Injectable hypoxia-preconditioned cartilage progenitor cells-laden GelMA microspheres system for enhanced osteoarthritis treatment

Latourte, 2020, Emerging pharmaceutical therapies for osteoarthritis, Nat. Rev. Rheumatol., 16, 673, 10.1038/s41584-020-00518-6 Hodgkinson, 2022, Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis, Nat. Rev. Rheumatol., 18, 67, 10.1038/s41584-021-00724-w Zheng, 2021, The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis, Ageing Res. Rev., 66, 10.1016/j.arr.2020.101249 Peng, 2021, The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration, Biomaterials, 268, 10.1016/j.biomaterials.2020.120555 Gao, 2022, Overcoming barriers for intra-articular delivery of disease-modifying osteoarthritis drugs, Trends Pharmacol. Sci., 43, 171, 10.1016/j.tips.2021.12.004 Lee, 2014, Clinical translation of stem cells: insight for cartilage therapies, Crit. Rev. Biotechnol., 34, 89, 10.3109/07388551.2013.823596 Ma, 2018, Different sources of stem cells and their application in cartilage tissue engineering, Curr. Stem Cell Res. Ther., 13, 568, 10.2174/1574888X13666180122151909 Kangari, 2020, Mesenchymal stem cells: amazing remedies for bone and cartilage defects, Stem Cell Res. Ther., 11, 492, 10.1186/s13287-020-02001-1 Jessop, 2020, Isolation and characterisation of nasoseptal cartilage stem/progenitor cells and their role in the chondrogenic niche, Stem Cell Res. Ther., 11, 177, 10.1186/s13287-020-01663-1 Mantripragada, 2019, Native-osteoarthritic joint resident stem and progenitor cells for cartilage cell-based therapies: a quantitative comparison with respect to concentration and biological performance, Am. J. Sports Med., 47, 3521, 10.1177/0363546519880905 Vinod, 2021, Comparison of the efficiency of laminin versus fibronectin as a differential adhesion assay for isolation of human articular cartilage derived chondroprogenitors, Connect. Tissue Res., 62, 427, 10.1080/03008207.2020.1761344 Vinod, 2021, Pondering the potential of hyaline cartilage-derived chondroprogenitors for tissue regeneration: a systematic review, Cartilage, 13, 34S, 10.1177/1947603520951631 Kim, 2022 Levato, 2017, The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells, Acta Biomater., 61, 41, 10.1016/j.actbio.2017.08.005 Xue, 2019, Cartilage progenitor cells combined with PHBV in cartilage tissue engineering, J. Transl. Med., 17, 104, 10.1186/s12967-019-1855-x Zhang, 2017, Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury, Neurochem. Int., 111, 69, 10.1016/j.neuint.2016.08.003 Han, 2022, Three-dimensional-cultured MSC-derived exosome-hydrogel hybrid microneedle array patch for spinal cord repair, Nano Lett., 22, 6391, 10.1021/acs.nanolett.2c02259 Lee, 2022, 3D spheroid cultures of stem cells and exosome applications for cartilage repair, Life, 12, 10.3390/life12070939 Gara, 2022, 3D culturing of human pluripotent stem cells-derived endothelial cells for vascular regeneration, Theranostics, 12, 4684, 10.7150/thno.69938 Yuan, 2022, Adipose-derived stromal/stem cells are verified to be potential seed candidates for bio-root regeneration in three-dimensional culture, Stem Cell Res. Ther., 13, 234, 10.1186/s13287-022-02907-y Cui, 2023, Nanoengineered hydrogels as 3D biomimetic extracellular matrix with injectable and sustained delivery capability for cartilage regeneration, Bioact. Mater., 19, 487 Xie, 2022, Three-dimensional culture and chondrogenic differentiation of mesenchymal stem cells in interconnected collagen scaffolds, Biomed. Mater., 17, 10.1088/1748-605X/ac61f9 Bogers, 2022, Three-dimensional culture of equine bone marrow-derived mesenchymal stem cells enhances anti-inflammatory properties in a donor-dependent manner, Stem Cell. Dev., 31, 777, 10.1089/scd.2022.0074 Yang, 2022, Hypoxia-conditioned mesenchymal stem cells in tissue regeneration application, Tissue Eng. B Rev., 28, 966, 10.1089/ten.teb.2021.0145 Carmona, 2022, Hypoxia preconditioning increases the ability of healthy but not diabetic rat-derived adipose stromal/stem cells (ASC) to improve histological lesions of streptozotocin-induced diabetic nephropathy, Pathol. Res. Pract., 230, 10.1016/j.prp.2021.153756 Archacka, 2021, Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration, Stem Cell Res. Ther., 12, 448, 10.1186/s13287-021-02530-3 Peng, 2022, Hypoxia pretreatment improves the therapeutic potential of bone marrow mesenchymal stem cells in hindlimb ischemia via upregulation of NRG-1, Cell Tissue Res., 388, 105, 10.1007/s00441-021-03562-0 Ranmuthu, 2022, Evaluating the effect of hypoxia on human adult mesenchymal stromal cell chondrogenesis in vitro: a systematic review, Int. J. Mol. Sci., 23, 10.3390/ijms232315210 Nowak-Stepniowska, 2022, Insight in hypoxia-mimetic agents as potential tools for mesenchymal stem cell priming in regenerative medicine, Stem Cell. Int., 2022 Lu, 2018, The regulation of mesenchymal stem cell therapy through magnetic resonance imaging agents-based cellular condition and oxygen environment, J. Biomed. Nanotechnol., 14, 1906, 10.1166/jbn.2018.2639 Cai, 2019, 7,8-Dihydroxyflavone activates Nrf2/HO-1 signaling pathways and protects against osteoarthritis, Exp. Ther. Med., 18, 1677 Zhou, 2022, Melatonin prevents cartilage degradation in early-stage osteoarthritis through activation of miR-146a/NRF2/HO-1 Axis, J. Bone Miner. Res., 37, 1056, 10.1002/jbmr.4527 Luo, 2022, Astaxanthin attenuates ferroptosis via Keap1-Nrf2/HO-1 signaling pathways in LPS-induced acute lung injury, Life Sci., 311 Qiu, 2022, Asiatic acid alleviates LPS-induced acute kidney injury in broilers by inhibiting oxidative stress and ferroptosis via activation of the Nrf2 pathway, Food Chem. Toxicol., 170, 10.1016/j.fct.2022.113468 Yang, 2022, Role of Nrf2 in Parkinson's disease: toward new perspectives, Front. Pharmacol., 13 Xiang, 2022, The Nrf2 antioxidant defense system in intervertebral disc degeneration: molecular insights, Exp. Mol. Med., 54, 1067, 10.1038/s12276-022-00829-6 Xue, 2020, Nomilin targets the Keap1-Nrf2 signalling and ameliorates the development of osteoarthritis, J. Cell Mol. Med., 24, 8579, 10.1111/jcmm.15484 Zhu, 2022, Ellagic acid attenuates interleukin-1beta-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, Bioengineered, 13, 9233, 10.1080/21655979.2022.2059995 Jin, 2021, Limonin inhibits IL-1beta-induced inflammation and catabolism in chondrocytes and ameliorates osteoarthritis by activating Nrf2, Oxid. Med. Cell. Longev., 2021, 10.1155/2021/7292512 Wang, 2019, Chondrogenic progenitor cells exhibit superiority over mesenchymal stem cells and chondrocytes in platelet-rich plasma scaffold-based cartilage regeneration, Am. J. Sports Med., 47, 2200, 10.1177/0363546519854219 Gu, 2022, Effects of cartilage progenitor cells, bone marrow mesenchymal stem cells and chondrocytes on cartilage repair as seed cells: an in vitro study, Drug Des. Dev. Ther., 16, 1217, 10.2147/DDDT.S356936 Wu, 2019, miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis, Biomaterials, 206, 87, 10.1016/j.biomaterials.2019.03.022 Feng, 2021, Reversing the surface charge of MSC-derived small extracellular vesicles by epsilonPL-PEG-DSPE for enhanced osteoarthritis treatment, J. Extracell. Vesicles, 10 Feng, 2019, Curcumin inhibits the PERK-eIF2alpha-CHOP pathway through promoting SIRT1 expression in oxidative stress-induced rat chondrocytes and ameliorates osteoarthritis progression in a rat model, Oxid. Med. Cell. Longev., 2019, 10.1155/2019/8574386 Feng, 2019, Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model, J. Cell. Physiol., 234, 18192, 10.1002/jcp.28452 Zhu, 2022, Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway, Chem. Biol. Drug Des., 100, 108, 10.1111/cbdd.14056 Woo, 2020, Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration, J. Extracell. Vesicles, 9 Gerwin, 2010, The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat, Osteoarthritis Cartilage, 18, S24, 10.1016/j.joca.2010.05.030 Kang, 2022, Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis, Nat. Commun., 13, 779, 10.1038/s41467-022-28385-7 Lee, 2017, Cartilage repair by mesenchymal stem cells: clinical trial update and perspectives, J Orthop Translat, 9, 76, 10.1016/j.jot.2017.03.005 Richardson, 2016, Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration, Methods, 99, 69, 10.1016/j.ymeth.2015.09.015 De Bari, 2018, Stem cell-based therapeutic strategies for cartilage defects and osteoarthritis, Curr. Opin. Pharmacol., 40, 74, 10.1016/j.coph.2018.03.009 Ansari, 2020, Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols, Biomed. Pharmacother., 129, 10.1016/j.biopha.2020.110452 Lepetsos, 2016, ROS/oxidative stress signaling in osteoarthritis, Biochim. Biophys. Acta, 1862, 576, 10.1016/j.bbadis.2016.01.003 Poulet, 2016, Targeting oxidative stress to reduce osteoarthritis, Arthritis Res. Ther., 18, 32, 10.1186/s13075-015-0908-7 Bellezza, 2018, Nrf2-Keap1 signaling in oxidative and reductive stress, Biochim. Biophys. Acta Mol. Cell Res., 1865, 721, 10.1016/j.bbamcr.2018.02.010 Ma, 2013, Role of nrf2 in oxidative stress and toxicity, Annu. Rev. Pharmacol. Toxicol., 53, 401, 10.1146/annurev-pharmtox-011112-140320 Togo, 2006, Identification of cartilage progenitor cells in the adult ear perichondrium: utilization for cartilage reconstruction, Lab. Invest., 86, 445, 10.1038/labinvest.3700409