13871 Wang, 2007, Inhibition of terminal complement components in presensitized transplant recipients prevents antibody-mediated rejection leading to long-term graft survival and accommodation, J Immunol, 179, 4451, 10.4049/jimmunol.179.7.4451 Stegall, 2011, Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients, Am J Transplant, 11, 2405, 10.1111/j.1600-6143.2011.03757.x Cornell, 2015, Positive crossmatch kidney transplant recipients treated with eculizumab: outcomes beyond 1 year, Am J Transplant, 15, 1293, 10.1111/ajt.13168 Tillou, 2010, Recombinant human C1-inhibitor prevents acute antibody-mediated rejection in alloimmunized baboons, Kidney Int, 78, 152, 10.1038/ki.2010.75 Vangerow, 2001, C1-Inhibitor for treatment of acute vascular xenograft rejection in cynomolgus recipients of h-DAF transgenic porcine kidneys, Xenotransplantation, 8, 266, 10.1034/j.1399-3089.2001.00130.x Fiane, 1999, C1-inhibitor attenuates hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig-to-human perfusion model, Immunopharmacology, 42, 231, 10.1016/S0162-3109(99)00008-9 Caliezi, 2002, C1-inhibitor in patients with severe sepsis and septic shock: beneficial effect on renal dysfunction, Crit Care Med, 30, 1722, 10.1097/00003246-200208000-00008 Vo, 2015, A phase I/II placebo-controlled trial of C1-inhibitor for prevention of antibody-mediated rejection in HLA sensitized patients, Transplantation, 99, 299, 10.1097/TP.0000000000000592 Ito, 2016, Possible efficacy of recombinant human soluble thrombomodulin for the treatment of thrombotic microangiopathy after liver transplantation, Liver Transpl, 22, 689, 10.1002/lt.24411 Ito, 2016, Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases, Expert Opin Ther Targets, 20, 151, 10.1517/14728222.2016.1086750 Karegli, 2016, Thrombalexins: cell-localized inhibition of thrombin and its effects in a model of high-risk renal transplantation, Am J Transplant Burghuber, 2016, Antibody-mediated rejection in sensitized nonhuman primates: modeling human biology, Am J Transplant, 16, 1726, 10.1111/ajt.13688 Manook, 2017, Thrombalexin: use of a cytotopic anticoagulant to reduce thrombotic microangiopathy in a highly sensitized model of kidney transplantation, Am J Transplant, 10.1111/ajt.14234 Kassimatis, 2017, A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial, Trials, 18, 255, 10.1186/s13063-017-1972-x Ekdahl, 2015, Thromboinflammation in therapeutic medicine, Adv Exp Med Biol, 865, 3, 10.1007/978-3-319-18603-0_1