Innate Immunity toAspergillusSpecies

Clinical Microbiology Reviews - Tập 22 Số 4 - Trang 535-551 - 2009
Stacy J. Park1, Borna Mehrad2
1Department of Microbiology
2Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia 22908

Tóm tắt

SUMMARYAll humans are continuously exposed to inhaledAspergillusconidia, yet healthy hosts clear the organism without developing disease and without the development of antibody- or cell-mediated acquired immunity to this organism. This suggests that for most healthy humans, innate immunity is sufficient to clear the organism. A failure of these defenses results in a uniquely diverse set of illnesses caused byAspergillusspecies, which includes diseases caused by the colonization of the respiratory tract, invasive infection, and hypersensitivity. A key concept in immune responses toAspergillusspecies is that the susceptibilities of the host determine the morphological form, antigenic structure, and physical location of the fungus. In this review, we summarize the current literature on the multiple layers of innate defenses againstAspergillusspecies that dictate the outcome of this host-microbe interaction.

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Clinical Microbiology Reviews

Tập 22 Số 4

535-551

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