Initial Experience With Single-Isocenter Radiosurgery to Target Multiple Brain Metastases Using an Automated Treatment Planning Software: Clinical Outcomes and Optimal Target Volume Margins Strategy

Kocher, 2011, Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952-26001 study, J Clin Oncol, 29, 134, 10.1200/JCO.2010.30.1655 Brown, 2016, Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: A randomized clinical trial, JAMA, 316, 401, 10.1001/jama.2016.9839 Grandhi, 2012, Stereotactic radiosurgery using the Leksell Gamma Knife Perfexion unit in the management of patients with 10 or more brain metastases, J Neurosurg, 117, 237, 10.3171/2012.4.JNS11870 Hunter, 2012, Treatment of five or more brain metastases with stereotactic radiosurgery, Int J Radiat Oncol Biol Phys, 83, 1394, 10.1016/j.ijrobp.2011.10.026 Yamamoto, 2014, Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): A multi-institutional prospective observational study, Lancet Oncol, 15, 387, 10.1016/S1470-2045(14)70061-0 Clark, 2010, Feasibility of single-isocenter volumetric modulated arc radiosurgery for treatment of multiple brain metastases, Int J Radiat Oncol Biol Phys, 76, 296, 10.1016/j.ijrobp.2009.05.029 Nath, 2010, Single-isocenter frameless intensity-modulated stereotactic radiosurgery for simultaneous treatment of multiple brain metastases: Clinical experience, Int J Radiat Oncol Biol Phys, 78, 91, 10.1016/j.ijrobp.2009.07.1726 Huang, 2012, SU-E-T-645: Treatment of multiple brain metastases using stereotactic radiosurgery with single-isocenter volumetric modulated arc therapy: Comparison with conventional dynamic conformal arc and static beam stereotactic radiosurgery, Med Phys, 39, 3854, 10.1118/1.4735734 Lau, 2015, Single-isocenter frameless volumetric modulated arc radiosurgery for multiple intracranial metastases, Neurosurgery, 77, 233, 10.1227/NEU.0000000000000763 Limon, 2017, Single fraction stereotactic radiosurgery for multiple brain metastases, Adv Radiat Oncol, 2, 555, 10.1016/j.adro.2017.09.002 Chang, 2018, Restricted single isocenter for multiple targets dynamic conformal arc (RSIMT DCA) technique for brain stereotactic radiosurgery (SRS) planning, J Radiosurg SBRT, 5, 145 Ruggieri, 2018, Linac-based VMAT radiosurgery for multiple brain lesions: Comparison between a conventional multi-isocenter approach and a new dedicated mono-isocenter technique, Radiat Oncol, 13, 38, 10.1186/s13014-018-0985-2 Hofmaier, 2019, Single isocenter stereotactic radiosurgery for patients with multiple brain metastases: Dosimetric comparison of VMAT and a dedicated DCAT planning tool, Radiat Oncol, 14, 103, 10.1186/s13014-019-1315-z Roper, 2015, Single-isocenter multiple-target stereotactic radiosurgery: Risk of compromised coverage, Int J Radiat Oncol Biol Phys, 93, 540, 10.1016/j.ijrobp.2015.07.2262 Morrison, 2016, Is a single isocenter sufficient for volumetric modulated arc therapy radiosurgery when multiple intracranial metastases are spatially dispersed?, Med Dosim, 41, 285, 10.1016/j.meddos.2016.06.007 Stanhope, 2016, Physics considerations for single-isocenter, volumetric modulated arc radiosurgery for treatment of multiple intracranial targets, Pract Radiat Oncol, 6, 207, 10.1016/j.prro.2015.10.010 Ezzell, 2017, The spatial accuracy of two frameless, linear accelerator-based systems for single-isocenter, multitarget cranial radiosurgery, J Appl Clin Med Phys, 18, 37, 10.1002/acm2.12044 2010 Lin, 2015, Response Assessment in Neuro-Oncology (RANO) group. Response assessment criteria for brain metastases: Proposal from the RANO group, Lancet Oncol, 16, e270, 10.1016/S1470-2045(15)70057-4 Gevaert, 2016, Evaluation of a dedicated brain metastases treatment planning optimization for radiosurgery: A new treatment paradigm?, Radiat Oncol, 11, 13, 10.1186/s13014-016-0593-y Korytko, 2006, 12 Gy gamma knife radiosurgical volume is a predictor for radiation necrosis in non-AVM intracranial tumors, Int J Radiat Oncol Biol Phys, 64, 419, 10.1016/j.ijrobp.2005.07.980 Blonigen, 2010, Irradiated volume as a predictor of brain radionecrosis after linear accelerator stereotactic radiosurgery, Int J Radiat Oncol Biol Phys, 77, 996, 10.1016/j.ijrobp.2009.06.006 Minniti, 2011, Stereotactic radiosurgery for brain metastases: Analysis of outcome and risk of brain radionecrosis, Radiat Oncol, 15, 48, 10.1186/1748-717X-6-48 Ramakrishna, 2010, A clinical comparison of patient setup and intra-fraction motion using frame-based radiosurgery versus a frameless image-guided radiosurgery system for intracranial lesions, Radiother Oncol, 95, 109, 10.1016/j.radonc.2009.12.030 Gevaert, 2012, Setup accuracy of the Novalis ExacTrac 6DOF system for frameless radiosurgery, Int J Radiat Oncol Biol Phys, 82, 1627, 10.1016/j.ijrobp.2011.01.052 Gevaert, 2013, Evaluation of the clinical usefulness for using verification images during frameless radiosurgery, Radiother Oncol, 108, 114, 10.1016/j.radonc.2013.04.018 Hartgerink, 2019, LINAC based stereotactic radiosurgery for multiple brain metastases: Guidance for clinical implementation, Acta Oncol, 58, 1275, 10.1080/0284186X.2019.1633016 Huang, 2014, Radiosurgery of multiple brain metastases with single-isocenter dynamic conformal arcs (SIDCA), Radiother Oncol, 112, 128, 10.1016/j.radonc.2014.05.009 Ruggieri, 2019, Linac-based radiosurgery for multiple brain metastases: Comparison between two mono-isocenter techniques with multiple non-coplanar arcs, Radiother Oncol, 132, 70, 10.1016/j.radonc.2018.11.014 Liu, 2020, Interinstitutional plan quality assessment of 2 linac-based, single-isocenter, multiple metastasis radiosurgery techniques, Adv Radiat Oncol, 10.1016/j.adro.2019.10.007 Torrens, 2014, Standardization of terminology in stereotactic radiosurgery: Report from the Standardization Committee of the International Leksell Gamma Knife Society: Special topic, J Neurosurg, 121, 2, 10.3171/2014.7.GKS141199 Minniti, 2020, Neurological outcome and memory performance in patients with 10 or more brain metastases treated with frameless linear accelerator (LINAC)-based stereotactic radiosurgery, J Neurooncol, 148, 47, 10.1007/s11060-020-03442-7 Palmer, 2020, Single-isocenter multitarget stereotactic radiosurgery is safe and effective in the treatment of multiple brain metastases, Adv Radiat Oncol, 5, 70, 10.1016/j.adro.2019.08.013 Thomas, 2014, Comparison of plan quality and delivery time between volumetric arc therapy (RapidArc) and Gamma Knife radiosurgery for multiple cranial metastases, Neurosurgery, 75, 409, 10.1227/NEU.0000000000000448