Injurious mechanical ventilation causes kidney apoptosis and dysfunction during sepsis but not after intra-tracheal acid instillation: an experimental study

Jan Willem Kuiper1, AB Johan Groeneveld2, Jack J. Haitsma3, Lonneke Smeding4, Mark P.V. Begieneman5, Serge Jothy6, Rosanna Vaschetto7, Frans B. Plötz8
1Department of Paediatric Intensive Care, Erasmus MC – Sophia Children’s Hospital, Dr. Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
2Department of Intensive Care, Erasmus Medical Center, Rotterdam, The Netherlands
3The Keenan Research Centre at the Li Ka Shing Knowledge Institute of St. Michael’s Hospital and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
4Department of Pediatrics and Pediatric Intensive Care, VU Medical Center, Amsterdam. Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
5Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
6Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto,Toronto, Ontario, Canada
7Departments of Anesthesiology and Critical Care Medicine, Università del Piemonte Orientale “A. Avogadro” Alessandria-Novara-Vercelli, Viale Teresa Michel, 11, Alessandria, Italy
8Department of Pediatrics, Tergooiziekenhuizen, Blaricum, The Netherlands

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