Innate immunity, hemostasis and matrix remodeling: PTX3 as a link

Seminars in Immunology - Tập 28 - Trang 570-577 - 2016
Andrea Doni1, Cecilia Garlanda1,2, Alberto Mantovani1,2
1Istituto Clinico Humanitas IRCCS, via Manzoni 113, 20089 Rozzano, Italy
2Humanitas University, via Manzoni 113, 20089 Rozzano, Italy

Tài liệu tham khảo

Dushay, 2009, Insect hemolymph clotting, Cell. Mol. Life Sci.: CMLS, 66, 2643, 10.1007/s00018-009-0036-0 Hanington, 2011, The primary role of fibrinogen-related proteins in invertebrates is defense, not coagulation, J. Innate Immun., 3, 17, 10.1159/000321882 Holmskov, 2003, Collections and ficolins: humoral lectins of the innate immune defense, Annu. Rev. Immunol., 21, 547, 10.1146/annurev.immunol.21.120601.140954 Engelmann, 2013, Thrombosis as an intravascular effector of innate immunity, Nat. Rev. Immunol., 13, 34, 10.1038/nri3345 Levi, 2004, Bidirectional relation between inflammation and coagulation, Circulation, 109, 2698, 10.1161/01.CIR.0000131660.51520.9A Nurden, 2011, Platelets, inflammation and tissue regeneration, Thromb. Haemost., 105, S13, 10.1160/THS10-11-0720 Medzhitov, 2008, Origin and physiological roles of inflammation, Nature, 454, 428, 10.1038/nature07201 Yeaman, 2014, Platelets: at the nexus of antimicrobial defence, Nat. Rev. Microbiol., 12, 426, 10.1038/nrmicro3269 Semple, 2011, Platelets and the immune continuum, Nat. Rev. Immunol., 11, 264, 10.1038/nri2956 Fitzgerald, 2006, The interaction of bacterial pathogens with platelets, Nat. Rev. Microbiol., 4, 445, 10.1038/nrmicro1425 Foster, 2005, Immune evasion by staphylococci, Nat. Rev. Microbiol., 3, 948, 10.1038/nrmicro1289 Tsuruta, 2007, Involvement of vitronectin in lipopolysaccaride-induced acute lung injury, J. Immunol., 179, 7079, 10.4049/jimmunol.179.10.7079 Millien, 2013, Cleavage of fibrinogen by proteinases elicits allergic responses through toll-like receptor 4, Science, 341, 792, 10.1126/science.1240342 Wong, 2013, Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance, Nat. Immunol., 14, 785, 10.1038/ni.2631 He, 2004, The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens, Nat. Immunol., 5, 88, 10.1038/ni1021 Gerold, 2008, A toll-like receptor 2-integrin beta3 complex senses bacterial lipopeptides via vitronectin, Nat. Immunol., 9, 761, 10.1038/ni.1618 Schack, 2009, Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin, J. Immunol., 182, 6943, 10.4049/jimmunol.0900065 Salonen, 1984, Binding of fibronectin by the acute phase reactant C-reactive protein, JBC, 259, 1496, 10.1016/S0021-9258(17)43435-1 Doni, 2016, Humoral innate immunity at the crossroad between microbe and matrix recognition: the role of PTX3 in tissue damage, Semin. Cell Dev. Biol., 10.1016/j.semcdb.2016.07.026 Entwistle, 1988, C1q component of complement binds to fibrinogen and fibrin, Biochemistry, 27, 507, 10.1021/bi00401a073 Endo, 2010, Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway, J. Innate Immun., 2, 33, 10.1159/000227805 Tseng, 1989, The effect of human C-reactive protein on the cell-attachment activity of fibronectin and laminin, Exp. Cell Res., 180, 303, 10.1016/0014-4827(89)90059-1 Zahedi, 1996, Characterization of the binding of serum amyloid P to type IV collagen, JBC, 271, 14897, 10.1074/jbc.271.25.14897 Zahedi, 1997, Characterization of the binding of serum amyloid P to laminin, JBC, 272, 2143, 10.1074/S0021-9258(19)78482-8 Bottazzi, 2010, An integrated view of humoral innate immunity: pentraxins as a paradigm, Annu. Rev. Immunol., 28, 157, 10.1146/annurev-immunol-030409-101305 Ma, 2009, Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition, JBC, 284, 28263, 10.1074/jbc.M109.009225 Ma, 2013, Ficolin-1-PTX3 complex formation promotes clearance of altered self-cells and modulates IL-8 production, J. Immunol., 191, 1324, 10.4049/jimmunol.1300382 Ma, 2011, Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system, JBC, 286, 3405, 10.1074/jbc.M110.190637 Gout, 2011, M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules, J. Immunol., 186, 5815, 10.4049/jimmunol.1100180 Wasylnka, 2000, Adhesion of Aspergillus species to extracellular matrix proteins: evidence for involvement of negatively charged carbohydrates on the conidial surface, IAI, 68, 3377, 10.1128/IAI.68.6.3377-3384.2000 Flick, 2013, Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia, Blood, 121, 1783, 10.1182/blood-2012-09-453894 Ko, 2013, Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface, PLoS Pathog., 9, e1003816, 10.1371/journal.ppat.1003816 Singh, 2010, Vitronectin in bacterial pathogenesis: a host protein used in complement escape and cellular invasion, Mol. Microbiol., 78, 545, 10.1111/j.1365-2958.2010.07373.x Dejana, 1985, Interaction between fibrinogen and cultured endothelial cells: induction of migration and specific binding, JCI, 75, 11, 10.1172/JCI111661 Ploplis, 1995, Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice, Circulation, 92, 2585, 10.1161/01.CIR.92.9.2585 Gladysheva, 2003, Coevolutionary patterns in plasminogen activation, PNAS, 100, 9168, 10.1073/pnas.1631716100 Sun, 2004, Plasminogen is a critical host pathogenicity factor for group A streptococcal infection, Science, 305, 1283, 10.1126/science.1101245 Sodeinde, 1992, A surface protease and the invasive character of plague, Science, 258, 1004, 10.1126/science.1439793 Berri, 2013, Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis, PLoS Pathog., 9, e1003229, 10.1371/journal.ppat.1003229 Zaas, 2008, Plasminogen alleles influence susceptibility to invasive aspergillosis, PLoS Gen., 4, e1000101, 10.1371/journal.pgen.1000101 Mullarky, 2005, Infection-stimulated fibrin deposition controls hemorrhage and limits hepatic bacterial growth during listeriosis, IAI, 73, 3888, 10.1128/IAI.73.7.3888-3895.2005 Szaba, 2002, Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo, Blood, 99, 1053, 10.1182/blood.V99.3.1053 Ruf, 1995, Platelet-induced neutrophil activation: platelet-expressed fibrinogen induces the oxidative burst in neutrophils by an interaction with CD11C/CD18, BJH, 90, 791, 10.1111/j.1365-2141.1995.tb05197.x Flick, 2004, Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo, JCI, 113, 1596, 10.1172/JCI20741 Luo, 2011, Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica, J. Immunol., 187, 1866, 10.4049/jimmunol.1101094 Cohen, 2002, The immunopathogenesis of sepsis, Nature, 420, 885, 10.1038/nature01326 Niessen, 2008, Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation, Nature, 452, 654, 10.1038/nature06663 Sambrano, 2001, Role of thrombin signalling in platelets in haemostasis and thrombosis, Nature, 413, 74, 10.1038/35092573 Mantovani, 1992, Cytokine regulation of endothelial cell function, FASEB J., 6, 2591, 10.1096/fasebj.6.8.1592209 Coughlin, 2000, Thrombin signalling and protease-activated receptors, Nature, 407, 258, 10.1038/35025229 Antoniak, 2013, PAR-1 contributes to the innate immune response during viral infection, JCI, 123, 1310, 10.1172/JCI66125 Pawlinski, 2004, Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia, Blood, 103, 1342, 10.1182/blood-2003-09-3051 Taylor, 1987, Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon, JCI, 79, 918, 10.1172/JCI112902 Geisbert, 2003, Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys, Lancet, 362, 1953, 10.1016/S0140-6736(03)15012-X Begonja, 2005, Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway, Blood, 106, 2757, 10.1182/blood-2005-03-1047 Wachowicz, 2002, Generation of reactive oxygen species in blood platelets, Platelets, 13, 175, 10.1080/09533710022149395 Johansson, 2011, Platelet and neutrophil responses to Gram positive pathogens in patients with bacteremic infection, PLoS One, 6, e26928, 10.1371/journal.pone.0026928 Clark, 2007, Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood, Nat. Med., 13, 463, 10.1038/nm1565 Sreeramkumar, 2014, Neutrophils scan for activated platelets to initiate inflammation, Science, 346, 1234, 10.1126/science.1256478 Ohlenschlaeger, 2004, Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus, NEJM, 351, 260, 10.1056/NEJMoa033122 Oikonomopoulou, 2012, Interactions between coagulation and complement–their role in inflammation, Semin. Immunopathol., 34, 151, 10.1007/s00281-011-0280-x Del Conde, 2005, Platelet activation leads to activation and propagation of the complement system, JEM, 201, 871, 10.1084/jem.20041497 Huber-Lang, 2006, Generation of C5a in the absence of C3: a new complement activation pathway, Nat. Med., 12, 682, 10.1038/nm1419 Ghebrehiwet, 1983, Mechanisms of activation of the classical pathway of complement by Hageman factor fragment, JCI, 71, 1450, 10.1172/JCI110898 Blasi, 2002, uPAR: a versatile signalling orchestrator, Nat. Rev. Mol. Cell Biol., 3, 932, 10.1038/nrm977 Carmeliet, 1994, Physiological consequences of loss of plasminogen activator gene function in mice, Nature, 368, 419, 10.1038/368419a0 Rijneveld, 2002, Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia, J. Immunol., 168, 3507, 10.4049/jimmunol.168.7.3507 Syrovets, 2012, Plasmin as a proinflammatory cell activator, JLB, 92, 509 Das, 2014, Plasminogen promotes macrophage phagocytosis in mice, Blood, 124, 679, 10.1182/blood-2014-01-549659 Guo, 2008, Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis, Arthritis Rheum., 58, 764, 10.1002/art.23263 Kwiecinski, 2010, Activation of plasminogen by staphylokinase reduces the severity of Staphylococcus aureus systemic infection, J. Infect. Dis., 202, 1041, 10.1086/656140 Guo, 2011, Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice, PLoS One, 6, e24774, 10.1371/journal.pone.0024774 Rakoff-Nahoum, 2009, Toll-like receptors and cancer, Nat. Rev. Cancer, 9, 57, 10.1038/nrc2541 Brown, 1988, Fibronectin receptors of phagocytes: characterization of the Arg-Gly-Asp binding proteins of human monocytes and polymorphonuclear leukocytes, JEM, 167, 777, 10.1084/jem.167.3.777 Garnotel, 1995, The binding of type I collagen to lymphocyte function-associated antigen (LFA) 1 integrin triggers the respiratory burst of human polymorphonuclear neutrophils. Role of calcium signaling and tyrosine phosphorylation of LFA 1, JBC, 270, 27495, 10.1074/jbc.270.46.27495 Byrd, 2013, An extracellular matrix-based mechanism of rapid neutrophil extracellular trap formation in response to Candida albicans, J. Immunol., 190, 4136, 10.4049/jimmunol.1202671 Clark, 2001, Fibrin and wound healing, Ann. N. Y. Acad. Sci., 936, 355, 10.1111/j.1749-6632.2001.tb03522.x Mazzucco, 2010, Platelet-derived factors involved in tissue repair-from signal to function, Transfus. Med. Rev., 24, 218, 10.1016/j.tmrv.2010.03.004 Singer, 1999, Cutaneous wound healing, NEJM, 341, 738, 10.1056/NEJM199909023411006 Drew, 2001, Wound-healing defects in mice lacking fibrinogen, Blood, 97, 3691, 10.1182/blood.V97.12.3691 Xu, 2010, Factor VII deficiency impairs cutaneous wound healing in mice, Mol. Med., 16, 167, 10.2119/molmed.2009.00171 Hoffman, 2006, Cutaneous wound healing is impaired in hemophilia B, Blood, 108, 3053, 10.1182/blood-2006-05-020495 Carney, 1992, Role of high-affinity thrombin receptors in postclotting cellular effects of thrombin, Semin. Thromb. Hemost., 18, 91, 10.1055/s-2007-1002414 Golebiewska, 2015, Platelet secretion: from haemostasis to wound healing and beyond, Blood Rev., 29, 153, 10.1016/j.blre.2014.10.003 Blair, 2009, Platelet alpha-granules: basic biology and clinical correlates, Blood Rev., 23, 177, 10.1016/j.blre.2009.04.001 Peterson, 1999, Expression of thrombomodulin and consequences of thrombomodulin deficiency during healing of cutaneous wounds, Am. J. Pathol., 155, 1569, 10.1016/S0002-9440(10)65473-9 Chen, 2013, Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis, FASEB J., 27, 4520, 10.1096/fj.13-227561 Howell, 2001, Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis, Am. J. Pathol., 159, 1383, 10.1016/S0002-9440(10)62525-4 Yasui, 2001, Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse, Am. J. Respir. Crit. Care Med., 163, 1660, 10.1164/ajrccm.163.7.9911068 Gieseler, 2013, Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact, Cell Commun. Signal., 11, 86, 10.1186/1478-811X-11-86 Chambers, 2003, Role of coagulation cascade proteases in lung repair and fibrosis, Eur. Respir. J. Suppl., 44, 33s, 10.1183/09031936.03.00001003 Fiorucci, 2004, PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation, Hepatology, 39, 365, 10.1002/hep.20054 Romer, 1996, Impaired wound healing in mice with a disrupted plasminogen gene, Nat. Med., 2, 287, 10.1038/nm0396-287 Bugge, 1996, Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency, Cell, 87, 709, 10.1016/S0092-8674(00)81390-2 Ghosh, 2012, PAI-1 in tissue fibrosis, J. Cell. Physiol., 227, 493, 10.1002/jcp.22783 de Giorgio-Miller, 2005, Fibrin-induced skin fibrosis in mice deficient in tissue plasminogen activator, Am. J. Pathol., 167, 721, 10.1016/S0002-9440(10)62046-9 Bottazzi, 2016, The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling, J. Hepatol., 64, 1416, 10.1016/j.jhep.2016.02.029 Mantovani, 2008, Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3, J. Clin. Immunol., 28, 1, 10.1007/s10875-007-9126-7 Du Clos, 2011, Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcgamma receptors, Curr. Opin. Organ Transplant., 16, 15, 10.1097/MOT.0b013e32834253c7 Pepys, 2003, C-reactive protein: a critical update, JCI, 111, 1805, 10.1172/JCI200318921 Mantovani, 2013, The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules, Ann. N. Y. Acad. Sci., 1285, 1, 10.1111/nyas.12043 Emsley, 1994, Structure of pentameric human serum amyloid P component, Nature, 367, 338, 10.1038/367338a0 Lu, 2008, Structural recognition and functional activation of FcgammaR by innate pentraxins, Nature, 456, 989, 10.1038/nature07468 Casas, 2008, C-reactive protein and coronary heart disease: a critical review, J. Intern. Med., 264, 295, 10.1111/j.1365-2796.2008.02015.x Botto, 1997, Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene, Nat. Med., 3, 855, 10.1038/nm0897-855 Ng, 2007, C-reactive protein collaborates with plasma lectins to boost immune response against bacteria, EMBO J., 26, 3431, 10.1038/sj.emboj.7601762 Garlanda, 2005, Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility, Annu. Rev. Immunol., 23, 337, 10.1146/annurev.immunol.23.021704.115756 Jaillon, 2007, The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps, JEM, 204, 793, 10.1084/jem.20061301 Jaillon, 2014, The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection, Immunity, 40, 621, 10.1016/j.immuni.2014.02.015 Bonavita, 2015, PTX3 is an extrinsic oncosuppressor regulating complement-Dependent inflammation in cancer, Cell, 160, 700, 10.1016/j.cell.2015.01.004 Doni, 2015, An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode, JEM, 212, 905, 10.1084/jem.20141268 Han, 2005, TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK, J. Immunol., 175, 8303, 10.4049/jimmunol.175.12.8303 Lopez, 2014, Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing, Thromb. Haemost., 112, 992, 10.1160/TH14-01-0034 Garlanda, 2002, Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response, Nature, 420, 182, 10.1038/nature01195 Cunha, 2014, Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation, NEJM, 370, 421, 10.1056/NEJMoa1211161 Cunha, 2015, PTX3-Based genetic testing for risk of aspergillosis after lung transplant, Clin. Infect. Dis., 61, 1893, 10.1093/cid/civ679 Magrini, 2016, The dual complexity of PTX3 in health and disease: a balancing act, Trends Mol. Med., 22, 497, 10.1016/j.molmed.2016.04.007 Jeannin, 2005, Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors, Immunity, 22, 551, 10.1016/j.immuni.2005.03.008 Moalli, 2011, The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa, J. Immunol., 186, 5425, 10.4049/jimmunol.1002035 Bozza, 2006, Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation, Blood, 108, 3387, 10.1182/blood-2006-03-009266 Reading, 2008, Antiviral activity of the long chain pentraxin PTX3 against influenza viruses, J. Immunol., 180, 3391, 10.4049/jimmunol.180.5.3391 Moalli, 2010, Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus, Blood, 116, 5170, 10.1182/blood-2009-12-258376 Olesen, 2007, DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans, Genes Immun., 8, 456, 10.1038/sj.gene.6364410 Chiarini, 2010, PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients, Genes Immun., 11, 665, 10.1038/gene.2010.41 Foo, 2015, Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation, PLoS path., 11, e1004649, 10.1371/journal.ppat.1004649 Daigo, 2014, The yin-yang of long pentraxin PTX3 in inflammation and immunity, Immunol. Lett., 161, 38, 10.1016/j.imlet.2014.04.012 Dias, 2001, TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis, JLB, 69, 928 Salio, 2008, Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction, Circulation, 117, 1055, 10.1161/CIRCULATIONAHA.107.749234 Lech, 2013, Endogenous and exogenous pentraxin-3 limits postischemic acute and chronic kidney injury, Kidney Int., 83, 647, 10.1038/ki.2012.463 Han, 2012, Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice, Lab. Invest., 92, 1285, 10.1038/labinvest.2012.92 Deban, 2010, Regulation of leukocyte recruitment by the long pentraxin PTX3, Nat. Immunol., 11, 328, 10.1038/ni.1854 Doni, 2012, Interactions of the humoral pattern recognition molecule PTX3 with the complement system, Immunobiology, 217, 1122, 10.1016/j.imbio.2012.07.004 Roumenina, 2006, Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains, Biochemistry, 45, 4093, 10.1021/bi052646f Deban, 2008, Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation, J. Immunol., 181, 8433, 10.4049/jimmunol.181.12.8433 Braunschweig, 2011, Human pentraxin 3 binds to the complement regulator c4b-binding protein, PLoS One, 6, e23991, 10.1371/journal.pone.0023991 Wang, 2011, Aberrant methylation of the 3q25 tumor suppressor gene PTX3 in human esophageal squamous cell carcinoma, World J. Gastroenterol., 17, 4225, 10.3748/wjg.v17.i37.4225 Tsuji, 2016, Network-based analysis for identification of candidate genes for colorectal cancer progression, Biochem. Biophys. Res. Commun., 476, 534, 10.1016/j.bbrc.2016.05.158 Cappuzzello, 2016, Mesenchymal stromal cell-derived PTX3 promotes wound healing via fibrin remodeling, J. Invest. Dermatol., 136, 293, 10.1038/JID.2015.346 Bonacina, 2016, Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation, Biochim. Biophys. Acta, 1862, 1182, 10.1016/j.bbadis.2016.03.007 Xiao, 2014, Pentraxin 3 inhibits acute renal injury-induced interstitial fibrosis through suppression of IL-6/Stat3 pathway, Inflammation, 37, 1895, 10.1007/s10753-014-9921-2 Rodriguez-Grande, 2014, The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury, J. Cereb. Blood Flow Metab., 34, 480, 10.1038/jcbfm.2013.224 Ying, 2016, Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells, Sci. Rep., 6, 29385, 10.1038/srep29385 Law, 2012, The X-ray crystal structure of full-length human plasminogen, Cell Rep., 1, 185, 10.1016/j.celrep.2012.02.012 Pilling, 2014, Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice, PLoS One, 9, e93730, 10.1371/journal.pone.0093730 Cox, 2015, DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice, PNAS, 112, 8385, 10.1073/pnas.1500956112 Dillingh, 2013, Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis, Pulm. Pharmacol. Ther., 26, 672, 10.1016/j.pupt.2013.01.008